ES2042488T3 - Productos intermedios para la produccion de podofilotoxina, y compuestos relacionados y procedimientos para su preparacion y utilizacion. - Google Patents

Productos intermedios para la produccion de podofilotoxina, y compuestos relacionados y procedimientos para su preparacion y utilizacion.

Info

Publication number
ES2042488T3
ES2042488T3 ES86116961T ES86116961T ES2042488T3 ES 2042488 T3 ES2042488 T3 ES 2042488T3 ES 86116961 T ES86116961 T ES 86116961T ES 86116961 T ES86116961 T ES 86116961T ES 2042488 T3 ES2042488 T3 ES 2042488T3
Authority
ES
Spain
Prior art keywords
related compounds
preparation
podofilotoxina
procedures
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES86116961T
Other languages
English (en)
Inventor
Takushi Kaneko
Henry S L Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ES2042488T3 publication Critical patent/ES2042488T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

CONSISTE EN EL USO DE INTERMEDIADORES QUE PUEDEN SER CONVERTIDOS EN PODOFILOTOXINA Y SUS COMPUESTOS, QUE SON CONOCIDOS COMO AGENTES ANTINEOPLASTICOS. COMPRENDE ADEMAS LOS PROCESOS PARA LA PREPARACION DE TALES INTERMEDIADORES Y PROCESOS PARA LA CONVERSION DE LOS INTERMEDIADORES EN INTERMEDIADORES CONOCIDOS QUE SON CONVERTIDOS EN PODOFILOTOXINA Y SUS COMPUESTOS RELATIVOS.
ES86116961T 1985-12-05 1986-12-05 Productos intermedios para la produccion de podofilotoxina, y compuestos relacionados y procedimientos para su preparacion y utilizacion. Expired - Lifetime ES2042488T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/805,484 US4734512A (en) 1985-12-05 1985-12-05 Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof

Publications (1)

Publication Number Publication Date
ES2042488T3 true ES2042488T3 (es) 1993-12-16

Family

ID=25191684

Family Applications (1)

Application Number Title Priority Date Filing Date
ES86116961T Expired - Lifetime ES2042488T3 (es) 1985-12-05 1986-12-05 Productos intermedios para la produccion de podofilotoxina, y compuestos relacionados y procedimientos para su preparacion y utilizacion.

Country Status (13)

Country Link
US (2) US4734512A (es)
EP (1) EP0224938B1 (es)
JP (1) JPS62145093A (es)
KR (1) KR900004129B1 (es)
AT (1) ATE77380T1 (es)
AU (2) AU599937B2 (es)
CA (4) CA1318321C (es)
DE (1) DE3685727T2 (es)
ES (1) ES2042488T3 (es)
GR (1) GR3005053T3 (es)
HU (5) HU198938B (es)
IL (3) IL80853A (es)
ZA (1) ZA869184B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011948A (en) * 1985-04-12 1991-04-30 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US4644072A (en) * 1985-04-12 1987-02-17 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US4734512A (en) * 1985-12-05 1988-03-29 Bristol-Myers Company Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof
JPS6393796A (ja) * 1986-10-09 1988-04-25 Shin Etsu Chem Co Ltd ペプチド合成の脱保護基用薬剤
GB9422946D0 (en) * 1994-11-14 1995-01-04 Univ Salamanca Antineoplastic cyclolignan derivatives
PL1792927T3 (pl) 2004-09-22 2013-09-30 Nippon Kayaku Kk Nowy kopolimer blokowy, preparat micelarny i lek przeciwnowotworowy zawierający ten preparat micelarny jako składnik czynny
WO2007111211A1 (ja) 2006-03-28 2007-10-04 Nippon Kayaku Kabushiki Kaisha タキサン類の高分子結合体
CA2652656A1 (en) * 2006-05-18 2007-11-29 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of podophyllotoxins
CA2664852A1 (en) * 2006-10-03 2008-04-10 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of resorcinol derivatives
WO2008056596A1 (en) 2006-11-06 2008-05-15 Nippon Kayaku Kabushiki Kaisha Polymeric derivative of nucleic acid metabolic antagonist
EP2090607B1 (en) 2006-11-08 2015-05-20 Nippon Kayaku Kabushiki Kaisha Polymeric derivative of nucleic acid metabolic antagonist
USRE46190E1 (en) 2007-09-28 2016-11-01 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of steroids
US8920788B2 (en) * 2008-03-18 2014-12-30 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of physiologically active substances
EP2284209B1 (en) 2008-05-08 2016-08-31 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of folic acid or folic acid derivative
EP2431403B1 (en) 2009-05-15 2016-09-28 Nipponkayaku Kabushikikaisha Polymer conjugate of bioactive substance having hydroxy group
CN103221054A (zh) 2010-11-17 2013-07-24 日本化药株式会社 新的胞苷类代谢拮抗剂的高分子衍生物
BR112014005452B1 (pt) 2011-09-11 2021-03-16 Nippon Kayaku Kabushiki Kaisha método de produção de copolímero de bloco

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4294763A (en) * 1980-03-05 1981-10-13 University Of Rochester Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof
US4391982A (en) * 1980-03-05 1983-07-05 The University Of Rochester Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof
US4644072A (en) * 1985-04-12 1987-02-17 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US4734512A (en) * 1985-12-05 1988-03-29 Bristol-Myers Company Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof

Also Published As

Publication number Publication date
DE3685727T2 (de) 1993-01-21
US4845248A (en) 1989-07-04
CA1321596C (en) 1993-08-24
HU198940B (en) 1989-12-28
ATE77380T1 (de) 1992-07-15
HUT47114A (en) 1989-01-30
AU631216B2 (en) 1992-11-19
IL93999A (en) 1991-09-16
JPS62145093A (ja) 1987-06-29
EP0224938B1 (en) 1992-06-17
HUT48878A (en) 1989-07-28
AU599937B2 (en) 1990-08-02
EP0224938A3 (en) 1989-11-02
HU198465B (en) 1989-10-30
CA1321597C (en) 1993-08-24
IL80853A (en) 1991-09-16
KR900004129B1 (ko) 1990-06-16
IL93999A0 (en) 1991-01-31
HUT47559A (en) 1989-03-28
AU6587086A (en) 1987-06-11
IL94000A0 (en) 1991-01-31
CA1318321C (en) 1993-05-25
HUT47560A (en) 1989-03-28
HU198939B (en) 1989-12-28
US4734512A (en) 1988-03-29
AU5715190A (en) 1990-10-04
HUT48888A (en) 1989-07-28
HU198938B (en) 1989-12-28
KR870006032A (ko) 1987-07-08
ZA869184B (en) 1987-07-29
EP0224938A2 (en) 1987-06-10
IL94000A (en) 1991-09-16
CA1321595C (en) 1993-08-24
GR3005053T3 (es) 1993-05-24
DE3685727D1 (de) 1992-07-23

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