ZA909899B - Process for the preparation of optically pure diastereoisomers of tetrahydrofolate compounds - Google Patents

Process for the preparation of optically pure diastereoisomers of tetrahydrofolate compounds

Info

Publication number
ZA909899B
ZA909899B ZA909899A ZA909899A ZA909899B ZA 909899 B ZA909899 B ZA 909899B ZA 909899 A ZA909899 A ZA 909899A ZA 909899 A ZA909899 A ZA 909899A ZA 909899 B ZA909899 B ZA 909899B
Authority
ZA
South Africa
Prior art keywords
preparation
optically pure
pure diastereoisomers
tetrahydrofolate
compounds
Prior art date
Application number
ZA909899A
Other languages
English (en)
Inventor
Gerhard Schlingmann
Schlingmann Gerhard
Stuart Alan Rosenfeld
Alan Rosenfeld Stuart
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ZA909899B publication Critical patent/ZA909899B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/842—Clostridium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA909899A 1989-12-11 1990-12-10 Process for the preparation of optically pure diastereoisomers of tetrahydrofolate compounds ZA909899B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44966289A 1989-12-11 1989-12-11

Publications (1)

Publication Number Publication Date
ZA909899B true ZA909899B (en) 1991-10-30

Family

ID=23785009

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA909899A ZA909899B (en) 1989-12-11 1990-12-10 Process for the preparation of optically pure diastereoisomers of tetrahydrofolate compounds

Country Status (24)

Country Link
US (1) US5334535A (de)
EP (1) EP0432441B1 (de)
JP (1) JP3027613B2 (de)
KR (1) KR0172118B1 (de)
CN (1) CN1031804C (de)
AR (1) AR245134A1 (de)
AT (1) ATE139799T1 (de)
AU (1) AU641710B2 (de)
CA (1) CA2031784C (de)
CZ (1) CZ279998B6 (de)
DE (1) DE69027585T2 (de)
DK (1) DK0432441T3 (de)
ES (1) ES2090075T3 (de)
FI (1) FI103804B (de)
GR (1) GR3021060T3 (de)
HU (1) HU209761B (de)
IE (1) IE904439A1 (de)
IL (1) IL96265A0 (de)
NO (1) NO177541C (de)
NZ (1) NZ236370A (de)
PL (1) PL166096B1 (de)
PT (1) PT96120B (de)
SK (1) SK279435B6 (de)
ZA (1) ZA909899B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH681303A5 (de) * 1991-01-16 1993-02-26 Eprova Ag
DE4136921A1 (de) * 1991-11-11 1993-05-13 Knoll Ag Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
CH683262A5 (it) * 1992-01-22 1994-02-15 Applied Pharma Res Procedimento per la separazione dei diastereomeri del sale di calcio dell'acido (6(R,S)-N-formiltetraidrofolico).
IT1254635B (it) * 1992-02-20 1995-09-28 Bracco Spa Processo per la separazione degli stereoisomeri dell'acido folinico
CH686369A5 (de) 1994-05-09 1996-03-15 Eprova Ag Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure.
CH693255A5 (de) * 1997-06-13 2003-05-15 Eprova Ag Verwendung von Tetrahydrofolaten in der natürlichenstereoisomeren Form zur Herstellung einer pharmazeutischenZubereitung geeignet zur Beeinflussung des Homocystein-Spiegels.
CH694251A5 (de) * 1999-07-14 2004-10-15 Eprova Ag Herstellung von Tetrahydropterin und Derivaten.
WO2001077367A1 (en) * 2000-04-05 2001-10-18 Rothenberg Sheldon P Radioenzymatic assay for methylenetetrahydrofolate reductase
CH696699A5 (de) * 2006-01-19 2007-10-15 Cerbios Pharma Sa Verfahren zur regioselektiven N(5) -Formylierung von (6S) -5, 6, 7, 8-Tetrahydropteroinsäure und Derivaten davon.
WO2010017526A1 (en) * 2008-08-08 2010-02-11 The Scripps Research Institute Purine nucleotides isotopically labeled in the purine base, methods of making thereof and uses thereof
WO2014018873A2 (en) * 2012-07-27 2014-01-30 Chemic Laboratories Inc. Compositions comprising folic acid derivatives. their preparations and methods of use
CN115656372A (zh) * 2022-10-27 2023-01-31 北京斯利安药业有限公司 一种s-四氢叶酸异构体手性分析方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4500711A (en) * 1977-03-21 1985-02-19 Burroughs Wellcome Co. Synthesis of leucovorin
US4148999A (en) * 1977-08-22 1979-04-10 The Government Of The United States Of America Preparation and purification of citrovorum factor
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
US4746662A (en) * 1987-02-20 1988-05-24 American Cyanamid Company Treatment of arthritis with 3,5-dichloromethotrexate
DE3821875C1 (de) * 1988-06-29 1990-02-15 Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
FR2643081B1 (fr) * 1989-02-14 1991-06-07 Panmedica Sa Folates de magnesium, procede de preparation et compositions pharmaceutiques
CH680731A5 (de) * 1990-04-12 1992-10-30 Sapec Fine Chemicals
JPH07332120A (ja) * 1994-06-08 1995-12-22 Sanshin Ind Co Ltd 多気筒エンジン

Also Published As

Publication number Publication date
JPH0491089A (ja) 1992-03-24
EP0432441A1 (de) 1991-06-19
GR3021060T3 (en) 1996-12-31
NZ236370A (en) 1993-04-28
FI103804B1 (fi) 1999-09-30
KR0172118B1 (ko) 1999-02-01
HU908159D0 (en) 1991-06-28
NO905325L (no) 1991-06-12
EP0432441B1 (de) 1996-06-26
HU209761B (en) 1994-10-28
PT96120A (pt) 1991-09-30
ES2090075T3 (es) 1996-10-16
HUT61335A (en) 1992-12-28
JP3027613B2 (ja) 2000-04-04
CN1031804C (zh) 1996-05-15
CZ610390A3 (en) 1995-06-14
IL96265A0 (en) 1991-08-16
CA2031784C (en) 2000-05-30
ATE139799T1 (de) 1996-07-15
CZ279998B6 (cs) 1995-09-13
AR245134A1 (es) 1993-12-30
DE69027585T2 (de) 1997-01-16
FI906072A0 (fi) 1990-12-10
DK0432441T3 (da) 1996-07-29
SK610390A3 (en) 1998-11-04
DE69027585D1 (de) 1996-08-01
SK279435B6 (sk) 1998-11-04
NO177541B (no) 1995-06-26
AU6793290A (en) 1991-06-13
KR910012262A (ko) 1991-08-07
CN1052509A (zh) 1991-06-26
FI906072A (fi) 1991-06-12
PT96120B (pt) 1998-08-31
US5334535A (en) 1994-08-02
PL288204A1 (en) 1991-12-16
CA2031784A1 (en) 1991-06-12
FI103804B (fi) 1999-09-30
NO177541C (no) 1995-10-04
PL166096B1 (pl) 1995-03-31
NO905325D0 (no) 1990-12-10
IE904439A1 (en) 1991-06-19
AU641710B2 (en) 1993-09-30

Similar Documents

Publication Publication Date Title
HU891461D0 (en) Process for the preparation of novel compounds
EP0428003A3 (en) Process for the preparation of polyetherglycols
HU891463D0 (en) Process for the preparation of novel compounds
HU901593D0 (en) Process for the preparation of novel compounds
BG51041A3 (en) Process for the preparation of (s)- alpha- ethyl- 2- oxo- 1- pyrrolidineacetamide
AR245134A1 (es) Procedimiento para la preparacion de diastereoisomeros opticamente puros de compuestos de tetrahidrofoliato.
GB8917385D0 (en) Process for the preparation of nylon salts
EP0335524A3 (en) Process for the preparation of indigo compounds
HU895849D0 (en) Process for the preparation of 1-threonine
EP0330419A3 (en) Process for the preparation of indigo compound
EP0476649A3 (en) Process for the preparation of carbapeneme compounds
EP0365970A3 (en) Process for the preparation of cyclopropanamide
ZA902149B (en) Process for the preparation of o-carboxypyridyl-and o-carboxyquinolylimidazolinones
HU901603D0 (en) Process for the preparation of fluoro-phenols
IL93596A0 (en) Process for the preparation of n-allylmetatrifluoromethyl-aniline
GB2217707B (en) Process for the preparation of acryloyloxyethoxymethyl-melamines
EP0415189A3 (en) Process for the preparation of aminbenzylalcohol
EP0412361A3 (en) Process for the preparation of 4-methylentetrahydropyran
IL95496A0 (en) Process for the preparation of fluoropyridines
EP0324336A3 (en) Process for the preparation of 3-cyano-4-aryl-pyrroles
ZA909346B (en) Process for the preparation of alkylene-bis(2-pyridylamine)compounds
GB2224026B (en) Process for the preparation of 3-phenoxybenzylalcohol
GB2236535B (en) Process for the preparation of nu-substituted nitro-p-phenylenediamines
EP0368508A3 (en) Process for the preparation of indigo compounds
EP0437820A3 (en) Process for the preparation of glycosyl-anthracyclinones