IL115196A - Benzoylguanidines substituted by heterocyclic n-oxide, process and intermediates for their preparation and pharmaceutical and diagnostic compositions containing them - Google Patents

Benzoylguanidines substituted by heterocyclic n-oxide, process and intermediates for their preparation and pharmaceutical and diagnostic compositions containing them

Info

Publication number
IL115196A
IL115196A IL11519695A IL11519695A IL115196A IL 115196 A IL115196 A IL 115196A IL 11519695 A IL11519695 A IL 11519695A IL 11519695 A IL11519695 A IL 11519695A IL 115196 A IL115196 A IL 115196A
Authority
IL
Israel
Prior art keywords
alkyl
opt
ome
oxide
nme2
Prior art date
Application number
IL11519695A
Other languages
English (en)
Other versions
IL115196A0 (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL115196A0 publication Critical patent/IL115196A0/xx
Publication of IL115196A publication Critical patent/IL115196A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C07D215/60—N-oxides

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
IL11519695A 1994-09-09 1995-09-06 Benzoylguanidines substituted by heterocyclic n-oxide, process and intermediates for their preparation and pharmaceutical and diagnostic compositions containing them IL115196A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4432106A DE4432106A1 (de) 1994-09-09 1994-09-09 Mit Heterocyclen-N-Oxid-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum, sie enthaltendes Medikament sowie Zwischenprodukte zu ihrer Herstellung

Publications (2)

Publication Number Publication Date
IL115196A0 IL115196A0 (en) 1995-12-31
IL115196A true IL115196A (en) 2003-01-12

Family

ID=6527788

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11519695A IL115196A (en) 1994-09-09 1995-09-06 Benzoylguanidines substituted by heterocyclic n-oxide, process and intermediates for their preparation and pharmaceutical and diagnostic compositions containing them

Country Status (22)

Country Link
US (1) US5641792A (ja)
EP (1) EP0700904B1 (ja)
JP (1) JP4113262B2 (ja)
KR (1) KR960010619A (ja)
CN (1) CN1119643A (ja)
AT (1) ATE210121T1 (ja)
AU (1) AU695342B2 (ja)
CA (1) CA2157855C (ja)
CZ (1) CZ291188B6 (ja)
DE (2) DE4432106A1 (ja)
DK (1) DK0700904T3 (ja)
ES (1) ES2168324T3 (ja)
FI (1) FI954190A (ja)
HU (1) HU219976B (ja)
IL (1) IL115196A (ja)
NO (1) NO305202B1 (ja)
NZ (1) NZ272946A (ja)
PL (1) PL310346A1 (ja)
PT (1) PT700904E (ja)
RU (1) RU2160727C2 (ja)
SI (1) SI9500280B (ja)
ZA (1) ZA957548B (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0765867A1 (de) * 1995-09-27 1997-04-02 Hoechst Aktiengesellschaft Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Antiarrhytmika oder Diagnostikum sowie sie enthaltendes Medikament
DE19540995A1 (de) * 1995-11-03 1997-05-07 Hoechst Ag Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19542306A1 (de) * 1995-11-14 1997-05-15 Hoechst Ag Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
PL316439A1 (en) * 1995-11-20 1997-05-26 Hoechst Ag Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
DE19546736A1 (de) * 1995-12-14 1997-06-19 Hoechst Ag Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
DE19621319A1 (de) * 1996-05-28 1997-12-04 Hoechst Ag Bis-ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19737224A1 (de) 1997-08-27 1999-03-18 Hoechst Marion Roussel De Gmbh Pharmazeutisches Kombinationspräparat aus einem Inhibitor des Natrium-Wasserstoff-Austauschers und einem Arzneimittel zur Behandlung von Herz-Kreislauferkrankungen
US6852739B1 (en) * 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
US6455554B1 (en) 1999-06-07 2002-09-24 Targacept, Inc. Oxopyridinyl pharmaceutical compositions and methods for use
CA2493618A1 (en) * 2002-08-01 2004-02-12 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
KR20070085379A (ko) * 2004-11-16 2007-08-27 머크 앤드 캄파니 인코포레이티드 뇌졸중 치료용 (2ｒ)-2-프로필옥탄산의 프로드럭

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE271903C (ja) *
US3780027A (en) 1970-04-29 1973-12-18 Merck & Co Inc Anthranilic acid derivatives
DE2258276C3 (de) * 1972-11-28 1981-08-13 Bayer Ag, 5090 Leverkusen Triazolyl-stilbene, sowie deren Herstellung und Verwendung als optische Aufheller
US3931181A (en) * 1973-07-27 1976-01-06 Hoffmann-La Roche Inc. 2,4-Diamino-5-benzylpyrimidines
JPS59510B2 (ja) * 1973-11-22 1984-01-07 塩野義製薬株式会社 ピリジンユウドウタイ ノ セイゾウホウ
US4373024A (en) 1980-12-02 1983-02-08 Phillips Petroleum Company Apparatus useful for foam breaking
US4617307A (en) * 1984-06-20 1986-10-14 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors
DD271903A1 (de) * 1988-05-17 1989-09-20 Univ Halle Wittenberg Verfahren zur herstellung stabiler, 2-unsubstituierter imidazol-3-oxide
US4959377A (en) * 1989-06-29 1990-09-25 Hoechst-Roussel Pharmaceuticals Inc. Phenoxypyridinamine compounds which are use as a dermatological composition
DE3929582A1 (de) 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
US5212182A (en) * 1990-10-03 1993-05-18 American Home Products Corpooration Substituted quinolinyl- and naphthalenylbenzamides or benzylamines and related compounds useful as analgesics
DK0556674T3 (da) * 1992-02-15 1996-10-14 Hoechst Ag 3,5-Substituerede benzoylguanidiner med antiarytmisk virkning og inhiberende virkning på celleproliferation
TW250479B (ja) * 1992-12-15 1995-07-01 Hoechst Ag

Also Published As

Publication number Publication date
PT700904E (pt) 2002-05-31
HU219976B (hu) 2001-10-28
NZ272946A (en) 1996-12-20
EP0700904A1 (de) 1996-03-13
EP0700904B1 (de) 2001-12-05
FI954190A (fi) 1996-03-10
FI954190A0 (fi) 1995-09-07
CA2157855A1 (en) 1996-03-10
NO305202B1 (no) 1999-04-19
DK0700904T3 (da) 2002-03-18
CN1119643A (zh) 1996-04-03
SI9500280A (en) 1996-04-30
SI9500280B (en) 2001-12-31
AU695342B2 (en) 1998-08-13
CZ231595A3 (en) 1996-04-17
ATE210121T1 (de) 2001-12-15
CZ291188B6 (cs) 2003-01-15
HUT72630A (en) 1996-05-28
JP4113262B2 (ja) 2008-07-09
DE4432106A1 (de) 1996-03-14
ES2168324T3 (es) 2002-06-16
ZA957548B (en) 1996-04-17
JPH0892215A (ja) 1996-04-09
US5641792A (en) 1997-06-24
HU9502634D0 (en) 1995-11-28
RU2160727C2 (ru) 2000-12-20
CA2157855C (en) 2009-04-21
DE59509899D1 (de) 2002-01-17
NO953555L (no) 1996-03-11
AU3050495A (en) 1996-03-21
IL115196A0 (en) 1995-12-31
PL310346A1 (en) 1996-03-18
NO953555D0 (no) 1995-09-08
KR960010619A (ko) 1996-04-20

Similar Documents

Publication Publication Date Title
IL115196A (en) Benzoylguanidines substituted by heterocyclic n-oxide, process and intermediates for their preparation and pharmaceutical and diagnostic compositions containing them
HRP960496B1 (en) Substituted sulphonimidamides, method for their preparation, their use as medicament or diagnostic, and medicament containing them
GR3030365T3 (en) Substituted benzoylguanidines, a process for their preparation, their use as drug or diagnostic agents as well as medicaments containing them
CH676202A5 (ja)
HU913520D0 (en) Process for the production of 7-acyl-3(substituted carbamoiloxy)-cefem-derivatives and of the medical preparations containing them
HUT58110A (en) New compound
GB1060133A (en) A derivative of -aminobenzylpenicillin
GB1465783A (en) Pyrrolyl compounds and processes for their manufacture
GB1239567A (ja)
ES8607319A1 (es) "un procedimiento para la preparacion de un derivado de ce- falosporina"
JPH06700B2 (ja) 安定な水性液剤
GB1274553A (en) Hydroxyalkylene-substituted benzoxazines and benzothiazines
GB1065617A (en) Nitrofuran derivatives
KR940002255A (ko) 디히드록시알릴세펨 화합물 및 이의 제조방법

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed