AP352A - Benzopyran and related LTB4 antagonists. - Google Patents

Benzopyran and related LTB4 antagonists. Download PDF

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Publication number
AP352A
AP352A APAP/P/1992/000449A AP9200449A AP352A AP 352 A AP352 A AP 352A AP 9200449 A AP9200449 A AP 9200449A AP 352 A AP352 A AP 352A
Authority
AP
ARIPO
Prior art keywords
formula
alkyl
carboxy
compound
phenyl
Prior art date
Application number
APAP/P/1992/000449A
Other languages
English (en)
Other versions
AP9200449A0 (en
Inventor
Kevin Koch
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AP9200449A0 publication Critical patent/AP9200449A0/xx
Application granted granted Critical
Publication of AP352A publication Critical patent/AP352A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
APAP/P/1992/000449A 1992-01-23 1992-11-20 Benzopyran and related LTB4 antagonists. AP352A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82441292A 1992-01-23 1992-01-23

Publications (2)

Publication Number Publication Date
AP9200449A0 AP9200449A0 (en) 1993-01-31
AP352A true AP352A (en) 1994-08-10

Family

ID=25241346

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1992/000449A AP352A (en) 1992-01-23 1992-11-20 Benzopyran and related LTB4 antagonists.

Country Status (37)

Country Link
US (2) US5552435A (cs)
EP (1) EP0623123B1 (cs)
JP (1) JP2765757B2 (cs)
KR (2) KR0124802B1 (cs)
CN (1) CN1041311C (cs)
AP (1) AP352A (cs)
AT (1) ATE152108T1 (cs)
AU (1) AU666896B2 (cs)
BG (1) BG62331B1 (cs)
BR (1) BR9207061A (cs)
CA (1) CA2126752C (cs)
CZ (1) CZ282400B6 (cs)
DE (1) DE69219364T2 (cs)
DK (1) DK0623123T3 (cs)
EG (1) EG20202A (cs)
FI (1) FI943474L (cs)
GR (1) GR3023657T3 (cs)
HK (1) HK1000245A1 (cs)
HU (1) HU221194B1 (cs)
IL (1) IL104386A (cs)
IS (1) IS1795B (cs)
MX (1) MX9300312A (cs)
MY (1) MY109144A (cs)
NO (1) NO306508B1 (cs)
NZ (1) NZ245735A (cs)
OA (1) OA11456A (cs)
PH (1) PH30346A (cs)
PL (1) PL171003B1 (cs)
PT (1) PT101183B (cs)
RO (1) RO112031B1 (cs)
RU (1) RU2114110C1 (cs)
SG (1) SG49813A1 (cs)
SK (1) SK280451B6 (cs)
TW (1) TW213907B (cs)
WO (1) WO1993015067A1 (cs)
YU (1) YU48949B (cs)
ZA (1) ZA93486B (cs)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2084547B1 (es) * 1993-07-12 1997-01-16 Pfizer Antagonistas benzopiranicos y relacionados de leucotrieno b4.
NZ285156A (en) * 1994-10-13 1999-01-28 Pfizer Benzopyran and benzo-fused compounds, preparation and use as leukotriene b4 antagonists (ltb4)
CN1166834A (zh) * 1994-10-13 1997-12-03 美国辉瑞有限公司 苯并吡喃和苯并稠合化合物，其制备方法和它们作为白三烯b4(ltb4)拮抗剂的用途
IL128732A0 (en) * 1996-09-16 2000-01-31 Pfizer Processes and intermediates for preparing substituted chromanol derivatives
US6416733B1 (en) 1996-10-07 2002-07-09 Bristol-Myers Squibb Pharma Company Radiopharmaceuticals for imaging infection and inflammation
IL121931A (en) * 1996-10-17 2000-02-17 Pfizer Pharmaceutical compositions for preventing allograft rejection
EP0963755A3 (en) * 1998-04-16 2001-03-14 Pfizer Products Inc. Use of benzopyranes for preventing allograft rejection
US6436987B1 (en) * 2000-06-08 2002-08-20 Pfizer Inc. Crystalline forms of (3S-trans)-2-[3,4-dihydro-4-hydroxy-3-(phenylmethyl)-2H-1-benzopyran-7-yl]-4-(trifluoromethyl)-benzoic acid
AU2002230576A1 (en) 2000-11-03 2002-05-15 Bristol-Myers Squibb Pharma Company Simultaneous dual isotope imaging of cardiac perfusion and cardiac inflammation
JP2004518685A (ja) * 2001-01-30 2004-06-24 ファイザー・プロダクツ・インク クロマニル安息香酸の調製方法
AU4239302A (en) * 2001-06-28 2003-01-02 Pfizer Products Inc. Benzoic acid substituted benzopyrans for the treatment of atherosclerosis
KR20070035101A (ko) * 2004-07-22 2007-03-29 파마시아 코포레이션 Ｃｏｘ-2 선택적 억제제 및 ｌｔｂ4 수용체 길항제의조합을 이용한 염증 및 통증 치료 조성물
EP3383388B1 (en) 2015-11-30 2021-04-14 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as blt1 antagonists
EP3383868B1 (en) 2015-11-30 2022-10-05 Merck Sharp & Dohme LLC Aryl sulfonamides as blt1 antagonists
WO2017095723A1 (en) 2015-11-30 2017-06-08 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as blt1 antagonists
WO2017095725A1 (en) 2015-11-30 2017-06-08 Merck Sharp & Dohme Corp. Aryl sulfonamides as blt1 antagonists

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2309282A1 (de) * 1973-02-24 1974-08-29 Hoechst Ag Verfahren zur herstellung von 4-hydroxy-thiochromanen
EP0313295A2 (en) * 1987-10-19 1989-04-26 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
EP0391625A1 (en) * 1989-04-07 1990-10-10 Pfizer Inc. Substituted chromans in the treatment of asthma, arthritis and related diseases
EP0404440A2 (en) * 1989-06-22 1990-12-27 Pfizer Inc. Substituted sulfonamides and related compounds in the treatment of asthma, arthritis, and related diseases
EP0441515A1 (en) * 1990-02-07 1991-08-14 Pfizer Inc. Tetralin and chroman derivatives in the treatment of asthma, arthritis and related diseases
US5059609A (en) * 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2745305A1 (de) * 1977-10-07 1979-04-19 Bayer Ag Insektizide und akarizide mittel
US4565882A (en) * 1984-01-06 1986-01-21 G. D. Searle & Co. Substituted dihydrobenzopyran-2-carboxylates
CA1320490C (en) * 1987-01-12 1993-07-20 Darrel M. Gapinski Anti-inflammatory agents
JPS63292977A (ja) * 1987-05-25 1988-11-30 片山　晋 スキ−用のビンディング固定板
DE69217998T2 (de) * 1992-01-23 1997-06-12 Pfizer Benzopyrane und ähnliche LTB4-Antagonisten
SG65570A1 (en) * 1992-02-25 1999-06-22 Recordati Chem Pharm Heterobicyclic compounds
FR2693196B1 (fr) * 1992-07-03 1994-12-23 Lipha Dérivés de benzopyranone ou de benzothiopyranone, procédé de préparation et composition pharmaceutique les contenant.

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2309282A1 (de) * 1973-02-24 1974-08-29 Hoechst Ag Verfahren zur herstellung von 4-hydroxy-thiochromanen
EP0313295A2 (en) * 1987-10-19 1989-04-26 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
US5059609A (en) * 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
EP0391625A1 (en) * 1989-04-07 1990-10-10 Pfizer Inc. Substituted chromans in the treatment of asthma, arthritis and related diseases
EP0404440A2 (en) * 1989-06-22 1990-12-27 Pfizer Inc. Substituted sulfonamides and related compounds in the treatment of asthma, arthritis, and related diseases
EP0441515A1 (en) * 1990-02-07 1991-08-14 Pfizer Inc. Tetralin and chroman derivatives in the treatment of asthma, arthritis and related diseases

Also Published As

Publication number Publication date
IL104386A (en) 2001-05-20
YU3393A (sh) 1996-07-24
SK84494A3 (en) 1995-05-10
CZ282400B6 (cs) 1997-07-16
WO1993015067A1 (en) 1993-08-05
JP2765757B2 (ja) 1998-06-18
DE69219364D1 (de) 1997-05-28
PH30346A (en) 1997-04-02
ATE152108T1 (de) 1997-05-15
MX9300312A (es) 1993-07-31
DK0623123T3 (da) 1997-10-13
FI943474A0 (fi) 1994-07-22
HU221194B1 (en) 2002-08-28
ZA93486B (en) 1994-07-22
PT101183B (pt) 1999-09-30
FI943474A7 (fi) 1994-07-22
MY109144A (en) 1996-12-31
US5552435A (en) 1996-09-03
RO112031B1 (ro) 1997-04-30
AU666896B2 (en) 1996-02-29
BG98867A (bg) 1995-03-31
IS1795B (is) 2001-12-18
BG62331B1 (bg) 1999-08-31
KR950700273A (ko) 1995-01-16
KR0124802B1 (ko) 1997-11-25
CA2126752A1 (en) 1993-08-05
OA11456A (en) 2003-11-18
CN1075318A (zh) 1993-08-18
YU48949B (sh) 2003-01-31
FI943474L (fi) 1994-07-22
NO306508B1 (no) 1999-11-15
IS3969A (is) 1993-07-24
AU3065092A (en) 1993-09-01
BR9207061A (pt) 1995-12-26
JPH07502536A (ja) 1995-03-16
US5684046A (en) 1997-11-04
DE69219364T2 (de) 1997-08-07
GR3023657T3 (en) 1997-09-30
RU94035964A (ru) 1997-05-27
PL171003B1 (pl) 1997-02-28
CZ176294A3 (en) 1995-02-15
SG49813A1 (en) 1998-06-15
AP9200449A0 (en) 1993-01-31
EG20202A (en) 1997-10-30
CN1041311C (zh) 1998-12-23
SK280451B6 (sk) 2000-02-14
NZ245735A (en) 1995-04-27
NO942759L (no) 1994-07-22
EP0623123A1 (en) 1994-11-09
HU9401979D0 (en) 1994-09-28
HUT68790A (en) 1995-07-28
RU2114110C1 (ru) 1998-06-27
TW213907B (cs) 1993-10-01
EP0623123B1 (en) 1997-04-23
CA2126752C (en) 2000-05-16
NO942759D0 (no) 1994-07-22
HK1000245A1 (en) 1998-02-13
IL104386A0 (en) 1993-05-13
PT101183A (pt) 1994-03-31

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