ATE201868T1 - Benzimidazol-, benzoxazol-, und benzothiazolderivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten - Google Patents

Benzimidazol-, benzoxazol-, und benzothiazolderivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten

Info

Publication number
ATE201868T1
ATE201868T1 AT98401920T AT98401920T ATE201868T1 AT E201868 T1 ATE201868 T1 AT E201868T1 AT 98401920 T AT98401920 T AT 98401920T AT 98401920 T AT98401920 T AT 98401920T AT E201868 T1 ATE201868 T1 AT E201868T1
Authority
AT
Austria
Prior art keywords
aryl
optionally substituted
alkyl
sulphonyl
amino
Prior art date
Application number
AT98401920T
Other languages
English (en)
Inventor
Guillaume De Nateuil
Bernard Portevin
Jacqueline Bonnet
Armel Fradin
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Application granted granted Critical
Publication of ATE201868T1 publication Critical patent/ATE201868T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT98401920T 1997-07-30 1998-07-28 Benzimidazol-, benzoxazol-, und benzothiazolderivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten ATE201868T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9709710A FR2766822B1 (fr) 1997-07-30 1997-07-30 Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ATE201868T1 true ATE201868T1 (de) 2001-06-15

Family

ID=9509817

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98401920T ATE201868T1 (de) 1997-07-30 1998-07-28 Benzimidazol-, benzoxazol-, und benzothiazolderivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten

Country Status (19)

Country Link
US (1) US6040327A (de)
EP (1) EP0894795B1 (de)
JP (1) JPH11100368A (de)
CN (1) CN1087740C (de)
AT (1) ATE201868T1 (de)
AU (1) AU734447B2 (de)
BR (1) BR9802804A (de)
CA (1) CA2244438A1 (de)
DE (1) DE69800882T2 (de)
DK (1) DK0894795T3 (de)
ES (1) ES2159922T3 (de)
FR (1) FR2766822B1 (de)
GR (1) GR3036473T3 (de)
HU (1) HUP9801725A1 (de)
NO (1) NO983493L (de)
NZ (1) NZ331153A (de)
PL (1) PL327748A1 (de)
PT (1) PT894795E (de)
ZA (1) ZA986814B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6248770B1 (en) * 1998-07-09 2001-06-19 Boehringer Ingelheim Pharma Kg Benzimidazoles having antithrombotic activity
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
US6451832B2 (en) 1999-12-23 2002-09-17 Boehringer Ingelheim Pharma Kg Benzimidazoles with antithrombotic activity
US6660858B2 (en) 2001-03-28 2003-12-09 Lion Bioscience Ag 2-aminobenzoxazole derivatives and combinatorial libraries thereof
WO2003002187A2 (en) * 2001-06-26 2003-01-09 Photomed Technologies, Inc. Multiple wavelength illuminator
CA2451955C (en) 2001-06-26 2015-09-29 Abgenix, Inc. Antibodies to opgl
EP1490058B1 (de) * 2002-02-21 2007-10-10 Eli Lilly And Company Modulatoren von peroxisome proliferator-aktivierten rezeptoren
WO2004060911A2 (en) * 2002-12-30 2004-07-22 Amgen Inc. Combination therapy with co-stimulatory factors
WO2005080380A1 (en) * 2004-02-03 2005-09-01 Eli Lilly And Company Kinase inhibitors
TW200804345A (en) * 2005-08-30 2008-01-16 Novartis Ag Substituted benzimidazoles and methods of preparation
KR101047221B1 (ko) * 2005-09-02 2011-07-06 에프. 호프만-라 로슈 아게 벤조옥사졸, 옥사졸로피리딘, 벤조싸이아졸 및싸이아졸로피리딘 유도체
KR101503286B1 (ko) * 2006-12-15 2015-03-17 얀센 파마슈티카 엔.브이. 벤즈이미다졸 ｔｒｐｖ1 저해제
US9242933B2 (en) * 2007-05-25 2016-01-26 AbbVie Deutschland GmbH & Co. KG Heterocyclic compounds as positive modulators of metabotropic glutamate receptor 2 (mGlu2 receptor)
US20110052562A1 (en) * 2007-12-19 2011-03-03 The Scripps Research Institute Benzimidazoles and analogs as rho kinase inhibitors
JP2011507848A (ja) * 2007-12-21 2011-03-10 ザ スクリプス リサーチ インスティチュート Ｒｈｏキナーゼインヒビターとしてのベンゾピランおよびアナログ
CN102271511A (zh) * 2008-10-29 2011-12-07 默沙东公司 可用作抗糖尿病剂的新颖的环状苯并咪唑衍生物
TWI644899B (zh) 2013-02-04 2018-12-21 健生藥品公司 Ｆｌａｐ調節劑
WO2014121055A2 (en) * 2013-02-04 2014-08-07 Janssen Pharmaceutica Nv Flap modulators
EP3350177B1 (de) * 2015-09-18 2021-07-07 Merck Patent GmbH Heteroaryle verbindungen als irak-inhibitoren und verwendungen davon
WO2020035482A1 (en) 2018-08-13 2020-02-20 Iltoo Pharma Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE465803A (de) * 1944-01-22
US3182070A (en) * 1962-05-24 1965-05-04 Dow Chemical Co Benzimidazole compounds
FR1450560A (fr) * 1965-05-26 1966-06-24 Chimetron Sarl Nouveaux benzimidazoles possédant deux substituants hétérocycliques
DE3039208A1 (de) * 1980-10-17 1982-05-13 Basf Ag, 6700 Ludwigshafen Neue sulfone, deren herstellung und verwendung
CA1279648C (en) * 1986-07-11 1991-01-29 Haruo Kuriyama 2-(4-pyridylaminometyl)-benzimidazole derivatives having antiviral activity
DE3819823A1 (de) * 1988-06-08 1989-12-21 Schering Ag Durch zum teil kondensierte heterocyclen substituierte indole, indazole und benzimidazole, verfahren zu ihrer herstellung und ihre verwendung als mittel mit herbizider wirkung
JP2869561B2 (ja) * 1989-05-22 1999-03-10 大塚製薬株式会社 血小板粘着抑制剤
JPH03232868A (ja) * 1990-02-05 1991-10-16 Nippon Telegr & Teleph Corp <Ntt> 新規光学活性化合物及び液晶組成物
US5612360A (en) * 1992-06-03 1997-03-18 Eli Lilly And Company Angiotensin II antagonists
US6815461B1 (en) * 1994-01-20 2004-11-09 The University Of North Carolina At Chapel Hill Method of inhibiting retroviral integrase
US5552426A (en) * 1994-04-29 1996-09-03 Eli Lilly And Company Methods for treating a physiological disorder associated with β-amyloid peptide
WO1996011917A1 (en) * 1994-10-12 1996-04-25 Euro-Celtique, S.A. Novel benzoxazoles
CA2260999C (en) * 1996-07-19 2006-07-11 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use in tyrosine kinase inhibition
FR2751649B1 (fr) * 1996-07-26 1998-08-28 Adir Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
NO983493L (no) 1999-02-01
ES2159922T3 (es) 2001-10-16
CN1087740C (zh) 2002-07-17
DE69800882D1 (de) 2001-07-12
CN1210859A (zh) 1999-03-17
HUP9801725A1 (hu) 2000-11-28
JPH11100368A (ja) 1999-04-13
DE69800882T2 (de) 2002-03-28
GR3036473T3 (en) 2001-11-30
EP0894795A1 (de) 1999-02-03
AU734447B2 (en) 2001-06-14
ZA986814B (en) 1999-02-02
BR9802804A (pt) 2000-05-02
PT894795E (pt) 2001-09-28
FR2766822B1 (fr) 2001-02-23
AU7860898A (en) 1999-02-11
HK1018440A1 (en) 1999-12-24
NO983493D0 (no) 1998-07-29
DK0894795T3 (da) 2001-09-03
HU9801725D0 (en) 1998-09-28
FR2766822A1 (fr) 1999-02-05
US6040327A (en) 2000-03-21
EP0894795B1 (de) 2001-06-06
CA2244438A1 (fr) 1999-01-30
NZ331153A (en) 1999-07-29
PL327748A1 (en) 1999-02-01

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