FR2225406A1 - Sodium-free heparin salts - by cation exchange of sodium salts, anticoagulants without side-effects - Google Patents

Sodium-free heparin salts - by cation exchange of sodium salts, anticoagulants without side-effects

Info

Publication number
FR2225406A1
FR2225406A1 FR7313580A FR7313580A FR2225406A1 FR 2225406 A1 FR2225406 A1 FR 2225406A1 FR 7313580 A FR7313580 A FR 7313580A FR 7313580 A FR7313580 A FR 7313580A FR 2225406 A1 FR2225406 A1 FR 2225406A1
Authority
FR
France
Prior art keywords
salts
sodium
cation exchange
salt
metal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7313580A
Other languages
French (fr)
Other versions
FR2225406B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Choay SA
Original Assignee
Choay SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Choay SA filed Critical Choay SA
Priority to FR7313580A priority Critical patent/FR2225406A1/en
Priority to CA197,189A priority patent/CA1042001A/en
Priority to US05/459,712 priority patent/US4168377A/en
Priority to AR253259A priority patent/AR210456A1/en
Priority to NL7405033A priority patent/NL7405033A/xx
Priority to GB1620974A priority patent/GB1471482A/en
Priority to CH511774A priority patent/CH597259A5/xx
Priority to DE2417859A priority patent/DE2417859C2/en
Priority to AU67836/74A priority patent/AU504218B2/en
Priority to BE143197A priority patent/BE813707A/en
Priority to JP49040463A priority patent/JPS5052217A/ja
Priority to ES425303A priority patent/ES425303A1/en
Publication of FR2225406A1 publication Critical patent/FR2225406A1/en
Application granted granted Critical
Publication of FR2225406B1 publication Critical patent/FR2225406B1/fr
Priority to IT30216/78A priority patent/IT1100950B/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Abstract

Single-metal salts of heparin with metals other than Na or mixed heparin salts are prepd. by contacting a suitable single-metal salt (esp. Na salt) with a metal salt so as to cause cation exchange, and then in a second stage, the ions released in this exchange process are removed and the resultant salt contacted with the exchanging metal again, opt. this treatment cycle is repeated until cation exchange is essentially complete. Ions released may be removed by dialysis and/or pptn. with aq. alcohol. Mixed salts and Ca salts contg. practically no Na are new cpds; esp. pref. are Ca salts contg. 10.3-10.6 wt.% ca and 0.1 wt.% Na. These salts do not cause skin bleeding or haematosis as does the Na salt.
FR7313580A 1973-04-13 1973-04-13 Sodium-free heparin salts - by cation exchange of sodium salts, anticoagulants without side-effects Granted FR2225406A1 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
FR7313580A FR2225406A1 (en) 1973-04-13 1973-04-13 Sodium-free heparin salts - by cation exchange of sodium salts, anticoagulants without side-effects
CA197,189A CA1042001A (en) 1973-04-13 1974-04-09 Mixed heparin salts
AR253259A AR210456A1 (en) 1973-04-13 1974-04-10 PROCEDURE FOR THE MANUFACTURE OF CALCIUM OR MAGNESIUM SALTS OF HEPARIN
US05/459,712 US4168377A (en) 1973-04-13 1974-04-10 Process of preparing mixed heparin salts
GB1620974A GB1471482A (en) 1973-04-13 1974-04-11 Heparing salts
CH511774A CH597259A5 (en) 1973-04-13 1974-04-11
NL7405033A NL7405033A (en) 1973-04-13 1974-04-11
DE2417859A DE2417859C2 (en) 1973-04-13 1974-04-11 Process for the preparation of simple or mixed heparin salts and medicaments containing them
AU67836/74A AU504218B2 (en) 1973-04-13 1974-04-11 Preparation of heparin salts
BE143197A BE813707A (en) 1973-04-13 1974-04-12 PROCESS FOR MANUFACTURING SINGLE HEPARIN SALTS CONTAINING METAL CATIONS OTHER THAN SODIUM
JP49040463A JPS5052217A (en) 1973-04-13 1974-04-12
ES425303A ES425303A1 (en) 1973-04-13 1974-04-13 Process of preparing mixed heparin salts
IT30216/78A IT1100950B (en) 1973-04-13 1978-11-27 MANUFACTURING PROCESS OF SIMPLE HEPARINE SALTS CONTAINING METALLIC CATIONS OTHER THAN SODIUM, OR MIXED

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7313580A FR2225406A1 (en) 1973-04-13 1973-04-13 Sodium-free heparin salts - by cation exchange of sodium salts, anticoagulants without side-effects

Publications (2)

Publication Number Publication Date
FR2225406A1 true FR2225406A1 (en) 1974-11-08
FR2225406B1 FR2225406B1 (en) 1976-06-11

Family

ID=9117970

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7313580A Granted FR2225406A1 (en) 1973-04-13 1973-04-13 Sodium-free heparin salts - by cation exchange of sodium salts, anticoagulants without side-effects

Country Status (1)

Country Link
FR (1) FR2225406A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2400036A1 (en) * 1977-08-08 1979-03-09 Choay Sa PURIFIED HEPARINS AND THEIR PREPARATION

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2400036A1 (en) * 1977-08-08 1979-03-09 Choay Sa PURIFIED HEPARINS AND THEIR PREPARATION

Also Published As

Publication number Publication date
FR2225406B1 (en) 1976-06-11

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Legal Events

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ST Notification of lapse