ZA986814B - Benzimidazole benzoxazole and benzothiazole compounds a process for their preparation and pharmaceutical compositions containing them - Google Patents

Benzimidazole benzoxazole and benzothiazole compounds a process for their preparation and pharmaceutical compositions containing them

Info

Publication number
ZA986814B
ZA986814B ZA986814A ZA986814A ZA986814B ZA 986814 B ZA986814 B ZA 986814B ZA 986814 A ZA986814 A ZA 986814A ZA 986814 A ZA986814 A ZA 986814A ZA 986814 B ZA986814 B ZA 986814B
Authority
ZA
South Africa
Prior art keywords
aryl
optionally substituted
alkyl
sulphonyl
amino
Prior art date
Application number
ZA986814A
Other languages
English (en)
Inventor
Guillaume De Nateuil
Bernard Portevin
Jacqueline Bonnet
Armel Fradin
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of ZA986814B publication Critical patent/ZA986814B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ZA986814A 1997-07-30 1998-07-30 Benzimidazole benzoxazole and benzothiazole compounds a process for their preparation and pharmaceutical compositions containing them ZA986814B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9709710A FR2766822B1 (fr) 1997-07-30 1997-07-30 Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ZA986814B true ZA986814B (en) 1999-02-02

Family

ID=9509817

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA986814A ZA986814B (en) 1997-07-30 1998-07-30 Benzimidazole benzoxazole and benzothiazole compounds a process for their preparation and pharmaceutical compositions containing them

Country Status (20)

Country Link
US (1) US6040327A (xx)
EP (1) EP0894795B1 (xx)
JP (1) JPH11100368A (xx)
CN (1) CN1087740C (xx)
AT (1) ATE201868T1 (xx)
AU (1) AU734447B2 (xx)
BR (1) BR9802804A (xx)
CA (1) CA2244438A1 (xx)
DE (1) DE69800882T2 (xx)
DK (1) DK0894795T3 (xx)
ES (1) ES2159922T3 (xx)
FR (1) FR2766822B1 (xx)
GR (1) GR3036473T3 (xx)
HK (1) HK1018440A1 (xx)
HU (1) HUP9801725A1 (xx)
NO (1) NO983493L (xx)
NZ (1) NZ331153A (xx)
PL (1) PL327748A1 (xx)
PT (1) PT894795E (xx)
ZA (1) ZA986814B (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6248770B1 (en) * 1998-07-09 2001-06-19 Boehringer Ingelheim Pharma Kg Benzimidazoles having antithrombotic activity
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
US6451832B2 (en) 1999-12-23 2002-09-17 Boehringer Ingelheim Pharma Kg Benzimidazoles with antithrombotic activity
US6660858B2 (en) 2001-03-28 2003-12-09 Lion Bioscience Ag 2-aminobenzoxazole derivatives and combinatorial libraries thereof
CA2451955C (en) 2001-06-26 2015-09-29 Abgenix, Inc. Antibodies to opgl
WO2003002187A2 (en) * 2001-06-26 2003-01-09 Photomed Technologies, Inc. Multiple wavelength illuminator
EP1490058B1 (en) * 2002-02-21 2007-10-10 Eli Lilly And Company Peroxisome proliferator activated receptor modulators
JP2006517191A (ja) * 2002-12-30 2006-07-20 アムジエン・インコーポレーテツド 共刺激因子を用いた併用療法
US7863310B2 (en) * 2004-02-03 2011-01-04 Eli Lilly And Company Kinase inhibitors
PE20070335A1 (es) * 2005-08-30 2007-04-21 Novartis Ag Benzimidazoles sustituidos y metodos para su preparacion
KR101047221B1 (ko) * 2005-09-02 2011-07-06 에프. 호프만-라 로슈 아게 벤조옥사졸, 옥사졸로피리딘, 벤조싸이아졸 및싸이아졸로피리딘 유도체
AU2007333990A1 (en) * 2006-12-15 2008-06-26 Janssen Pharmaceutica N.V. Benzimidazole TRPV1 inhibitors
CN101687790B (zh) * 2007-05-25 2015-02-11 Abbvie公司 作为代谢型谷氨酸受体2(mglu2受体)的正向调节剂的杂环化合物
EP2234487A4 (en) * 2007-12-19 2011-09-07 Scripps Research Inst ANILIDES AND ANALOGUES AS INHIBITORS OF RHO KINASE
CA2709918A1 (en) * 2007-12-21 2009-06-25 The Scripps Research Institute Benzopyrans and analogs as rho kinase inhibitors
WO2010051176A1 (en) * 2008-10-29 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
TWI644899B (zh) 2013-02-04 2018-12-21 健生藥品公司 Ｆｌａｐ調節劑
US9745328B2 (en) 2013-02-04 2017-08-29 Janssen Pharmaceutica Nv Flap modulators
AU2016323612B2 (en) * 2015-09-18 2021-04-08 Merck Patent Gmbh Heteroaryl compounds as IRAK inhibitors and uses thereof
WO2020035482A1 (en) 2018-08-13 2020-02-20 Iltoo Pharma Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE465803A (xx) * 1944-01-22
US3182070A (en) * 1962-05-24 1965-05-04 Dow Chemical Co Benzimidazole compounds
FR1450560A (fr) * 1965-05-26 1966-06-24 Chimetron Sarl Nouveaux benzimidazoles possédant deux substituants hétérocycliques
DE3039208A1 (de) * 1980-10-17 1982-05-13 Basf Ag, 6700 Ludwigshafen Neue sulfone, deren herstellung und verwendung
CA1279648C (en) * 1986-07-11 1991-01-29 Haruo Kuriyama 2-(4-pyridylaminometyl)-benzimidazole derivatives having antiviral activity
DE3819823A1 (de) * 1988-06-08 1989-12-21 Schering Ag Durch zum teil kondensierte heterocyclen substituierte indole, indazole und benzimidazole, verfahren zu ihrer herstellung und ihre verwendung als mittel mit herbizider wirkung
JP2869561B2 (ja) * 1989-05-22 1999-03-10 大塚製薬株式会社 血小板粘着抑制剤
JPH03232868A (ja) * 1990-02-05 1991-10-16 Nippon Telegr & Teleph Corp <Ntt> 新規光学活性化合物及び液晶組成物
US5612360A (en) * 1992-06-03 1997-03-18 Eli Lilly And Company Angiotensin II antagonists
US6815461B1 (en) * 1994-01-20 2004-11-09 The University Of North Carolina At Chapel Hill Method of inhibiting retroviral integrase
US5552426A (en) * 1994-04-29 1996-09-03 Eli Lilly And Company Methods for treating a physiological disorder associated with β-amyloid peptide
ATE248153T1 (de) * 1994-10-12 2003-09-15 Euro Celtique Sa Neue benzoxazole
EP0912562A1 (en) * 1996-07-19 1999-05-06 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use
FR2751649B1 (fr) * 1996-07-26 1998-08-28 Adir Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
NO983493D0 (no) 1998-07-29
EP0894795A1 (fr) 1999-02-03
HUP9801725A1 (hu) 2000-11-28
CA2244438A1 (fr) 1999-01-30
NO983493L (no) 1999-02-01
PL327748A1 (en) 1999-02-01
ES2159922T3 (es) 2001-10-16
JPH11100368A (ja) 1999-04-13
DE69800882T2 (de) 2002-03-28
AU734447B2 (en) 2001-06-14
AU7860898A (en) 1999-02-11
EP0894795B1 (fr) 2001-06-06
US6040327A (en) 2000-03-21
BR9802804A (pt) 2000-05-02
GR3036473T3 (en) 2001-11-30
FR2766822B1 (fr) 2001-02-23
FR2766822A1 (fr) 1999-02-05
CN1087740C (zh) 2002-07-17
HK1018440A1 (en) 1999-12-24
DE69800882D1 (de) 2001-07-12
ATE201868T1 (de) 2001-06-15
PT894795E (pt) 2001-09-28
DK0894795T3 (da) 2001-09-03
NZ331153A (en) 1999-07-29
CN1210859A (zh) 1999-03-17
HU9801725D0 (en) 1998-09-28

Similar Documents

Publication Publication Date Title
HU9801725D0 (en) New benzimidazole, benzoxazole and benzothiazole compounds, a process for their preparation and pharmaceutical compositions containing them
NO304946B1 (no) Xantinderivat samt dets anvendelse
KR920702349A (ko) N-치환 복소환식 유도체, 그의 제조방법 및 그를 함유하는 약학 조성물
DE69523574D1 (de) Carbapenem-derivate
KR870010067A (ko) 신규의 디포스폰산 화합물, 이들의 제조 방법 및 이들을 함유하는 제약조성물
KR910000765A (ko) 포스핀산 유도체
ATE110386T1 (de) Cephalosporinderivate, verfahren zu ihrer herstellung und antibakterielle präparate.
ZA976655B (en) Benzimidazole, benzoxazole and benzothiazole compounds, process for preparing them and pharmaceutical compositions containing them.
FI953308A0 (fi) Uudet bentsopyraaniyhdisteet, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
FI960689A0 (fi) Substituoituja bentseenisulfonyyliureoita ja -tioureoita, menetelmä niiden valmistamiseksi, niiden käyttö lääkkeenä tai diagnostisena aineena sekä niitä sisältävä lääke
PT91607A (pt) Process for the preparation of substituted beta-diketones and of pharmaceutical compositions containing them
ES2106439T3 (es) 5-(piperazinilalquil)-1,5-benzotiazepinonas utiles como antagonistas de calcio.
KR890003779A (ko) β-락탐 화합물, 이 화합물의 제조방법, 이 화합물의 합성용 중간체 및 이 화합물을 함유하는 세균감염 질환 치료용 의약조성물
JPS54106495A (en) Cephem derivative
KR900014400A (ko) 신규 화합물
TH4132A (th) เอสเทอร์ของ 7 เบต้า-(2-(2-อะมิโน-4-ไธอาซอลิ)-2-แอลเคโนอิลอะมิโน)-3-เซเฟม-4-คาร์บอกซิลิค แอซิด
KR830004313A (ko) 7-아실아미도-3-비닐세팔로스포란산 유도체와 제조방법
TH6470B (th) เอสเทอร์ของ 7 เบต้า-(2-(2-อะมิโน-4-ไธอาซอลิ)-2-แอลเคโนอิลอะมิโน)-3-เซเฟม-4-คาร์บอกซิลิค แอซิด
DE2963724D1 (en) Clavulanic acid derivatives, their preparation and pharmaceutical compositions containing them
KR910000774A (ko) 앙골라마이신 유도체, 그의 제조방법 및 용도
TH8885A (th) สารประกอบเฮเทอโรไซคลิค
TH13243A (th) อนุพันธ์ไธอะโซลิดิโนนและออกซาโซลิดิโนนและการเตรียมสารนั้นและการใช้เป็นยาทำให้หลอดเลือดขยายตัว