ZA86838B - Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same - Google Patents
Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using sameInfo
- Publication number
- ZA86838B ZA86838B ZA86838A ZA86838A ZA86838B ZA 86838 B ZA86838 B ZA 86838B ZA 86838 A ZA86838 A ZA 86838A ZA 86838 A ZA86838 A ZA 86838A ZA 86838 B ZA86838 B ZA 86838B
- Authority
- ZA
- South Africa
- Prior art keywords
- same
- tetracyclines
- preparing
- methods
- possessing anti
- Prior art date
Links
- 239000004098 Tetracycline Substances 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 235000019364 tetracycline Nutrition 0.000 title abstract 4
- 150000003522 tetracyclines Chemical class 0.000 title abstract 4
- 230000000791 anti-collagenolytic effect Effects 0.000 title abstract 2
- 229960002180 tetracycline Drugs 0.000 title 1
- 229930101283 tetracycline Natural products 0.000 title 1
- 229940040944 tetracyclines Drugs 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 102000008186 Collagen Human genes 0.000 abstract 1
- 108010035532 Collagen Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 235000019728 animal nutrition Nutrition 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229920001436 collagen Polymers 0.000 abstract 1
- 229960002424 collagenase Drugs 0.000 abstract 1
- 201000007717 corneal ulcer Diseases 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229940088598 enzyme Drugs 0.000 abstract 1
- 238000010348 incorporation Methods 0.000 abstract 1
- 208000028169 periodontal disease Diseases 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 230000004584 weight gain Effects 0.000 abstract 1
- 235000019786 weight gain Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fodder In General (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/699,048 US4704383A (en) | 1983-12-29 | 1985-02-07 | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA86838B true ZA86838B (en) | 1986-10-29 |
Family
ID=24807719
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA86838A ZA86838B (en) | 1985-02-07 | 1986-02-05 | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
Country Status (12)
Country | Link |
---|---|
US (1) | US4704383A (ja) |
EP (1) | EP0195906B1 (ja) |
JP (1) | JP2676080B2 (ja) |
AT (1) | ATE81460T1 (ja) |
AU (1) | AU583884B2 (ja) |
CA (1) | CA1297410C (ja) |
DE (1) | DE3686956T2 (ja) |
DK (1) | DK174997B1 (ja) |
ES (1) | ES8708182A1 (ja) |
GR (1) | GR860333B (ja) |
IE (1) | IE58813B1 (ja) |
ZA (1) | ZA86838B (ja) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE34656E (en) * | 1983-12-29 | 1994-07-05 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency |
ES8802468A1 (es) * | 1985-05-02 | 1988-07-16 | Research Corp | Metodo de preparar medicamentos que incluyen un agente buscador de hueso y un inhibidor de anhidrasa carbonica, para impedir y curar enfermedades oseas. |
US5308839A (en) * | 1989-12-04 | 1994-05-03 | The Research Foundation Of State University Of New York | Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline |
JP3016587B2 (ja) * | 1989-12-04 | 2000-03-06 | ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク | 非ステロイド抗炎症剤及びテトラサイクリンの配合 |
US5045538A (en) * | 1990-06-28 | 1991-09-03 | The Research Foundation Of State University Of New York | Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines |
US5223248A (en) * | 1991-02-11 | 1993-06-29 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing antiplaque properties |
US5770588A (en) * | 1991-02-11 | 1998-06-23 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions of the prevention and treatment of root caries |
CA2094874C (en) * | 1992-04-27 | 2003-02-11 | Thomas F. Mcnamara | Non-antibacterial tetracycline compositons possessing antiplaque properties |
US5258371A (en) * | 1992-05-29 | 1993-11-02 | Kuraray Co., Ltd. | Method to reduce connective tissue destruction |
US5700485A (en) * | 1992-09-10 | 1997-12-23 | Children's Medical Center Corporation | Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid |
ES2170074T3 (es) * | 1992-09-10 | 2002-08-01 | Childrens Medical Center | Matrices de polimero biodegradables para la liberacion prolongada de agentes anestesicos locales. |
US5922340A (en) | 1992-09-10 | 1999-07-13 | Children's Medical Center Corporation | High load formulations and methods for providing prolonged local anesthesia |
US5523297A (en) * | 1993-03-02 | 1996-06-04 | The Research Foundation Of State University Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
US6043231A (en) * | 1993-03-02 | 2000-03-28 | The Research Foundation Of State Univ. Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
US5641636A (en) * | 1994-05-20 | 1997-06-24 | University Of Pennsylvania | Method of predicting fetal membrane rupture based on matrix metalloproteinase-9 activity |
US6140099A (en) * | 1994-05-20 | 2000-10-31 | The Trustees Of The University Of Pennsylvania | Method of delaying fetal membrane rupture by inhibiting matrix metalloproteinase-9 activity |
KR100245395B1 (ko) | 1995-06-09 | 2000-03-02 | 그린 마틴, 브라이언 쥐 테슬리 | 장기간의 국소 마취를 제공하는 제형 및 그 방법 |
AU733867B2 (en) | 1996-06-24 | 2001-05-31 | Euro-Celtique S.A. | Methods for providing safe local anesthesia |
US5827840A (en) * | 1996-08-01 | 1998-10-27 | The Research Foundation Of State University Of New York | Promotion of wound healing by chemically-modified tetracyclines |
US6046187A (en) | 1996-09-16 | 2000-04-04 | Children's Medical Center Corporation | Formulations and methods for providing prolonged local anesthesia |
US5773430A (en) * | 1997-03-13 | 1998-06-30 | Research Foundation Of State University Of New York | Serine proteinase inhibitory activity by hydrophobic tetracycline |
JP2908375B2 (ja) * | 1997-04-01 | 1999-06-21 | ザ リサーチ ファンデーション オブ ステート ユニバーシティ オブ ニューヨーク | 非抗バクテリア性テトラサイクリン組成物 |
JP2000511941A (ja) | 1997-07-02 | 2000-09-12 | ユーロ−セルティーク エス.エイ. | 関節間隙および身体間隙における持効性麻酔 |
AU8918898A (en) | 1997-08-25 | 1999-03-16 | Harold Brem | Prevention of adhesions and excessive scar formation using angiogenesis inhibi tors |
WO1999030720A1 (en) * | 1997-12-19 | 1999-06-24 | New York University | Method for inhibiting cyclooxygenase-2 and tumor necrosis factor alpha |
ES2302373T3 (es) * | 1998-02-13 | 2008-07-01 | Nutramax Laboratories, Inc. | Agentes y metodos para la proteccion, tratamiento y reparacion de tejidos conectivos. |
US6277061B1 (en) * | 1998-03-31 | 2001-08-21 | The Research Foundation Of State University Of New York | Method of inhibiting membrane-type matrix metalloproteinase |
RU2211693C2 (ru) * | 1998-05-27 | 2003-09-10 | Юроселтик С.А. | Препараты для введения противовоспалительных, особенно антисептических веществ и/или веществ, способствующих заживлению ран, в верхние дыхательные пути и/или в ухо |
US6015804A (en) * | 1998-09-11 | 2000-01-18 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds to enhance interleukin-10 production |
US5998390A (en) * | 1998-09-28 | 1999-12-07 | The Research Foundation Of State University Of New York | Combination of bisphosphonate and tetracycline |
US6506740B1 (en) | 1998-11-18 | 2003-01-14 | Robert A. Ashley | 4-dedimethylaminotetracycline derivatives |
US6946453B2 (en) | 1998-11-18 | 2005-09-20 | Collagenex Pharmaceuticals, Inc. | 4-dedimethylaminotracycline derivatives |
US7300667B1 (en) | 1999-05-27 | 2007-11-27 | Euro-Celtique, S.A. | Preparations for the application of anti-inflammatory, especially antiseptic agents and/or agents promoting the healing of wounds, to the lower respiratory tract |
US6294694B1 (en) | 1999-06-04 | 2001-09-25 | Wisconsin Alumni Research Foundation | Matrix metalloproteinase inhibitors and method of using same |
US6673843B2 (en) * | 1999-06-30 | 2004-01-06 | Emory University | Curcumin and curcuminoid inhibition of angiogenesis |
US20020132798A1 (en) | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
JP2004525955A (ja) * | 2001-04-05 | 2004-08-26 | コッラジェネックス ファーマシューチカルス インコーポレイテッド | テトラサイクリン化合物およびテトラサイクリン誘導体の制御された伝達 |
US7211267B2 (en) * | 2001-04-05 | 2007-05-01 | Collagenex Pharmaceuticals, Inc. | Methods of treating acne |
JP2004537544A (ja) | 2001-07-13 | 2004-12-16 | パラテック ファーマシューティカルズ インコーポレイテッド | 標的治療活性を有するテトラサイクリン化合物 |
US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
EP1439843A4 (en) * | 2001-10-05 | 2007-01-03 | Tetragenex Pharmaceuticals Inc | TETRACYCLINE DERIVATIVES AND METHODS OF USE |
US7056902B2 (en) | 2002-01-08 | 2006-06-06 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino tetracycline compounds |
US20090011991A1 (en) * | 2002-03-08 | 2009-01-08 | Emory University | Novel Curcuminoid-Factor VIIA Constructs as Suppressors of Tumor Growth and Angiogenesis |
EA013819B1 (ru) | 2002-03-08 | 2010-08-30 | Паратек Фармасьютикалс, Инк. | Аминометилзамещенные тетрациклиновые соединения |
AU2003220091B2 (en) * | 2002-03-08 | 2006-02-16 | Emory University | Novel curcuminoid-factor VIIa constructs as suppressors of tumor growth and angiogenesis |
EA200401232A1 (ru) | 2002-03-21 | 2005-12-29 | Пэрэтек Фамэсьютикэлс, Инк. | Замещенные соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта |
EP1496742B1 (en) * | 2002-03-29 | 2010-11-24 | The Research Foundation Of State University Of New York | Use of non-antibacterial tetracycline analogs and formulations thereof for the treatment of bacterial exotoxins |
EP1534300A4 (en) | 2002-07-12 | 2008-04-23 | Paratek Pharm Innc | TETRACYCLINE COMPOUNDS SUBSTITUTED IN 3, 10, AND 12A |
AU2003296482A1 (en) * | 2002-12-13 | 2004-07-09 | The Research Foundation Of State University Of New York | Tetracyclines as anti-fungal agents for treatment of ringworm |
CA2894736C (en) * | 2003-04-07 | 2019-07-16 | Supernus Pharmaceuticals, Inc. | Once daily formulations of tetracyclines |
EA200600221A1 (ru) | 2003-07-09 | 2006-06-30 | Пэрэтек Фамэсьютикэлс, Инк. | Замещённые соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта |
EP1656341A1 (en) | 2003-07-09 | 2006-05-17 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
CA2544599A1 (en) * | 2003-11-06 | 2005-05-26 | Maria Emanuel Ryan | Methods of treating eczema |
EP1716101A1 (en) | 2004-01-15 | 2006-11-02 | Paratek Pharmaceuticals, Inc. | Aromatic a-ring derivatives of tetracycline compounds |
EP2301916A3 (en) | 2004-10-25 | 2011-09-28 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
EP2284150A3 (en) | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
BRPI0602372B8 (pt) | 2006-05-18 | 2021-06-22 | Einco Biomaterial Ltda | processo de preparação de compósitos em base de biocerâmicas e polímeros biodegradáveis e produto derivado |
PL2109602T3 (pl) | 2006-12-21 | 2014-09-30 | Paratek Pharm Innc | Pochodne tetracyliny do leczenia zakażeń bakteryjnych, wirusowych i pasożytniczych |
CA2892739A1 (en) * | 2006-12-21 | 2008-07-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of inflammatory skin disorders |
CA2688662A1 (en) * | 2007-04-27 | 2008-11-06 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing and purifying aminoalkyl tetracycline compounds |
EA201070233A1 (ru) * | 2007-07-06 | 2010-08-30 | Паратек Фармасьютикалс, Инк. | Способы синтеза замещённых соединений тетрациклина (варианты) |
TW202021946A (zh) | 2008-05-23 | 2020-06-16 | 美商派洛泰克藥物股份有限公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
HUE026562T2 (hu) | 2008-08-08 | 2016-06-28 | Tetraphase Pharmaceuticals Inc | C7-fluor-helyettesített tetraciklin vegyületek |
US9315451B2 (en) | 2009-05-08 | 2016-04-19 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
DK2470500T3 (en) | 2009-08-28 | 2018-01-08 | Tetraphase Pharmaceuticals Inc | tetracycline |
MX2012011453A (es) | 2010-03-31 | 2013-02-15 | Tetraphase Pharmaceuticals Inc | Compuestos de tetraciclina policíclica. |
WO2013177170A2 (en) * | 2012-05-21 | 2013-11-28 | Dcb-Usa Llc | Methods for drug screen using zebrafish model and the compounds screened thereform |
ES2712476T3 (es) | 2012-08-31 | 2019-05-13 | Tetraphase Pharmaceuticals Inc | Compuestos de tetraciclina |
SI3529236T1 (sl) | 2016-10-19 | 2024-08-30 | Tetraphase Pharmaceuticals, Inc. | Kristalinične oblike eravaciklina |
US20210395198A1 (en) | 2018-11-09 | 2021-12-23 | Tetraphase Pharmaceuticals, Inc. | Polymorphic forms of a compound and uses thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB787882A (en) * | 1955-01-26 | 1957-12-18 | Lepetit Spa | Desdimethylaminotetracyclines and pharmaceutical preparations containing same |
US2895880A (en) * | 1955-05-13 | 1959-07-21 | Smith Kline French Lab | Sustained release pharmaceutical product |
GB925282A (en) * | 1960-05-04 | 1963-05-08 | Lepetit Spa | Fermentation process for the production of demethyltetracycline |
US3304227A (en) * | 1965-07-15 | 1967-02-14 | Loyal E Loveless | Antibiotic-containing animal feed |
US3636202A (en) * | 1968-02-12 | 1972-01-18 | Lewis A Klein | Treatment of rheumatoid arthritis and related diseases |
US4371465A (en) * | 1981-10-07 | 1983-02-01 | American Home Products Corporation | Mammalian collagenase inhibitors |
US4454110A (en) * | 1982-05-24 | 1984-06-12 | Forsyth Dental Infirmary For Children | Self-gelling liquid composition for topical application in the oral cavity |
-
1985
- 1985-02-07 US US06/699,048 patent/US4704383A/en not_active Expired - Lifetime
-
1986
- 1986-01-21 CA CA000500004A patent/CA1297410C/en not_active Expired - Lifetime
- 1986-02-04 AU AU52984/86A patent/AU583884B2/en not_active Expired
- 1986-02-04 GR GR860333A patent/GR860333B/el unknown
- 1986-02-05 ZA ZA86838A patent/ZA86838B/xx unknown
- 1986-02-05 IE IE33386A patent/IE58813B1/en not_active IP Right Cessation
- 1986-02-06 ES ES551701A patent/ES8708182A1/es not_active Expired
- 1986-02-06 AT AT86101528T patent/ATE81460T1/de not_active IP Right Cessation
- 1986-02-06 EP EP86101528A patent/EP0195906B1/en not_active Expired - Lifetime
- 1986-02-06 DE DE8686101528T patent/DE3686956T2/de not_active Expired - Lifetime
- 1986-02-07 JP JP61026651A patent/JP2676080B2/ja not_active Expired - Lifetime
- 1986-02-07 DK DK198600622A patent/DK174997B1/da not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE3686956T2 (de) | 1993-05-06 |
US4704383A (en) | 1987-11-03 |
AU583884B2 (en) | 1989-05-11 |
DK174997B1 (da) | 2004-04-13 |
CA1297410C (en) | 1992-03-17 |
IE58813B1 (en) | 1993-11-17 |
GR860333B (en) | 1986-06-13 |
DK62286D0 (da) | 1986-02-07 |
JP2676080B2 (ja) | 1997-11-12 |
ATE81460T1 (de) | 1992-10-15 |
JPS61243023A (ja) | 1986-10-29 |
EP0195906B1 (en) | 1992-10-14 |
EP0195906A2 (en) | 1986-10-01 |
ES8708182A1 (es) | 1987-10-01 |
ES551701A0 (es) | 1987-10-01 |
IE860333L (en) | 1986-08-07 |
DE3686956D1 (de) | 1992-11-19 |
EP0195906A3 (en) | 1988-10-19 |
DK62286A (da) | 1986-08-08 |
AU5298486A (en) | 1986-08-14 |
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