ES425303A1 - Un procedimiento de fabricacion de sales de heparina sim- ples. - Google Patents

Un procedimiento de fabricacion de sales de heparina sim- ples.

Info

Publication number
ES425303A1
ES425303A1 ES425303A ES425303A ES425303A1 ES 425303 A1 ES425303 A1 ES 425303A1 ES 425303 A ES425303 A ES 425303A ES 425303 A ES425303 A ES 425303A ES 425303 A1 ES425303 A1 ES 425303A1
Authority
ES
Spain
Prior art keywords
heparin
sodium
salt
mixed
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES425303A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Choay SA
Original Assignee
Choay SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7313581A external-priority patent/FR2225149A1/fr
Priority claimed from FR7313580A external-priority patent/FR2225406A1/fr
Application filed by Choay SA filed Critical Choay SA
Publication of ES425303A1 publication Critical patent/ES425303A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

UN procedimiento de fabricación de sales de heparina simples que contienen cationes metálicos distinto del sodio, o sales de heparina mixtas, que comprende, en una primera fase, una puesta en contacto de una sal simple inicial de la heparina con una sal del metal que se desea sustituya al contenido en el heparinato inicial, caracterizado por el hecho de que se procede a continuación, en una segunda fase, al menos una vez, al ciclo de operaciones que comprenden la separación de los iones metálicos libres del heparinato obtenido, y la nueva puesta en contacto del heparinato obtenido con la sal que contiene el metal de sustitución
ES425303A 1973-04-13 1974-04-13 Un procedimiento de fabricacion de sales de heparina sim- ples. Expired ES425303A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7313581A FR2225149A1 (en) 1973-04-13 1973-04-13 Sodium-free heparin salts - by cation exchange of sodium salts, anticoagulants without side-effects
FR7313580A FR2225406A1 (en) 1973-04-13 1973-04-13 Sodium-free heparin salts - by cation exchange of sodium salts, anticoagulants without side-effects

Publications (1)

Publication Number Publication Date
ES425303A1 true ES425303A1 (es) 1976-12-16

Family

ID=26217686

Family Applications (1)

Application Number Title Priority Date Filing Date
ES425303A Expired ES425303A1 (es) 1973-04-13 1974-04-13 Un procedimiento de fabricacion de sales de heparina sim- ples.

Country Status (12)

Country Link
US (1) US4168377A (es)
JP (1) JPS5052217A (es)
AR (1) AR210456A1 (es)
AU (1) AU504218B2 (es)
BE (1) BE813707A (es)
CA (1) CA1042001A (es)
CH (1) CH597259A5 (es)
DE (1) DE2417859C2 (es)
ES (1) ES425303A1 (es)
GB (1) GB1471482A (es)
IT (1) IT1100950B (es)
NL (1) NL7405033A (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110878129A (zh) * 2019-12-06 2020-03-13 中国科学院烟台海岸带研究所 一种氨基葡萄糖肝素盐及其应用

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH636888A5 (fr) * 1977-08-08 1983-06-30 Choay Sa Heparines purifiees et leur preparation.
FR2440376A1 (fr) * 1978-11-06 1980-05-30 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
SE449753B (sv) * 1978-11-06 1987-05-18 Choay Sa Mukopolysackaridkomposition med reglerande verkan pa koagulation, lekemedel innehallande densamma samt forfarande for framstellning derav
US4500519A (en) * 1978-11-06 1985-02-19 Choay S.A. Mucopolysaccharides having biological properties, preparation and method of use
US4692435A (en) * 1978-11-06 1987-09-08 Choay, S.A. Mucopolysaccharide composition having a regulatory action on coagulation, medicament containing same and process of preparation
IT1141263B (it) * 1980-02-29 1986-10-01 Italfarmaco Spa Metodo per la preparazione di eparinato di calcio
US4405612A (en) * 1980-05-23 1983-09-20 Riker Laboratories, Inc. Heparin web compositions
US4479799A (en) * 1981-05-21 1984-10-30 Riker Laboratories, Inc. Hypodermic syringe containing microfibers of an amorphous heparin salt
SE8702254D0 (sv) * 1987-05-29 1987-05-29 Kabivitrum Ab Novel heparin derivatives
US20050090662A1 (en) * 1997-01-15 2005-04-28 Beavers Ellington M. Method of making free acids from polysaccharide salts
US6969705B2 (en) * 2000-07-21 2005-11-29 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
US20040171819A1 (en) * 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
US7956046B2 (en) * 2003-07-24 2011-06-07 Aventis Pharma S.A. Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
CN105218704A (zh) * 2015-09-29 2016-01-06 山东绅联生物科技有限公司 一种肝素钙的制备方法
EP3791884A1 (en) 2019-09-16 2021-03-17 Oskar Bunz Combination of heparin and magnesium salt for the treatment of viral infections

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2623001A (en) * 1949-04-07 1952-12-23 Bengt E G V Sylven Preparing heparin
US3192114A (en) * 1952-06-21 1965-06-29 Leo Ab Preparations with protracted acth-effect
AT222807B (de) * 1960-08-26 1962-08-10 Fo We Forschungs Und Verwertun Verfahren zur Herstellung eines therapeutisch wirksamen Produktes
US3482014A (en) * 1966-06-29 1969-12-02 Canada Packers Ltd Orally active heparin and method for making and using same
US3506642A (en) * 1967-07-03 1970-04-14 Canada Packers Ltd Stable orally active heparinoid complexes
FR1538204A (fr) * 1967-09-27 1968-08-30 Canada Packers Ltd Dérivés de l'héparine et procédés pour leur préparation
FR6853M (es) * 1967-12-08 1969-04-08

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110878129A (zh) * 2019-12-06 2020-03-13 中国科学院烟台海岸带研究所 一种氨基葡萄糖肝素盐及其应用
CN110878129B (zh) * 2019-12-06 2022-02-01 中国科学院烟台海岸带研究所 一种氨基葡萄糖肝素盐及其应用

Also Published As

Publication number Publication date
NL7405033A (es) 1974-10-15
US4168377A (en) 1979-09-18
AU6783674A (en) 1975-10-16
BE813707A (fr) 1974-10-14
DE2417859A1 (de) 1974-10-24
IT7830216A0 (it) 1978-11-27
CH597259A5 (es) 1978-03-31
JPS5052217A (es) 1975-05-09
AR210456A1 (es) 1977-08-15
CA1042001A (en) 1978-11-07
IT1100950B (it) 1985-09-28
GB1471482A (en) 1977-04-27
AU504218B2 (en) 1979-10-04
DE2417859C2 (de) 1984-09-20

Similar Documents

Publication Publication Date Title
ES425303A1 (es) Un procedimiento de fabricacion de sales de heparina sim- ples.
PT78191A (en) Process for preparing novel salts of omeprazole and of pharmaceutical compositions containing the same
MY105168A (en) Novel compositions containing hyaluronic acid associates and a process for preparing same.
ES8402591A1 (es) Procedimiento para la obtencion de pirazolooxacinas, pirazolotiacinas y pirazoloquinolinas.
FR2501507B1 (es)
IL47860A0 (en) Novel 5,9 beta-disubstituted 2-tetrahydrofuryl-6,7-benzomorphans and their salts,their production and pharmaceutical compositions containing them
ES475633A1 (es) Procedimiento para la obtencion de derivados de 1-n-4,6-di-0-(aminoglicosil)-1,3-diamino-ciclitol.
DE2963990D1 (en) Analgesic tablet and process for its preparation
IL47237A (en) 15-hydroxy-13-thia prostanoic acid analogues,process for their preparation and pharmaceutical compositions containing them
IL46543A0 (en) New phenoxyalkyl-carboxylic acid derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
ES8503512A1 (es) Complejos de prostaglandinas
IL43927A0 (en) Lysino-calcium chloride and acid addition salts thereof,their preparation and pharmaceutical compositions containing them
ES8304152A1 (es) Procedimiento para la obtencion de derivzados de aminociclitol.
IL48352A (en) 4-o-(2',6-diamino-2',3-,6'-tridesoxy a-dribohexopyranosyl)-6-o-(3''-methyl amino-3'',4'',6''-tridesoxy- ,d-xylohexopyranosyl)-2-desoxystreptamine and its salts,process for por preparing them and pharmaceutical compositions containing them
ES450866A1 (es) Procedimiento para la preparacion de derivados de prostano.
ES486556A1 (es) Procedimiento de preparacion de nuevos poli (h-) sulfatos derutina y sales de los mismos
IL48189A (en) Substituted iminodiacetic acids,process for their preparation,chelating agents containing said substituted iminodiacetic acids and pharmaceutical compositions for treatment of renal calcule containing them
GB1469122A (en) Reagent for technetium-labelled complexes
ES8105316A1 (es) Procedimiento para preparar la sal de d-diamonio del anti- biotico de oxa-beta-lactama
IL48208A (en) L -fluoro-21-hydroxy-16 -methyl- 1,4,8-pregnatriene derivatives,process for their preparation and pharmaceutical compositions containing them
GB1492180A (en) Pharmaceutical composition for the treatment of hyperammoniemia
IL42865A (en) Plant growth regulating compositions containing 2,3,4,6-di-o-aliphatylidene-a-lxylo-2-hexulofuranosonic acid derivatives,their preparation and some new such compounds
GB1514838A (en) Stable suspension of calcium-magnesium oxytetracycline for intrauterine administration in the treatment of bovine metritis
ES425264A3 (es) Procedimiento para la obtencion de un preparado de insuli- na.
ES374950A2 (es) Un procedimiento para la preparacion de beta-naftilacetami-dina.