TNSN98200A1 - Composes therapeutiquement actifs contenant de l'indazole en remplacement bio-isosterique du catechol leur preparation et composition pharmaceutique les contenant - Google Patents
Composes therapeutiquement actifs contenant de l'indazole en remplacement bio-isosterique du catechol leur preparation et composition pharmaceutique les contenantInfo
- Publication number
- TNSN98200A1 TNSN98200A1 TNTNSN98200A TNSN98200A TNSN98200A1 TN SN98200 A1 TNSN98200 A1 TN SN98200A1 TN TNSN98200 A TNTNSN98200 A TN TNSN98200A TN SN98200 A TNSN98200 A TN SN98200A TN SN98200 A1 TNSN98200 A1 TN SN98200A1
- Authority
- TN
- Tunisia
- Prior art keywords
- activity
- compounds
- preparation
- therapeutically active
- catechol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'INVENTION CONCERNE DES COMPOSITIONS DE MATIERE THERAPEUTIQUEMENT ACTIVES COMPRENANT DES COMPOSES INDAZOLIQUES, CES COMPOSES ET LEUR ACTIVITE THERAPEUTIQUE RESULTANT DIRECTEMENT D'UN REMPLACEMENT BIO-ISOSTERIQUE DU CATECHOL PAR L'INDAZOLE DANS UN COMPOSE CONTENANT DU CATECHOL AYANT LA MEME ACTIVITE THERAPEUTIQUE, LES SUBSTITUANTS NON-CATECHOLS ETANT LES MEMES OU ETANT HOMOLOGUES AVANT ET APRES LE REMPLACEMENT, CES COMPOSES REPONDANT A LA FORMULE (I1) OU (12). OU UN SEL PHARMACEUTIQUEMENT ACCEPTABLE DE CES COMPOSES. L'INVENTION CONCERNE EGALEMENT LA PREPARATION DE CES COMPOSES ET DES PREPARATIONS PHARMACEUTIQUES QUI LES CONTIENNENT. L'ACTIVITE THERAPEUTIQUE MISE EN JEU PEUT COMPRENDRE UNE ACTIVITE INHIBITRICE DE CHOLINESTERASE, UNE ACTIVITE α1-ANTAGONISTE ET β1 -AGONISTE ADRENERGIQUE, UNE ACTIVITE INHIBITRICE DES CANAUX Ca2+, UNE ACTIVITE ANTI-NEOPLASIQUE ET UNE ACTIVITE INHIBITRICE DE PHOSPHODIESTERASE DU TYPE IV,
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6422897P | 1997-11-04 | 1997-11-04 | |
US6402497P | 1997-11-04 | 1997-11-04 | |
US6418797P | 1997-11-04 | 1997-11-04 | |
US6419897P | 1997-11-04 | 1997-11-04 | |
US6422997P | 1997-11-04 | 1997-11-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
TNSN98200A1 true TNSN98200A1 (fr) | 2005-03-15 |
Family
ID=27535645
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNTNSN98200A TNSN98200A1 (fr) | 1997-11-04 | 1998-11-03 | Composes therapeutiquement actifs contenant de l'indazole en remplacement bio-isosterique du catechol leur preparation et composition pharmaceutique les contenant |
Country Status (29)
Country | Link |
---|---|
US (1) | US6391872B1 (fr) |
EP (1) | EP1028946A1 (fr) |
JP (1) | JP2001521926A (fr) |
CN (1) | CN1284948A (fr) |
AP (1) | AP910A (fr) |
AR (1) | AR013746A1 (fr) |
AU (1) | AU754734B2 (fr) |
BG (1) | BG104450A (fr) |
BR (1) | BR9813926A (fr) |
CA (1) | CA2309150A1 (fr) |
CZ (1) | CZ20001621A3 (fr) |
DZ (1) | DZ2640A1 (fr) |
EA (1) | EA200000488A1 (fr) |
HR (1) | HRP20000253A2 (fr) |
HU (1) | HUP0004150A3 (fr) |
ID (1) | ID23921A (fr) |
IL (1) | IL135900A0 (fr) |
IS (1) | IS5465A (fr) |
MA (1) | MA26563A1 (fr) |
NO (1) | NO20002129L (fr) |
NZ (1) | NZ503918A (fr) |
OA (1) | OA11354A (fr) |
PE (1) | PE129199A1 (fr) |
PL (1) | PL340753A1 (fr) |
SK (1) | SK6252000A3 (fr) |
TN (1) | TNSN98200A1 (fr) |
TR (1) | TR200001234T2 (fr) |
WO (1) | WO1999023077A1 (fr) |
YU (1) | YU25000A (fr) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU25400A (sh) * | 1997-11-04 | 2003-07-07 | Pfizer Products Inc. | Terapeutski aktivna jedinjenja sa indazolom |
UA71971C2 (en) | 1999-06-04 | 2005-01-17 | Agoron Pharmaceuticals Inc | Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases |
TWI262914B (en) | 1999-07-02 | 2006-10-01 | Agouron Pharma | Compounds and pharmaceutical compositions for inhibiting protein kinases |
US7141581B2 (en) | 1999-07-02 | 2006-11-28 | Agouron Pharmaceuticals, Inc. | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use |
PE20010306A1 (es) * | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
JP2001031549A (ja) * | 1999-07-14 | 2001-02-06 | Pola Chem Ind Inc | 真皮コラーゲン線維束再構築剤及びそれを含有する化粧料 |
PT1202746E (pt) * | 1999-08-12 | 2007-01-31 | Wyeth Corp | Composição contendo um nsaid e um inibidor de cinase de efgr para o tratamento de inibição pólipos do cólon e do cancro colo-rectal |
US6432979B1 (en) | 1999-08-12 | 2002-08-13 | American Cyanamid Company | Method of treating or inhibiting colonic polyps and colorectal cancer |
YU54202A (sh) | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
HN2001000008A (es) | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
US7005443B1 (en) * | 2000-03-17 | 2006-02-28 | Alcon, Inc. | 5-Hydroxy indazole derivatives for treating glaucoma |
JP2004501083A (ja) | 2000-04-18 | 2004-01-15 | アゴーロン・ファーマシューティカルズ・インコーポレイテッド | プロテインキナーゼを阻害するためのピラゾール |
CA2440842A1 (fr) | 2001-04-16 | 2002-10-24 | Eisai Co., Ltd. | Nouveau compose a base de 1h-indazoles |
DE60218497T2 (de) | 2001-09-19 | 2007-11-08 | Nycomed Gmbh | Kombination eines nsaids und eines pde-4 inhibitors |
WO2003024456A1 (fr) * | 2001-09-20 | 2003-03-27 | Eisai Co., Ltd. | Methodes de traitement et de prevention des migraines |
AU2003201149A1 (en) * | 2002-02-13 | 2003-09-04 | Koninklijke Philips Electronics N.V. | Integrated semiconductor optical device, method and apparatus for manufacturing such a device |
US7972632B2 (en) | 2003-02-28 | 2011-07-05 | Unigen Pharmaceuticals, Inc. | Identification of Free-B-Ring flavonoids as potent COX-2 inhibitors |
US7108868B2 (en) | 2002-03-22 | 2006-09-19 | Unigen Pharmaceuticals, Inc. | Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia |
US8034387B2 (en) | 2002-04-30 | 2011-10-11 | Unigen, Inc. | Formulation of a mixture of free-B-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments |
JP4723239B2 (ja) | 2002-04-30 | 2011-07-13 | ユニジェン・インコーポレーテッド | 治療剤としての遊離−b−環フラボノイド類とフラバン類との混合物の製剤 |
CN100439341C (zh) | 2002-12-02 | 2008-12-03 | 弗·哈夫曼-拉罗切有限公司 | 作为促肾上腺皮质激素释放因子拮抗剂的吲唑衍生物 |
PL378120A1 (pl) | 2003-02-14 | 2006-03-06 | Wyeth | Heterocyklilo-3-sulfonyloindazole jako ligandy 5-hydroksytryptaminy |
US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
AU2004228021B2 (en) | 2003-04-04 | 2010-09-02 | Unigen, Inc. | Formulation of dual cycloxygenase (COX) and lipoxygenase (LOX) inhibitors for mammal skin care |
US6984652B2 (en) * | 2003-09-05 | 2006-01-10 | Warner-Lambert Company Llc | Gyrase inhibitors |
JP2007523936A (ja) | 2004-02-27 | 2007-08-23 | エフ.ホフマン−ラ ロシュ アーゲー | ヘテロアリール縮合ピラゾロ誘導体 |
RU2006134022A (ru) | 2004-02-27 | 2008-04-10 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные индазола и содержащие их фармацевтические композиции |
US7844309B2 (en) * | 2004-02-27 | 2010-11-30 | Nokia Corporation | Exchangeable keymat |
BRPI0508036A (pt) | 2004-02-27 | 2007-07-17 | Hoffmann La Roche | derivados fundidos de pirazola |
US7601847B2 (en) | 2004-10-26 | 2009-10-13 | Wyeth | Preparation and purification of 4-(indazol-3-yl)phenols |
WO2006056873A2 (fr) * | 2004-11-29 | 2006-06-01 | Warner-Lambert Company Llc | Pyrazolo[3,4-b] pyridines et indazoles therapeutiques |
CA2619010C (fr) * | 2005-08-15 | 2013-10-01 | Wyeth | Derives de 3-sulfonylindazole substitues en tant que ligands de 5-hydroxytryptamine-6 |
CN101291913A (zh) * | 2005-08-15 | 2008-10-22 | 惠氏公司 | 作为5-羟色胺-6配体的吖嗪基-3-磺酰基吲唑衍生物 |
KR101011956B1 (ko) | 2005-08-25 | 2011-01-31 | 에프. 호프만-라 로슈 아게 | P38 mαp 키나아제 저해제 및 이의 사용 방법 |
EP1928866A1 (fr) | 2005-09-05 | 2008-06-11 | Ranbaxy Laboratories Limited | Indazoles substitues utilises en tant qu'inhibiteurs de phosphodiesterase de type-iv |
WO2007031838A1 (fr) | 2005-09-16 | 2007-03-22 | Ranbaxy Laboratories Limited | Pyrazolo[3,4-b]pyridines substituees en tant qu'inhibiteurs de la phosphodiesterase |
CA2628413C (fr) * | 2005-11-03 | 2014-09-23 | Allergan, Inc. | Prostaglandines et analogues utilises en tant qu'agents pour abaisser la pression intraoculaire |
AU2007206016A1 (en) | 2006-01-13 | 2007-07-26 | Wyeth | Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors |
NZ570846A (en) | 2006-01-31 | 2011-08-26 | Array Biopharma Inc | Kinase inhibitors and methods of use thereof |
EP2562168B1 (fr) | 2006-02-28 | 2014-04-16 | Dart Neuroscience (Cayman) Ltd | Pipérazines thérapeutiques en tant qu'inhibiteurs de PDE4 |
US8084485B2 (en) | 2006-03-31 | 2011-12-27 | Vitae Pharmaceuticals, Inc. | 6-(aminoalkyl)indazoles |
EP2001865A1 (fr) * | 2006-04-05 | 2008-12-17 | Wyeth a Corporation of the State of Delaware | Dérivés de sulfonyl-3-hétérocyclylindazole utilisés en tant que ligands de la 5-hydroxytryptamine-6 |
WO2007120596A1 (fr) * | 2006-04-12 | 2007-10-25 | Wyeth | DÉRIVÉS DE DIHYDRO[1,4]DIOXINO[2,3-e]INDAZOLE EN TANT QUE LIGANDS DE 5-HYDROXYTRYPTAMINE-6 |
US8012886B2 (en) * | 2007-03-07 | 2011-09-06 | Asm Assembly Materials Ltd | Leadframe treatment for enhancing adhesion of encapsulant thereto |
MX2009009793A (es) | 2007-03-14 | 2009-10-16 | Ranbaxy Lab Ltd | Derivados de pirazolo (3,4-b) piridina como inhibidores de fosfodiesterasa. |
WO2011034217A1 (fr) * | 2009-09-18 | 2011-03-24 | 株式会社Riverson | Dérivé de polyphénol et son procédé de production |
CA2799154A1 (fr) | 2010-05-12 | 2011-11-17 | Abbvie Inc. | Inhibiteurs indazoliques des kinases |
CN103709146B (zh) * | 2014-01-15 | 2015-11-25 | 中国药科大学 | 一类含苯并咪唑结构的喹啉-4-胺衍生物、其制法及医药用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0338087A4 (en) * | 1987-10-13 | 1991-07-24 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused pyrazole compounds, process for their preparation, and their medicinal use |
WO1989003385A1 (fr) * | 1987-10-13 | 1989-04-20 | Yoshitomi Pharmaceutical Industries, Ltd. | Composes de pyrazole fusionnes, procede de preparation et utilisation en medecine |
US5593997A (en) * | 1995-05-23 | 1997-01-14 | Pfizer Inc. | 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors |
AP1147A (en) * | 1996-05-03 | 2003-02-25 | Pfizer | Substituted indazole derivatives and related compounds. |
TR199900481T2 (xx) * | 1996-09-04 | 1999-06-21 | Pfizer Inc. | �ndazol t�revleri; fosfodiesteraz tip IV inhibit�rleri olarak kullan�mlar�. |
-
1998
- 1998-10-26 TR TR2000/01234T patent/TR200001234T2/xx unknown
- 1998-10-26 EP EP98947732A patent/EP1028946A1/fr not_active Withdrawn
- 1998-10-26 YU YU25000A patent/YU25000A/sh unknown
- 1998-10-26 IL IL13590098A patent/IL135900A0/xx unknown
- 1998-10-26 CN CN98812929A patent/CN1284948A/zh active Pending
- 1998-10-26 PL PL98340753A patent/PL340753A1/xx not_active Application Discontinuation
- 1998-10-26 EA EA200000488A patent/EA200000488A1/ru unknown
- 1998-10-26 WO PCT/IB1998/001710 patent/WO1999023077A1/fr not_active Application Discontinuation
- 1998-10-26 AU AU94552/98A patent/AU754734B2/en not_active Ceased
- 1998-10-26 ID IDW20000819A patent/ID23921A/id unknown
- 1998-10-26 CA CA002309150A patent/CA2309150A1/fr not_active Abandoned
- 1998-10-26 CZ CZ20001621A patent/CZ20001621A3/cs unknown
- 1998-10-26 NZ NZ503918A patent/NZ503918A/en unknown
- 1998-10-26 BR BR9813926-6A patent/BR9813926A/pt not_active IP Right Cessation
- 1998-10-26 HU HU0004150A patent/HUP0004150A3/hu unknown
- 1998-10-26 SK SK625-2000A patent/SK6252000A3/sk unknown
- 1998-10-26 US US09/381,425 patent/US6391872B1/en not_active Expired - Fee Related
- 1998-10-26 JP JP2000518952A patent/JP2001521926A/ja active Pending
- 1998-10-29 AP APAP/P/1998/001375A patent/AP910A/en active
- 1998-11-03 MA MA25332A patent/MA26563A1/fr unknown
- 1998-11-03 AR ARP980105534A patent/AR013746A1/es not_active Application Discontinuation
- 1998-11-03 DZ DZ980250A patent/DZ2640A1/fr active
- 1998-11-03 TN TNTNSN98200A patent/TNSN98200A1/fr unknown
- 1998-11-03 PE PE1998001041A patent/PE129199A1/es not_active Application Discontinuation
-
2000
- 2000-04-19 IS IS5465A patent/IS5465A/is unknown
- 2000-04-26 NO NO20002129A patent/NO20002129L/no not_active Application Discontinuation
- 2000-04-28 OA OA1200000127A patent/OA11354A/en unknown
- 2000-04-28 HR HR20000253A patent/HRP20000253A2/hr not_active Application Discontinuation
- 2000-05-17 BG BG104450A patent/BG104450A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
JP2001521926A (ja) | 2001-11-13 |
PE129199A1 (es) | 1999-12-16 |
TR200001234T2 (tr) | 2000-08-21 |
WO1999023077A1 (fr) | 1999-05-14 |
EP1028946A1 (fr) | 2000-08-23 |
AU9455298A (en) | 1999-05-24 |
HRP20000253A2 (en) | 2001-06-30 |
IL135900A0 (en) | 2001-05-20 |
NO20002129D0 (no) | 2000-04-26 |
OA11354A (en) | 2003-12-23 |
CZ20001621A3 (cs) | 2001-08-15 |
EA200000488A1 (ru) | 2000-10-30 |
US6391872B1 (en) | 2002-05-21 |
HUP0004150A3 (en) | 2001-08-28 |
AP910A (en) | 2000-12-05 |
NO20002129L (no) | 2000-07-03 |
DZ2640A1 (fr) | 2003-03-08 |
MA26563A1 (fr) | 2004-12-20 |
AP9801375A0 (en) | 1998-12-31 |
BR9813926A (pt) | 2000-09-19 |
BG104450A (en) | 2000-12-29 |
AR013746A1 (es) | 2001-01-10 |
CA2309150A1 (fr) | 1999-05-14 |
PL340753A1 (en) | 2001-02-26 |
SK6252000A3 (en) | 2001-11-06 |
IS5465A (is) | 2000-04-19 |
ID23921A (id) | 2000-05-25 |
YU25000A (sh) | 2003-12-31 |
HUP0004150A2 (hu) | 2001-05-28 |
NZ503918A (en) | 2002-03-28 |
CN1284948A (zh) | 2001-02-21 |
AU754734B2 (en) | 2002-11-21 |
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