ZA971107B - Thrombin muteins as antidote for thrombin inhibitors - Google Patents
Thrombin muteins as antidote for thrombin inhibitorsInfo
- Publication number
- ZA971107B ZA971107B ZA971107A ZA971107A ZA971107B ZA 971107 B ZA971107 B ZA 971107B ZA 971107 A ZA971107 A ZA 971107A ZA 971107 A ZA971107 A ZA 971107A ZA 971107 B ZA971107 B ZA 971107B
- Authority
- ZA
- South Africa
- Prior art keywords
- thrombin
- antidote
- muteins
- inhibitors
- thrombin inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19605126A DE19605126A1 (de) | 1996-02-12 | 1996-02-12 | Thrombinmuteine als Antidot für Thrombininhibitoren |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA971107B true ZA971107B (en) | 1998-08-11 |
Family
ID=7785198
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA971107A ZA971107B (en) | 1996-02-12 | 1997-02-11 | Thrombin muteins as antidote for thrombin inhibitors |
Country Status (18)
Country | Link |
---|---|
US (1) | US6060300A (de) |
EP (1) | EP0880591A1 (de) |
JP (1) | JPH11512621A (de) |
KR (1) | KR19990082479A (de) |
CN (1) | CN1211280A (de) |
AR (1) | AR005797A1 (de) |
AU (1) | AU1768497A (de) |
BR (1) | BR9707280A (de) |
CA (1) | CA2245546A1 (de) |
CO (1) | CO4600682A1 (de) |
CZ (1) | CZ247798A3 (de) |
DE (1) | DE19605126A1 (de) |
HR (1) | HRP970077A2 (de) |
HU (1) | HUP9900574A2 (de) |
IL (1) | IL125077A0 (de) |
NO (1) | NO983677D0 (de) |
WO (1) | WO1997029198A1 (de) |
ZA (1) | ZA971107B (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20000018933A (ko) * | 1998-09-07 | 2000-04-06 | 김승수 | 내피세포 성장억제 활성을 가지는 사람 프로트롬빈 크링글단백질 및 이를 암호하는 유전자 |
GB2355161B (en) * | 1999-10-05 | 2001-09-12 | 3Com Corp | Network device incorporating selective compression of stored data packets |
KR20020008471A (ko) * | 2000-07-20 | 2002-01-31 | 김승수 | 내피세포 성장 억제활성을 가지는 인간 프로트롬빈크링글, 그것의 재조합벡터 및 이를 발현하는 재조합 숙주 |
EP1996186A4 (de) * | 2006-03-06 | 2009-07-22 | Humagene Inc | Verfahren zur herstellung von rekombinantem menschlichen thrombin und fibrinogen |
PL3078743T3 (pl) | 2007-09-28 | 2020-11-02 | Portola Pharmaceuticals, Inc. | Antidotum dla inhibitorów czynnika XA i sposoby ich stosowania |
JP5709316B2 (ja) | 2008-11-14 | 2015-04-30 | ポートラ ファーマシューティカルズ, インコーポレイテッド | 第Xa因子阻害剤のための解毒剤および血液凝固剤と組み合わせて該解毒剤を使用する方法 |
EP3604510A1 (de) | 2009-03-30 | 2020-02-05 | Portola Pharmaceuticals, Inc. | Gegenmittel für faktor-xa-inhibitoren und verfahren zur verwendung davon |
US9056106B2 (en) | 2009-07-15 | 2015-06-16 | Portola Pharmaceuticals, Inc. | Unit dose formulation of antidotes for factor Xa inhibitors and methods of using the same |
ES2620421T3 (es) * | 2009-10-30 | 2017-06-28 | Senova Gesellschaft für Biowissenschaft und Technik mbH | Peptidasas acopladas a polímero |
AR079944A1 (es) | 2010-01-20 | 2012-02-29 | Boehringer Ingelheim Int | Anticuerpo neutralizante de la actividad de un anticoagulante |
JP2014515740A (ja) | 2011-03-30 | 2014-07-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗凝固薬の解毒剤 |
WO2015183085A1 (en) | 2014-05-26 | 2015-12-03 | Academisch Ziekenhuis Leiden | Prohemostatic proteins for the treatment of bleeding |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4203965A1 (de) * | 1992-02-11 | 1993-08-12 | Max Planck Gesellschaft | Antidot fuer hirudin und synthetische thrombininhibitoren |
-
1996
- 1996-02-12 DE DE19605126A patent/DE19605126A1/de not_active Withdrawn
-
1997
- 1997-02-11 US US09/117,708 patent/US6060300A/en not_active Expired - Fee Related
- 1997-02-11 AU AU17684/97A patent/AU1768497A/en not_active Abandoned
- 1997-02-11 HU HU9900574A patent/HUP9900574A2/hu unknown
- 1997-02-11 ZA ZA971107A patent/ZA971107B/xx unknown
- 1997-02-11 HR HR19605126.6A patent/HRP970077A2/hr not_active Application Discontinuation
- 1997-02-11 IL IL12507797A patent/IL125077A0/xx unknown
- 1997-02-11 JP JP9528173A patent/JPH11512621A/ja active Pending
- 1997-02-11 KR KR1019980706212A patent/KR19990082479A/ko not_active Application Discontinuation
- 1997-02-11 EP EP97903254A patent/EP0880591A1/de not_active Withdrawn
- 1997-02-11 BR BR9707280A patent/BR9707280A/pt not_active Application Discontinuation
- 1997-02-11 CO CO97006960A patent/CO4600682A1/es unknown
- 1997-02-11 WO PCT/EP1997/000612 patent/WO1997029198A1/de not_active Application Discontinuation
- 1997-02-11 CA CA002245546A patent/CA2245546A1/en not_active Abandoned
- 1997-02-11 CN CN97192210A patent/CN1211280A/zh active Pending
- 1997-02-11 CZ CZ982477A patent/CZ247798A3/cs unknown
- 1997-02-12 AR ARP970100548A patent/AR005797A1/es unknown
-
1998
- 1998-08-11 NO NO983677A patent/NO983677D0/no unknown
Also Published As
Publication number | Publication date |
---|---|
EP0880591A1 (de) | 1998-12-02 |
CA2245546A1 (en) | 1997-08-14 |
HUP9900574A2 (hu) | 1999-06-28 |
JPH11512621A (ja) | 1999-11-02 |
DE19605126A1 (de) | 1997-08-14 |
KR19990082479A (ko) | 1999-11-25 |
WO1997029198A1 (de) | 1997-08-14 |
AU1768497A (en) | 1997-08-28 |
US6060300A (en) | 2000-05-09 |
CO4600682A1 (es) | 1998-05-08 |
BR9707280A (pt) | 1999-07-20 |
IL125077A0 (en) | 1999-01-26 |
NO983677L (no) | 1998-08-11 |
CN1211280A (zh) | 1999-03-17 |
HRP970077A2 (en) | 1998-04-30 |
CZ247798A3 (cs) | 1999-03-17 |
AR005797A1 (es) | 1999-07-14 |
NO983677D0 (no) | 1998-08-11 |
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