AP832A - 3-Tetrahydrofuran and tetrohydropyrinol ephynolsporens and analogues. - Google Patents

3-Tetrahydrofuran and tetrohydropyrinol ephynolsporens and analogues. Download PDF

Info

Publication number
AP832A
AP832A APAP/P/1991/000305A AP9100305A AP832A AP 832 A AP832 A AP 832A AP 9100305 A AP9100305 A AP 9100305A AP 832 A AP832 A AP 832A
Authority
AP
ARIPO
Prior art keywords
carboxylate
tetrahydrofuran
ceph
compound
aminothiazol
Prior art date
Application number
APAP/P/1991/000305A
Other languages
English (en)
Other versions
AP9100305A0 (en
Inventor
John Hargreaves Bateson
Stephen Christopher Martin Fell
George Burton
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909016189A external-priority patent/GB9016189D0/en
Priority claimed from GB919109540A external-priority patent/GB9109540D0/en
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of AP9100305A0 publication Critical patent/AP9100305A0/xx
Application granted granted Critical
Publication of AP832A publication Critical patent/AP832A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
APAP/P/1991/000305A 1990-07-24 1991-07-22 3-Tetrahydrofuran and tetrohydropyrinol ephynolsporens and analogues. AP832A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909016189A GB9016189D0 (en) 1990-07-24 1990-07-24 Novel compounds
GB919109540A GB9109540D0 (en) 1991-05-02 1991-05-02 Novel compounds

Publications (2)

Publication Number Publication Date
AP9100305A0 AP9100305A0 (en) 1991-07-31
AP832A true AP832A (en) 2000-05-03

Family

ID=26297372

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1991/000305A AP832A (en) 1990-07-24 1991-07-22 3-Tetrahydrofuran and tetrohydropyrinol ephynolsporens and analogues.

Country Status (26)

Country Link
EP (2) EP0540609B1 (fi)
JP (2) JPH05509089A (fi)
KR (1) KR100189075B1 (fi)
CN (2) CN1061046C (fi)
AP (1) AP832A (fi)
AT (1) ATE185567T1 (fi)
AU (1) AU648329B2 (fi)
CA (2) CA2087967C (fi)
CZ (1) CZ6493A3 (fi)
DE (2) DE69131714T2 (fi)
DK (1) DK0540609T3 (fi)
ES (1) ES2137162T3 (fi)
FI (1) FI930270A (fi)
GR (1) GR3031711T3 (fi)
HU (1) HUT63628A (fi)
IE (1) IE912569A1 (fi)
IL (1) IL98909A0 (fi)
LU (1) LU91290I2 (fi)
MX (1) MX9100317A (fi)
MY (1) MY106399A (fi)
NL (1) NL300249I2 (fi)
NO (1) NO930226L (fi)
NZ (1) NZ239061A (fi)
PT (1) PT98426A (fi)
WO (2) WO1992001696A1 (fi)
YU (1) YU129691A (fi)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9125645D0 (en) * 1991-12-03 1992-01-29 Smithkline Beecham Plc Novel compounds
DE69331047T2 (de) * 1992-01-22 2002-03-21 Pfizer Inc., New York 2-isocephem und -oxacephemderivate,verfahren zu deren herstellung, deren zwischenprodukte und verwendung als antibakterielle mittel
GB9212609D0 (en) * 1992-06-13 1992-07-29 Smithkline Beecham Plc Novel compounds
GB9213567D0 (en) * 1992-06-26 1992-08-12 Smithkline Beecham Plc Novel compounds
GB9424847D0 (en) * 1994-12-09 1995-02-08 Smithkline Beecham Plc Novel process
GB2300856A (en) * 1995-05-16 1996-11-20 Pfizer Ltd Beta-lactam preparation
AU4398297A (en) * 1996-10-02 1998-04-24 Daiichi Pharmaceutical Co., Ltd. Method for esterifying carboxylic compounds
FR2776292B1 (fr) 1998-03-20 2004-09-10 Oncopharm Cephalotaxanes porteurs de chaine laterale et leur procede de synthese
GB0019124D0 (en) 2000-08-03 2000-09-27 Pfizer Novel process
JP2004515503A (ja) * 2000-12-04 2004-05-27 ファイザー・プロダクツ・インク セファロスポリン系抗生物質の製造のために有用な方法及びエステル誘導体
PL362144A1 (en) * 2000-12-04 2004-10-18 Pfizer Products Inc. Coupling process and intermediates useful for preparing cephalosphorins
US7378408B2 (en) * 2001-11-30 2008-05-27 Pfizer Inc. Methods of treatment and formulations of cephalosporin
KR100710555B1 (ko) 2001-12-04 2007-04-24 에스케이 주식회사 광학적으로 순수한 (ｒ)-폼 또는 (ｓ)-폼의테트라히드로퓨라닐 케톤의 제조방법
SG11201402826YA (en) 2011-12-22 2014-12-30 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
EA027929B1 (ru) 2012-05-25 2017-09-29 Янссен Сайенсиз Айрлэнд Юси Нуклеозиды на основе урацила и спирооксетана
SG11201504554UA (en) 2012-12-21 2015-07-30 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
CN105254648B (zh) * 2015-11-13 2018-04-03 广东温氏大华农生物科技有限公司 一种头孢维星及其钠盐的合成方法
GB2575261B (en) 2018-07-02 2022-03-09 Norbrook Lab Ltd Intermediates in the synthesis of C3-substituted cephalosporins
CN112638944A (zh) 2018-08-23 2021-04-09 西进公司 抗tigit抗体
TW202128675A (zh) 2019-12-06 2021-08-01 美商維泰克斯製藥公司 作為鈉通道調節劑之經取代四氫呋喃
JP7429799B2 (ja) 2020-02-18 2024-02-08 ギリアード サイエンシーズ， インコーポレイテッド 抗ウイルス化合物
TWI775313B (zh) 2020-02-18 2022-08-21 美商基利科學股份有限公司 抗病毒化合物
TW202322824A (zh) 2020-02-18 2023-06-16 美商基利科學股份有限公司 抗病毒化合物
CN111620893B (zh) * 2020-06-08 2021-12-14 重庆医药高等专科学校 C-3位四氢呋喃取代的头孢菌素-铁载体耦合物及其制备方法和应用
EP4323362A1 (en) 2021-04-16 2024-02-21 Gilead Sciences, Inc. Methods of preparing carbanucleosides using amides
PE20241335A1 (es) 2021-06-04 2024-07-03 Vertex Pharma N-(hidroxialquil (hetero)aril) tetrahidrofurano carboxamidas como moduladores de canales de sodio
US12116380B2 (en) 2021-08-18 2024-10-15 Gilead Sciences, Inc. Phospholipid compounds and methods of making and using the same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2300009A1 (de) * 1971-12-31 1973-07-12 Roussel Uclaf Verfahren zur herstellung neuer cephalosporinderivate sowie die erhaltenen produkte
GB1385831A (en) * 1972-05-05 1975-03-05 Hoechst Ag Acylamino-cephem-carboxylic acids and process for their preparation
EP0075805A1 (en) * 1981-09-18 1983-04-06 Kyowa Hakko Kogyo Co., Ltd Beta-lactam compound and a pharmaceutical composition containing the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2197573A1 (en) * 1972-09-07 1974-03-29 Roussel Uclaf 7-substd-phenylacetamido-cephalosporin derivs - - antibiotics active against streptococci and staphylococci
BE791160A (fr) * 1972-01-03 1973-05-09 Beecham Group Ltd Nouveaux cephemes substitues
BE791161A (fr) * 1972-01-03 1973-05-09 Beecham Group Ltd Procede pour la preparation d'analogues des cephalosporines
GB8821797D0 (en) * 1988-09-16 1988-10-19 Beecham Group Plc Novel compounds
ES2121745T3 (es) * 1989-03-30 1998-12-16 Pfizer Cefalosporinas y sus homologos, procedimiento para su preparacion y composiciones farmaceuticas.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2300009A1 (de) * 1971-12-31 1973-07-12 Roussel Uclaf Verfahren zur herstellung neuer cephalosporinderivate sowie die erhaltenen produkte
GB1385831A (en) * 1972-05-05 1975-03-05 Hoechst Ag Acylamino-cephem-carboxylic acids and process for their preparation
EP0075805A1 (en) * 1981-09-18 1983-04-06 Kyowa Hakko Kogyo Co., Ltd Beta-lactam compound and a pharmaceutical composition containing the same

Also Published As

Publication number Publication date
KR100189075B1 (ko) 1999-06-01
KR930701456A (ko) 1993-06-11
CA2087967A1 (en) 1992-01-25
ES2137162T3 (es) 1999-12-16
ATE185567T1 (de) 1999-10-15
CZ6493A3 (en) 1994-04-13
FI930270A (fi) 1993-03-22
HUT63628A (en) 1993-09-28
IL98909A0 (en) 1992-07-15
EP0540609B1 (en) 1999-10-13
NO930226L (no) 1993-03-23
IE912569A1 (en) 1992-01-29
NL300249I1 (nl) 2007-02-01
FI930270A0 (fi) 1993-01-22
NZ239061A (en) 1993-11-25
MY106399A (en) 1995-05-30
NO930226D0 (no) 1993-01-22
AP9100305A0 (en) 1991-07-31
PT98426A (pt) 1992-05-29
AU8222491A (en) 1992-02-18
GR3031711T3 (en) 2000-02-29
HU9300177D0 (en) 1993-04-28
WO1992001695A1 (en) 1992-02-06
JPH05509089A (ja) 1993-12-16
NL300249I2 (en) 2007-02-01
DE69131714D1 (de) 1999-11-18
DE122006000065I2 (de) 2007-09-13
MX9100317A (es) 1992-02-28
CA2359744C (en) 2007-02-13
JPH05509305A (ja) 1993-12-22
EP0540609A1 (en) 1993-05-12
EP0540606A1 (en) 1993-05-12
CN1111410C (zh) 2003-06-18
CN1223859A (zh) 1999-07-28
DK0540609T3 (da) 1999-12-27
YU129691A (sh) 1994-01-20
WO1992001696A1 (en) 1992-02-06
DE69131714T2 (de) 2000-02-24
CN1061046C (zh) 2001-01-24
CA2359744A1 (en) 1992-02-06
LU91290I2 (fr) 2007-01-22
AU648329B2 (en) 1994-04-21
CN1060469A (zh) 1992-04-22
DE122006000065I1 (de) 2007-03-01
CA2087967C (en) 2002-09-10
JP2851428B2 (ja) 1999-01-27

Similar Documents

Publication Publication Date Title
AP832A (en) 3-Tetrahydrofuran and tetrohydropyrinol ephynolsporens and analogues.
EP0395219B1 (en) Cephalosporins and their homologues, process for their preparation and pharmaceutical compositions
US5064649A (en) Cephalosporin derivatives
EP0265185A2 (en) Cephalosporins, processes for their preparation and pharmaceutical compositions containing them
US6077952A (en) Cephaloporins and homologues
US5578591A (en) 2-isocephem and oxacephem derivatives, and use as antibacterial agents
US5158946A (en) Cephalosporin derivatives and pharmaceutical compositions
EP0548186B1 (en) Cephalosporin derivatives and their homologues
US6020329A (en) Cephaloporins and homologues, preparations and pharmaceutical compositions
EP0287734A1 (en) 2-Beta-substituted methyl-penam derivatives
US6080855A (en) 2-isocephem and oxacephem derivatives and use as antibacterial agents
EP0644886A1 (en) 3-substituted carbacephems
EP0416810A2 (en) Cephalosporin compounds, process for their preparation, pharmaceutical compositions and intermediates
US5602117A (en) Cephalosporin compounds
EP0293532A1 (en) 6- or 7-beta-[2-[4-(substituted)-2,3-dioxopiperazin-1-yl) carbonylamino]-(substituted)acetamido]-penicillin and cephalosporin derivatives
EP0354757A2 (en) Cephalosporins and homologous compounds, process for their preparation and pharmaceutical compositions containing them
AP199A (en) Novel B-Lactam and a novel class cephalosporins.
EP0689540A1 (en) Carbacephalosporin compound, their preparation and use
EP0521887A1 (en) Cephalosporins, process for their preparation and pharmaceutical compositions containing them
EP0389178A2 (en) Acrylamido-penicillanic-acid derivatives
IE904401A1 (en) Novel compounds