AP526A - The ethyl ester of (E)-3-[2-n-butyl-1-{(4-carboxynaphth-1-yl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl) methyl-2-propenoic acid and pharmaceutical compositions containing this compound. - Google Patents

The ethyl ester of (E)-3-[2-n-butyl-1-{(4-carboxynaphth-1-yl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl) methyl-2-propenoic acid and pharmaceutical compositions containing this compound. Download PDF

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Publication number
AP526A
AP526A APAP/P/1995/000741A AP9500741A AP526A AP 526 A AP526 A AP 526A AP 9500741 A AP9500741 A AP 9500741A AP 526 A AP526 A AP 526A
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AP
ARIPO
Prior art keywords
methyl
compounds
compound
butyl
imidazol
Prior art date
Application number
APAP/P/1995/000741A
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English (en)
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AP9500741A0 (en
Inventor
Richard Mccullock Keenan
Joseph Weinstock
Original Assignee
Smithkline Beecham Corp
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Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of AP9500741A0 publication Critical patent/AP9500741A0/xx
Application granted granted Critical
Publication of AP526A publication Critical patent/AP526A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
APAP/P/1995/000741A 1991-08-14 1992-08-14 The ethyl ester of (E)-3-[2-n-butyl-1-{(4-carboxynaphth-1-yl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl) methyl-2-propenoic acid and pharmaceutical compositions containing this compound. AP526A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/746,262 US5185351A (en) 1989-06-14 1991-08-14 Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists

Publications (2)

Publication Number Publication Date
AP9500741A0 AP9500741A0 (en) 1995-07-31
AP526A true AP526A (en) 1996-09-06

Family

ID=25000103

Family Applications (3)

Application Number Title Priority Date Filing Date
APAP/P/1995/000741A AP526A (en) 1991-08-14 1992-08-14 The ethyl ester of (E)-3-[2-n-butyl-1-{(4-carboxynaphth-1-yl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl) methyl-2-propenoic acid and pharmaceutical compositions containing this compound.
APAP/P/1995/000742A AP527A (en) 1991-08-14 1992-08-14 The methanesulfonate salt of (E)-3-(2-n-butyl-1-((4-carboxypenyl) methyl) -1H- imidazol-5-yl)-2-(thienyl)methyl-2-propenoic acid and pharmaceutical compositions containing this compound.
APAP/P/1992/000416A AP525A (en) 1991-08-14 1992-08-14 Imidazol-alkenoic acid and pharmaceutical compositions containing them.

Family Applications After (2)

Application Number Title Priority Date Filing Date
APAP/P/1995/000742A AP527A (en) 1991-08-14 1992-08-14 The methanesulfonate salt of (E)-3-(2-n-butyl-1-((4-carboxypenyl) methyl) -1H- imidazol-5-yl)-2-(thienyl)methyl-2-propenoic acid and pharmaceutical compositions containing this compound.
APAP/P/1992/000416A AP525A (en) 1991-08-14 1992-08-14 Imidazol-alkenoic acid and pharmaceutical compositions containing them.

Country Status (32)

Country Link
US (1) US5185351A (ro)
EP (1) EP0641203B1 (ro)
JP (1) JPH07500579A (ro)
CN (1) CN1036396C (ro)
AP (3) AP526A (ro)
AT (1) ATE226073T1 (ro)
AU (1) AU667824B2 (ro)
BG (1) BG61593B1 (ro)
BR (1) BR9206443A (ro)
CA (1) CA2115170C (ro)
CZ (1) CZ281635B6 (ro)
DE (1) DE69232817T2 (ro)
DK (1) DK0641203T3 (ro)
ES (1) ES2185617T3 (ro)
FI (1) FI114796B (ro)
HU (1) HU225048B1 (ro)
IL (1) IL102813A (ro)
MA (1) MA22626A1 (ro)
MX (1) MX9204737A (ro)
MY (1) MY110205A (ro)
NO (1) NO305172B1 (ro)
NZ (1) NZ243966A (ro)
OA (1) OA09884A (ro)
PL (1) PL177234B1 (ro)
PT (1) PT100779B (ro)
RO (1) RO113643B1 (ro)
RU (1) RU2124513C1 (ro)
SK (1) SK281252B6 (ro)
TW (1) TW234690B (ro)
UA (1) UA40587C2 (ro)
WO (1) WO1993003722A1 (ro)
ZA (1) ZA926133B (ro)

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UA40587C2 (uk) 2001-08-15
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FI940642L (fi) 1994-02-11
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US5185351A (en) 1993-02-09
MA22626A1 (fr) 1993-04-01
ES2185617T3 (es) 2003-05-01
EP0641203A4 (en) 1994-06-09
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ATE226073T1 (de) 2002-11-15
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AP9500741A0 (en) 1995-07-31
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CA2115170C (en) 2004-05-25
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IL102813A (en) 1999-07-14
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AU667824B2 (en) 1996-04-18
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