AP910A - Indazole bioisostere replacement of catechol in therapeutically active compounds. - Google Patents
Indazole bioisostere replacement of catechol in therapeutically active compounds. Download PDFInfo
- Publication number
- AP910A AP910A APAP/P/1998/001375A AP9801375A AP910A AP 910 A AP910 A AP 910A AP 9801375 A AP9801375 A AP 9801375A AP 910 A AP910 A AP 910A
- Authority
- AP
- ARIPO
- Prior art keywords
- catechol
- indazole
- replacement
- activity
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6419897P | 1997-11-04 | 1997-11-04 | |
US6422997P | 1997-11-04 | 1997-11-04 | |
US6418797P | 1997-11-04 | 1997-11-04 | |
US6422897P | 1997-11-04 | 1997-11-04 | |
US6402497P | 1997-11-04 | 1997-11-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
AP9801375A0 AP9801375A0 (en) | 1998-12-31 |
AP910A true AP910A (en) | 2000-12-05 |
Family
ID=27535645
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
APAP/P/1998/001375A AP910A (en) | 1997-11-04 | 1998-10-29 | Indazole bioisostere replacement of catechol in therapeutically active compounds. |
Country Status (29)
Country | Link |
---|---|
US (1) | US6391872B1 (fr) |
EP (1) | EP1028946A1 (fr) |
JP (1) | JP2001521926A (fr) |
CN (1) | CN1284948A (fr) |
AP (1) | AP910A (fr) |
AR (1) | AR013746A1 (fr) |
AU (1) | AU754734B2 (fr) |
BG (1) | BG104450A (fr) |
BR (1) | BR9813926A (fr) |
CA (1) | CA2309150A1 (fr) |
CZ (1) | CZ20001621A3 (fr) |
DZ (1) | DZ2640A1 (fr) |
EA (1) | EA200000488A1 (fr) |
HR (1) | HRP20000253A2 (fr) |
HU (1) | HUP0004150A3 (fr) |
ID (1) | ID23921A (fr) |
IL (1) | IL135900A0 (fr) |
IS (1) | IS5465A (fr) |
MA (1) | MA26563A1 (fr) |
NO (1) | NO20002129L (fr) |
NZ (1) | NZ503918A (fr) |
OA (1) | OA11354A (fr) |
PE (1) | PE129199A1 (fr) |
PL (1) | PL340753A1 (fr) |
SK (1) | SK6252000A3 (fr) |
TN (1) | TNSN98200A1 (fr) |
TR (1) | TR200001234T2 (fr) |
WO (1) | WO1999023077A1 (fr) |
YU (1) | YU25000A (fr) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL340799A1 (en) * | 1997-11-04 | 2001-02-26 | Pfizer Prod Inc | Therapeutically active compounds based on a substitution of indazole bioisoster for cathechol in pde 4 inhibitors |
UA71971C2 (en) | 1999-06-04 | 2005-01-17 | Agoron Pharmaceuticals Inc | Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases |
PE20010306A1 (es) * | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
US7141581B2 (en) | 1999-07-02 | 2006-11-28 | Agouron Pharmaceuticals, Inc. | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use |
TWI262914B (en) | 1999-07-02 | 2006-10-01 | Agouron Pharma | Compounds and pharmaceutical compositions for inhibiting protein kinases |
JP2001031549A (ja) * | 1999-07-14 | 2001-02-06 | Pola Chem Ind Inc | 真皮コラーゲン線維束再構築剤及びそれを含有する化粧料 |
US6432979B1 (en) | 1999-08-12 | 2002-08-13 | American Cyanamid Company | Method of treating or inhibiting colonic polyps and colorectal cancer |
DE60031127T2 (de) * | 1999-08-12 | 2007-02-01 | Wyeth Holdings Corp. | Nsaid und egfr kinase inhibitoren enthaltende pharmazeutische formulierung zur behandlung oder inhibierung von dickdarmpolypen und kolorektalem krebs |
YU54202A (sh) | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
HN2001000008A (es) | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
US7005443B1 (en) * | 2000-03-17 | 2006-02-28 | Alcon, Inc. | 5-Hydroxy indazole derivatives for treating glaucoma |
AU2001249865A1 (en) | 2000-04-18 | 2001-10-30 | Agouron Pharmaceuticals, Inc. | Pyrazoles for inhibiting protein kinase |
DE60234510D1 (de) | 2001-04-16 | 2010-01-07 | Eisai R&D Man Co Ltd | 1h-indazolverbindungen die jnk hemmen |
AU2002337105B2 (en) | 2001-09-19 | 2008-03-20 | Takeda Gmbh | Combination of a NSAID and a PDE-4 inhibitor |
WO2003024456A1 (fr) * | 2001-09-20 | 2003-03-27 | Eisai Co., Ltd. | Methodes de traitement et de prevention des migraines |
JP2005518097A (ja) * | 2002-02-13 | 2005-06-16 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 集積半導体光学装置並びにこのような装置を製造する方法及び装置 |
US7108868B2 (en) | 2002-03-22 | 2006-09-19 | Unigen Pharmaceuticals, Inc. | Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia |
US7972632B2 (en) | 2003-02-28 | 2011-07-05 | Unigen Pharmaceuticals, Inc. | Identification of Free-B-Ring flavonoids as potent COX-2 inhibitors |
NZ535988A (en) | 2002-04-30 | 2005-09-30 | Unigen Pharmaceuticals Inc | Formulation of a mixture of free-B-ring flavonoids and flavans as a therapeutic agent |
US8034387B2 (en) | 2002-04-30 | 2011-10-11 | Unigen, Inc. | Formulation of a mixture of free-B-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments |
ES2309368T3 (es) | 2002-12-02 | 2008-12-16 | F. Hoffmann-La Roche Ag | Derivados de indazol como antagonista del crf. |
KR20050101551A (ko) | 2003-02-14 | 2005-10-24 | 와이어쓰 | 5-하이드록시트립타민-6 리간드로서의헤테로사이클릴-3-설포닐인다졸 |
US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
CA2521429A1 (fr) * | 2003-04-04 | 2004-10-21 | Unigen Pharmaceuticals, Inc. | Formulation destinee a inhiber la cyclooxygenase (cox) et la lipoxygenase (lox) utilisee dans les soins cutanes |
US6984652B2 (en) * | 2003-09-05 | 2006-01-10 | Warner-Lambert Company Llc | Gyrase inhibitors |
CA2557268A1 (fr) | 2004-02-27 | 2005-09-15 | F. Hoffmann-La Roche Ag | Derives d'indazole et compositions pharmaceutiques renfermant ceux-ci |
US7844309B2 (en) * | 2004-02-27 | 2010-11-30 | Nokia Corporation | Exchangeable keymat |
KR100843526B1 (ko) | 2004-02-27 | 2008-07-03 | 에프. 호프만-라 로슈 아게 | 피라졸의 접합 유도체 |
BRPI0508220A (pt) | 2004-02-27 | 2007-07-17 | Hoffmann La Roche | derivados de pirazol heteroarila fundidos |
US7601847B2 (en) | 2004-10-26 | 2009-10-13 | Wyeth | Preparation and purification of 4-(indazol-3-yl)phenols |
KR20070094747A (ko) * | 2004-11-29 | 2007-09-21 | 워너-램버트 캄파니 엘엘씨 | 치료용 피라졸로[3,4-b]피리딘 및 인다졸 |
AU2006291414A1 (en) * | 2005-08-15 | 2007-03-22 | Wyeth | Azinyl-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands |
CN101282938A (zh) * | 2005-08-15 | 2008-10-08 | 惠氏公司 | 作为5-羟色胺-6配体的经取代3-磺酰基吲唑衍生物 |
CN101243088B (zh) | 2005-08-25 | 2011-06-29 | 霍夫曼-拉罗奇有限公司 | p38 MAP激酶抑制剂及使用它的方法 |
WO2007029077A1 (fr) * | 2005-09-05 | 2007-03-15 | Ranbaxy Laboratories Limited | Indazoles substitues utilises en tant qu'inhibiteurs de phosphodiesterase de type-iv |
WO2007031838A1 (fr) | 2005-09-16 | 2007-03-22 | Ranbaxy Laboratories Limited | Pyrazolo[3,4-b]pyridines substituees en tant qu'inhibiteurs de la phosphodiesterase |
AU2006311942B2 (en) * | 2005-11-03 | 2012-11-22 | Allergan, Inc. | Prostaglandins and analogues as agents for lowering intraocular pressure |
US7645752B2 (en) | 2006-01-13 | 2010-01-12 | Wyeth Llc | Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors |
CN101415685B (zh) | 2006-01-31 | 2011-08-24 | 阿雷生物药品公司 | 激酶抑制剂及其使用方法 |
JP2009528363A (ja) | 2006-02-28 | 2009-08-06 | ヘリコン セラピューティクス,インコーポレイテッド | Pde4インヒビターとしての治療用ピペラジン |
WO2007120523A2 (fr) * | 2006-03-31 | 2007-10-25 | Vitae Pharmaceuticals, Inc. | 6-(aminoalkyl)indazoles |
JP2009532471A (ja) * | 2006-04-05 | 2009-09-10 | ワイス | 5−ヒドロキシトリプタミン−6リガンドとしてのスルホニル−3−ヘテロシクリルインダゾール誘導体 |
WO2007120596A1 (fr) * | 2006-04-12 | 2007-10-25 | Wyeth | DÉRIVÉS DE DIHYDRO[1,4]DIOXINO[2,3-e]INDAZOLE EN TANT QUE LIGANDS DE 5-HYDROXYTRYPTAMINE-6 |
US8012886B2 (en) * | 2007-03-07 | 2011-09-06 | Asm Assembly Materials Ltd | Leadframe treatment for enhancing adhesion of encapsulant thereto |
PT2124944E (pt) | 2007-03-14 | 2012-05-17 | Ranbaxy Lab Ltd | Derivados de pirazolo[3,4-b]piridina como inibidores de fosfodiesterase |
WO2011034217A1 (fr) * | 2009-09-18 | 2011-03-24 | 株式会社Riverson | Dérivé de polyphénol et son procédé de production |
JP2013526542A (ja) | 2010-05-12 | 2013-06-24 | アッヴィ・インコーポレイテッド | キナーゼのインダゾール阻害薬 |
CN103709146B (zh) * | 2014-01-15 | 2015-11-25 | 中国药科大学 | 一类含苯并咪唑结构的喹啉-4-胺衍生物、其制法及医药用途 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0338087A1 (fr) * | 1987-10-13 | 1989-10-25 | Yoshitomi Pharmaceutical Industries, Ltd. | Composes de pyrazole fusionnes, procede de preparation et utilisation en medecine |
US5593997A (en) * | 1995-05-23 | 1997-01-14 | Pfizer Inc. | 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989003385A1 (fr) * | 1987-10-13 | 1989-04-20 | Yoshitomi Pharmaceutical Industries, Ltd. | Composes de pyrazole fusionnes, procede de preparation et utilisation en medecine |
AP1147A (en) * | 1996-05-03 | 2003-02-25 | Pfizer | Substituted indazole derivatives and related compounds. |
AU724549B2 (en) * | 1996-09-04 | 2000-09-28 | Pfizer Inc. | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) |
-
1998
- 1998-10-26 EP EP98947732A patent/EP1028946A1/fr not_active Withdrawn
- 1998-10-26 PL PL98340753A patent/PL340753A1/xx not_active Application Discontinuation
- 1998-10-26 HU HU0004150A patent/HUP0004150A3/hu unknown
- 1998-10-26 CZ CZ20001621A patent/CZ20001621A3/cs unknown
- 1998-10-26 NZ NZ503918A patent/NZ503918A/en unknown
- 1998-10-26 ID IDW20000819A patent/ID23921A/id unknown
- 1998-10-26 IL IL13590098A patent/IL135900A0/xx unknown
- 1998-10-26 SK SK625-2000A patent/SK6252000A3/sk unknown
- 1998-10-26 US US09/381,425 patent/US6391872B1/en not_active Expired - Fee Related
- 1998-10-26 TR TR2000/01234T patent/TR200001234T2/xx unknown
- 1998-10-26 YU YU25000A patent/YU25000A/sh unknown
- 1998-10-26 AU AU94552/98A patent/AU754734B2/en not_active Ceased
- 1998-10-26 BR BR9813926-6A patent/BR9813926A/pt not_active IP Right Cessation
- 1998-10-26 WO PCT/IB1998/001710 patent/WO1999023077A1/fr not_active Application Discontinuation
- 1998-10-26 JP JP2000518952A patent/JP2001521926A/ja active Pending
- 1998-10-26 EA EA200000488A patent/EA200000488A1/ru unknown
- 1998-10-26 CN CN98812929A patent/CN1284948A/zh active Pending
- 1998-10-26 CA CA002309150A patent/CA2309150A1/fr not_active Abandoned
- 1998-10-29 AP APAP/P/1998/001375A patent/AP910A/en active
- 1998-11-03 MA MA25332A patent/MA26563A1/fr unknown
- 1998-11-03 DZ DZ980250A patent/DZ2640A1/fr active
- 1998-11-03 PE PE1998001041A patent/PE129199A1/es not_active Application Discontinuation
- 1998-11-03 TN TNTNSN98200A patent/TNSN98200A1/fr unknown
- 1998-11-03 AR ARP980105534A patent/AR013746A1/es not_active Application Discontinuation
-
2000
- 2000-04-19 IS IS5465A patent/IS5465A/is unknown
- 2000-04-26 NO NO20002129A patent/NO20002129L/no not_active Application Discontinuation
- 2000-04-28 HR HR20000253A patent/HRP20000253A2/hr not_active Application Discontinuation
- 2000-04-28 OA OA1200000127A patent/OA11354A/en unknown
- 2000-05-17 BG BG104450A patent/BG104450A/xx unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0338087A1 (fr) * | 1987-10-13 | 1989-10-25 | Yoshitomi Pharmaceutical Industries, Ltd. | Composes de pyrazole fusionnes, procede de preparation et utilisation en medecine |
US5593997A (en) * | 1995-05-23 | 1997-01-14 | Pfizer Inc. | 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors |
Also Published As
Publication number | Publication date |
---|---|
US6391872B1 (en) | 2002-05-21 |
AR013746A1 (es) | 2001-01-10 |
AU754734B2 (en) | 2002-11-21 |
SK6252000A3 (en) | 2001-11-06 |
MA26563A1 (fr) | 2004-12-20 |
AP9801375A0 (en) | 1998-12-31 |
OA11354A (en) | 2003-12-23 |
EP1028946A1 (fr) | 2000-08-23 |
CN1284948A (zh) | 2001-02-21 |
AU9455298A (en) | 1999-05-24 |
TNSN98200A1 (fr) | 2005-03-15 |
JP2001521926A (ja) | 2001-11-13 |
YU25000A (sh) | 2003-12-31 |
BR9813926A (pt) | 2000-09-19 |
NZ503918A (en) | 2002-03-28 |
DZ2640A1 (fr) | 2003-03-08 |
PE129199A1 (es) | 1999-12-16 |
EA200000488A1 (ru) | 2000-10-30 |
BG104450A (en) | 2000-12-29 |
HUP0004150A3 (en) | 2001-08-28 |
HRP20000253A2 (en) | 2001-06-30 |
PL340753A1 (en) | 2001-02-26 |
CZ20001621A3 (cs) | 2001-08-15 |
TR200001234T2 (tr) | 2000-08-21 |
CA2309150A1 (fr) | 1999-05-14 |
IS5465A (is) | 2000-04-19 |
NO20002129L (no) | 2000-07-03 |
NO20002129D0 (no) | 2000-04-26 |
IL135900A0 (en) | 2001-05-20 |
WO1999023077A1 (fr) | 1999-05-14 |
HUP0004150A2 (hu) | 2001-05-28 |
ID23921A (id) | 2000-05-25 |
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