DE3685727D1 - Zwischenprodukte fuer die produktion von podophyllotoxin und verwandte verbindungen und verfahren zu deren herstellung und deren verwendung. - Google Patents

Zwischenprodukte fuer die produktion von podophyllotoxin und verwandte verbindungen und verfahren zu deren herstellung und deren verwendung.

Info

Publication number
DE3685727D1
DE3685727D1 DE8686116961T DE3685727T DE3685727D1 DE 3685727 D1 DE3685727 D1 DE 3685727D1 DE 8686116961 T DE8686116961 T DE 8686116961T DE 3685727 T DE3685727 T DE 3685727T DE 3685727 D1 DE3685727 D1 DE 3685727D1
Authority
DE
Germany
Prior art keywords
production
podophyllotoxin
related compounds
intermediate products
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686116961T
Other languages
English (en)
Other versions
DE3685727T2 (de
Inventor
Takushi Kaneko
Henry S L Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DE3685727D1 publication Critical patent/DE3685727D1/de
Publication of DE3685727T2 publication Critical patent/DE3685727T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Steroid Compounds (AREA)
DE8686116961T 1985-12-05 1986-12-05 Zwischenprodukte fuer die produktion von podophyllotoxin und verwandte verbindungen und verfahren zu deren herstellung und deren verwendung. Expired - Fee Related DE3685727T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/805,484 US4734512A (en) 1985-12-05 1985-12-05 Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof

Publications (2)

Publication Number Publication Date
DE3685727D1 true DE3685727D1 (de) 1992-07-23
DE3685727T2 DE3685727T2 (de) 1993-01-21

Family

ID=25191684

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686116961T Expired - Fee Related DE3685727T2 (de) 1985-12-05 1986-12-05 Zwischenprodukte fuer die produktion von podophyllotoxin und verwandte verbindungen und verfahren zu deren herstellung und deren verwendung.

Country Status (13)

Country Link
US (2) US4734512A (de)
EP (1) EP0224938B1 (de)
JP (1) JPS62145093A (de)
KR (1) KR900004129B1 (de)
AT (1) ATE77380T1 (de)
AU (2) AU599937B2 (de)
CA (4) CA1318321C (de)
DE (1) DE3685727T2 (de)
ES (1) ES2042488T3 (de)
GR (1) GR3005053T3 (de)
HU (5) HUT47560A (de)
IL (3) IL93999A (de)
ZA (1) ZA869184B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4644072A (en) * 1985-04-12 1987-02-17 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US5011948A (en) * 1985-04-12 1991-04-30 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US4734512A (en) * 1985-12-05 1988-03-29 Bristol-Myers Company Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof
JPS6393796A (ja) * 1986-10-09 1988-04-25 Shin Etsu Chem Co Ltd ペプチド合成の脱保護基用薬剤
GB9422946D0 (en) * 1994-11-14 1995-01-04 Univ Salamanca Antineoplastic cyclolignan derivatives
KR101203475B1 (ko) * 2004-09-22 2012-11-21 니폰 가야꾸 가부시끼가이샤 신규 블록 공중합체, 미셀 제제물 및 이를 유효성분으로함유하는 항암제
KR20080106254A (ko) 2006-03-28 2008-12-04 니폰 가야꾸 가부시끼가이샤 탁산류의 고분자 결합체
US8940332B2 (en) * 2006-05-18 2015-01-27 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of podophyllotoxins
JP5548364B2 (ja) * 2006-10-03 2014-07-16 日本化薬株式会社 レゾルシノール誘導体の高分子結合体
EP2080779B1 (de) 2006-11-06 2016-05-18 Nippon Kayaku Kabushiki Kaisha Polymeres derivat eines nucleinsäuremetabolismus-antagonisten
JP5548365B2 (ja) 2006-11-08 2014-07-16 日本化薬株式会社 核酸系代謝拮抗剤の高分子誘導体
JP5349318B2 (ja) 2007-09-28 2013-11-20 日本化薬株式会社 ステロイド類の高分子結合体
EP2258397B1 (de) * 2008-03-18 2017-10-11 Nippon Kayaku Kabushiki Kaisha Polymerkonjugat aus einem physiologisch aktiven stoff
WO2009136572A1 (ja) 2008-05-08 2009-11-12 日本化薬株式会社 葉酸若しくは葉酸誘導体の高分子結合体
CN102421827B (zh) 2009-05-15 2014-07-30 日本化药株式会社 具有羟基的生理活性物质的高分子结合体
EP2641605B1 (de) 2010-11-17 2018-03-07 Nippon Kayaku Kabushiki Kaisha Polymerderivat für einen cytidinstoffwechselantagonisten
EP2754682B1 (de) 2011-09-11 2017-06-07 Nippon Kayaku Kabushiki Kaisha Verfahren zur herstellung von blockcopolymer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4294763A (en) * 1980-03-05 1981-10-13 University Of Rochester Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof
US4391982A (en) * 1980-03-05 1983-07-05 The University Of Rochester Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof
US4644072A (en) * 1985-04-12 1987-02-17 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US4734512A (en) * 1985-12-05 1988-03-29 Bristol-Myers Company Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof

Also Published As

Publication number Publication date
IL80853A (en) 1991-09-16
ES2042488T3 (es) 1993-12-16
HU198940B (en) 1989-12-28
IL94000A0 (en) 1991-01-31
EP0224938A3 (en) 1989-11-02
DE3685727T2 (de) 1993-01-21
HUT48888A (en) 1989-07-28
JPS62145093A (ja) 1987-06-29
HU198465B (en) 1989-10-30
CA1321597C (en) 1993-08-24
HUT47559A (en) 1989-03-28
US4734512A (en) 1988-03-29
EP0224938A2 (de) 1987-06-10
HUT47114A (en) 1989-01-30
GR3005053T3 (de) 1993-05-24
IL93999A0 (en) 1991-01-31
CA1318321C (en) 1993-05-25
AU5715190A (en) 1990-10-04
AU599937B2 (en) 1990-08-02
HUT47560A (en) 1989-03-28
AU631216B2 (en) 1992-11-19
KR900004129B1 (ko) 1990-06-16
US4845248A (en) 1989-07-04
HUT48878A (en) 1989-07-28
ZA869184B (en) 1987-07-29
IL94000A (en) 1991-09-16
AU6587086A (en) 1987-06-11
CA1321596C (en) 1993-08-24
HU198939B (en) 1989-12-28
IL93999A (en) 1991-09-16
HU198938B (en) 1989-12-28
ATE77380T1 (de) 1992-07-15
CA1321595C (en) 1993-08-24
EP0224938B1 (de) 1992-06-17
KR870006032A (ko) 1987-07-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee