ZA869184B - Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof - Google Patents

Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof

Info

Publication number
ZA869184B
ZA869184B ZA869184A ZA869184A ZA869184B ZA 869184 B ZA869184 B ZA 869184B ZA 869184 A ZA869184 A ZA 869184A ZA 869184 A ZA869184 A ZA 869184A ZA 869184 B ZA869184 B ZA 869184B
Authority
ZA
South Africa
Prior art keywords
intermediates
podophyllotoxin
processes
related compounds
preparation
Prior art date
Application number
ZA869184A
Other languages
English (en)
Inventor
Takushi Kaneko
Henry S L Wong
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ZA869184B publication Critical patent/ZA869184B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Steroid Compounds (AREA)
ZA869184A 1985-12-05 1986-12-04 Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof ZA869184B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/805,484 US4734512A (en) 1985-12-05 1985-12-05 Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof

Publications (1)

Publication Number Publication Date
ZA869184B true ZA869184B (en) 1987-07-29

Family

ID=25191684

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA869184A ZA869184B (en) 1985-12-05 1986-12-04 Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof

Country Status (13)

Country Link
US (2) US4734512A (ko)
EP (1) EP0224938B1 (ko)
JP (1) JPS62145093A (ko)
KR (1) KR900004129B1 (ko)
AT (1) ATE77380T1 (ko)
AU (2) AU599937B2 (ko)
CA (4) CA1318321C (ko)
DE (1) DE3685727T2 (ko)
ES (1) ES2042488T3 (ko)
GR (1) GR3005053T3 (ko)
HU (5) HUT47560A (ko)
IL (3) IL93999A (ko)
ZA (1) ZA869184B (ko)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4644072A (en) * 1985-04-12 1987-02-17 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US5011948A (en) * 1985-04-12 1991-04-30 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US4734512A (en) * 1985-12-05 1988-03-29 Bristol-Myers Company Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof
JPS6393796A (ja) * 1986-10-09 1988-04-25 Shin Etsu Chem Co Ltd ペプチド合成の脱保護基用薬剤
GB9422946D0 (en) * 1994-11-14 1995-01-04 Univ Salamanca Antineoplastic cyclolignan derivatives
KR101203475B1 (ko) * 2004-09-22 2012-11-21 니폰 가야꾸 가부시끼가이샤 신규 블록 공중합체, 미셀 제제물 및 이를 유효성분으로함유하는 항암제
KR20080106254A (ko) 2006-03-28 2008-12-04 니폰 가야꾸 가부시끼가이샤 탁산류의 고분자 결합체
US8940332B2 (en) * 2006-05-18 2015-01-27 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of podophyllotoxins
JP5548364B2 (ja) * 2006-10-03 2014-07-16 日本化薬株式会社 レゾルシノール誘導体の高分子結合体
EP2080779B1 (en) 2006-11-06 2016-05-18 Nippon Kayaku Kabushiki Kaisha Polymeric derivative of nucleic acid metabolic antagonist
JP5548365B2 (ja) 2006-11-08 2014-07-16 日本化薬株式会社 核酸系代謝拮抗剤の高分子誘導体
JP5349318B2 (ja) 2007-09-28 2013-11-20 日本化薬株式会社 ステロイド類の高分子結合体
EP2258397B1 (en) * 2008-03-18 2017-10-11 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of physiologically active substance
WO2009136572A1 (ja) 2008-05-08 2009-11-12 日本化薬株式会社 葉酸若しくは葉酸誘導体の高分子結合体
CN102421827B (zh) 2009-05-15 2014-07-30 日本化药株式会社 具有羟基的生理活性物质的高分子结合体
EP2641605B1 (en) 2010-11-17 2018-03-07 Nippon Kayaku Kabushiki Kaisha Polymer derivative of cytidine metabolism antagonist
EP2754682B1 (en) 2011-09-11 2017-06-07 Nippon Kayaku Kabushiki Kaisha Method for manufacturing block copolymer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4294763A (en) * 1980-03-05 1981-10-13 University Of Rochester Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof
US4391982A (en) * 1980-03-05 1983-07-05 The University Of Rochester Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof
US4644072A (en) * 1985-04-12 1987-02-17 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US4734512A (en) * 1985-12-05 1988-03-29 Bristol-Myers Company Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof

Also Published As

Publication number Publication date
IL80853A (en) 1991-09-16
ES2042488T3 (es) 1993-12-16
HU198940B (en) 1989-12-28
IL94000A0 (en) 1991-01-31
EP0224938A3 (en) 1989-11-02
DE3685727T2 (de) 1993-01-21
HUT48888A (en) 1989-07-28
JPS62145093A (ja) 1987-06-29
HU198465B (en) 1989-10-30
CA1321597C (en) 1993-08-24
HUT47559A (en) 1989-03-28
US4734512A (en) 1988-03-29
EP0224938A2 (en) 1987-06-10
HUT47114A (en) 1989-01-30
DE3685727D1 (de) 1992-07-23
GR3005053T3 (ko) 1993-05-24
IL93999A0 (en) 1991-01-31
CA1318321C (en) 1993-05-25
AU5715190A (en) 1990-10-04
AU599937B2 (en) 1990-08-02
HUT47560A (en) 1989-03-28
AU631216B2 (en) 1992-11-19
KR900004129B1 (ko) 1990-06-16
US4845248A (en) 1989-07-04
HUT48878A (en) 1989-07-28
IL94000A (en) 1991-09-16
AU6587086A (en) 1987-06-11
CA1321596C (en) 1993-08-24
HU198939B (en) 1989-12-28
IL93999A (en) 1991-09-16
HU198938B (en) 1989-12-28
ATE77380T1 (de) 1992-07-15
CA1321595C (en) 1993-08-24
EP0224938B1 (en) 1992-06-17
KR870006032A (ko) 1987-07-08

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