ZA958081B - N-substituted piperidinyl bicyclic benzoate derivatives - Google Patents

N-substituted piperidinyl bicyclic benzoate derivatives

Info

Publication number
ZA958081B
ZA958081B ZA958081A ZA958081A ZA958081B ZA 958081 B ZA958081 B ZA 958081B ZA 958081 A ZA958081 A ZA 958081A ZA 958081 A ZA958081 A ZA 958081A ZA 958081 B ZA958081 B ZA 958081B
Authority
ZA
South Africa
Prior art keywords
6alkyl
substituted
halo
hydrogen
alk
Prior art date
Application number
ZA958081A
Other languages
English (en)
Inventor
Georges Henri Paul Van Daele
Jean-Paul Rene Marie A Bosmans
Frans Maria Alfons Van Keybus
Original Assignee
Janssen Pharmaceuica N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuica N V filed Critical Janssen Pharmaceuica N V
Publication of ZA958081B publication Critical patent/ZA958081B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA958081A 1994-09-27 1995-09-26 N-substituted piperidinyl bicyclic benzoate derivatives ZA958081B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94202792 1994-09-27
US45548695A 1995-05-31 1995-05-31

Publications (1)

Publication Number Publication Date
ZA958081B true ZA958081B (en) 1997-03-26

Family

ID=26136613

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA958081A ZA958081B (en) 1994-09-27 1995-09-26 N-substituted piperidinyl bicyclic benzoate derivatives

Country Status (23)

Country Link
EP (1) EP0784620B1 (zh)
JP (1) JP3953097B2 (zh)
CN (1) CN1068880C (zh)
AT (1) ATE187453T1 (zh)
AU (1) AU699152B2 (zh)
BR (1) BR9509036A (zh)
CA (1) CA2200578C (zh)
CZ (1) CZ289031B6 (zh)
DE (1) DE69513846T2 (zh)
DK (1) DK0784620T3 (zh)
ES (1) ES2141383T3 (zh)
FI (1) FI119640B (zh)
GR (1) GR3032646T3 (zh)
HU (1) HU218698B (zh)
IL (1) IL115413A (zh)
MY (1) MY113202A (zh)
NO (1) NO313238B1 (zh)
NZ (1) NZ293605A (zh)
PL (1) PL182502B1 (zh)
PT (1) PT784620E (zh)
RU (1) RU2154064C2 (zh)
WO (1) WO1996010027A1 (zh)
ZA (1) ZA958081B (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU753706B2 (en) * 1998-05-14 2002-10-24 Egis Gyogyszergyar Rt. Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
KR101023433B1 (ko) * 2002-01-16 2011-03-25 얀센 파마슈티카 엔.브이. 프루칼로프리드-ｎ-옥사이드
ES2340855T3 (es) 2003-12-23 2010-06-10 Serodus As Modulares de receptores 5-ht perifericos.
NZ551603A (en) 2004-06-24 2010-11-26 Incyte Corp N-substituted piperidines and their use as pharmaceuticals
EP1945632B1 (en) 2005-11-08 2013-09-18 Vertex Pharmaceuticals Incorporated Heterocyclic modulators of atp-binding cassette transporters
NZ581259A (en) 2007-05-09 2012-07-27 Vertex Pharma Modulators of cystic fibrosis transmembrane conductance regulator
DK2639224T3 (en) 2007-12-07 2016-10-17 Vertex Pharma A process for the preparation of cycloalkylcarboxiamido-pyridinbenzoesyrer
NZ702159A (en) 2007-12-07 2016-03-31 Vertex Pharma Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
NZ720282A (en) 2008-02-28 2017-12-22 Vertex Pharma Heteroaryl derivatives as cftr modulators
EP3150198B1 (en) 2010-04-07 2021-09-22 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyriodin-2-yl)benzoic acid and administration thereof
SI2555754T1 (sl) * 2010-04-07 2016-07-29 Vertex Pharmaceuticals Incorporated Trdne farmacevtske oblike 3-(6-(1-(2,2-difluoro-benzo(d)(1,3)dioksol-5- il)ciklopropankarboksamido)-3-metilpiridin-2-il)benzojske kisline
KR102280372B1 (ko) 2013-11-12 2021-07-22 버텍스 파마슈티칼스 인코포레이티드 Cftr 매개된 질환 치료용 약제학적 조성물의 제조 방법
HUE055423T2 (hu) 2014-11-18 2021-11-29 Vertex Pharma Eljárás nagy áteresztõképességû tesztelõ nagy teljesítményû folyadék-kromatográfia elvégzésére

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
DE3810552A1 (de) * 1988-03-29 1989-10-19 Sandoz Ag Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
CA2116024A1 (en) * 1991-08-20 1993-03-04 Francis David King 5-ht4 receptor antagonists
MX9306311A (es) * 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen

Also Published As

Publication number Publication date
CZ289031B6 (cs) 2001-10-17
NZ293605A (en) 1998-07-28
ES2141383T3 (es) 2000-03-16
RU2154064C2 (ru) 2000-08-10
MX9702363A (es) 1997-10-31
EP0784620B1 (en) 1999-12-08
AU699152B2 (en) 1998-11-26
JP3953097B2 (ja) 2007-08-01
CA2200578A1 (en) 1996-04-04
JPH10506118A (ja) 1998-06-16
IL115413A (en) 2000-02-17
PT784620E (pt) 2000-05-31
FI971274A0 (fi) 1997-03-26
CN1068880C (zh) 2001-07-25
MY113202A (en) 2001-12-31
CN1166171A (zh) 1997-11-26
NO971376L (no) 1997-05-05
NO313238B1 (no) 2002-09-02
CZ91897A3 (en) 1997-12-17
PL182502B1 (pl) 2002-01-31
ATE187453T1 (de) 1999-12-15
PL319997A1 (en) 1997-09-01
WO1996010027A1 (en) 1996-04-04
EP0784620A1 (en) 1997-07-23
NO971376D0 (no) 1997-03-24
HUT77173A (hu) 1998-03-02
GR3032646T3 (en) 2000-06-30
FI119640B (fi) 2009-01-30
BR9509036A (pt) 1997-10-14
CA2200578C (en) 2006-11-07
AU3608195A (en) 1996-04-19
HU218698B (hu) 2000-11-28
FI971274A (fi) 1997-03-26
DK0784620T3 (da) 2000-05-22
DE69513846T2 (de) 2000-07-06
IL115413A0 (en) 1995-12-31
DE69513846D1 (de) 2000-01-13

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