ZA895259B - Process for the production of o2,2'-anhydro-1-(beta-d-arabinofuranosyl)thymine - Google Patents

Process for the production of o2,2'-anhydro-1-(beta-d-arabinofuranosyl)thymine

Info

Publication number
ZA895259B
ZA895259B ZA895259A ZA895259A ZA895259B ZA 895259 B ZA895259 B ZA 895259B ZA 895259 A ZA895259 A ZA 895259A ZA 895259 A ZA895259 A ZA 895259A ZA 895259 B ZA895259 B ZA 895259B
Authority
ZA
South Africa
Prior art keywords
beta
arabinofuranosyl
anhydro
thymine
production
Prior art date
Application number
ZA895259A
Other languages
English (en)
Inventor
Charles William Murtiashaw
William Murtiashaw Charles
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA895259B publication Critical patent/ZA895259B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/09—Pyrimidine radicals with arabinosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA895259A 1988-07-12 1989-07-11 Process for the production of o2,2'-anhydro-1-(beta-d-arabinofuranosyl)thymine ZA895259B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/217,906 US5008384A (en) 1988-07-12 1988-07-12 Process for the production of O.sup. 2,2'-anhydro-1-(β-D-arabinofuranosyl)thymine

Publications (1)

Publication Number Publication Date
ZA895259B true ZA895259B (en) 1991-02-27

Family

ID=22812966

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA895259A ZA895259B (en) 1988-07-12 1989-07-11 Process for the production of o2,2'-anhydro-1-(beta-d-arabinofuranosyl)thymine

Country Status (21)

Country Link
US (1) US5008384A (fr)
EP (1) EP0351126B1 (fr)
JP (1) JPH075626B2 (fr)
KR (1) KR910008112B1 (fr)
CN (1) CN1039423A (fr)
AT (1) ATE117314T1 (fr)
AU (1) AU603042B2 (fr)
CA (1) CA1315776C (fr)
DD (2) DD292003A5 (fr)
DE (1) DE68920648T2 (fr)
DK (1) DK342189A (fr)
ES (1) ES2066853T3 (fr)
FI (1) FI893364A (fr)
GR (1) GR3015293T3 (fr)
HU (1) HUT50843A (fr)
IE (1) IE65735B1 (fr)
IL (1) IL90884A0 (fr)
NO (1) NO892821L (fr)
PT (1) PT91113B (fr)
YU (1) YU138789A (fr)
ZA (1) ZA895259B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3065350B2 (ja) * 1990-11-30 2000-07-17 ヤマサ醤油株式会社 １―（２，３―ジデオキシ―β―Ｄ―グリセロ―ペント―２―エノフラノシル）チミンの製造法
ES2125408T3 (es) * 1994-05-20 1999-03-01 Council Scient Ind Res Un procedimiento para la preparacion de beta-timidina.
US7125983B2 (en) 2000-11-29 2006-10-24 Mitsui Chemicals, Inc. L-nucleic acid derivatives and process for the synthesis thereof
ES2243726T3 (es) * 2001-03-30 2005-12-01 Gilead Sciences, Inc. Procedimiento de preparacion de 2'-halo-beta-l-arabinofuranosil nucleosidos.
DE10216426A1 (de) * 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Verfahren zur Herstellung von beta-L-2'Deoxy-Thymidin
KR20060015542A (ko) 2003-04-28 2006-02-17 이데닉스 (케이만) 리미티드 산업 규모의 뉴클레오시드 합성
WO2005003374A2 (fr) 2003-06-30 2005-01-13 Idenix (Cayman) Limited Synthese de nucleosides ?-l-2-desoxy
EP2007784A2 (fr) 2006-03-15 2008-12-31 Novartis AG Procédé de synthèse de dérivés d'acides b-nucléiques et intermédiaires
JP5504179B2 (ja) 2008-03-03 2014-05-28 トスク インコーポレーティッド 毒性を低減するためのメトトレキセートアジュバントおよびその使用法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322747A (en) * 1965-04-01 1967-05-30 Merck & Co Inc Thionocarbonate nucleosides
US3463850A (en) * 1967-01-03 1969-08-26 Merck & Co Inc Arabinofuranosyl 2-thiopyrimidines and pharmaceutical compositions thereof
US3658788A (en) * 1969-06-06 1972-04-25 Salk Inst For Biological Studi Aminooxazolines and products thereof and processes for synthesizing same
US3812098A (en) * 1970-03-19 1974-05-21 Syntex Inc O2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosine derivatives and methods of making and related procedures
US3709874A (en) * 1970-03-19 1973-01-09 Syntex Corp 1-beta-d-arabinofuranosyl cytosine derivatives and methods of preparing
US3792040A (en) * 1970-03-19 1974-02-12 Syntex Corp Acyl derivatives of o2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosines and methods of preparing
US3920630A (en) * 1970-09-24 1975-11-18 Upjohn Co 2,2{40 -Anhydro-ara-cytidine compounds and process of preparation
SE391183B (sv) * 1971-04-15 1977-02-07 Asahi Chemical Ind 2',3'-0-sulfinylcytidin och syraadditionssalter derav till anvendning som mellanprodukt for framstellning av 2,2'-anhydro-(1-beta-d-arabinofuranosyl) cytosin
US3978042A (en) * 1975-01-31 1976-08-31 The Upjohn Company Process for preparing cyclocytidine derivatives
US4140850A (en) * 1977-08-29 1979-02-20 The Upjohn Company 2,2'-Anhydrotriazine nucleosides and process for preparing the same
JPS5649398A (en) * 1979-09-28 1981-05-02 Yamasa Shoyu Co Ltd Preparation of 1-beta-d-arabinofuranosyl-2,2'-cyclothymine
JPS636557A (ja) * 1986-06-26 1988-01-12 Sharp Corp 微細パタ−ン形成方法

Also Published As

Publication number Publication date
JPH075626B2 (ja) 1995-01-25
DK342189D0 (da) 1989-07-11
EP0351126A2 (fr) 1990-01-17
ES2066853T3 (es) 1995-03-16
EP0351126A3 (en) 1990-10-24
NO892821L (no) 1990-01-15
KR910008112B1 (ko) 1991-10-10
ATE117314T1 (de) 1995-02-15
FI893364A (fi) 1990-01-13
IE892233L (en) 1990-01-12
PT91113B (pt) 1995-01-31
DD284024A5 (de) 1990-10-31
IL90884A0 (en) 1990-02-09
AU603042B2 (en) 1990-11-01
US5008384A (en) 1991-04-16
GR3015293T3 (en) 1995-06-30
IE65735B1 (en) 1995-11-15
EP0351126B1 (fr) 1995-01-18
DE68920648D1 (de) 1995-03-02
NO892821D0 (no) 1989-07-07
JPH0259598A (ja) 1990-02-28
KR900001704A (ko) 1990-02-27
PT91113A (pt) 1990-02-08
DK342189A (da) 1990-01-15
FI893364A0 (fi) 1989-07-11
DE68920648T2 (de) 1995-05-18
YU138789A (en) 1990-12-31
CN1039423A (zh) 1990-02-07
HUT50843A (en) 1990-03-28
AU3802089A (en) 1990-04-26
DD292003A5 (de) 1991-07-18
CA1315776C (fr) 1993-04-06

Similar Documents

Publication Publication Date Title
IE851917L (en) Hydroxylamine derivatives, azetidinones and process for¹preparing azetidinones
DE69004164D1 (de) Diphenylharnstoffderivate.
SE8302694D0 (sv) Immunomodulating agent
ZA895259B (en) Process for the production of o2,2'-anhydro-1-(beta-d-arabinofuranosyl)thymine
IT1225484B (it) Procedimento di sintesi dell'amikacina
PT85035A (en) Process for preparing antiallergy and antiinflammatory agents of benzoxazolones of analogs
DK0662475T3 (da) Fremgangsmåde til fremstilling af 2-perfluoralkyl-3-oxazolin-5-on.
DE3851783D1 (de) Verfahren zur Herstellung von 6-[D(-)-alpha-(4-Äthyl-2,3-dioxo-1-piperazin-carboxamido)-phenylacetamido]penicillansäure.
AU2124892A (en) A method and intermediates for the preparation of 6-fluorobenzisothiazoles
PT86567A (en) Process for preparing thiazolo]3,2-a"benzimidazoles and intermediates used thekein
FI872135A0 (fi) Foerfarande foer framstaellning av kefalosporinderivat.
DK0557519T3 (da) Fremgangsmåde til fremstilling af sulfonamidderivater af norbornan
DK33187A (da) Bicycliske forbindelser
KR830006284A (ko) 5-치환된 옥사졸리딘-2,4-디온의 제조방법