ZA948086B - Subtilisin variants - Google Patents
Subtilisin variantsInfo
- Publication number
- ZA948086B ZA948086B ZA948086A ZA948086A ZA948086B ZA 948086 B ZA948086 B ZA 948086B ZA 948086 A ZA948086 A ZA 948086A ZA 948086 A ZA948086 A ZA 948086A ZA 948086 B ZA948086 B ZA 948086B
- Authority
- ZA
- South Africa
- Prior art keywords
- carbonyl
- hydrolase
- amino acid
- precursor
- hydrolases
- Prior art date
Links
- 108090000787 Subtilisin Proteins 0.000 title abstract 2
- 108090000604 Hydrolases Proteins 0.000 abstract 7
- 102000004157 Hydrolases Human genes 0.000 abstract 7
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 6
- 239000002243 precursor Substances 0.000 abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 2
- 241000193744 Bacillus amyloliquefaciens Species 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000002797 proteolythic effect Effects 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38609—Protease or amylase in solid compositions only
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Detergent Compositions (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Fats And Perfumes (AREA)
- Separation Of Suspended Particles By Flocculating Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13724093A | 1993-10-14 | 1993-10-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA948086B true ZA948086B (en) | 1995-06-07 |
Family
ID=22476438
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA948086A ZA948086B (en) | 1993-10-14 | 1994-10-14 | Subtilisin variants |
Country Status (24)
Country | Link |
---|---|
US (2) | US6586221B2 (de) |
EP (2) | EP0723590B1 (de) |
JP (1) | JP4086207B2 (de) |
KR (1) | KR100344976B1 (de) |
CN (1) | CN1056649C (de) |
AT (1) | ATE284962T1 (de) |
AU (1) | AU700373B2 (de) |
BR (1) | BR9407825A (de) |
CA (1) | CA2173973C (de) |
CZ (1) | CZ289323B6 (de) |
DE (1) | DE69434187T2 (de) |
DK (1) | DK0723590T3 (de) |
ES (1) | ES2235164T3 (de) |
FI (1) | FI119697B (de) |
HK (1) | HK1000649A1 (de) |
MA (1) | MA23346A1 (de) |
NO (1) | NO325568B1 (de) |
NZ (1) | NZ274998A (de) |
PL (1) | PL178478B1 (de) |
PT (1) | PT723590E (de) |
RU (1) | RU2136756C1 (de) |
TW (1) | TW448230B (de) |
WO (1) | WO1995010615A1 (de) |
ZA (1) | ZA948086B (de) |
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA23346A1 (fr) * | 1993-10-14 | 1995-04-01 | Genencor Int | Variantes de la subtilisine |
DE69434962T2 (de) * | 1993-10-14 | 2008-01-17 | The Procter & Gamble Company, Cincinnati | Proteasehaltige reinigungsmittel |
JP2888986B2 (ja) * | 1993-10-14 | 1999-05-10 | ザ、プロクター、エンド、ギャンブル、カンパニー | プロテアーゼ酵素を含んでなる漂白組成物 |
US6066611A (en) * | 1994-10-13 | 2000-05-23 | The Procter & Gamble Company | Bleaching compositions comprising protease enzymes |
CA2217162A1 (en) * | 1995-05-05 | 1996-11-07 | Unilever Plc | Subtilisin variants |
US5837517A (en) * | 1995-05-05 | 1998-11-17 | Novo Nordisk A/S | Protease variants and compositions |
DE19530816A1 (de) * | 1995-08-23 | 1997-02-27 | Cognis Bio Umwelt | Verwendung von mutierter Subtilisin-Protease in kosmetischen Produkten |
DE19535082A1 (de) | 1995-09-21 | 1997-03-27 | Henkel Ecolab Gmbh & Co Ohg | Pastenförmiges Wasch- und Reinigungsmittel |
US5858948A (en) * | 1996-05-03 | 1999-01-12 | Procter & Gamble Company | Liquid laundry detergent compositions comprising cotton soil release polymers and protease enzymes |
DE19636035A1 (de) | 1996-09-05 | 1998-03-12 | Henkel Ecolab Gmbh & Co Ohg | Pastenförmiges Wasch- und Reinigungsmittel |
KR100591553B1 (ko) * | 1996-11-04 | 2006-06-19 | 노보자임스 에이/에스 | 섭틸라제 변종과 조성물 |
DE19703364A1 (de) | 1997-01-30 | 1998-08-06 | Henkel Ecolab Gmbh & Co Ohg | Pastenförmiges Wasch- und Reinigungsmittel |
DE69819892T2 (de) * | 1997-06-04 | 2004-08-26 | The Procter & Gamble Company, Cincinnati | Enzympartikel für waschmittel mit wasserlöslicher carboxylatsperrschicht und diese enthaltende zusammensetzungen |
WO1998055634A1 (en) * | 1997-06-04 | 1998-12-10 | The Procter & Gamble Company | Protease enzymes for tough cleaning and/or spot and film reduction and compositions incorporating same |
BR9810081A (pt) * | 1997-06-04 | 2000-08-08 | Procter & Gamble | Sistemas de enzima protease mista para limpeza de sujeiras à base de proteìna e composições incorporando os mesmos |
US6284246B1 (en) | 1997-07-30 | 2001-09-04 | The Procter & Gamble Co. | Modified polypeptides with high activity and reduced allergenicity |
AU2002325461B2 (en) * | 1997-10-23 | 2006-05-11 | Genencor International, Inc. | Multiply-substituted protease variants with altered net charge for use in detergents |
ES2367505T3 (es) * | 1997-10-23 | 2011-11-04 | Danisco Us Inc. | Variantes de proteasa con sustituciones múltiples con carga neta alterada para usar en detergentes. |
MA25044A1 (fr) * | 1997-10-23 | 2000-10-01 | Procter & Gamble | Compositions de lavage contenant des variants de proteases multisubstituees. |
CA2313950A1 (en) * | 1997-12-24 | 1999-07-08 | James T. Kellis, Jr. | An improved method of assaying for a preferred enzyme and /or preferred detergent composition |
GB9727470D0 (en) | 1997-12-30 | 1998-02-25 | Genencor Int Bv | Proteases from gram positive organisms |
US6599731B1 (en) | 1997-12-30 | 2003-07-29 | Genencor International, Inc. | Proteases from gram positive organisms |
US6528255B1 (en) | 1997-12-30 | 2003-03-04 | Genencor International, Inc. | Proteases from gram positive organisms |
US6465186B1 (en) | 1997-12-30 | 2002-10-15 | Genecor International, Inc. | Proteases from gram positive organisms |
CA2325568A1 (en) | 1998-03-26 | 1999-09-30 | The Procter & Gamble Company | Serine protease variants having amino acid substitutions |
US6495136B1 (en) | 1998-03-26 | 2002-12-17 | The Procter & Gamble Company | Proteases having modified amino acid sequences conjugated to addition moieties |
US6908757B1 (en) | 1998-03-26 | 2005-06-21 | The Procter & Gamble Company | Serine protease variants having amino acid deletions and substitutions |
DE19857687A1 (de) | 1998-12-15 | 2000-06-21 | Henkel Ecolab Gmbh & Co Ohg | Pastenförmiges Waschmittel |
KR100660818B1 (ko) * | 1998-12-18 | 2006-12-26 | 노보자임스 에이/에스 | 활성부위 루프 영역에 추가적 아미노산 잔기를 가지는서브그룹 i-s1과 i-s2의 서브틸라제 효소 |
DE69941223D1 (de) | 1998-12-21 | 2009-09-17 | Billig Fritz | Chemisch modifizierte enzymen mit mehrfachgeladenen varianten |
US6946128B1 (en) | 1999-07-22 | 2005-09-20 | The Procter & Gamble Company | Protease conjugates having sterically protected epitope regions |
CA2376045A1 (en) | 1999-07-22 | 2001-02-01 | The Procter & Gamble Company | Subtilisin protease variants having amino acid substitutions in defined epitope regions |
WO2001007575A2 (en) | 1999-07-22 | 2001-02-01 | The Procter & Gamble Company | Subtilisin protease variants having amino acid deletions and substitutions in defined epitope regions |
AU5928400A (en) | 1999-07-22 | 2001-02-13 | Procter & Gamble Company, The | Protease conjugates having sterically protected clip sites |
CN1375000A (zh) * | 1999-09-09 | 2002-10-16 | 宝洁公司 | 含有蛋白酶的洗涤剂组合物 |
AU782372B2 (en) * | 1999-12-15 | 2005-07-21 | Novozymes A/S | Subtilase variants having an improved wash performance on egg stains |
JP2003516751A (ja) * | 1999-12-15 | 2003-05-20 | ノボザイムス アクティーゼルスカブ | 卵の染みに及ぼす洗浄性能改良を示すズブチラーゼ変異体 |
US6777218B1 (en) | 2000-03-14 | 2004-08-17 | Novozymes A/S | Subtilase enzymes having an improved wash performance on egg stains |
US7303907B2 (en) | 2001-01-08 | 2007-12-04 | Health Protection Agency | Degradation and detection of TSE infectivity |
CA2441595C (en) * | 2001-03-23 | 2012-07-03 | Genencor International, Inc. | Proteins producing an altered immunogenic response and methods of making and using the same |
DK200101090A (da) | 2001-07-12 | 2001-08-16 | Novozymes As | Subtilase variants |
US7153820B2 (en) | 2001-08-13 | 2006-12-26 | Ecolab Inc. | Solid detergent composition and method for solidifying a detergent composition |
US20030157645A1 (en) * | 2001-12-21 | 2003-08-21 | Direvo Bio Tech Ag. | Subtilisin variants with improved characteristics |
BR0215383A (pt) * | 2001-12-31 | 2006-11-28 | Genencor Int | proteases que produzem resposta imunogênica alterada e métodos de fabricação e uso das mesmas |
EP1530631B1 (de) * | 2002-01-16 | 2013-08-07 | Genencor International, Inc. | Mehrfachsubstituierte proteasevarianten |
PT1523553E (pt) * | 2002-01-16 | 2010-03-03 | Genencor Int | Variantes de protease de substituições múltiplas |
CA2526341C (en) * | 2003-05-07 | 2013-02-19 | Novozymes A/S | Variant subtilisin enzymes (subtilases) |
US20090060933A1 (en) * | 2004-06-14 | 2009-03-05 | Estell David A | Proteases producing an altered immunogenic response and methods of making and using the same |
SI2586456T1 (sl) | 2004-10-29 | 2016-05-31 | Ratiopharm Gmbh | Preoblikovanje in glikopegliacija fibroblastnega rastnega faktorja (FGF) |
KR20090031906A (ko) * | 2006-07-18 | 2009-03-30 | 다니스코 유에스 인크. | 광범위한 온도에 걸쳐 활성인 프로테아제 변이형 |
WO2008048537A1 (en) * | 2006-10-16 | 2008-04-24 | Danisco Us, Inc. Genencor Division | Non-phosphate dish detergents |
US8093200B2 (en) | 2007-02-15 | 2012-01-10 | Ecolab Usa Inc. | Fast dissolving solid detergent |
ES2439958T3 (es) | 2007-10-18 | 2014-01-27 | Ecolab Inc. | Composiciones de limpieza sólidas, céreas y comprimidas, y métodos de hacerlas |
US20110256609A1 (en) * | 2008-06-06 | 2011-10-20 | Basler Joshua R | Compositions And Methods Comprising Variant Microbial Proteases |
WO2010056634A1 (en) * | 2008-11-11 | 2010-05-20 | Danisco Us Inc. | Compositions and methods comprising a subtilisin variant |
CA2743302A1 (en) * | 2008-11-11 | 2010-05-20 | Danisco Us Inc. | Proteases comprising one or more combinable mutations |
US8778650B2 (en) * | 2009-04-30 | 2014-07-15 | Kao Corporation | Alkaline protease variants |
DE102009029513A1 (de) * | 2009-09-16 | 2011-03-24 | Henkel Ag & Co. Kgaa | Lagerstabiles flüssiges Wasch- oder Reinigungsmittel enthaltend Proteasen |
BR112012028466B1 (pt) * | 2010-05-06 | 2020-03-17 | The Procter & Gamble Company | Composição de produtos com variantes de protease e método para tratar e/ou limpar uma superfície |
DE102010028951A1 (de) | 2010-05-12 | 2011-11-17 | Henkel Ag & Co. Kgaa | Lagerstabiles flüssiges Wasch- oder Reinigungsmittel enthaltend Protease und Lipase |
DE102010063458A1 (de) * | 2010-12-17 | 2012-06-21 | Henkel Ag & Co. Kgaa | Lagerstabiles flüssiges Wasch- oder Reinigungsmittel enthaltend Protease und Amylase |
DE102010063457A1 (de) * | 2010-12-17 | 2012-06-21 | Henkel Ag & Co. Kgaa | Lagerstabiles flüssiges Wasch- oder Reinigungsmittel enthaltend Protease und Cellulase |
EP2705146B1 (de) * | 2011-05-05 | 2018-11-07 | Danisco US Inc. | Zusammensetzungen und verfahren mit serinproteasevarianten |
ES2752079T3 (es) | 2011-05-20 | 2020-04-02 | Ecolab Usa Inc | Formulaciones ácidas para uso en un sistema de lavado de utensilios |
EP2792737A1 (de) | 2011-05-20 | 2014-10-22 | Ecolab USA Inc. | Phosphatfreie Reinigungsmittel und phosphatfreie Säuren in einem alternierenden Alkali-/Säuresystem zur Reinigung von Artikeln |
ES2750872T3 (es) | 2011-12-13 | 2020-03-27 | Ecolab Usa Inc | Método de lavado de vajilla |
DE102012201522A1 (de) * | 2012-02-02 | 2013-08-08 | Basf Se | Lagerstabiles flüssiges Geschirrspülmittel enthaltend Protease und Amylase |
EP2628785B1 (de) * | 2012-02-17 | 2016-05-18 | Henkel AG & Co. KGaA | Reinigungsmittelzusammensetzungen mit Subtilasevarianten |
DE102012215107A1 (de) | 2012-08-24 | 2014-02-27 | Basf Se | Festes Geschirrspülmittel mit verbesserter Proteaseleistung |
US9745543B2 (en) | 2012-09-10 | 2017-08-29 | Ecolab Usa Inc. | Stable liquid manual dishwashing compositions containing enzymes |
CN103013960A (zh) * | 2012-12-21 | 2013-04-03 | 青岛蔚蓝生物集团有限公司 | 一种碱性蛋白酶及其重组表达工程菌 |
BR112016005143B1 (pt) | 2013-09-09 | 2021-10-19 | Ecolab Usa Inc | Composição detergente concentrada, solução aquosa e uso de uma composição detergente concentrada |
MX2016002906A (es) | 2013-09-09 | 2016-06-06 | Ecolab Usa Inc | Eliminacion sinergica de manchas a traves de una combinacion de quelacion novedosa. |
EP4276163A1 (de) | 2013-10-24 | 2023-11-15 | Ecolab USA Inc. | Zusammensetzungen und verfahren zum entfernen von schmutz von oberflächen |
US10626388B2 (en) | 2014-07-04 | 2020-04-21 | Novozymes A/S | Subtilase variants and polynucleotides encoding same |
EP3227444B1 (de) * | 2014-12-04 | 2020-02-12 | Novozymes A/S | Subtilasevarianten und polynukleotide zur codierung davon |
WO2016183509A1 (en) * | 2015-05-13 | 2016-11-17 | Danisco Us Inc. | AprL-CLADE PROTEASE VARIANTS AND USES THEREOF |
CN108291179B (zh) | 2015-11-25 | 2020-07-07 | 荷兰联合利华有限公司 | 液体洗涤剂组合物 |
WO2017210295A1 (en) * | 2016-05-31 | 2017-12-07 | Danisco Us Inc. | Protease variants and uses thereof |
WO2018045200A2 (en) * | 2016-09-02 | 2018-03-08 | The Regent Of The University Ofcalifornia | Engineered subtiligase variants for versatile, site-specific labeling of proteins |
CN111373039A (zh) * | 2017-11-29 | 2020-07-03 | 丹尼斯科美国公司 | 具有改善的稳定性的枯草杆菌蛋白酶变体 |
WO2021022045A1 (en) | 2019-07-31 | 2021-02-04 | Ecolab Usa Inc. | Personal protective equipment free delimer compositions |
US11492571B2 (en) * | 2019-10-24 | 2022-11-08 | The Procter & Gamble Company | Automatic dishwashing detergent composition comprising a protease |
WO2023225459A2 (en) | 2022-05-14 | 2023-11-23 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
CN114836408B (zh) * | 2022-05-28 | 2023-09-19 | 湖北大学 | 含有前肽突变体的碱性蛋白酶及应用 |
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DE69434962T2 (de) * | 1993-10-14 | 2008-01-17 | The Procter & Gamble Company, Cincinnati | Proteasehaltige reinigungsmittel |
JP2888986B2 (ja) * | 1993-10-14 | 1999-05-10 | ザ、プロクター、エンド、ギャンブル、カンパニー | プロテアーゼ酵素を含んでなる漂白組成物 |
MA23346A1 (fr) * | 1993-10-14 | 1995-04-01 | Genencor Int | Variantes de la subtilisine |
MA25044A1 (fr) * | 1997-10-23 | 2000-10-01 | Procter & Gamble | Compositions de lavage contenant des variants de proteases multisubstituees. |
US6835550B1 (en) * | 1998-04-15 | 2004-12-28 | Genencor International, Inc. | Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins |
DE69941223D1 (de) * | 1998-12-21 | 2009-09-17 | Billig Fritz | Chemisch modifizierte enzymen mit mehrfachgeladenen varianten |
CA2441595C (en) * | 2001-03-23 | 2012-07-03 | Genencor International, Inc. | Proteins producing an altered immunogenic response and methods of making and using the same |
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1994
- 1994-10-11 MA MA23668A patent/MA23346A1/fr unknown
- 1994-10-13 AU AU80157/94A patent/AU700373B2/en not_active Expired
- 1994-10-13 DK DK94931345T patent/DK0723590T3/da active
- 1994-10-13 WO PCT/US1994/011562 patent/WO1995010615A1/en active IP Right Grant
- 1994-10-13 DE DE69434187T patent/DE69434187T2/de not_active Expired - Lifetime
- 1994-10-13 PT PT94931345T patent/PT723590E/pt unknown
- 1994-10-13 CA CA002173973A patent/CA2173973C/en not_active Expired - Lifetime
- 1994-10-13 ES ES94931345T patent/ES2235164T3/es not_active Expired - Lifetime
- 1994-10-13 CZ CZ19961065A patent/CZ289323B6/cs not_active IP Right Cessation
- 1994-10-13 EP EP94931345A patent/EP0723590B1/de not_active Expired - Lifetime
- 1994-10-13 NZ NZ274998A patent/NZ274998A/en not_active IP Right Cessation
- 1994-10-13 JP JP51201395A patent/JP4086207B2/ja not_active Expired - Lifetime
- 1994-10-13 BR BR9407825A patent/BR9407825A/pt not_active IP Right Cessation
- 1994-10-13 CN CN94193785A patent/CN1056649C/zh not_active Expired - Lifetime
- 1994-10-13 US US08/322,678 patent/US6586221B2/en not_active Expired - Lifetime
- 1994-10-13 EP EP04024046A patent/EP1526182A3/de not_active Withdrawn
- 1994-10-13 PL PL94313942A patent/PL178478B1/pl unknown
- 1994-10-13 AT AT94931345T patent/ATE284962T1/de active
- 1994-10-13 KR KR1019960701923A patent/KR100344976B1/ko not_active IP Right Cessation
- 1994-10-13 RU RU96109372A patent/RU2136756C1/ru active
- 1994-10-14 ZA ZA948086A patent/ZA948086B/xx unknown
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1995
- 1995-01-18 TW TW084100420A patent/TW448230B/zh not_active IP Right Cessation
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1996
- 1996-04-12 FI FI961631A patent/FI119697B/fi not_active IP Right Cessation
- 1996-04-12 NO NO19961468A patent/NO325568B1/no not_active IP Right Cessation
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1997
- 1997-11-11 HK HK97102150A patent/HK1000649A1/xx not_active IP Right Cessation
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2002
- 2002-12-18 US US10/323,324 patent/US7250281B2/en not_active Expired - Fee Related
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