ZA97369B - A method of separating the racemate of tramadol. - Google Patents

A method of separating the racemate of tramadol.

Info

Publication number
ZA97369B
ZA97369B ZA9700369A ZA97369A ZA97369B ZA 97369 B ZA97369 B ZA 97369B ZA 9700369 A ZA9700369 A ZA 9700369A ZA 97369 A ZA97369 A ZA 97369A ZA 97369 B ZA97369 B ZA 97369B
Authority
ZA
South Africa
Prior art keywords
tramadol
racemate
separating
Prior art date
Application number
ZA9700369A
Other languages
English (en)
Inventor
Helmut Buschmann
Werner Vinter
Ivars Graudums
Peter Jansen
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of ZA97369B publication Critical patent/ZA97369B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA9700369A 1996-01-19 1997-01-16 A method of separating the racemate of tramadol. ZA97369B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19601745A DE19601745C1 (de) 1996-01-19 1996-01-19 Verfahren zur Racematspaltung von Tramadol

Publications (1)

Publication Number Publication Date
ZA97369B true ZA97369B (en) 1997-07-29

Family

ID=7783112

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9700369A ZA97369B (en) 1996-01-19 1997-01-16 A method of separating the racemate of tramadol.

Country Status (31)

Country Link
US (1) US5723668A (he)
EP (1) EP0787715B1 (he)
JP (1) JPH09216858A (he)
KR (1) KR100505527B1 (he)
CN (1) CN1131203C (he)
AR (1) AR005391A1 (he)
AT (1) ATE189205T1 (he)
AU (1) AU711750B2 (he)
BR (1) BR9700094A (he)
CA (1) CA2195370C (he)
CO (1) CO4520185A1 (he)
CZ (1) CZ291775B6 (he)
DE (2) DE19601745C1 (he)
DK (1) DK0787715T3 (he)
ES (1) ES2145373T3 (he)
GR (1) GR3032489T3 (he)
HU (1) HU223067B1 (he)
IL (1) IL120028A (he)
IN (1) IN182218B (he)
MY (1) MY116583A (he)
NO (1) NO306059B1 (he)
NZ (1) NZ299999A (he)
PE (1) PE29898A1 (he)
PL (1) PL187403B1 (he)
PT (1) PT787715E (he)
RU (1) RU2192407C2 (he)
SI (1) SI0787715T1 (he)
SK (1) SK281612B6 (he)
UA (1) UA45343C2 (he)
UY (1) UY24439A1 (he)
ZA (1) ZA97369B (he)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2130079B1 (es) 1997-07-10 2000-01-16 Esteve Labor Dr Resolucion de aminas
CN1151122C (zh) * 1997-07-15 2004-05-26 拉辛斯基有限公司 反胺苯环醇及其盐以及它们的制备方法
DE19821039A1 (de) 1998-05-11 1999-11-18 Bayer Ag Verfahren zur Herstellung von (S,S)-Benzyl-2,8-diazabicyclo[4.3.0]nonan
GB9826540D0 (en) 1998-12-02 1999-01-27 Darwin Discovery Ltd Process
KR100342919B1 (ko) * 1999-10-21 2002-07-04 박노중 트랜스체 염산 트라마돌의 분리 제조방법
JP2004513091A (ja) * 2000-10-03 2004-04-30 ペンウェスト　ファーマシューティカルズ　カンパニー 異なる速度の複数の医薬活性成分の送達系
DE10108122A1 (de) 2001-02-21 2002-10-02 Gruenenthal Gmbh Arzneimittel auf Basis von Tramadol
CN1289071C (zh) 2001-03-16 2006-12-13 Dmi生物科学公司 曲马朵物质在制备用于延缓男性射精的药物中的用途
US6649783B2 (en) * 2001-10-03 2003-11-18 Euro-Celtique, S.A. Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
AU2002364517A1 (en) 2001-11-30 2003-06-17 Sepracor Inc. Tramadol analogs and uses thereof
US20040248979A1 (en) * 2003-06-03 2004-12-09 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
CA2595519C (en) 2005-01-26 2013-10-29 Allergan, Inc. Methods of using as analgesics 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds
EP1785412A1 (en) 2005-11-14 2007-05-16 IPCA Laboratories Limited Tramadol recovery process
KR20140054312A (ko) * 2007-02-12 2014-05-08 디엠아이 바이오사이언시스 인코포레이티드 조루 및 발기부전을 동시에 치료하는 방법
CA2677691C (en) 2007-02-12 2012-07-31 David Bar-Or Reducing side effects of tramadol
DE102013009114A1 (de) 2013-05-29 2014-12-04 Franz Gerstheimer Pharmazeutische Zusammensetzung zur Überwindung von Metabolisierungsproblemen
KR102136004B1 (ko) 2018-06-18 2020-07-22 (주)센텍코리아 감지부의 잔존 수명을 추정할 수 있는 음주측정기

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2528267A (en) * 1950-10-31 Eobeet j
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
IL50080A (en) * 1975-07-29 1979-07-25 Beecham Group Ltd 4-oxa-1-azabicyclo(3.2.0)heptan-7-one-2-car boxylic acid derivatives and their preparation
JPH06122686A (ja) * 1992-10-12 1994-05-06 Fujisawa Pharmaceut Co Ltd ラセミ体の光学分割法

Also Published As

Publication number Publication date
ES2145373T3 (es) 2000-07-01
SI0787715T1 (en) 2000-04-30
PT787715E (pt) 2000-06-30
IL120028A0 (en) 1997-04-15
AR005391A1 (es) 1999-04-28
BR9700094A (pt) 1998-09-22
CZ15697A3 (cs) 1998-05-13
MY116583A (en) 2004-02-28
CA2195370C (en) 2005-07-12
AU1223297A (en) 1997-07-24
HU223067B1 (hu) 2004-03-01
HUP9700141A2 (hu) 1998-01-28
NO970211L (no) 1997-07-21
PE29898A1 (es) 1998-08-08
CZ291775B6 (cs) 2003-05-14
KR100505527B1 (ko) 2005-10-19
CO4520185A1 (es) 1997-10-15
PL187403B1 (pl) 2004-07-30
NZ299999A (en) 1998-01-26
RU2192407C2 (ru) 2002-11-10
CN1131203C (zh) 2003-12-17
PL318003A1 (en) 1997-07-21
ATE189205T1 (de) 2000-02-15
DE19601745C1 (de) 1997-10-09
NO306059B1 (no) 1999-09-13
KR970059155A (ko) 1997-08-12
JPH09216858A (ja) 1997-08-19
UA45343C2 (uk) 2002-04-15
GR3032489T3 (en) 2000-05-31
SK281612B6 (sk) 2001-05-10
UY24439A1 (es) 1997-01-30
DE59604295D1 (de) 2000-03-02
EP0787715A1 (de) 1997-08-06
DK0787715T3 (da) 2000-04-25
US5723668A (en) 1998-03-03
HU9700141D0 (en) 1997-03-28
CN1161957A (zh) 1997-10-15
IN182218B (he) 1999-02-06
SK6897A3 (en) 1997-08-06
CA2195370A1 (en) 1997-07-20
IL120028A (en) 1999-12-22
NO970211D0 (no) 1997-01-17
AU711750B2 (en) 1999-10-21
MX9700483A (es) 1997-07-31
HUP9700141A3 (en) 2000-03-28
EP0787715B1 (de) 2000-01-26

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