AP765A - Ziprasidone mesylate dihydrates and its uses as dopamine D2 atagonists. - Google Patents

Ziprasidone mesylate dihydrates and its uses as dopamine D2 atagonists. Download PDF

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Publication number
AP765A
AP765A APAP/P/1997/000976A AP9700976A AP765A AP 765 A AP765 A AP 765A AP 9700976 A AP9700976 A AP 9700976A AP 765 A AP765 A AP 765A
Authority
AP
ARIPO
Prior art keywords
ziprasidone mesylate
ziprasidone
crystals
mesylate
dihydrate
Prior art date
Application number
APAP/P/1997/000976A
Other languages
English (en)
Other versions
AP9700976A0 (en
Inventor
Frank Robert Busch
Carol Anne Rose
Russell James Shine
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AP9700976A0 publication Critical patent/AP9700976A0/xx
Application granted granted Critical
Publication of AP765A publication Critical patent/AP765A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Saccharide Compounds (AREA)
APAP/P/1997/000976A 1996-05-07 1997-04-30 Ziprasidone mesylate dihydrates and its uses as dopamine D2 atagonists. AP765A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1675796P 1996-05-07 1996-05-07

Publications (2)

Publication Number Publication Date
AP9700976A0 AP9700976A0 (en) 1997-07-31
AP765A true AP765A (en) 1999-09-17

Family

ID=21778804

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1997/000976A AP765A (en) 1996-05-07 1997-04-30 Ziprasidone mesylate dihydrates and its uses as dopamine D2 atagonists.

Country Status (41)

Country Link
US (1) US6245765B1 (es)
EP (1) EP0918772B1 (es)
JP (1) JP3494659B2 (es)
KR (1) KR100333215B1 (es)
CN (1) CN1091769C (es)
AP (1) AP765A (es)
AR (1) AR007004A1 (es)
AT (1) ATE278689T1 (es)
AU (1) AU731267B2 (es)
BG (1) BG63544B1 (es)
BR (1) BR9709889A (es)
CA (1) CA2252898C (es)
CO (1) CO4940466A1 (es)
CZ (1) CZ289215B6 (es)
DE (1) DE69731094T2 (es)
DK (1) DK0918772T3 (es)
DZ (1) DZ2222A1 (es)
EA (1) EA001190B1 (es)
EG (1) EG24076A (es)
ES (1) ES2229342T3 (es)
GT (1) GT199700052A (es)
HK (1) HK1017892A1 (es)
HR (1) HRP970236B1 (es)
ID (1) ID16867A (es)
IL (1) IL126591A (es)
IS (1) IS2080B (es)
MA (1) MA24171A1 (es)
MY (1) MY119997A (es)
NO (1) NO312514B1 (es)
NZ (1) NZ332218A (es)
OA (1) OA10909A (es)
PL (1) PL188330B1 (es)
PT (1) PT918772E (es)
SI (1) SI0918772T1 (es)
SK (1) SK282837B6 (es)
TN (1) TNSN97074A1 (es)
TR (1) TR199802240T2 (es)
TW (1) TW491847B (es)
UA (1) UA46840C2 (es)
WO (1) WO1997042191A1 (es)
ZA (1) ZA973876B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1996000101A (es) * 1996-02-28 1997-06-26 Inc Pfizer Terapia combinada para la osteoporosis
UA57734C2 (uk) 1996-05-07 2003-07-15 Пфайзер Інк. Комплекси включення арилгетероциклічних солей
IL127497A (en) * 1997-12-18 2002-07-25 Pfizer Prod Inc Medicinal products containing piperazinyl-heterocyclic compounds for the treatment of psychiatric disorders
US20080113025A1 (en) * 1998-11-02 2008-05-15 Elan Pharma International Limited Compositions comprising nanoparticulate naproxen and controlled release hydrocodone
DE60124093D1 (de) * 2000-06-02 2006-12-07 Pfizer Prod Inc S-methyl-dihydro-ziprasidon zur Behandlung von Augenerkrankungen.
UY27668A1 (es) * 2002-02-20 2003-10-31 Pfizer Prod Inc Composición de ziprasidona y controles sintéticos
US20040048876A1 (en) * 2002-02-20 2004-03-11 Pfizer Inc. Ziprasidone composition and synthetic controls
BRPI0410271A (pt) 2003-05-16 2006-05-16 Pfizer Prod Inc combinações terapêuticas de antipsicóticos atìpicos com moduladores de gaba, anticonvulsivantes ou benzodiazepinas
EP1546146A1 (en) 2003-06-03 2005-06-29 Teva Pharmaceutical Industries Limited POLYMORPHIC FORMS OF ZIPRASIDONE HCl AND PROCESSES FOR THEIR PREPARATION
WO2005040160A2 (en) 2003-10-24 2005-05-06 Teva Pharmaceutical Industries Ltd. Processes for preparation of ziprasidone
WO2005107808A2 (en) * 2004-05-11 2005-11-17 Pfizer Products Inc. Combination of atypical antipsychotics and 5-ht1b receptor antagonists
CA2467538C (en) 2004-05-14 2010-08-24 Apotex Pharmachem Inc. New amorphous ziprasidone hydrochloride (5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride) and processes to produce the same
CA2471219A1 (en) 2004-06-14 2005-12-14 Apotex Pharmachem Inc. Improved preparation of an anhydrate form of 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride)
US7777037B2 (en) * 2004-10-27 2010-08-17 Dr. Reddy's Laboratories Limited Ziprasidone process
JP5324098B2 (ja) * 2004-11-16 2013-10-23 アルケルメス ファーマ アイルランド リミテッド 注射可能なナノ粒子のオランザピン製剤
EP1863806A1 (en) * 2005-02-11 2007-12-12 Teva Pharmaceutical Industries Ltd Amorphous ziprasidone mesylate
CA2591670A1 (en) * 2005-02-11 2006-08-17 Teva Pharmaceutical Industries Ltd. Process of preparing ziprasidone mesylate
US20080254114A1 (en) * 2005-03-03 2008-10-16 Elan Corporation Plc Controlled Release Compositions Comprising Heterocyclic Amide Derivative Nanoparticles
ITMI20050346A1 (it) 2005-03-07 2006-09-08 Dipharma Spa Forma solida di ziprasidone cloridrato
CA2500667C (en) 2005-03-11 2013-01-15 Apotex Pharmachem Inc. Preparation of acid addition salts of ziprasidone and intermediates thereof by solid phase-gas phase reactions
EP1858891A2 (en) * 2005-03-14 2007-11-28 Teva Pharmaceutical Industries Ltd. Crystalline forms of ziprasidone mesylate
US20060270685A1 (en) * 2005-03-14 2006-11-30 Judith Aronhime Anhydrous ziprasidone mesylate and a process for its preparation
ITMI20052216A1 (it) * 2005-11-18 2007-05-19 Dipharma Spa Procedimento per la preparazione di ziprasidone
KR20100017109A (ko) * 2007-05-18 2010-02-16 싸이도우스 엘엘씨. 지프라시돈 제제
WO2009156889A1 (en) * 2008-06-25 2009-12-30 Pfizer Inc. Diaryl compounds and uses thereof
US9469630B2 (en) * 2010-10-18 2016-10-18 Sumitomo Dainippon Pharma Co., Ltd. Sustained-release formulation for injection
SI23610A (sl) 2011-01-13 2012-07-31 Diagen@d@o@o Nove adicijske soli ziprasidona postopek za njihovo pripravo in njihova uporaba v terapiji
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4831031A (en) * 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
EP0584903A1 (en) * 1992-08-26 1994-03-02 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds
WO1995000510A1 (en) * 1993-06-28 1995-01-05 Pfizer Inc. Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
US5312925A (en) 1992-09-01 1994-05-17 Pfizer Inc. Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one-hydrochloride
IL126590A (en) 1996-05-07 2001-11-25 Pfizer Trihydrate salt of -5 (-2 (-4 (1 (2, 2-benzothiazole - 3yl) -1-piperazinyl) ethyl) - 6-chloro-1, 3-dihydro-2 (1H) - indole - 2On (= Ziprasidone) and pharmaceutical preparations containing it

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4831031A (en) * 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
EP0584903A1 (en) * 1992-08-26 1994-03-02 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds
WO1995000510A1 (en) * 1993-06-28 1995-01-05 Pfizer Inc. Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one

Also Published As

Publication number Publication date
EA001190B1 (ru) 2000-12-25
BR9709889A (pt) 1999-08-10
BG63544B1 (bg) 2002-04-30
CA2252898C (en) 2003-04-08
KR20000010824A (ko) 2000-02-25
EA199800912A1 (ru) 1999-04-29
NO985194L (no) 1998-11-06
KR100333215B1 (ko) 2002-06-20
NO312514B1 (no) 2002-05-21
AU2174797A (en) 1997-11-26
TNSN97074A1 (fr) 2005-03-15
JPH11509867A (ja) 1999-08-31
SI0918772T1 (en) 2005-02-28
ZA973876B (en) 1998-11-06
US6245765B1 (en) 2001-06-12
CN1091769C (zh) 2002-10-02
HRP970236A2 (en) 1998-06-30
CZ349398A3 (cs) 1999-09-15
TW491847B (en) 2002-06-21
DE69731094D1 (de) 2004-11-11
SK282837B6 (sk) 2002-12-03
OA10909A (en) 2001-10-26
EG24076A (en) 2008-05-11
AU731267B2 (en) 2001-03-29
IS2080B (is) 2006-02-15
MA24171A1 (fr) 1997-12-31
IS4874A (is) 1998-10-20
ATE278689T1 (de) 2004-10-15
CN1216991A (zh) 1999-05-19
BG102892A (en) 1999-09-30
AP9700976A0 (en) 1997-07-31
AR007004A1 (es) 1999-10-13
SK150898A3 (en) 2000-02-14
JP3494659B2 (ja) 2004-02-09
GT199700052A (es) 2001-08-29
CZ289215B6 (cs) 2001-12-12
DE69731094T2 (de) 2006-02-23
DK0918772T3 (da) 2005-01-10
HRP970236B1 (en) 2002-12-31
IL126591A0 (en) 1999-08-17
HK1017892A1 (en) 1999-12-03
DZ2222A1 (fr) 2002-12-03
UA46840C2 (uk) 2002-06-17
PL329884A1 (en) 1999-04-12
ID16867A (id) 1997-11-20
MY119997A (en) 2005-08-30
ES2229342T3 (es) 2005-04-16
TR199802240T2 (es) 1999-02-22
NO985194D0 (no) 1998-11-06
IL126591A (en) 2001-11-25
NZ332218A (en) 2005-02-25
CA2252898A1 (en) 1997-11-13
EP0918772A1 (en) 1999-06-02
PT918772E (pt) 2004-12-31
CO4940466A1 (es) 2000-07-24
PL188330B1 (pl) 2005-01-31
EP0918772B1 (en) 2004-10-06
WO1997042191A1 (en) 1997-11-13

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AP765A (en) Ziprasidone mesylate dihydrates and its uses as dopamine D2 atagonists.
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