AU2001256834A1 - Indazoles substituted with 1,1-dioxoisothiazolidine useful as inhibitors of cellproliferation - Google Patents

Indazoles substituted with 1,1-dioxoisothiazolidine useful as inhibitors of cellproliferation

Info

Publication number
AU2001256834A1
AU2001256834A1 AU2001256834A AU5683401A AU2001256834A1 AU 2001256834 A1 AU2001256834 A1 AU 2001256834A1 AU 2001256834 A AU2001256834 A AU 2001256834A AU 5683401 A AU5683401 A AU 5683401A AU 2001256834 A1 AU2001256834 A1 AU 2001256834A1
Authority
AU
Australia
Prior art keywords
dioxoisothiazolidine
inhibitors
useful
cellproliferation
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001256834A
Inventor
Sei Hyun Choi
Hyun Ho Chung
Chang Yong Hong
Kwang Yeon Hwang
Shin Wu Jeong
Jong Hyun Kim
Jin Ho Lee
Tae Sik Park
Dong Kyu Shin
Sook Kyung Yoon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LG Chem Ltd
Original Assignee
LG Chem Investment Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LG Chem Investment Co Ltd filed Critical LG Chem Investment Co Ltd
Publication of AU2001256834A1 publication Critical patent/AU2001256834A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to an indazole derivative, pharmaceutically acceptable salt, solvated product and isomer thereof substituted with 1,1-dioxoisothiazolidine which are useful as inhibitors for Cyclin Dependent Kinase(CDK). The present invention also relates to an agent for inhibiting and treating diseases involving cell proliferation, e.g., cancer, inflammation, restenosis, angiogenesis, etc. which comprises the compound of formula (1) as an active ingredient together with a pharmaceutically acceptable carrier.
AU2001256834A 2000-05-10 2001-05-10 Indazoles substituted with 1,1-dioxoisothiazolidine useful as inhibitors of cellproliferation Abandoned AU2001256834A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20000024861 2000-05-10
KR0024861 2000-05-10
PCT/KR2001/000759 WO2001085726A1 (en) 2000-05-10 2001-05-10 Indazoles substituted with 1,1-dioxoisothiazolidine useful as inhibitors of cell proliferation

Publications (1)

Publication Number Publication Date
AU2001256834A1 true AU2001256834A1 (en) 2001-11-20

Family

ID=19668316

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001256834A Abandoned AU2001256834A1 (en) 2000-05-10 2001-05-10 Indazoles substituted with 1,1-dioxoisothiazolidine useful as inhibitors of cellproliferation

Country Status (10)

Country Link
US (1) US6620831B2 (en)
EP (1) EP1280802B1 (en)
JP (1) JP2003532730A (en)
KR (1) KR100423899B1 (en)
CN (1) CN1432015A (en)
AT (1) ATE266028T1 (en)
AU (1) AU2001256834A1 (en)
CA (1) CA2408448A1 (en)
DE (1) DE60103147T2 (en)
WO (1) WO2001085726A1 (en)

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ATE494388T1 (en) 1999-01-13 2011-01-15 Univ New York State Res Found NEW METHOD FOR CREATING PROTEIN KINASE INHIBITORS
KR100423899B1 (en) * 2000-05-10 2004-03-24 주식회사 엘지생명과학 Indazoles substituted with 1,1-dioxoisothiazolidine useful as inhibitors of cell proliferation
KR100406634B1 (en) * 2001-03-12 2003-11-20 주식회사 엘지생명과학 3,5-Diaminoindazole derivatives, their preparation and their use as inhibitors for cyclin dependent kinases
US7129225B2 (en) 2001-10-22 2006-10-31 The Research Foundation Of State University Of New York Protection against and treatment of hearing loss
US7005445B2 (en) 2001-10-22 2006-02-28 The Research Foundation Of State University Of New York Protein kinase and phosphatase inhibitors and methods for designing them
DE10155075A1 (en) * 2001-11-09 2003-05-22 Merck Patent Gmbh Cyclic sulfonamides
AU2002353186A1 (en) * 2001-12-19 2003-06-30 Smithkline Beecham P.L.C. (1-h-indazol-3-yl) -amide derivatives as gsk-3 inhibitors
FR2836915B1 (en) * 2002-03-11 2008-01-11 Aventis Pharma Sa AMINOINDAZOLE DERIVATIVES, PREPARATION METHOD AND INTERMEDIATES THEREOF AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
FR2836914B1 (en) 2002-03-11 2008-03-14 Aventis Pharma Sa SUBSTITUTED INDAZOLES, COMPOSITIONS CONTAINING SAME, METHOD OF MANUFACTURE AND USE
GB0218625D0 (en) * 2002-08-10 2002-09-18 Astex Technology Ltd Pharmaceutical compounds
FR2845382A1 (en) 2002-10-02 2004-04-09 Sanofi Synthelabo INDAZOLECARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THERAPEUTICS
US7008953B2 (en) 2003-07-30 2006-03-07 Agouron Pharmaceuticals, Inc. 3, 5 Disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
US7977322B2 (en) 2004-08-20 2011-07-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
EP3219709B1 (en) * 2004-01-30 2020-03-18 Vertex Pharmaceuticals Incorporated Intermediate compound of modulators of atp-binding cassette transporters
FR2867778B1 (en) 2004-03-16 2006-06-09 Sanofi Synthelabo USE OF INDAZOLECARBOXAMIDE DERIVATIVES FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT AND PREVENTION OF MALARIA
JP5122287B2 (en) * 2004-10-07 2013-01-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング PI3 kinase
UY29149A1 (en) * 2004-10-07 2006-05-31 Boehringer Ingelheim Int TIAZOLIL-DIHIDRO-INDAZOLES
US7632854B2 (en) * 2004-11-17 2009-12-15 Pfizer Italia S.R.L. Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
US7968574B2 (en) 2004-12-28 2011-06-28 Kinex Pharmaceuticals, Llc Biaryl compositions and methods for modulating a kinase cascade
KR101328273B1 (en) 2004-12-28 2013-11-14 키넥스 파마슈티컬즈, 엘엘씨 Compositions and methods of treating cell proliferation disorders
EP2041071B1 (en) 2006-06-29 2014-06-18 Kinex Pharmaceuticals, LLC Biaryl compositions and methods for modulating a kinase cascade
US7838542B2 (en) 2006-06-29 2010-11-23 Kinex Pharmaceuticals, Llc Bicyclic compositions and methods for modulating a kinase cascade
TWI457336B (en) 2006-12-28 2014-10-21 Kinex Pharmaceuticals Llc Composition and methods for modulating a kinase cascade
US7939529B2 (en) 2007-05-17 2011-05-10 Kinex Pharmaceuticals, Llc Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof
US7935697B2 (en) 2006-12-28 2011-05-03 Kinex Pharmaceuticals, Llc Compositions for modulating a kinase cascade and methods of use thereof
UA103918C2 (en) * 2009-03-02 2013-12-10 Айерем Элелси N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators
CN102905700A (en) 2010-04-16 2013-01-30 金克斯医药品有限公司 Compositions and methods for the prevention and treatment of cancer
WO2013038390A1 (en) 2011-09-16 2013-03-21 Novartis Ag N-substituted heterocyclyl carboxamides
JP6499076B2 (en) 2012-08-30 2019-04-10 アセネックス インコーポレイテッド N- (3-Fluorobenzyl) -2- (5- (4-morpholinophenyl) pyridin-2-yl) acetamide as a Protein Tyrosine Kinase Modulator
WO2014109858A1 (en) 2013-01-14 2014-07-17 Amgen Inc. Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture
KR101661723B1 (en) * 2015-06-09 2016-10-05 계명대학교 산학협력단 Composition comprising 2-([1,1'-biphenyl]-4-yl)-N-(5-(1,1- dioxidoisothiazolidin-2-yl)-1H-indazol-3-yl)acetamide for preventing or treating uterine myoma
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy
CN113912597B (en) * 2020-07-07 2023-06-13 赛诺哈勃药业（成都）有限公司 ROR gamma inhibitor, preparation method and medical application thereof
WO2023186773A1 (en) * 2022-03-30 2023-10-05 Nerviano Medical Sciences S.R.L. Substituted 3-amino indazole derivatives as kinase inhibitors

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IN164232B (en) 1986-04-11 1989-02-04 Hoechst India
GB2216875B (en) 1988-04-06 1992-01-08 Motorola Ltd Container
GB9104136D0 (en) * 1991-02-27 1991-04-17 Merck Sharp & Dohme Therapeutic agents
FR2741881B1 (en) 1995-12-01 1999-07-30 Centre Nat Rech Scient NOVEL PURINE DERIVATIVES HAVING IN PARTICULAR ANTI-PROLIFERATIVE PRORIETES AND THEIR BIOLOGICAL APPLICATIONS
AU749750B2 (en) * 1997-02-05 2002-07-04 Warner-Lambert Company Pyrido {2,3-d} pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation
AU736979B2 (en) * 1997-04-28 2001-08-09 United States of America, represented by the Secretary, Department of Health and Human Services, The National Institutes of Health, The Cyclin dependent kinase (CDK)4 inhibitors and their use for treating cancer
EP0983249B1 (en) * 1997-05-08 2002-03-13 Pfizer Products Inc. Processes and intermediates for preparing substituted indazole derivatives
WO1999002162A1 (en) * 1997-07-12 1999-01-21 Cancer Research Campaign Technology Limited Cyclin dependent kinase inhibiting purine derivatives
HUP0004512A3 (en) * 1997-10-27 2003-01-28 Agouron Pharmaceuticals Inc La 4-aminothiazole derivatives, their preparation and their use as inhibitors of cyclin-dependent kinases
ATE355841T1 (en) * 1997-12-13 2007-03-15 Bristol Myers Squibb Co USE OF PYRAZOLO (3,4-B)PYRIDINE AS A CYCLINE-DEPENDENT KINASE INHIBITOR
KR100423899B1 (en) * 2000-05-10 2004-03-24 주식회사 엘지생명과학 Indazoles substituted with 1,1-dioxoisothiazolidine useful as inhibitors of cell proliferation

Also Published As

Publication number Publication date
EP1280802B1 (en) 2004-05-06
US20030149034A1 (en) 2003-08-07
CN1432015A (en) 2003-07-23
DE60103147T2 (en) 2005-05-04
EP1280802A1 (en) 2003-02-05
EP1280802A4 (en) 2003-06-11
KR100423899B1 (en) 2004-03-24
WO2001085726A1 (en) 2001-11-15
CA2408448A1 (en) 2001-11-15
JP2003532730A (en) 2003-11-05
ATE266028T1 (en) 2004-05-15
DE60103147D1 (en) 2004-06-09
US6620831B2 (en) 2003-09-16
KR20010103618A (en) 2001-11-23

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