ZA957548B - Benzoylguanidines substituted by heterocyclic n-oxide process for their preparation their use as a medicament or diagnostic agent medicament containing them and intermediate products for their preparation - Google Patents
Benzoylguanidines substituted by heterocyclic n-oxide process for their preparation their use as a medicament or diagnostic agent medicament containing them and intermediate products for their preparationInfo
- Publication number
- ZA957548B ZA957548B ZA957548A ZA957548A ZA957548B ZA 957548 B ZA957548 B ZA 957548B ZA 957548 A ZA957548 A ZA 957548A ZA 957548 A ZA957548 A ZA 957548A ZA 957548 B ZA957548 B ZA 957548B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- preparation
- opt
- medicament
- ome
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
- C07D215/60—N-oxides
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Surgery (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Quinoline Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4432106A DE4432106A1 (de) | 1994-09-09 | 1994-09-09 | Mit Heterocyclen-N-Oxid-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum, sie enthaltendes Medikament sowie Zwischenprodukte zu ihrer Herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA957548B true ZA957548B (en) | 1996-04-17 |
Family
ID=6527788
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA957548A ZA957548B (en) | 1994-09-09 | 1995-09-08 | Benzoylguanidines substituted by heterocyclic n-oxide process for their preparation their use as a medicament or diagnostic agent medicament containing them and intermediate products for their preparation |
Country Status (22)
Country | Link |
---|---|
US (1) | US5641792A (ja) |
EP (1) | EP0700904B1 (ja) |
JP (1) | JP4113262B2 (ja) |
KR (1) | KR960010619A (ja) |
CN (1) | CN1119643A (ja) |
AT (1) | ATE210121T1 (ja) |
AU (1) | AU695342B2 (ja) |
CA (1) | CA2157855C (ja) |
CZ (1) | CZ291188B6 (ja) |
DE (2) | DE4432106A1 (ja) |
DK (1) | DK0700904T3 (ja) |
ES (1) | ES2168324T3 (ja) |
FI (1) | FI954190A (ja) |
HU (1) | HU219976B (ja) |
IL (1) | IL115196A (ja) |
NO (1) | NO305202B1 (ja) |
NZ (1) | NZ272946A (ja) |
PL (1) | PL310346A1 (ja) |
PT (1) | PT700904E (ja) |
RU (1) | RU2160727C2 (ja) |
SI (1) | SI9500280B (ja) |
ZA (1) | ZA957548B (ja) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0765867A1 (de) * | 1995-09-27 | 1997-04-02 | Hoechst Aktiengesellschaft | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Antiarrhytmika oder Diagnostikum sowie sie enthaltendes Medikament |
DE19540995A1 (de) * | 1995-11-03 | 1997-05-07 | Hoechst Ag | Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19542306A1 (de) * | 1995-11-14 | 1997-05-15 | Hoechst Ag | Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
PL316439A1 (en) * | 1995-11-20 | 1997-05-26 | Hoechst Ag | Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such |
DE19546736A1 (de) * | 1995-12-14 | 1997-06-19 | Hoechst Ag | Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate |
DE19621319A1 (de) * | 1996-05-28 | 1997-12-04 | Hoechst Ag | Bis-ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19737224A1 (de) | 1997-08-27 | 1999-03-18 | Hoechst Marion Roussel De Gmbh | Pharmazeutisches Kombinationspräparat aus einem Inhibitor des Natrium-Wasserstoff-Austauschers und einem Arzneimittel zur Behandlung von Herz-Kreislauferkrankungen |
US6852739B1 (en) * | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
US6455554B1 (en) | 1999-06-07 | 2002-09-24 | Targacept, Inc. | Oxopyridinyl pharmaceutical compositions and methods for use |
CA2493618A1 (en) * | 2002-08-01 | 2004-02-12 | Nitromed, Inc. | Nitrosated proton pump inhibitors, compositions and methods of use |
KR20070085379A (ko) * | 2004-11-16 | 2007-08-27 | 머크 앤드 캄파니 인코포레이티드 | 뇌졸중 치료용 (2r)-2-프로필옥탄산의 프로드럭 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE271903C (ja) * | ||||
US3780027A (en) | 1970-04-29 | 1973-12-18 | Merck & Co Inc | Anthranilic acid derivatives |
DE2258276C3 (de) * | 1972-11-28 | 1981-08-13 | Bayer Ag, 5090 Leverkusen | Triazolyl-stilbene, sowie deren Herstellung und Verwendung als optische Aufheller |
US3931181A (en) * | 1973-07-27 | 1976-01-06 | Hoffmann-La Roche Inc. | 2,4-Diamino-5-benzylpyrimidines |
JPS59510B2 (ja) * | 1973-11-22 | 1984-01-07 | 塩野義製薬株式会社 | ピリジンユウドウタイ ノ セイゾウホウ |
US4373024A (en) | 1980-12-02 | 1983-02-08 | Phillips Petroleum Company | Apparatus useful for foam breaking |
US4617307A (en) * | 1984-06-20 | 1986-10-14 | Ciba-Geigy Corporation | Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors |
DD271903A1 (de) * | 1988-05-17 | 1989-09-20 | Univ Halle Wittenberg | Verfahren zur herstellung stabiler, 2-unsubstituierter imidazol-3-oxide |
US4959377A (en) * | 1989-06-29 | 1990-09-25 | Hoechst-Roussel Pharmaceuticals Inc. | Phenoxypyridinamine compounds which are use as a dermatological composition |
DE3929582A1 (de) | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
US5212182A (en) * | 1990-10-03 | 1993-05-18 | American Home Products Corpooration | Substituted quinolinyl- and naphthalenylbenzamides or benzylamines and related compounds useful as analgesics |
DK0556674T3 (da) * | 1992-02-15 | 1996-10-14 | Hoechst Ag | 3,5-Substituerede benzoylguanidiner med antiarytmisk virkning og inhiberende virkning på celleproliferation |
TW250479B (ja) * | 1992-12-15 | 1995-07-01 | Hoechst Ag |
-
1994
- 1994-09-09 DE DE4432106A patent/DE4432106A1/de not_active Withdrawn
-
1995
- 1995-09-04 DE DE59509899T patent/DE59509899D1/de not_active Expired - Lifetime
- 1995-09-04 DK DK95113845T patent/DK0700904T3/da active
- 1995-09-04 EP EP95113845A patent/EP0700904B1/de not_active Expired - Lifetime
- 1995-09-04 ES ES95113845T patent/ES2168324T3/es not_active Expired - Lifetime
- 1995-09-04 AT AT95113845T patent/ATE210121T1/de not_active IP Right Cessation
- 1995-09-04 PT PT95113845T patent/PT700904E/pt unknown
- 1995-09-06 IL IL11519695A patent/IL115196A/xx active IP Right Grant
- 1995-09-06 CN CN95116297A patent/CN1119643A/zh active Pending
- 1995-09-07 AU AU30504/95A patent/AU695342B2/en not_active Ceased
- 1995-09-07 FI FI954190A patent/FI954190A/fi unknown
- 1995-09-07 RU RU95115511/04A patent/RU2160727C2/ru not_active IP Right Cessation
- 1995-09-07 KR KR1019950029358A patent/KR960010619A/ko not_active Application Discontinuation
- 1995-09-07 NZ NZ272946A patent/NZ272946A/en unknown
- 1995-09-08 SI SI9500280A patent/SI9500280B/sl unknown
- 1995-09-08 CA CA002157855A patent/CA2157855C/en not_active Expired - Fee Related
- 1995-09-08 ZA ZA957548A patent/ZA957548B/xx unknown
- 1995-09-08 JP JP23096695A patent/JP4113262B2/ja not_active Expired - Fee Related
- 1995-09-08 US US08/525,156 patent/US5641792A/en not_active Expired - Lifetime
- 1995-09-08 CZ CZ19952315A patent/CZ291188B6/cs not_active IP Right Cessation
- 1995-09-08 PL PL95310346A patent/PL310346A1/xx unknown
- 1995-09-08 HU HU9502634A patent/HU219976B/hu not_active IP Right Cessation
- 1995-09-08 NO NO953555A patent/NO305202B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
PT700904E (pt) | 2002-05-31 |
HU219976B (hu) | 2001-10-28 |
NZ272946A (en) | 1996-12-20 |
EP0700904A1 (de) | 1996-03-13 |
EP0700904B1 (de) | 2001-12-05 |
FI954190A (fi) | 1996-03-10 |
FI954190A0 (fi) | 1995-09-07 |
CA2157855A1 (en) | 1996-03-10 |
NO305202B1 (no) | 1999-04-19 |
DK0700904T3 (da) | 2002-03-18 |
CN1119643A (zh) | 1996-04-03 |
SI9500280A (en) | 1996-04-30 |
SI9500280B (en) | 2001-12-31 |
AU695342B2 (en) | 1998-08-13 |
CZ231595A3 (en) | 1996-04-17 |
ATE210121T1 (de) | 2001-12-15 |
CZ291188B6 (cs) | 2003-01-15 |
HUT72630A (en) | 1996-05-28 |
JP4113262B2 (ja) | 2008-07-09 |
DE4432106A1 (de) | 1996-03-14 |
IL115196A (en) | 2003-01-12 |
ES2168324T3 (es) | 2002-06-16 |
JPH0892215A (ja) | 1996-04-09 |
US5641792A (en) | 1997-06-24 |
HU9502634D0 (en) | 1995-11-28 |
RU2160727C2 (ru) | 2000-12-20 |
CA2157855C (en) | 2009-04-21 |
DE59509899D1 (de) | 2002-01-17 |
NO953555L (no) | 1996-03-11 |
AU3050495A (en) | 1996-03-21 |
IL115196A0 (en) | 1995-12-31 |
PL310346A1 (en) | 1996-03-18 |
NO953555D0 (no) | 1995-09-08 |
KR960010619A (ko) | 1996-04-20 |
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