ES2121745T3 - Cefalosporinas y sus homologos, procedimiento para su preparacion y composiciones farmaceuticas. - Google Patents

Cefalosporinas y sus homologos, procedimiento para su preparacion y composiciones farmaceuticas.

Info

Publication number
ES2121745T3
ES2121745T3 ES90303177T ES90303177T ES2121745T3 ES 2121745 T3 ES2121745 T3 ES 2121745T3 ES 90303177 T ES90303177 T ES 90303177T ES 90303177 T ES90303177 T ES 90303177T ES 2121745 T3 ES2121745 T3 ES 2121745T3
Authority
ES
Spain
Prior art keywords
preparation
optionally
approvals
cephalosporins
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90303177T
Other languages
English (en)
Inventor
John Hargreaves Bateson
George Burton
Stephen Christopher Marti Fell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898907171A external-priority patent/GB8907171D0/en
Priority claimed from GB898920791A external-priority patent/GB8920791D0/en
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2121745T3 publication Critical patent/ES2121745T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

COMPUESTOS DE (BETA)-LACTAMA DE LA FORMULA (IA) QUE INCLUYE SALES FARMACEUTICAMENTE ACEPTABLES Y ESTERES HIDROLIZABLES "IN VIVO", PROCESOS PARA SU PREPARACION Y SU USO COMO ANTIBIOTICOS: EN DONDE R1 ES HIDROGENO, METOXILO O FORMAMIDO; R2 ES UN GRUPO ACILO, EN PARTICULAR EL DE UNA CEFALOSPORINA ANTIBACTERIANAMENTE ACTIVA; CO2R6 ES UN GRUPO CARBOXILO O UN ANION DE CARBOXILATO; R3 ES UN ANILLO DE GAMMA-LACTONA QUE OPCIONALMENTE CONTIENE UN ENLACE DOBLE ENDOCICLICO, CUYO ANILLO ES SUSTITUIDO OPCIONALMENTE EN CUALQUIER ATOMO DE CARBONO POR ALQUILO, DIALQUILAMINO, ALCOHOXILO, HIDROXILO, HALOGENO O ARILO, QUE, EN EL CASO DE MAS DE UN SUSTITUYENTE, PUEDE SER EL MISMO O DISTINTO, O ES OPCIONALMENTE DISUSTITUIDO EN DOS ATOMOS DE CARBONO ADYACENTES, QUE ESTAN DISPONIBLES PARA SU SUSTITUCION, A FIN DE FORMAR UN SISTEMA BICICLICO FUSIONADO AROMATICO; Y X ES S, SO, SO2, O O CH2.
ES90303177T 1989-03-30 1990-03-26 Cefalosporinas y sus homologos, procedimiento para su preparacion y composiciones farmaceuticas. Expired - Lifetime ES2121745T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898907171A GB8907171D0 (en) 1989-03-30 1989-03-30 Novel compounds
GB898920791A GB8920791D0 (en) 1989-09-14 1989-09-14 Novel compounds

Publications (1)

Publication Number Publication Date
ES2121745T3 true ES2121745T3 (es) 1998-12-16

Family

ID=26295148

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90303177T Expired - Lifetime ES2121745T3 (es) 1989-03-30 1990-03-26 Cefalosporinas y sus homologos, procedimiento para su preparacion y composiciones farmaceuticas.

Country Status (12)

Country Link
US (1) US5246926A (es)
EP (1) EP0395219B1 (es)
JP (1) JP2979235B2 (es)
KR (1) KR900014403A (es)
AT (1) ATE171705T1 (es)
AU (1) AU625844B2 (es)
CA (1) CA2013391A1 (es)
DE (1) DE69032681T2 (es)
DK (1) DK0395219T3 (es)
ES (1) ES2121745T3 (es)
PT (1) PT93602A (es)
ZA (1) ZA902378B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0432042B1 (en) * 1989-12-07 1996-08-28 Meiji Seika Kaisha Ltd. Cephalosporin derivatives and their production and uses
MY106399A (en) * 1990-07-24 1995-05-30 Pfizer Cephalosporins and homologeus, preparation and pharmaceutical composition
US6020329A (en) * 1990-07-24 2000-02-01 Pzifer Inc. Cephaloporins and homologues, preparations and pharmaceutical compositions
US6001997A (en) * 1990-07-24 1999-12-14 Bateson; John Hargreaves Cephalosporins and homologues, preparations and pharmaceutical compositions
GB9019743D0 (en) * 1990-09-10 1990-10-24 Beecham Group Plc Novel compounds
DE4037841A1 (de) * 1990-11-28 1992-06-04 Bayer Ag Neue 3-substituierte cephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
IT1251643B (it) * 1991-10-29 1995-05-17 Mini Ricerca Scient Tecnolog Derivati maleimmidici contenenti residui acrilici
GB9125645D0 (en) * 1991-12-03 1992-01-29 Smithkline Beecham Plc Novel compounds
US5302711A (en) * 1992-02-18 1994-04-12 Eli Lilly And Company Ester cleavage process for use with β-lactams
GB9212609D0 (en) * 1992-06-13 1992-07-29 Smithkline Beecham Plc Novel compounds
GB9213567D0 (en) * 1992-06-26 1992-08-12 Smithkline Beecham Plc Novel compounds
US5604222A (en) 1993-12-27 1997-02-18 Lupin Laboratories, Ltd. Method for the preparation of 2-chloro sulfinyl azetidinones
US5578721A (en) 1994-07-11 1996-11-26 Lupin Laboratories Limited Process for preparation of 3-exomethylene cepham sulfoxide esters
GB9424847D0 (en) * 1994-12-09 1995-02-08 Smithkline Beecham Plc Novel process
IT1277048B1 (it) * 1995-12-06 1997-11-04 3 Exo S R L Procedimento per la preparazione di cefalosporine attraverso ciclizzazione riduttiva dicarbonilica per trattamento con
WO2003053522A1 (en) * 2001-12-21 2003-07-03 Pfizer Products Inc. Methods of treating bacterial infections in dogs and cats
US20040002600A1 (en) * 2002-06-20 2004-01-01 Orchid Chemicals And Pharmaceuticals Limited Process for the conversion of penam ring system to cepham ring system
CA2700263A1 (en) * 2007-09-21 2009-03-26 Forest Laboratories Holdings Limited Soluble dosage forms containing cephem derivatives suitable for parenteral administration

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868173A (en) * 1984-11-20 1989-09-19 Ici Pharma Cephalosporin derivatives
GB8821797D0 (en) * 1988-09-16 1988-10-19 Beecham Group Plc Novel compounds

Also Published As

Publication number Publication date
DE69032681D1 (de) 1998-11-05
PT93602A (pt) 1990-11-20
CA2013391A1 (en) 1990-09-30
JPH02286680A (ja) 1990-11-26
AU5232190A (en) 1990-10-04
DE69032681T2 (de) 1999-02-25
JP2979235B2 (ja) 1999-11-15
DK0395219T3 (da) 1999-02-15
EP0395219A2 (en) 1990-10-31
ZA902378B (en) 1991-06-26
KR900014403A (ko) 1990-10-23
US5246926A (en) 1993-09-21
AU625844B2 (en) 1992-07-16
EP0395219B1 (en) 1998-09-30
EP0395219A3 (en) 1992-04-01
ATE171705T1 (de) 1998-10-15

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