UY27370A1 - Derivados de benzamida tiazol y composiciones farmacéuticas para inhibir la proliferación de células y métodos para su utilización - Google Patents

Derivados de benzamida tiazol y composiciones farmacéuticas para inhibir la proliferación de células y métodos para su utilización

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Publication number
UY27370A1
UY27370A1 UY27370A UY27370A UY27370A1 UY 27370 A1 UY27370 A1 UY 27370A1 UY 27370 A UY27370 A UY 27370A UY 27370 A UY27370 A UY 27370A UY 27370 A1 UY27370 A1 UY 27370A1
Authority
UY
Uruguay
Prior art keywords
inhibit
proliferation
benzamida
tiazol
derivatives
Prior art date
Application number
UY27370A
Other languages
English (en)
Inventor
Ted Michael Bleckman
Shao Song Chu
Larry Andrew Alegria
Wesley Chong
Rohit Duvadie
Lin Li
Siegfried Reich
William H Romines
Michael Wallace
Yi Yang
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma filed Critical Agouron Pharma
Publication of UY27370A1 publication Critical patent/UY27370A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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Abstract

Los compuestos aminotiazol con benzamida mono-di / sustituidos están representados por la Fórmula (I), y se describen sus sales farmacéuticamente aceptables, metabolitos farmacéuticamente activos, y sales farmacéticamente aceptables de dichos metabolitos. Estos agentes modulan y/o inhiben la proliferación de célula y la actividad de las quinazas de proteína y son útiles como farmacéuticos para tratar malignidades y otros desórdenes.
UY27370A 2001-07-06 2002-07-04 Derivados de benzamida tiazol y composiciones farmacéuticas para inhibir la proliferación de células y métodos para su utilización UY27370A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30367901P 2001-07-06 2001-07-06
US30527401P 2001-07-13 2001-07-13

Publications (1)

Publication Number Publication Date
UY27370A1 true UY27370A1 (es) 2003-04-30

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UY27370A UY27370A1 (es) 2001-07-06 2002-07-04 Derivados de benzamida tiazol y composiciones farmacéuticas para inhibir la proliferación de células y métodos para su utilización

Country Status (13)

Country Link
US (1) US6720346B2 (es)
EP (1) EP1438046A4 (es)
JP (1) JP2005521631A (es)
AU (1) AU2002354801A1 (es)
BR (1) BR0210874A (es)
CA (1) CA2452609A1 (es)
HN (1) HN2002000156A (es)
MX (1) MXPA04000069A (es)
PA (1) PA8550101A1 (es)
PE (1) PE20030269A1 (es)
SV (1) SV2003001148A (es)
UY (1) UY27370A1 (es)
WO (1) WO2003004467A2 (es)

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CA2452609A1 (en) 2003-01-16
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