ZA869184B - Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof - Google Patents
Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereofInfo
- Publication number
- ZA869184B ZA869184B ZA869184A ZA869184A ZA869184B ZA 869184 B ZA869184 B ZA 869184B ZA 869184 A ZA869184 A ZA 869184A ZA 869184 A ZA869184 A ZA 869184A ZA 869184 B ZA869184 B ZA 869184B
- Authority
- ZA
- South Africa
- Prior art keywords
- intermediates
- podophyllotoxin
- processes
- related compounds
- preparation
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 5
- 150000001875 compounds Chemical class 0.000 title abstract 3
- YJGVMLPVUAXIQN-UHFFFAOYSA-N epipodophyllotoxin Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YJGVMLPVUAXIQN-UHFFFAOYSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- YJGVMLPVUAXIQN-XVVDYKMHSA-N podophyllotoxin Chemical compound COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-XVVDYKMHSA-N 0.000 title abstract 3
- 229960001237 podophyllotoxin Drugs 0.000 title abstract 3
- YVCVYCSAAZQOJI-UHFFFAOYSA-N podophyllotoxin Natural products COC1=C(O)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YVCVYCSAAZQOJI-UHFFFAOYSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940034982 antineoplastic agent Drugs 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
There are disclosed intermediates which can be converted into podophyllotoxin and related compounds, which are known antineoplastic agents. There are also disclosed processes for the preparation of such intermediates, and processes for the conversion of the intermediates into known intermediates which are readily converted into podophyllotoxin and related compounds.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/805,484 US4734512A (en) | 1985-12-05 | 1985-12-05 | Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA869184B true ZA869184B (en) | 1987-07-29 |
Family
ID=25191684
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA869184A ZA869184B (en) | 1985-12-05 | 1986-12-04 | Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof |
Country Status (13)
Country | Link |
---|---|
US (2) | US4734512A (en) |
EP (1) | EP0224938B1 (en) |
JP (1) | JPS62145093A (en) |
KR (1) | KR900004129B1 (en) |
AT (1) | ATE77380T1 (en) |
AU (2) | AU599937B2 (en) |
CA (4) | CA1318321C (en) |
DE (1) | DE3685727T2 (en) |
ES (1) | ES2042488T3 (en) |
GR (1) | GR3005053T3 (en) |
HU (5) | HU198939B (en) |
IL (3) | IL93999A (en) |
ZA (1) | ZA869184B (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5011948A (en) * | 1985-04-12 | 1991-04-30 | Bristol-Myers Company | Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof |
US4644072A (en) * | 1985-04-12 | 1987-02-17 | Bristol-Myers Company | Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof |
US4734512A (en) * | 1985-12-05 | 1988-03-29 | Bristol-Myers Company | Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof |
JPS6393796A (en) * | 1986-10-09 | 1988-04-25 | Shin Etsu Chem Co Ltd | Agent for eliminating protecting group in peptide synthesis |
GB9422946D0 (en) * | 1994-11-14 | 1995-01-04 | Univ Salamanca | Antineoplastic cyclolignan derivatives |
BRPI0515573A (en) * | 2004-09-22 | 2008-07-29 | Nippon Kayaku Kk | block copolymer, micelle preparation and anticancer agent containing it as the active ingredient |
JP5249016B2 (en) | 2006-03-28 | 2013-07-31 | 日本化薬株式会社 | Taxane polymer conjugates |
JP5181347B2 (en) * | 2006-05-18 | 2013-04-10 | 日本化薬株式会社 | Polymer conjugates of podophyllotoxins |
ES2584840T3 (en) * | 2006-10-03 | 2016-09-29 | Nippon Kayaku Kabushiki Kaisha | Compound of a resorcinol derivative with a polymer |
WO2008056596A1 (en) | 2006-11-06 | 2008-05-15 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of nucleic acid metabolic antagonist |
WO2008056654A1 (en) | 2006-11-08 | 2008-05-15 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of nucleic acid metabolic antagonist |
US8703878B2 (en) * | 2007-09-28 | 2014-04-22 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of steroids |
EP2258397B1 (en) * | 2008-03-18 | 2017-10-11 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of physiologically active substance |
JP5366940B2 (en) | 2008-05-08 | 2013-12-11 | 日本化薬株式会社 | Polymer conjugate of folic acid or folic acid derivative |
CN102421827B (en) | 2009-05-15 | 2014-07-30 | 日本化药株式会社 | Polymer conjugate of bioactive substance having hydroxy group |
TW201304805A (en) | 2010-11-17 | 2013-02-01 | Nippon Kayaku Kk | Novel polymer derivative of cytidine metabolism antagonist |
CA2847114C (en) | 2011-09-11 | 2018-08-21 | Nippon Kayaku Kabushiki Kaisha | Method for manufacturing block copolymer |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4391982A (en) * | 1980-03-05 | 1983-07-05 | The University Of Rochester | Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof |
US4294763A (en) * | 1980-03-05 | 1981-10-13 | University Of Rochester | Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof |
US4644072A (en) * | 1985-04-12 | 1987-02-17 | Bristol-Myers Company | Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof |
US4734512A (en) * | 1985-12-05 | 1988-03-29 | Bristol-Myers Company | Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof |
-
1985
- 1985-12-05 US US06/805,484 patent/US4734512A/en not_active Expired - Fee Related
-
1986
- 1986-12-01 AU AU65870/86A patent/AU599937B2/en not_active Ceased
- 1986-12-03 IL IL93999A patent/IL93999A/en unknown
- 1986-12-03 IL IL80853A patent/IL80853A/en not_active IP Right Cessation
- 1986-12-03 IL IL94000A patent/IL94000A/en unknown
- 1986-12-04 JP JP61289727A patent/JPS62145093A/en active Pending
- 1986-12-04 HU HU884863A patent/HU198939B/en not_active IP Right Cessation
- 1986-12-04 KR KR1019860010378A patent/KR900004129B1/en not_active IP Right Cessation
- 1986-12-04 HU HU864862D patent/HU198465B/en not_active IP Right Cessation
- 1986-12-04 HU HU865028A patent/HU198938B/en not_active IP Right Cessation
- 1986-12-04 CA CA000524593A patent/CA1318321C/en not_active Expired - Fee Related
- 1986-12-04 HU HU864864A patent/HU198940B/en not_active IP Right Cessation
- 1986-12-04 ZA ZA869184A patent/ZA869184B/en unknown
- 1986-12-04 HU HU864865A patent/HUT47560A/en not_active IP Right Cessation
- 1986-12-05 DE DE8686116961T patent/DE3685727T2/en not_active Expired - Fee Related
- 1986-12-05 ES ES86116961T patent/ES2042488T3/en not_active Expired - Lifetime
- 1986-12-05 EP EP86116961A patent/EP0224938B1/en not_active Expired - Lifetime
- 1986-12-05 AT AT86116961T patent/ATE77380T1/en active
-
1987
- 1987-12-07 US US07/129,795 patent/US4845248A/en not_active Expired - Fee Related
-
1990
- 1990-06-15 AU AU57151/90A patent/AU631216B2/en not_active Ceased
-
1992
- 1992-04-15 CA CA000616352A patent/CA1321597C/en not_active Expired - Fee Related
- 1992-04-15 CA CA000616353A patent/CA1321595C/en not_active Expired - Fee Related
- 1992-04-15 CA CA000616355A patent/CA1321596C/en not_active Expired - Fee Related
- 1992-06-30 GR GR920401381T patent/GR3005053T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU6587086A (en) | 1987-06-11 |
AU5715190A (en) | 1990-10-04 |
CA1318321C (en) | 1993-05-25 |
US4845248A (en) | 1989-07-04 |
CA1321597C (en) | 1993-08-24 |
HU198938B (en) | 1989-12-28 |
HUT48888A (en) | 1989-07-28 |
HU198940B (en) | 1989-12-28 |
IL94000A (en) | 1991-09-16 |
ATE77380T1 (en) | 1992-07-15 |
HUT47114A (en) | 1989-01-30 |
HUT48878A (en) | 1989-07-28 |
EP0224938A3 (en) | 1989-11-02 |
HUT47559A (en) | 1989-03-28 |
KR870006032A (en) | 1987-07-08 |
HU198465B (en) | 1989-10-30 |
US4734512A (en) | 1988-03-29 |
EP0224938B1 (en) | 1992-06-17 |
DE3685727D1 (en) | 1992-07-23 |
IL93999A0 (en) | 1991-01-31 |
HU198939B (en) | 1989-12-28 |
CA1321595C (en) | 1993-08-24 |
IL93999A (en) | 1991-09-16 |
AU599937B2 (en) | 1990-08-02 |
KR900004129B1 (en) | 1990-06-16 |
EP0224938A2 (en) | 1987-06-10 |
GR3005053T3 (en) | 1993-05-24 |
IL80853A (en) | 1991-09-16 |
DE3685727T2 (en) | 1993-01-21 |
ES2042488T3 (en) | 1993-12-16 |
AU631216B2 (en) | 1992-11-19 |
IL94000A0 (en) | 1991-01-31 |
JPS62145093A (en) | 1987-06-29 |
CA1321596C (en) | 1993-08-24 |
HUT47560A (en) | 1989-03-28 |
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