JPS55153712A - Insulin pharmaceutical preparation and its production - Google Patents

Insulin pharmaceutical preparation and its production

Info

Publication number
JPS55153712A
JPS55153712A JP6129279A JP6129279A JPS55153712A JP S55153712 A JPS55153712 A JP S55153712A JP 6129279 A JP6129279 A JP 6129279A JP 6129279 A JP6129279 A JP 6129279A JP S55153712 A JPS55153712 A JP S55153712A
Authority
JP
Japan
Prior art keywords
acid
insulin
pharmaceutical preparation
excipien
tunica mucosa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP6129279A
Other languages
Japanese (ja)
Other versions
JPS5643443B2 (en
Inventor
Kenji Hara
Kyosaburo Tachibana
Seiji Naito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kao Corp
Original Assignee
Kao Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kao Corp filed Critical Kao Corp
Priority to JP6129279A priority Critical patent/JPS55153712A/en
Priority to FR8010946A priority patent/FR2456522A1/en
Priority to DE19803018843 priority patent/DE3018843A1/en
Publication of JPS55153712A publication Critical patent/JPS55153712A/en
Publication of JPS5643443B2 publication Critical patent/JPS5643443B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PURPOSE: An insulin pharmaceutical preparation capable of remedying diafetes, effective in a small amount, readily absorbable through the tunica mucosa especially in the form of a supporsitory or sublingual tablet, obtained by adding a specific acid to insulin and an excipien for preparing a drug absorbable through the tunica mucosa.
CONSTITUTION: Insulin and an excipien for preparing a drug absorbable through the tunica mucosa are blended with an acid, e.g, a 1W6C lower saturated fatty acid, lower aliphthatic oxycarboxylic acid, hydrochloric acid, phosphoric acid, benzoic acid, phthalic acid, monochloroacetic acid, acrylic acid, pyrubic acid, to give an insulin pharmaceutical preparation. The amount of the acid is 0.01W0.5wt%, preferably 0.02W0.1wt% based on the total composition. The addition of a protease inhibitor continues the effect of insulin. Insulin is dissolved in an aqueous acid solution, to which the excipien is added to give the insulin pharmaceutical preparation. By this method the absorption effect is improved. Effective in an amount of one-scores of insulin in a conventional suppository.
COPYRIGHT: (C)1980,JPO&Japio
JP6129279A 1979-05-18 1979-05-18 Insulin pharmaceutical preparation and its production Granted JPS55153712A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP6129279A JPS55153712A (en) 1979-05-18 1979-05-18 Insulin pharmaceutical preparation and its production
FR8010946A FR2456522A1 (en) 1979-05-18 1980-05-14 Insulin compsns. for admin via mucosa - contg. selected acids to increase absorption pref. also contg. a surfactant and a protease inhibitor
DE19803018843 DE3018843A1 (en) 1979-05-18 1980-05-16 INSULIN PREPARATION AND METHOD FOR PRODUCING THE SAME

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6129279A JPS55153712A (en) 1979-05-18 1979-05-18 Insulin pharmaceutical preparation and its production

Publications (2)

Publication Number Publication Date
JPS55153712A true JPS55153712A (en) 1980-11-29
JPS5643443B2 JPS5643443B2 (en) 1981-10-13

Family

ID=13166964

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6129279A Granted JPS55153712A (en) 1979-05-18 1979-05-18 Insulin pharmaceutical preparation and its production

Country Status (3)

Country Link
JP (1) JPS55153712A (en)
DE (1) DE3018843A1 (en)
FR (1) FR2456522A1 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56138112A (en) * 1980-03-31 1981-10-28 Teijin Ltd Suppository containing ascorbic acid or sodium ascorbate
JPS56138115A (en) * 1980-03-31 1981-10-28 Teijin Ltd Suppository containing acidic amino acid or derivative thereof
JPS56138110A (en) * 1980-03-28 1981-10-28 Teijin Ltd Suppository containing citric acid or salt thereof
JPS5780315A (en) * 1980-11-09 1982-05-19 Kyoto Yakuhin Kogyo Kk Absorption promotor for accelerating rectum absorption, base comprising it, and pharmaceutical preparation to be medicated to rectum
JPS5838210A (en) * 1981-08-31 1983-03-05 Taiho Yakuhin Kogyo Kk Preparation for rectal administration
JPS60197618A (en) * 1984-03-19 1985-10-07 Taiyo Kagaku Kk Medicinal composition for suppository
JPS62158207A (en) * 1986-01-06 1987-07-14 Showa Yakuhin Kako Kk Composition for rectal administration
US7635675B2 (en) 2003-08-13 2009-12-22 Biocon Limited Micro-particle fatty acid salt solid dosage formulations for therapeutic agents

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6321704Y2 (en) * 1981-06-02 1988-06-15
SU1011126A1 (en) * 1981-07-14 1983-04-15 Всесоюзный научно-исследовательский и испытательный институт медицинской техники Method of treating diabetes mellitus
JPS61138863A (en) * 1984-12-11 1986-06-26 Honda Motor Co Ltd Engine body of internal-conbustion engine
DE3532074A1 (en) * 1985-09-09 1987-03-12 Berlin Chemie Veb RESORPTION AGENT FOR BIOLOGICALLY ACTIVE PEPTIDES
JPH048302Y2 (en) * 1985-10-22 1992-03-03
AU618517B2 (en) * 1986-12-23 1992-01-02 Eugene J. Van Scott Additives enhancing topical actions of therapeutic agents
US5059587A (en) * 1987-08-03 1991-10-22 Toyo Jozo Company, Ltd. Physiologically active peptide composition for nasal administration
NZ228285A (en) * 1988-03-11 1991-08-27 Teikoku Seiyaku Kk Pharmaceutical composition comprising a polypeptide and adapted for intravaginal administration
CA2050425A1 (en) * 1990-09-03 1992-03-04 Yoshiaki Uda Pharmaceutical composition and its mucous use
DE10114178A1 (en) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinc-free and low-zinc insulin preparations with improved stability
US20030017181A1 (en) 2001-05-31 2003-01-23 Rood Gloria A. Dermatological compositions and methods
DE10227232A1 (en) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Sour insulin preparations with improved stability
IL152486A0 (en) 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US20080138296A1 (en) 2002-10-25 2008-06-12 Foamix Ltd. Foam prepared from nanoemulsions and uses
MXPA05004278A (en) 2002-10-25 2005-10-05 Foamix Ltd Cosmetic and pharmaceutical foam.
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US20070292355A1 (en) * 2002-10-25 2007-12-20 Foamix Ltd. Anti-infection augmentation foamable compositions and kit and uses thereof
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US7700076B2 (en) 2002-10-25 2010-04-20 Foamix, Ltd. Penetrating pharmaceutical foam
US20080260655A1 (en) 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
US9439857B2 (en) 2007-11-30 2016-09-13 Foamix Pharmaceuticals Ltd. Foam containing benzoyl peroxide
WO2009090495A2 (en) 2007-12-07 2009-07-23 Foamix Ltd. Oil and liquid silicone foamable carriers and formulations
RS56632B1 (en) 2008-10-17 2018-03-30 Sanofi Aventis Deutschland Combination of an insulin and a glp-1 agonist
CA2760186C (en) 2009-04-28 2019-10-29 Foamix Ltd. Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
WO2011013008A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
WO2011013009A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
CA2776366C (en) 2009-10-02 2017-07-18 Foamix Ltd. Surfactant-free water-free foamable compositions, breakable foams and gels and their uses
ES2855146T3 (en) 2009-11-13 2021-09-23 Sanofi Aventis Deutschland Pharmaceutical composition comprising a GLP-1 agonist, an insulin and methionine
PT3345593T (en) 2009-11-13 2023-11-27 Sanofi Aventis Deutschland Pharmaceutical composition comprising despro36exendin-4(1-39)-lys6-nh2 and methionine
HUE031181T2 (en) 2010-08-30 2017-06-28 Sanofi Aventis Deutschland Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
CN103917241A (en) 2011-08-29 2014-07-09 赛诺菲-安万特德国有限公司 Pharmaceutical combination for use in glycemic control in diabetes type 2 patients
AR087744A1 (en) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland PHARMACEUTICAL COMPOSITION FOR USE IN THE TREATMENT OF A NEURODEGENERATIVE DISEASE
JP6970615B2 (en) 2014-12-12 2021-11-24 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Insulin glargine / lixisenatide fixed ratio prescription
TWI748945B (en) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 Treatment type 2 diabetes mellitus patients
TW201705975A (en) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 Treatment of type 2 diabetes mellitus patients
MX2017011630A (en) 2016-09-08 2018-09-25 Foamix Pharmaceuticals Ltd Compositions and methods for treating rosacea and acne.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL45481C (en) * 1900-01-01
JPS5315412A (en) * 1976-07-27 1978-02-13 Ono Pharmaceut Co Ltd Suppository for diabetics
GB2051574B (en) * 1979-05-10 1984-01-18 Kyoto Pharma Ind Adjuvant for promoting absorption of pharmacologically active substances through the rectum

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56138110A (en) * 1980-03-28 1981-10-28 Teijin Ltd Suppository containing citric acid or salt thereof
JPS56138112A (en) * 1980-03-31 1981-10-28 Teijin Ltd Suppository containing ascorbic acid or sodium ascorbate
JPS56138115A (en) * 1980-03-31 1981-10-28 Teijin Ltd Suppository containing acidic amino acid or derivative thereof
JPS631923B2 (en) * 1980-03-31 1988-01-14 Teijin Ltd
JPH0242809B2 (en) * 1980-03-31 1990-09-26
JPS5780315A (en) * 1980-11-09 1982-05-19 Kyoto Yakuhin Kogyo Kk Absorption promotor for accelerating rectum absorption, base comprising it, and pharmaceutical preparation to be medicated to rectum
JPS5838210A (en) * 1981-08-31 1983-03-05 Taiho Yakuhin Kogyo Kk Preparation for rectal administration
JPH0136442B2 (en) * 1981-08-31 1989-07-31 Taiho Pharmaceutical Co Ltd
JPS60197618A (en) * 1984-03-19 1985-10-07 Taiyo Kagaku Kk Medicinal composition for suppository
JPS62158207A (en) * 1986-01-06 1987-07-14 Showa Yakuhin Kako Kk Composition for rectal administration
JPH0521895B2 (en) * 1986-01-06 1993-03-25 Showa Pharm Chem Ind
US7635675B2 (en) 2003-08-13 2009-12-22 Biocon Limited Micro-particle fatty acid salt solid dosage formulations for therapeutic agents

Also Published As

Publication number Publication date
JPS5643443B2 (en) 1981-10-13
DE3018843A1 (en) 1980-11-20
FR2456522A1 (en) 1980-12-12

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