AP713A - (-) cis-6(s)-phenyl-5 (R) (4-(2-pyrrolidin-1-yl ethoxy)phenyl)-5,6,7,8,- tetrahydronaphthalen-2-ol-d- tartrate. - Google Patents

(-) cis-6(s)-phenyl-5 (R) (4-(2-pyrrolidin-1-yl ethoxy)phenyl)-5,6,7,8,- tetrahydronaphthalen-2-ol-d- tartrate. Download PDF

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Publication number
AP713A
AP713A APAP/P/1996/000880A AP9600880A AP713A AP 713 A AP713 A AP 713A AP 9600880 A AP9600880 A AP 9600880A AP 713 A AP713 A AP 713A
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AP
ARIPO
Prior art keywords
mammal
compound
phenyl
solution
treatment
Prior art date
Application number
APAP/P/1996/000880A
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English (en)
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AP9600880A0 (en
Inventor
Charles Kwok-Fung Chiu
Morgan Meltz
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AP9600880A0 publication Critical patent/AP9600880A0/xx
Application granted granted Critical
Publication of AP713A publication Critical patent/AP713A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
APAP/P/1996/000880A 1995-11-02 1996-10-31 (-) cis-6(s)-phenyl-5 (R) (4-(2-pyrrolidin-1-yl ethoxy)phenyl)-5,6,7,8,- tetrahydronaphthalen-2-ol-d- tartrate. AP713A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US612595P 1995-11-02 1995-11-02

Publications (2)

Publication Number Publication Date
AP9600880A0 AP9600880A0 (en) 1997-01-31
AP713A true AP713A (en) 1998-12-28

Family

ID=21719433

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1996/000880A AP713A (en) 1995-11-02 1996-10-31 (-) cis-6(s)-phenyl-5 (R) (4-(2-pyrrolidin-1-yl ethoxy)phenyl)-5,6,7,8,- tetrahydronaphthalen-2-ol-d- tartrate.

Country Status (43)

Country Link
US (1) US5948809A (hu)
EP (1) EP0876359B1 (hu)
JP (1) JP3088020B2 (hu)
KR (1) KR19990067280A (hu)
CN (1) CN1067065C (hu)
AP (1) AP713A (hu)
AR (1) AR004078A1 (hu)
AT (1) ATE248827T1 (hu)
AU (1) AU708841B2 (hu)
BG (1) BG63943B1 (hu)
BR (1) BR9611436A (hu)
CA (1) CA2236673C (hu)
CO (1) CO4770967A1 (hu)
CZ (1) CZ287341B6 (hu)
DE (1) DE69629837T2 (hu)
DK (1) DK0876359T3 (hu)
DZ (1) DZ2114A1 (hu)
EG (1) EG21095A (hu)
ES (1) ES2203713T3 (hu)
GT (1) GT199600085A (hu)
HR (1) HRP960503B1 (hu)
HU (1) HU227521B1 (hu)
IL (1) IL124027A (hu)
IS (1) IS1855B (hu)
MA (1) MA23998A1 (hu)
NO (1) NO310358B1 (hu)
NZ (1) NZ318498A (hu)
OA (1) OA11009A (hu)
PE (1) PE17698A1 (hu)
PL (1) PL188633B1 (hu)
PT (1) PT876359E (hu)
RO (1) RO119829B1 (hu)
RU (1) RU2162465C2 (hu)
SI (1) SI0876359T1 (hu)
SK (1) SK282172B6 (hu)
TN (1) TNSN96134A1 (hu)
TR (1) TR199800783T2 (hu)
TW (2) TW581766B (hu)
UA (1) UA51676C2 (hu)
UY (1) UY24362A1 (hu)
WO (1) WO1997016434A1 (hu)
YU (1) YU49123B (hu)
ZA (1) ZA969212B (hu)

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IL120266A (en) 1996-02-28 2005-05-17 Pfizer Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions
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ZA993975B (en) * 1998-06-16 2000-12-15 Pfizer Prod Inc Combination therapy for musculoskeletal frailty.
DK0966968T3 (da) 1998-06-16 2004-08-30 Pfizer Prod Inc Terapeutiske kombinationer, der omfatter en selektiv östrogenreceptormodulator og prostaglandin E2
OA11569A (en) * 1998-06-16 2004-07-01 Pfizer Prod Inc Therapeutic combinations of (selective) estrogen receptor modulators (serm) and growth hormone secretagogues(GHS) for treating musculoskeletal frailty.
YU26700A (sh) * 1999-05-24 2002-06-19 Pfizer Products Inc. Postupak za cis-1-(2-(4-(6-metoksi-2-fenil-1,2,3,4- tetrahidronaftalen-1-il)fenoksi)etil)pirolidin
CO5271696A1 (es) * 2000-01-12 2003-04-30 Pfizer Prod Inc Procedimiento para reducir la morbilidad y el riesgo de mortalidad
CO5271697A1 (es) 2000-01-12 2003-04-30 Pfizer Prod Inc Composiciones y procedimientos para el tratamiento de afecciones que responden a un aumento de testosterona
CO5251465A1 (es) * 2000-01-26 2003-02-28 Pfizer Prod Inc Composiciones y procedimientos para tratar la osteoporosis y reducir el colesterol
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EP1156120B1 (en) 2000-05-08 2006-11-22 Pfizer Products Inc. Enzymatic resolution of selective estrogen receptor modulators
IL145838A (en) * 2000-10-16 2008-11-03 Pfizer Prod Inc Use of an estrogen agonist / antagonist to produce a drug for the treatment of vaginitis
TWI303990B (en) 2000-10-17 2008-12-11 Pfizer Prod Inc New use of estrogen agonists/antagonists for improving vascular health
AU781168B2 (en) * 2001-01-26 2005-05-12 Pfizer Products Inc. Method of treating certain cancers using an estrogen agonist/antagonist
AU2756602A (en) * 2001-04-25 2002-10-31 Pfizer Products Inc. Methods and kits for treating depression or preventing deterioration of cognitive function
KR100568380B1 (ko) 2001-05-01 2006-04-05 화이자 프로덕츠 인코포레이티드 저 투약량 약학 조성물의 제조 방법
WO2003011282A1 (en) 2001-07-31 2003-02-13 Pfizer Products Inc. Pharmaceutical compositions, kits and methods comprising combinations of estrogen agonists/antagonists, estrogens and progestins
RU2317104C2 (ru) * 2001-09-24 2008-02-20 Импиэриэл Инноувейшнс Лимитид Способ модификации пищевого поведения и применение pyy или его агониста в качестве средства для модификации пищевого поведения
HUP0500025A3 (en) * 2002-03-28 2005-10-28 Pfizer Prod Inc Purified lasofoxifene and a method for purification of racemic lasofoxifene by recrystallization
PA8576201A1 (es) * 2002-07-10 2004-05-26 Pfizer Prod Inc Composicion farmaceutica que tiene una distribucion y potencia uniforme de farmaco
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EP1765461A1 (en) * 2004-06-21 2007-03-28 Pharmacia & Upjohn Company LLC Pyk2 inhibitors for stimulation of osteoblast function
BRPI0512245A (pt) * 2004-06-30 2008-02-19 Lilly Co Eli composto, composição farmacêutica, e, uso do composto
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CZ2007373A3 (cs) * 2007-05-29 2008-12-10 Zentiva, A. S Zpusob prípravy lasofoxifenu
WO2010125578A2 (en) 2009-04-29 2010-11-04 Glenmark Generics Limited A process for the preparation of lasofoxifene tartrate
KR101149529B1 (ko) 2009-09-11 2012-05-25 한국화학연구원 인덴온 유도체 및 이를 포함하는 약학적 조성물
CN103113323B (zh) * 2013-02-05 2015-11-11 南京华威医药科技开发有限公司 酒石酸拉索昔芬中间体的制备方法
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Also Published As

Publication number Publication date
WO1997016434A1 (en) 1997-05-09
US5948809A (en) 1999-09-07
PE17698A1 (es) 1998-04-18
SI0876359T1 (en) 2003-12-31
KR19990067280A (ko) 1999-08-16
ATE248827T1 (de) 2003-09-15
CO4770967A1 (es) 1999-04-30
NO981962L (no) 1998-04-30
IL124027A (en) 2001-10-31
YU57896A (sh) 1998-12-23
ES2203713T3 (es) 2004-04-16
YU49123B (sh) 2004-03-12
PL326498A1 (en) 1998-09-28
SK54298A3 (en) 1999-07-12
DZ2114A1 (fr) 2002-07-22
EP0876359A1 (en) 1998-11-11
PL188633B1 (pl) 2005-03-31
JPH11502866A (ja) 1999-03-09
BR9611436A (pt) 1999-03-23
NZ318498A (en) 1999-06-29
HRP960503B1 (en) 2001-12-31
RU2162465C2 (ru) 2001-01-27
DE69629837T2 (de) 2004-05-06
JP3088020B2 (ja) 2000-09-18
CN1067065C (zh) 2001-06-13
IS4718A (is) 1998-04-16
UA51676C2 (uk) 2002-12-16
NO981962D0 (no) 1998-04-30
HRP960503A2 (en) 1998-04-30
RO119829B1 (ro) 2005-04-29
CN1201458A (zh) 1998-12-09
HUP9900087A2 (hu) 1999-05-28
AP9600880A0 (en) 1997-01-31
CA2236673C (en) 2002-03-19
DK0876359T3 (da) 2003-11-24
TW518327B (en) 2003-01-21
HU227521B1 (en) 2011-07-28
DE69629837D1 (de) 2003-10-09
OA11009A (en) 2003-03-03
AU6998496A (en) 1997-05-22
HUP9900087A3 (en) 1999-11-29
CA2236673A1 (en) 1997-05-09
TW581766B (en) 2004-04-01
TNSN96134A1 (fr) 1998-12-31
GT199600085A (es) 1998-04-04
BG102474A (en) 1999-06-30
PT876359E (pt) 2003-12-31
TR199800783T2 (xx) 1998-08-21
UY24362A1 (es) 1997-04-24
BG63943B1 (bg) 2003-07-31
ZA969212B (en) 1998-05-04
IS1855B (is) 2003-02-21
EP0876359B1 (en) 2003-09-03
MX9803544A (es) 1998-09-30
AR004078A1 (es) 1998-09-30
CZ287341B6 (en) 2000-10-11
MA23998A1 (fr) 1997-07-01
NO310358B1 (no) 2001-06-25
SK282172B6 (sk) 2001-11-06
CZ132098A3 (cs) 1999-03-17
EG21095A (en) 2000-10-31
AU708841B2 (en) 1999-08-12

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