HRP20151068T1 - Farmaceutska kombinacija za upotrebu za glikemijsku kontrolu kod pacijenata s dijabetesom tipa 2 - Google Patents
Farmaceutska kombinacija za upotrebu za glikemijsku kontrolu kod pacijenata s dijabetesom tipa 2 Download PDFInfo
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- HRP20151068T1 HRP20151068T1 HRP20151068TT HRP20151068T HRP20151068T1 HR P20151068 T1 HRP20151068 T1 HR P20151068T1 HR P20151068T T HRP20151068T T HR P20151068TT HR P20151068 T HRP20151068 T HR P20151068T HR P20151068 T1 HRP20151068 T1 HR P20151068T1
- Authority
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- Croatia
- Prior art keywords
- pharmaceutical combination
- use according
- diabetes
- type
- patient
- Prior art date
Links
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title claims 12
- 230000002641 glycemic effect Effects 0.000 title claims 2
- 150000003839 salts Chemical class 0.000 claims 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 6
- 239000008103 glucose Substances 0.000 claims 6
- NKOHRVBBQISBSB-UHFFFAOYSA-N 5-[(4-hydroxyphenyl)methyl]-1,3-thiazolidine-2,4-dione Chemical compound C1=CC(O)=CC=C1CC1C(=O)NC(=O)S1 NKOHRVBBQISBSB-UHFFFAOYSA-N 0.000 claims 3
- XVVOERDUTLJJHN-IAEQDCLQSA-N lixisenatide Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 XVVOERDUTLJJHN-IAEQDCLQSA-N 0.000 claims 3
- 235000012054 meals Nutrition 0.000 claims 2
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims 2
- 229960003105 metformin Drugs 0.000 claims 2
- HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 claims 2
- 230000003178 anti-diabetic effect Effects 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 229960005095 pioglitazone Drugs 0.000 claims 1
- 230000000291 postprandial effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Claims (16)
1. Farmaceutska kombinacija za upotrebu za glikemijsku kontrolu kod pacijenata s dijabetesom tipa 2, naznačena time da navedena kombinacija sadrži
(a) desPro36 Exendin-4(1-39)-Lys6-NH2 ili/i njegovu farmaceutski prihvatljivu sol, i
(b) glitazon ili/i njegovu farmaceutski prihvatljivu sol.
2. Farmaceutska kombinacija za upotrebu u skladu s patentnim zahtjevom 1, naznačena time da dodatno sadrži
(c) metformin ili/i njegovu farmaceutski prihvatljivu sol.
3. Farmaceutska kombinacija za upotrebu u skladu s patentnim zahtjevom 2, naznačena time da je metformin ili/i njegova farmaceutski prihvatljiva sol pripravljena za oralno davanje.
4. Farmaceutska kombinacija za upotrebu u skladu s bilo kojim od prethodnih zahtjeva, naznačena time da pacijent s dijabetesom tipa 2 je pretio.
5. Farmaceutska kombinacija za upotrebu u skladu s bilo kojim od prethodnih zahtjeva, naznačena time da pacijent s dijabetesom tipa 2 ima indeks tjelesne mase od barem 30 kg/m2.
6. Farmaceutska kombinacija za upotrebu u skladu s bilo kojim od prethodnih zahtjeva, naznačena time da pacijent s dijabetesom tipa 2 je odrasla osoba.
7. Farmaceutska kombinacija za upotrebu u skladu s bilo kojim od prethodnih zahtjeva, naznačena time da pacijent s dijabetesom tipa 2 ne prima antidijabetičko liječenje.
8. Farmaceutska kombinacija za upotrebu u skladu s bilo kojim od prethodnih zahtjeva, naznačena time da je kod pacijenta s dijabetesom tipa 2, dijabetes melitus tipa 2 dijagnosticiran barem 1 godinu ili barem 2 godine prije početka terapije.
9. Farmaceutska kombinacija za upotrebu u skladu s bilo kojim od prethodnih zahtjeva, naznačena time da pacijent s dijabetesom tipa 2 ima HbA1C vrijednost od oko 7 % do oko 10 %.
10. Farmaceutska kombinacija za upotrebu u skladu s bilo kojim od prethodnih zahtjeva, naznačena time da pacijent s dijabetesom tipa 2 ima natašte koncentraciju glukoze u plazmi od barem 8 mmol/L.
11. Farmaceutska kombinacija za upotrebu u skladu s bilo kojim od prethodnih zahtjeva, naznačena time da pacijent s dijabetesom tipa 2 ima koncentraciju glukoze u plazmi 2 sata poslije obroka od barem 10 mmol/L, barem 12 mmol/L, ili barem 14 mmol/L.
12. Farmaceutska kombinacija za upotrebu u skladu s bilo kojim od prethodnih zahtjeva, naznačena time da pacijent s dijabetesom tipa 2 ima promjenu glukoze od barem 2 mmol/L, barem 3 mmol/L, barem 4 mmol/L ili barem 5 mmol/L, pri čemu je promjena glukoze razlika između testa koncentracije glukoze u plazmi 2 sata poslije obroka i koncentracije glukoze u plazmi 30 minuta prije obroka.
13. Farmaceutska kombinacija za upotrebu u skladu s bilo kojim od prethodnih zahtjeva, naznačena time da desPro36Exendin-4(1-39)-Lys6-NH2 ili/i njegova farmaceutski prihvatljiva sol je pripravljena za parenteralno davanje.
14. Farmaceutska kombinacija za upotrebu u skladu s bilo kojim od prethodnih zahtjeva, naznačena time da desPro36Exendin-4(1-39)-Lys6-NH2 ili/i njegova farmaceutski prihvatljiva sol je pripravljena za davanje u dnevnoj dozi odabranoj iz raspona od 10 µg do 20 µg.
15. Farmaceutska kombinacija za upotrebu u skladu s bilo kojim od prethodnih zahtjeva, naznačena time da glitazon, ili/i njegova farmaceutski prihvatljiva sol je pripravljena za oralno davanje.
16. Farmaceutska kombinacija za upotrebu u skladu s bilo kojim od prethodnih zahtjeva, pri čemu glitazon je pioglitazon.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11179149 | 2011-08-29 | ||
PCT/EP2012/066617 WO2013030160A1 (en) | 2011-08-29 | 2012-08-27 | Pharmaceutical combination for use in glycemic control in diabetes type 2 patients |
EP12756417.7A EP2750699B1 (en) | 2011-08-29 | 2012-08-27 | Pharmaceutical combination for use in glycemic control in diabetes type 2 patients |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20151068T1 true HRP20151068T1 (hr) | 2016-01-01 |
Family
ID=46826464
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20151068TT HRP20151068T1 (hr) | 2011-08-29 | 2015-10-07 | Farmaceutska kombinacija za upotrebu za glikemijsku kontrolu kod pacijenata s dijabetesom tipa 2 |
Country Status (22)
Country | Link |
---|---|
US (5) | US9408893B2 (hr) |
EP (1) | EP2750699B1 (hr) |
JP (1) | JP6367115B2 (hr) |
KR (1) | KR101983982B1 (hr) |
CN (2) | CN103917241A (hr) |
AR (1) | AR087693A1 (hr) |
AU (1) | AU2012300978B2 (hr) |
BR (1) | BR112014004726A2 (hr) |
CA (1) | CA2846413C (hr) |
CY (1) | CY1116803T1 (hr) |
DK (1) | DK2750699T3 (hr) |
ES (1) | ES2550357T3 (hr) |
HK (1) | HK1196267A1 (hr) |
HR (1) | HRP20151068T1 (hr) |
HU (1) | HUE027989T2 (hr) |
MX (1) | MX370264B (hr) |
PL (1) | PL2750699T3 (hr) |
PT (1) | PT2750699E (hr) |
RU (1) | RU2650616C2 (hr) |
SI (1) | SI2750699T1 (hr) |
TW (1) | TWI608847B (hr) |
WO (1) | WO2013030160A1 (hr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS56632B1 (sr) | 2008-10-17 | 2018-03-30 | Sanofi Aventis Deutschland | Kombinacija insulina i glp-1-agonista |
PT3345593T (pt) | 2009-11-13 | 2023-11-27 | Sanofi Aventis Deutschland | Composição farmacêutica compreendendo despro36exendina- 4(1-39)-lys6-nh2 e metionina |
ES2855146T3 (es) | 2009-11-13 | 2021-09-23 | Sanofi Aventis Deutschland | Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina |
HUE031181T2 (en) | 2010-08-30 | 2017-06-28 | Sanofi Aventis Deutschland | Use of AVE0010 for the manufacture of a medicament for the treatment of type 2 diabetes |
CN103458919A (zh) * | 2011-02-02 | 2013-12-18 | 赛诺菲-安万特德国有限公司 | 在2型糖尿病患者中预防低血糖症 |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
CN103917241A (zh) | 2011-08-29 | 2014-07-09 | 赛诺菲-安万特德国有限公司 | 用于2型糖尿病患者中的血糖控制的药物组合 |
AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
TWI780236B (zh) | 2013-02-04 | 2022-10-11 | 法商賽諾菲公司 | 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物 |
BR112016013832A2 (pt) | 2014-01-09 | 2017-08-08 | Sanofi Sa | Uso de análogo e/ou derivado de insulina, formulação farmacêutica e processo para a preparação da mesma, kit e dispositivo médico |
EP3091964A1 (en) | 2014-01-09 | 2016-11-16 | Sanofi | Stabilized pharmaceutical formulations of insulin aspart |
US9839692B2 (en) | 2014-01-09 | 2017-12-12 | Sanofi | Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives |
JP6970615B2 (ja) | 2014-12-12 | 2021-11-24 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | インスリングラルギン/リキシセナチド固定比処方 |
US20160235818A1 (en) * | 2015-01-16 | 2016-08-18 | Sanofi-Aventis Deutschland Gmbh | Treatment of Pediatric Type 2 Diabetes Mellitus Patients |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患之治療 |
US10251852B2 (en) * | 2016-04-13 | 2019-04-09 | Children's Hospital Medical Center | Composition and methods for treatment of lung disorders characterized by cholesterol dysregulation |
KR102508255B1 (ko) | 2021-02-15 | 2023-03-09 | 연세대학교 산학협력단 | 비정형 pkc 활성화제를 함유하는 당 조절용 조성물 |
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TWI780236B (zh) | 2013-02-04 | 2022-10-11 | 法商賽諾菲公司 | 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物 |
GB201303771D0 (en) | 2013-03-04 | 2013-04-17 | Midatech Ltd | Nanoparticles peptide compositions |
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2012
- 2012-08-27 CN CN201280053404.6A patent/CN103917241A/zh active Pending
- 2012-08-27 KR KR1020147008240A patent/KR101983982B1/ko active IP Right Grant
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- 2012-08-27 WO PCT/EP2012/066617 patent/WO2013030160A1/en active Application Filing
- 2012-08-27 EP EP12756417.7A patent/EP2750699B1/en not_active Revoked
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