CU20210044A7 - Pirazoles como moduladores de hemoglobina - Google Patents

Pirazoles como moduladores de hemoglobina

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Publication number
CU20210044A7
CU20210044A7 CU2021000044A CU20210044A CU20210044A7 CU 20210044 A7 CU20210044 A7 CU 20210044A7 CU 2021000044 A CU2021000044 A CU 2021000044A CU 20210044 A CU20210044 A CU 20210044A CU 20210044 A7 CU20210044 A7 CU 20210044A7
Authority
CU
Cuba
Prior art keywords
modulators
pyrazole
tautomers
hbs
formula
Prior art date
Application number
CU2021000044A
Other languages
English (en)
Inventor
Shawn Cabral
Agustin Casimiro-Garcia
Ming Zhu Chen
Chulho Choi
Robert Lee Dow
Olugbeminiyi Omezia Fadeyi
Ariamala Gopalsamy
David Hepworth
Jayasankar Jasti
Lyn Howard Jones
Arjun Venkat Narayanan
Mihir Dineshkumar Parikh
David Walter Piotrowski
Lee Richard Roberts
Robinson, Jr
Hatice Gizem Yayla
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CU20210044A7 publication Critical patent/CU20210044A7/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

<p>La invención se relaciona con derivados de pirazol.</p> <p>Más particularmente la invención se relaciona con moduladores de HbS de la Fórmula (I)</p> <p>Espacio para la fórmula.</p> <p>o tautómeros de los mismos, o sales farmacéuticamente aceptables de los moduladores o tautómeros de los mismos, en donde X, Y, R² y R³ son como se definen en la descripción.</p> <p>Los moduladores de HbS son potencialmente útiles en el tratamiento de un amplio margen de trastornos, que incluyen enfermedad de células falciformes (SCD).</p>
CU2021000044A 2018-11-29 2019-11-26 Pirazoles como moduladores de hemoglobina CU20210044A7 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862772815P 2018-11-29 2018-11-29
US201962915784P 2019-10-16 2019-10-16
PCT/IB2019/060171 WO2020109994A1 (en) 2018-11-29 2019-11-26 Pyrazoles as modulators of hemoglobin

Publications (1)

Publication Number Publication Date
CU20210044A7 true CU20210044A7 (es) 2022-01-13

Family

ID=68807213

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2021000044A CU20210044A7 (es) 2018-11-29 2019-11-26 Pirazoles como moduladores de hemoglobina

Country Status (22)

Country Link
US (3) US11014908B2 (es)
EP (1) EP3886984A1 (es)
JP (1) JP2022510628A (es)
KR (1) KR20210097161A (es)
CN (1) CN113329789A (es)
AU (1) AU2019387290A1 (es)
BR (1) BR112021009057A2 (es)
CA (1) CA3121139A1 (es)
CO (1) CO2021006924A2 (es)
CR (1) CR20210284A (es)
CU (1) CU20210044A7 (es)
DO (1) DOP2021000103A (es)
EC (1) ECSP21037191A (es)
IL (1) IL283408A (es)
MA (1) MA54283A (es)
MX (1) MX2021006095A (es)
PE (1) PE20211592A1 (es)
PH (1) PH12021551035A1 (es)
SG (1) SG11202104585YA (es)
TW (2) TW202140452A (es)
UY (1) UY38488A (es)
WO (1) WO2020109994A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
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AU2019387290A1 (en) 2018-11-29 2021-05-27 Pfizer Inc. Pyrazoles as modulators of hemoglobin
WO2021148983A1 (en) 2020-01-24 2021-07-29 Pfizer Inc. Anti-e-selectin antibodies, compositions and methods of use
CN112079774A (zh) * 2020-10-17 2020-12-15 甘肃天后光学科技有限公司 软性隐形眼镜用蓝光吸收剂、其制备方法及应用方法

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CA3121139A1 (en) 2020-06-04
US20220348555A1 (en) 2022-11-03
EP3886984A1 (en) 2021-10-06
MX2021006095A (es) 2021-07-06
PE20211592A1 (es) 2021-08-18
US20200172512A1 (en) 2020-06-04
TW202140452A (zh) 2021-11-01
SG11202104585YA (en) 2021-06-29
KR20210097161A (ko) 2021-08-06
TW202033513A (zh) 2020-09-16
IL283408A (en) 2021-07-29
MA54283A (fr) 2022-03-09
JP2022510628A (ja) 2022-01-27
PH12021551035A1 (en) 2021-12-06
DOP2021000103A (es) 2021-07-30
ECSP21037191A (es) 2021-06-30
CR20210284A (es) 2021-07-09
US11702405B2 (en) 2023-07-18
CO2021006924A2 (es) 2021-06-10
BR112021009057A2 (pt) 2021-08-10
UY38488A (es) 2020-06-30
CN113329789A (zh) 2021-08-31
WO2020109994A1 (en) 2020-06-04
US12103921B2 (en) 2024-10-01
TWI736037B (zh) 2021-08-11
US20230382892A1 (en) 2023-11-30
US11014908B2 (en) 2021-05-25
AU2019387290A1 (en) 2021-05-27

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