ZA908343B - Antimuscarinic bronchodilators - Google Patents

Antimuscarinic bronchodilators

Info

Publication number
ZA908343B
ZA908343B ZA908343A ZA908343A ZA908343B ZA 908343 B ZA908343 B ZA 908343B ZA 908343 A ZA908343 A ZA 908343A ZA 908343 A ZA908343 A ZA 908343A ZA 908343 B ZA908343 B ZA 908343B
Authority
ZA
South Africa
Prior art keywords
halo
substituents
alkoxy
hydroxy
optionally substituted
Prior art date
Application number
ZA908343A
Other languages
English (en)
Inventor
Peter Edward Cross
Edward Cross Peter
Alan Stobie
Stobie Alan
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA908343B publication Critical patent/ZA908343B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Glass Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Feeding And Guiding Record Carriers (AREA)
ZA908343A 1989-10-19 1990-10-18 Antimuscarinic bronchodilators ZA908343B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898923590A GB8923590D0 (en) 1989-10-19 1989-10-19 Antimuscarinic bronchodilators

Publications (1)

Publication Number Publication Date
ZA908343B true ZA908343B (en) 1992-06-24

Family

ID=10664848

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA908343A ZA908343B (en) 1989-10-19 1990-10-18 Antimuscarinic bronchodilators

Country Status (19)

Country Link
US (1) US5171744A (fr)
EP (1) EP0424021B1 (fr)
JP (1) JPH06780B2 (fr)
KR (1) KR930004845B1 (fr)
CN (1) CN1022488C (fr)
AT (1) ATE102198T1 (fr)
AU (1) AU616362B2 (fr)
CA (1) CA2027896A1 (fr)
DE (1) DE69007009T2 (fr)
FI (1) FI905147A0 (fr)
GB (1) GB8923590D0 (fr)
HU (1) HU206345B (fr)
NO (1) NO174256C (fr)
NZ (1) NZ235750A (fr)
PL (1) PL287365A1 (fr)
PT (1) PT95610A (fr)
RU (1) RU2005721C1 (fr)
YU (1) YU197290A (fr)
ZA (1) ZA908343B (fr)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE205844T1 (de) * 1990-09-06 2001-10-15 Pfizer Anti-muscarin bronchodilatoren
GB9119705D0 (en) * 1991-09-14 1991-10-30 Pfizer Ltd Therapeutic compounds
US5340826A (en) * 1993-02-04 1994-08-23 Pfizer Inc. Pharmaceutical agents for treatment of urinary incontinence
FR2754261B1 (fr) * 1996-10-08 1998-10-30 Synthelabo Derives de quinuclidine, leur preparation et leur application en therapeutique
US5981549A (en) * 1997-02-14 1999-11-09 Synapse Pharmaceutical International Method for controlling or alleviating the symptoms of respiratory disease and allergies
AU762245B2 (en) * 1998-09-18 2003-06-19 Vertex Pharmaceuticals Incorporated Inhibitors of p38
JP2003089688A (ja) * 1998-12-25 2003-03-28 Mitsubishi-Tokyo Pharmaceuticals Inc イミダゾリン化合物
EP1191930A2 (fr) * 1999-05-20 2002-04-03 Sepracor Inc. Procedes de traitement de l'asthme a l'aide de s-oxybutynine
US7214687B2 (en) 1999-07-14 2007-05-08 Almirall Ag Quinuclidine derivatives and medicinal compositions containing the same
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
KR100869722B1 (ko) 2000-12-22 2008-11-21 알미랄 에이쥐 퀴누클리딘 카르바메이트 유도체 및 ｍ3 길항제로서 그의사용
ATE334128T1 (de) 2000-12-28 2006-08-15 Almirall Prodesfarma Ag Neue chinuclidinderivate und medizinische zusammensetzungen, die diese verbindungen enthalten
ES2203327B1 (es) 2002-06-21 2005-06-16 Almirall Prodesfarma, S.A. Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen.
ES2204295B1 (es) 2002-07-02 2005-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de quinuclidina-amida.
TW200519106A (en) 2003-05-02 2005-06-16 Novartis Ag Organic compounds
CN1893948A (zh) * 2003-10-14 2007-01-10 葛兰素集团有限公司 蕈毒碱性乙酰胆碱受体拮抗剂
GB0401334D0 (en) 2004-01-21 2004-02-25 Novartis Ag Organic compounds
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
ES2246170B1 (es) * 2004-07-29 2007-04-01 Almirall Prodesfarma, S.A. Nuevo procedimiento para preparar derivados de carbamato de quinuclidinio.
GT200500281A (es) 2004-10-22 2006-04-24 Novartis Ag Compuestos organicos.
GB0426164D0 (en) 2004-11-29 2004-12-29 Novartis Ag Organic compounds
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
CA2625664C (fr) 2005-10-21 2016-01-05 Novartis Ag Molecules organiques
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
ATE549337T1 (de) 2006-04-21 2012-03-15 Novartis Ag Purinderivate zur verwendung als adenosin-a2a- rezeptoragonisten
ES2298049B1 (es) 2006-07-21 2009-10-20 Laboratorios Almirall S.A. Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.
WO2008037477A1 (fr) 2006-09-29 2008-04-03 Novartis Ag PYRAZOLOPYRIMIDINES UTILISÉES COMME INHIBITEURS DES LIPIDES KINASES Pl3K
US20100113510A1 (en) * 2006-12-19 2010-05-06 Rhonan Ford Quinuclidinol derivatives as muscarinic receptor antagonists
PL2104535T3 (pl) 2007-01-10 2011-05-31 Irm Llc Związki i kompozycje jako inhibitory proteazy aktywujące kanały
ES2361595T3 (es) 2007-05-07 2011-06-20 Novartis Ag Compuestos orgánicos.
US8415390B2 (en) 2008-05-30 2013-04-09 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
KR20100021451A (ko) * 2007-05-30 2010-02-24 마이크로도스 테라퍼스, 인코포레이티드 옥시부티닌 투여를 위한 방법 및 조성물
US9119777B2 (en) 2008-05-30 2015-09-01 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
MX2010006421A (es) 2007-12-10 2010-06-25 Novartis Ag Compuestos organicos.
MX2010007604A (es) 2008-01-11 2010-08-02 Novartis Ag Pirimidinas como inhibidores de cinasa.
EP2100598A1 (fr) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Composition à inhaler comprenant aclidinium pour le traitement de l'asthme et de maladies respiratoires obstructives chroniques
EP2100599A1 (fr) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Composition à inhaler comprenant aclidinium pour le traitement de l'asthme et de maladies respiratoires obstructives chroniques
US8268834B2 (en) 2008-03-19 2012-09-18 Novartis Ag Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
BRPI0915018A2 (pt) 2008-06-10 2015-10-27 Novartis Ag compostos orgânicos
EP2206712A1 (fr) 2008-12-23 2010-07-14 CHIESI FARMACEUTICI S.p.A. Dérivés d'amino-ester d'alcaloïde et sa composition médicale
WO2010088335A1 (fr) 2009-01-29 2010-08-05 Novartis Ag Benzimidazoles substitués destinés au traitement d'astrocytomes
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
BR112012003262A8 (pt) 2009-08-12 2016-05-17 Novartis Ag compostos de hidrazona heterocíclica e seus usos para tratar câncer e inflamação
IN2012DN01961A (fr) 2009-08-17 2015-08-21 Intellikine Llc
CA2771432A1 (fr) 2009-08-20 2011-02-24 Novartis Ag Composes d'oximes heterocycliques
EP2490687A1 (fr) 2009-10-22 2012-08-29 Vertex Pharmaceuticals Incorporated Compositions destinées au traitement de la mucoviscidose et d'autres maladies chroniques
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
CN102947298B (zh) * 2010-06-22 2016-03-02 奇斯药制品公司 生物碱氨基酯衍生物及其药物组合物
UY33597A (es) 2010-09-09 2012-04-30 Irm Llc Compuestos y composiciones como inhibidores de la trk
WO2012034095A1 (fr) 2010-09-09 2012-03-15 Irm Llc Composés et compositions comme inhibiteurs de trk
US8372845B2 (en) 2010-09-17 2013-02-12 Novartis Ag Pyrazine derivatives as enac blockers
WO2012107500A1 (fr) 2011-02-10 2012-08-16 Novartis Ag Composés de [1, 2, 4] triazolo [4, 3 -b] pyridazine en tant qu'inhibiteurs de la tyrosine kinase c-met
EP2678016B1 (fr) 2011-02-23 2016-08-10 Intellikine, LLC Composés hétérocycliques et leurs utilisations
BR112013021638A2 (pt) 2011-02-25 2016-08-02 Irm Llc "compostos inibidores de trk, seu uso e composições que os compreendem"
EP2510928A1 (fr) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium pour l'amélioration du sommeil des patients avec des maldadies respiratoires
US8883819B2 (en) 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
MX339302B (es) 2011-09-15 2016-05-19 Novartis Ag 3-(quinolin-6-il-tio)-[1,2,4]-triazolo-[4,3-a]-piridinas 6-sustituidas como cinasas de tirosina.
WO2013038386A1 (fr) 2011-09-16 2013-03-21 Novartis Ag Composés hétérocycliques destinés au traitement de la mucosviscidose
WO2013038381A1 (fr) 2011-09-16 2013-03-21 Novartis Ag Dérivés d'amide pyridine/pyrazine
WO2013038373A1 (fr) 2011-09-16 2013-03-21 Novartis Ag Dérivés pyrimidinamides
JP6165733B2 (ja) 2011-09-16 2017-07-19 ノバルティス アーゲー Ｎ−置換ヘテロシクリルカルボキサミド類
WO2013038378A1 (fr) 2011-09-16 2013-03-21 Novartis Ag Dérivés pyridinamides
WO2013078440A2 (fr) 2011-11-23 2013-05-30 Intellikine, Llc Régimes de traitement améliorés utilisant des inhibiteurs de mtor
US8809340B2 (en) 2012-03-19 2014-08-19 Novartis Ag Crystalline form
ES2894830T3 (es) 2012-04-03 2022-02-16 Novartis Ag Productos combinados con inhibidores de tirosina·cinasa y su uso
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
WO2014151147A1 (fr) 2013-03-15 2014-09-25 Intellikine, Llc Combinaison d'inhibiteurs de kinase et ses utilisations
TW201605450A (zh) 2013-12-03 2016-02-16 諾華公司 Ｍｄｍ２抑制劑與ＢＲＡＦ抑制劑之組合及其用途
MX2016013981A (es) 2014-04-24 2016-11-15 Novartis Ag Derivados de amino-piridina como inhibidores de fosfatidil-inositol-3-cinasa.
JP6404944B2 (ja) 2014-04-24 2018-10-17 ノバルティス アーゲー ホスファチジルイノシトール３−キナーゼ阻害薬としてのピラジン誘導体
CA2945212A1 (fr) 2014-04-24 2015-10-29 Novartis Ag Derives amines de pyrazine utilisables en tant qu'inhibiteurs de la phosphatidylinositol 3-kinase
WO2016011658A1 (fr) 2014-07-25 2016-01-28 Novartis Ag Polythérapie
US10195208B2 (en) 2014-07-31 2019-02-05 Novartis Ag Combination therapy
KR20220019015A (ko) 2019-06-10 2022-02-15 노파르티스 아게 Cf, copd, 및 기관지확장증 치료를 위한 피리딘 및 피라진 유도체
WO2021038426A1 (fr) 2019-08-28 2021-03-04 Novartis Ag Dérivés de 1,3-phényl hétéroaryle substitués et leur utilisation dans le traitement d'une maladie
TW202140550A (zh) 2020-01-29 2021-11-01 瑞士商諾華公司 使用抗ｔｓｌｐ抗體治療炎性或阻塞性氣道疾病之方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1219606A (en) * 1968-07-15 1971-01-20 Rech S Et D Applic Scient Soge Quinuclidinol derivatives and preparation thereof
US4644003A (en) * 1985-04-03 1987-02-17 Research Corporation 3-quinuclidinol esters, useful as antagonists of muscarinic acetylcholine receptors
US4843074A (en) * 1988-05-17 1989-06-27 Marion Laboratories, Inc. 1-azabicyclo[2.2.2]octan-3-yl 2-aryl-3-azacyclo-2-hydroxypropionates and their quaternary salts
IT1228288B (it) * 1989-01-09 1991-06-07 Zambon Spa Composti ad attivita' antiserotoninica

Also Published As

Publication number Publication date
HU906495D0 (en) 1991-04-29
US5171744A (en) 1992-12-15
NZ235750A (en) 1992-03-26
YU197290A (sh) 1993-10-20
CN1051041A (zh) 1991-05-01
PL287365A1 (en) 1991-06-03
RU2005721C1 (ru) 1994-01-15
KR930004845B1 (ko) 1993-06-09
CN1022488C (zh) 1993-10-20
HU206345B (en) 1992-10-28
NO174256C (no) 1994-04-06
CA2027896A1 (fr) 1991-04-20
NO174256B (no) 1993-12-27
JPH06780B2 (ja) 1994-01-05
NO904523L (no) 1991-04-22
EP0424021A1 (fr) 1991-04-24
NO904523D0 (no) 1990-10-18
ATE102198T1 (de) 1994-03-15
GB8923590D0 (en) 1989-12-06
FI905147A0 (fi) 1990-10-18
AU6472690A (en) 1991-07-25
DE69007009T2 (de) 1994-06-09
KR910007924A (ko) 1991-05-30
AU616362B2 (en) 1991-10-24
JPH03133980A (ja) 1991-06-07
HUT56365A (en) 1991-08-28
EP0424021B1 (fr) 1994-03-02
PT95610A (pt) 1991-09-13
DE69007009D1 (de) 1994-04-07

Similar Documents

Publication Publication Date Title
GB8923590D0 (en) Antimuscarinic bronchodilators
ES515098A0 (es) Procedimiento para la preparacion de nuevos derivados de carbapenem.
EP0283970A3 (fr) Composés peptidiques, leur procédé de préparation et les compositions pharmaceutiques les contenant
AU2629992A (en) Fungicidal silicon-containing compounds, their preparation and their agrochemical and medicinal uses
EP0632036A3 (fr) Dérivés d'amide et d'urée ayant un activité anti-hypercholestérolémique, leur préparation et leurs applications thérapeutiques
TW240249B (fr)
CA2073005A1 (fr) Bronchodilatateurs antimuscariniques
GR3005990T3 (fr)
CA2116356A1 (fr) Bronchodilatateurs antimuscariniques
PL243329A1 (en) Process for preparing novel derivatives of 7-beta-/(z)-2-/2-aminothiazolyl-4-/2-oxyiminoacetamido/-3-cephemo-4-carboxylic acid
CA2026516A1 (fr) Preparations injectables contenant de la cephalosporine
EP0826684A4 (fr) Derives de piperidine
EP0347902A3 (fr) Dérivés de l'acide pyrrolecarboxylique
AU2983792A (en) Diaminomethyleneamino substituted substituted phenyl thiazoles
AU655869B2 (en) An amphoteric tricyclic compound
EP0201349A3 (fr) Dérivés de tétrazole
EP0335390A3 (fr) Composés de céphalosporine
ZA957025B (en) Process for the preparation of the (-)-N-methyl-N-(4-(4-phenyl-4-acetylaminopiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl) benzamide and its pharmaceutically acceptable salts
JPS57139083A (en) Cephalosporin derivative
JPS57139082A (en) Acid addition salt of cephalosporin derivative