ZA886182B - Antiviral-compounds - Google Patents

Antiviral-compounds

Info

Publication number
ZA886182B
ZA886182B ZA886182A ZA886182A ZA886182B ZA 886182 B ZA886182 B ZA 886182B ZA 886182 A ZA886182 A ZA 886182A ZA 886182 A ZA886182 A ZA 886182A ZA 886182 B ZA886182 B ZA 886182B
Authority
ZA
South Africa
Prior art keywords
compounds
dideoxy
antiviral
fluorothymidine
serotype
Prior art date
Application number
ZA886182A
Other languages
English (en)
Inventor
John William Talbot Selway
William Talbot Selway John
Lowrie Miller Beacham Iii
Miller Beacham Lowrie Iii
Susan Mary Daluge
Mary Daluge Susan
Joel Van Tuttle
Van Tuttle Joel
Thomas Anthony Krenitsky
Anthony Krenitsky Thomas
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of ZA886182B publication Critical patent/ZA886182B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
ZA886182A 1987-08-22 1988-08-19 Antiviral-compounds ZA886182B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878719877A GB8719877D0 (en) 1987-08-22 1987-08-22 Antiviral compounds

Publications (1)

Publication Number Publication Date
ZA886182B true ZA886182B (en) 1990-04-25

Family

ID=10622673

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA886182A ZA886182B (en) 1987-08-22 1988-08-19 Antiviral-compounds

Country Status (19)

Country Link
US (2) US5070078A (da)
EP (2) EP0305117B1 (da)
JP (1) JP2634202B2 (da)
KR (1) KR890003382A (da)
AT (1) ATE82681T1 (da)
AU (1) AU613659B2 (da)
CA (1) CA1333361C (da)
DE (1) DE3876174T2 (da)
DK (3) DK169657B1 (da)
ES (1) ES2052732T3 (da)
GB (1) GB8719877D0 (da)
GR (1) GR3006510T3 (da)
HU (1) HU211666A9 (da)
IE (2) IE940696L (da)
MX (1) MX9203416A (da)
NZ (1) NZ225881A (da)
PT (1) PT88306B (da)
SG (1) SG26364G (da)
ZA (1) ZA886182B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8719877D0 (en) * 1987-08-22 1987-09-30 Wellcome Found Antiviral compounds
GB8726136D0 (en) * 1987-11-07 1987-12-09 Wellcome Found Therapeutic nucleosides
US5157114A (en) * 1988-08-19 1992-10-20 Burroughs Wellcome Co. 2',3'-dideoxy-3'-fluoro-5-ethyngluridine
WO1990003978A1 (en) * 1988-10-03 1990-04-19 Stichting Rega Vzw 5-halogeno-3'-fluoro-2',3'-dideoxyuridine compounds and their therapeutic application
GB9003543D0 (en) * 1990-02-16 1990-04-11 Wellcome Found Therapeutic nucleosides
US5166327A (en) * 1990-07-31 1992-11-24 Yuki Gosei Kogyo Co., Ltd. Process for producing 3'-deoxy-3-'-fluorothymidine
JP2804184B2 (ja) * 1991-05-14 1998-09-24 シャープ株式会社 ファクシミリ装置
DE4121001C1 (da) * 1991-06-21 1993-05-06 Max-Delbrueck-Centrum Fuer Molekulare Medizin Berlin-Buch, O-1115 Berlin, De
US5341595A (en) * 1992-06-15 1994-08-30 Environmental Growth Chambers Environmental chamber for plant growth analysis
GB9309787D0 (en) * 1993-05-12 1993-06-23 Rhone Poulenc Chemicals Purification of fluoronucleosides
ATE169027T1 (de) * 1993-05-12 1998-08-15 Rhodia Limited Herstellung von fluoro-nukleosiden und dafür geeignete zwischenprodukte
SE503787C2 (sv) * 1994-12-07 1996-09-02 Electrolux Ab Anordning för att tillhandahålla kylda eller frysta varor
US5690202A (en) * 1996-04-15 1997-11-25 Myers; John E. Overrunning clutch mechanism
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
US6855561B2 (en) * 2001-09-10 2005-02-15 Quidel Corporation Method for adding an apparent non-signal line to a lateral flow assay
US20030236218A1 (en) * 2002-06-12 2003-12-25 Uckun Fatih M. Aryl phosphate derivatives of d4T with selective activity against adenovirus and HIV
US20060084627A1 (en) * 2002-06-27 2006-04-20 Medivir Ab Synergistic interaction of abacavir and alovudine
CN1248266C (zh) * 2002-12-26 2006-03-29 邱智铭 一种转动式电开关结构
US20050131224A1 (en) * 2003-12-15 2005-06-16 Cti Pet Systems, Inc. Method for preparing radiolabeled thymidine
US7160537B2 (en) * 2003-12-15 2007-01-09 Siemens Medical Solutions Usa, Inc. Method for preparing radiolabeled thymidine having low chromophoric byproducts
RU2628456C1 (ru) * 2016-06-29 2017-08-17 Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) Новые пиримидиновые ингибиторы репликации аденовируса человека

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE103241C (da) *
GB1251828A (da) * 1968-12-19 1971-11-03
DE1913384C2 (de) * 1968-12-20 1982-12-16 Akademie Der Wissenschaften Der Ddr, Ddr 1199 Berlin 1-(2',3'-Didesoxy-3'-fluor-β-D-xylofuranosyl)-thymin, Verfahren zu seiner Herstellung und dieses enthaltende Cytostatica
GB1189973A (en) * 1969-02-14 1970-04-29 Akad Wissenschaften Ddr Cytostatically-Active 2',3'-Didesoxy-3'-Fluoropyrimidine-Nucleosides
US3775397A (en) * 1969-11-12 1973-11-27 Akad Wissenschaften Ddr Novel cytostatic 2',3'-dideoxy-3'-fluoropyrimidine-nucleosides
DD103241A1 (da) * 1972-12-12 1974-01-12
EP0265431A1 (de) * 1985-07-23 1988-05-04 WOLF, Karl Schaltungsanordnung zum starten und zum betrieb mindestens einer niederdruck- oder hochdruck-gasentladungslampe mit hochfrequenten schwingungen
DK167377B1 (da) * 1985-09-17 1993-10-25 Wellcome Found 3'-azidopyrimidinnucleosider eller farmaceutisk acceptable salte eller estere deraf til anvendelse ved behandling af eller profylakse for en human retrovirusinfektion
US4710492A (en) * 1986-06-23 1987-12-01 Yale University 3'-azido-2',3'-dideoxy-5-halouridine and its use in treating patients infected with retroviruses
SE8602981D0 (sv) * 1986-07-04 1986-07-04 Astra Laekemedel Ab Novel medicinal use
DD279407A1 (de) * 1986-07-24 1990-06-06 Akad Wissenschaften Ddr Verfahren zur herstellung eines mittels gegen aids
EP0332626A1 (en) * 1986-11-21 1989-09-20 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Compositions for treating viral infections in humans
US4880782A (en) * 1986-11-21 1989-11-14 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. Method of treating viral infections in humans and compositions therefor
GB8719877D0 (en) * 1987-08-22 1987-09-30 Wellcome Found Antiviral compounds
WO1990003978A1 (en) * 1988-10-03 1990-04-19 Stichting Rega Vzw 5-halogeno-3'-fluoro-2',3'-dideoxyuridine compounds and their therapeutic application

Also Published As

Publication number Publication date
DK91692D0 (da) 1992-07-14
AU2142988A (en) 1989-05-25
IE882533L (en) 1989-02-22
DE3876174T2 (de) 1993-04-01
GB8719877D0 (en) 1987-09-30
CA1333361C (en) 1994-12-06
GR3006510T3 (da) 1993-06-30
EP0305117A2 (en) 1989-03-01
SG26364G (en) 1995-09-18
ATE82681T1 (de) 1992-12-15
KR890003382A (ko) 1989-04-14
DK468288D0 (da) 1988-08-19
PT88306B (pt) 1995-12-29
ES2052732T3 (es) 1994-07-16
DK169437B1 (da) 1994-10-31
IE940696L (en) 1989-02-22
DK468288A (da) 1989-02-23
US5376644A (en) 1994-12-27
NZ225881A (en) 1991-03-26
DE3876174D1 (de) 1993-01-07
PT88306A (pt) 1989-06-30
HU211666A9 (en) 1995-12-28
EP0479336A1 (en) 1992-04-08
DK140393D0 (da) 1993-12-17
IE63655B1 (en) 1995-05-31
JP2634202B2 (ja) 1997-07-23
DK91692A (da) 1992-07-14
EP0305117B1 (en) 1992-11-25
DK169657B1 (da) 1995-01-09
US5070078A (en) 1991-12-03
AU613659B2 (en) 1991-08-08
MX9203416A (es) 1992-07-01
EP0305117A3 (en) 1989-12-27
JPS6468325A (en) 1989-03-14
DK140393A (da) 1993-12-17

Similar Documents

Publication Publication Date Title
ZA886182B (en) Antiviral-compounds
MY104069A (en) Therapeutic nucleosides
MX9203808A (es) Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos.
HUT61989A (en) Process for producing 2-deoxy-2,3-didehydro-n-acetylneuraminic acid derivatives and analogs, as well as pharmaceutical compositions comprising same as active ingredient
AU4613999A (en) 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
ES8801303A1 (es) Un procedimiento para preparar una formulacion farmaceutica que contiene un 2'3'-didesoxi-nucleosido.
WO1999038877A3 (en) 2-(PURIN-9-yl)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES
AU2724292A (en) Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of alpha-d-neuraminic acid
PT86186A (en) Process for the preparation of benzimidazol derivatives and of pharmaceutical compositions containing the same
ES2115760T3 (es) Derivados de 4''-desoxieritromicina.
TNSN90021A1 (fr) Procede de preparation de tetrahydroimidazo (1,4) benzodiazepin -2- thiones antivirales
DK306584A (da) Anthracyclinderivater og syreadditionssalte deraf, deres fremstilling ved fermentering og deres anvendelse som laegemidler
GB1506664A (en) Antiviral compositions
ES8301244A1 (es) Procedimiento para la obtencion de derivados de sisomicina.
ES8102147A1 (es) Procedimiento para la obtencion de derivados de sisomicina
ES8305783A1 (es) Procedimiento para la obtencion de derivados de aminociclitol saturados.
ES8304152A1 (es) Procedimiento para la obtencion de derivzados de aminociclitol.
DK0742716T3 (da) Farmaceutisk sammensætning til systemisk transdermal indgivelse med det aktive middel morphin-6-glucuronid
AU622521B2 (en) Pyrimidinetrione derivatives, processes for their preparation, agents containing them and their use as agents for combating pests
MY111746A (en) Therapeutic nucleosides.
FR2617164B1 (fr) Nouveaux derives de la decahydroquinoleine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
HUT52111A (en) Process for producing cytidine-5'-diphosphatealkanols and -glycerine derivatives, as well pharmaceutical compositions comprising such compounds as active ingredient
MX9700360A (es) Dinoclesido-5, 5 -pirofosfatos.
MY103900A (en) 6-substituted 2'', 3''-dideoxynucleosides and pharmaceutical compositions
JO1664B1 (en) The compound has the effect of immobilizing gastric acid and the process of preparing it