DK62286A - Ikke-antibakterielle tetracyclinpraeparater med anticollagenolytiske egenskaber - Google Patents
Ikke-antibakterielle tetracyclinpraeparater med anticollagenolytiske egenskaber Download PDFInfo
- Publication number
- DK62286A DK62286A DK62286A DK62286A DK62286A DK 62286 A DK62286 A DK 62286A DK 62286 A DK62286 A DK 62286A DK 62286 A DK62286 A DK 62286A DK 62286 A DK62286 A DK 62286A
- Authority
- DK
- Denmark
- Prior art keywords
- tetracyclines
- anticollagenolytic
- properties
- compositions containing
- same
- Prior art date
Links
- 239000004098 Tetracycline Substances 0.000 title abstract 4
- 235000019364 tetracycline Nutrition 0.000 title abstract 4
- 150000003522 tetracyclines Chemical class 0.000 title abstract 4
- 230000000791 anti-collagenolytic effect Effects 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- 229960002180 tetracycline Drugs 0.000 title 1
- 229930101283 tetracycline Natural products 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 229940040944 tetracyclines Drugs 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 102000008186 Collagen Human genes 0.000 abstract 1
- 108010035532 Collagen Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 235000019728 animal nutrition Nutrition 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229920001436 collagen Polymers 0.000 abstract 1
- 229960002424 collagenase Drugs 0.000 abstract 1
- 201000007717 corneal ulcer Diseases 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229940088598 enzyme Drugs 0.000 abstract 1
- 238000010348 incorporation Methods 0.000 abstract 1
- 208000028169 periodontal disease Diseases 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 230000004584 weight gain Effects 0.000 abstract 1
- 235000019786 weight gain Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Fodder In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69904885 | 1985-02-07 | ||
US06/699,048 US4704383A (en) | 1983-12-29 | 1985-02-07 | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
Publications (3)
Publication Number | Publication Date |
---|---|
DK62286D0 DK62286D0 (da) | 1986-02-07 |
DK62286A true DK62286A (da) | 1986-08-08 |
DK174997B1 DK174997B1 (da) | 2004-04-13 |
Family
ID=24807719
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK198600622A DK174997B1 (da) | 1985-02-07 | 1986-02-07 | Ikke-antibakterielle tetracyclinpræparater med anticollagennolytiske egenskaber |
Country Status (12)
Country | Link |
---|---|
US (1) | US4704383A (da) |
EP (1) | EP0195906B1 (da) |
JP (1) | JP2676080B2 (da) |
AT (1) | ATE81460T1 (da) |
AU (1) | AU583884B2 (da) |
CA (1) | CA1297410C (da) |
DE (1) | DE3686956T2 (da) |
DK (1) | DK174997B1 (da) |
ES (1) | ES8708182A1 (da) |
GR (1) | GR860333B (da) |
IE (1) | IE58813B1 (da) |
ZA (1) | ZA86838B (da) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE34656E (en) * | 1983-12-29 | 1994-07-05 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency |
GR861167B (en) * | 1985-05-02 | 1986-09-30 | Research Corp | Bone targeted inhibitors of carbonic anhydrase |
US5308839A (en) * | 1989-12-04 | 1994-05-03 | The Research Foundation Of State University Of New York | Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline |
JP3016587B2 (ja) * | 1989-12-04 | 2000-03-06 | ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク | 非ステロイド抗炎症剤及びテトラサイクリンの配合 |
US5045538A (en) * | 1990-06-28 | 1991-09-03 | The Research Foundation Of State University Of New York | Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines |
WO1992012717A2 (en) * | 1991-01-15 | 1992-08-06 | A composition containing a tetracycline and use for inhibiting angiogenesis | |
US5770588A (en) * | 1991-02-11 | 1998-06-23 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions of the prevention and treatment of root caries |
US5223248A (en) * | 1991-02-11 | 1993-06-29 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing antiplaque properties |
CA2094874C (en) * | 1992-04-27 | 2003-02-11 | Thomas F. Mcnamara | Non-antibacterial tetracycline compositons possessing antiplaque properties |
US5258371A (en) * | 1992-05-29 | 1993-11-02 | Kuraray Co., Ltd. | Method to reduce connective tissue destruction |
ES2170074T3 (es) * | 1992-09-10 | 2002-08-01 | Childrens Medical Center | Matrices de polimero biodegradables para la liberacion prolongada de agentes anestesicos locales. |
US5922340A (en) | 1992-09-10 | 1999-07-13 | Children's Medical Center Corporation | High load formulations and methods for providing prolonged local anesthesia |
US5700485A (en) * | 1992-09-10 | 1997-12-23 | Children's Medical Center Corporation | Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid |
US6043231A (en) * | 1993-03-02 | 2000-03-28 | The Research Foundation Of State Univ. Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
US5523297A (en) * | 1993-03-02 | 1996-06-04 | The Research Foundation Of State University Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
US5641636A (en) * | 1994-05-20 | 1997-06-24 | University Of Pennsylvania | Method of predicting fetal membrane rupture based on matrix metalloproteinase-9 activity |
US6140099A (en) * | 1994-05-20 | 2000-10-31 | The Trustees Of The University Of Pennsylvania | Method of delaying fetal membrane rupture by inhibiting matrix metalloproteinase-9 activity |
CA2195119C (en) | 1995-06-09 | 2001-09-11 | Mark Chasin | Formulations and methods for providing prolonged local anesthesia |
EP0954301A4 (en) | 1996-06-24 | 2006-03-08 | Euro Celtique Sa | SAFE METHODS OF LOCAL ANESTHESIA |
US5827840A (en) * | 1996-08-01 | 1998-10-27 | The Research Foundation Of State University Of New York | Promotion of wound healing by chemically-modified tetracyclines |
US6046187A (en) | 1996-09-16 | 2000-04-04 | Children's Medical Center Corporation | Formulations and methods for providing prolonged local anesthesia |
US5773430A (en) * | 1997-03-13 | 1998-06-30 | Research Foundation Of State University Of New York | Serine proteinase inhibitory activity by hydrophobic tetracycline |
JP2908375B2 (ja) | 1997-04-01 | 1999-06-21 | ザ リサーチ ファンデーション オブ ステート ユニバーシティ オブ ニューヨーク | 非抗バクテリア性テトラサイクリン組成物 |
KR100367144B1 (ko) | 1997-07-02 | 2003-01-14 | 유로-셀티크 소시에떼 아노뉨 | 관절과 체강(body space)내에서 연장된 마취 |
JP2001513559A (ja) | 1997-08-25 | 2001-09-04 | ブレム,ハロルド | 新脈管形成インヒビターを用いる癒着および過剰な瘢痕形成の予防 |
CA2316972C (en) * | 1997-12-19 | 2009-02-24 | New York University | Method for inhibiting cyclooxygenase-2 and tumor necrosis factor alpha |
PT1053000E (pt) * | 1998-02-13 | 2008-07-11 | Nutramax Lab Inc | Agentes e métodos para protecção, tratamento e reparação do tecido conjuntivo |
US6277061B1 (en) * | 1998-03-31 | 2001-08-21 | The Research Foundation Of State University Of New York | Method of inhibiting membrane-type matrix metalloproteinase |
KR20010043820A (ko) * | 1998-05-27 | 2001-05-25 | 유로셀띠끄 소시에떼 아노님 | 치밀하게 컴팩트된 고체약물스톡을 포함하는 약물전달시스템 |
US6015804A (en) * | 1998-09-11 | 2000-01-18 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds to enhance interleukin-10 production |
US5998390A (en) * | 1998-09-28 | 1999-12-07 | The Research Foundation Of State University Of New York | Combination of bisphosphonate and tetracycline |
US6946453B2 (en) | 1998-11-18 | 2005-09-20 | Collagenex Pharmaceuticals, Inc. | 4-dedimethylaminotracycline derivatives |
US6506740B1 (en) * | 1998-11-18 | 2003-01-14 | Robert A. Ashley | 4-dedimethylaminotetracycline derivatives |
US7300667B1 (en) | 1999-05-27 | 2007-11-27 | Euro-Celtique, S.A. | Preparations for the application of anti-inflammatory, especially antiseptic agents and/or agents promoting the healing of wounds, to the lower respiratory tract |
US6294694B1 (en) | 1999-06-04 | 2001-09-25 | Wisconsin Alumni Research Foundation | Matrix metalloproteinase inhibitors and method of using same |
US6673843B2 (en) | 1999-06-30 | 2004-01-06 | Emory University | Curcumin and curcuminoid inhibition of angiogenesis |
US20020132798A1 (en) | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
US7211267B2 (en) * | 2001-04-05 | 2007-05-01 | Collagenex Pharmaceuticals, Inc. | Methods of treating acne |
EP2311440A1 (en) | 2001-04-05 | 2011-04-20 | Collagenex Pharmaceuticals, Inc. | Controlled delivery of tetracycline compounds and tetracycline derivatives |
US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
WO2003005971A2 (en) | 2001-07-13 | 2003-01-23 | Paratek Pharmaceuticals, Inc. | Tetracycline compounds having target therapeutic activities |
US7214669B2 (en) * | 2001-10-05 | 2007-05-08 | Tetragenex Pharmaceuticals, Inc. | Tetracycline derivatives and methods of use thereof |
EP1474380A4 (en) | 2002-01-08 | 2007-04-18 | Paratek Pharm Innc | 4-DESDIMETHYL AMINO TETRA CYCLINE COMPOUNDS |
EA200802365A1 (ru) | 2002-03-08 | 2009-08-28 | Паратек Фармасьютикалс, Инк. | Аминометилзамещенные тетрациклиновые соединения |
US20090011991A1 (en) * | 2002-03-08 | 2009-01-08 | Emory University | Novel Curcuminoid-Factor VIIA Constructs as Suppressors of Tumor Growth and Angiogenesis |
CA2478522A1 (en) * | 2002-03-08 | 2003-09-18 | Emory University | Novel curcuminoid-factor viia constructs as suppressors of tumor growth and angiogenesis |
EP1503981A4 (en) | 2002-03-21 | 2007-08-15 | Paratek Pharm Innc | SUBSTITUTED TETRACYCLINE COMPOUNDS |
KR20040094833A (ko) | 2002-03-29 | 2004-11-10 | 더 리서치 파운데이션 오브 스테이트 유니버시티 오브 뉴욕 | 비-항균성 테트라사이클린 동족체의 용도 및 박테리아외독소의 치료를 위한 이의 제형 |
EP1534300A4 (en) | 2002-07-12 | 2008-04-23 | Paratek Pharm Innc | TETRACYCLINE COMPOUNDS SUBSTITUTED IN 3, 10, AND 12A |
WO2004054509A2 (en) * | 2002-12-13 | 2004-07-01 | The Research Foundation Of State University Of New York | Tetracyclines as anti-fungal agents for treatment of ringworm |
ES2391385T3 (es) | 2003-04-07 | 2012-11-23 | Supernus Pharmaceuticals, Inc. | Formulaciones de doxiciclinas en dosis única diaria |
AU2004259661B2 (en) | 2003-07-09 | 2011-11-10 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
JP4733028B2 (ja) | 2003-07-09 | 2011-07-27 | パラテック ファーマシューティカルズ インコーポレイテッド | 置換テトラサイクリン化合物 |
EP1684768A4 (en) * | 2003-11-06 | 2007-06-06 | Univ New York State Res Found | METHOD FOR TREATING ECCEM |
EP1716101A1 (en) * | 2004-01-15 | 2006-11-02 | Paratek Pharmaceuticals, Inc. | Aromatic a-ring derivatives of tetracycline compounds |
EP2949644A3 (en) | 2004-10-25 | 2016-04-20 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
EP1805134B1 (en) | 2004-10-25 | 2012-06-20 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
BRPI0602372B8 (pt) | 2006-05-18 | 2021-06-22 | Einco Biomaterial Ltda | processo de preparação de compósitos em base de biocerâmicas e polímeros biodegradáveis e produto derivado |
MX2009006846A (es) | 2006-12-21 | 2009-08-20 | Paratek Pharm Innc | Derivados de tetraciclina para el tratamiento de infecciones bacterianas, virales y parasitarias. |
CA2892739A1 (en) | 2006-12-21 | 2008-07-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of inflammatory skin disorders |
JP2010525069A (ja) | 2007-04-27 | 2010-07-22 | パラテック ファーマシューティカルズ インコーポレイテッド | アミノアルキルテトラサイクリン化合物の合成方法および精製方法 |
CN101784517A (zh) * | 2007-07-06 | 2010-07-21 | 帕拉特克药品公司 | 合成取代的四环素化合物的方法 |
TW202021946A (zh) * | 2008-05-23 | 2020-06-16 | 美商派洛泰克藥物股份有限公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
KR101856178B1 (ko) | 2008-08-08 | 2018-05-10 | 테트라페이즈 파마슈티컬스, 인코포레이티드 | C7-플루오로 치환된 테트라시클린 화합물 |
WO2010129057A2 (en) | 2009-05-08 | 2010-11-11 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
NO2470500T3 (da) | 2009-08-28 | 2018-03-03 | ||
TWI592390B (zh) | 2010-03-31 | 2017-07-21 | 四相製藥公司 | 聚環狀四環素化合物 |
KR101953736B1 (ko) * | 2012-05-21 | 2019-03-04 | 디씨비-유에스에이 엘엘씨 | 제브라피시 모델을 사용한 약물 스크리닝 방법 및 이 방법으로 스크린된 화합물 |
BR112015004523B1 (pt) | 2012-08-31 | 2020-08-04 | Tetraphase Pharmaceuticals, Inc | Compostos de tetraciclina, composições farmacêuticas e seus usos |
SG11201903327PA (en) | 2016-10-19 | 2019-05-30 | Tetraphase Pharmaceuticals Inc | Crystalline forms of eravacycline |
WO2020097450A1 (en) | 2018-11-09 | 2020-05-14 | Tetraphase Pharmaceuticals, Inc. | Polymorphic forms of a compound and uses thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB787882A (en) * | 1955-01-26 | 1957-12-18 | Lepetit Spa | Desdimethylaminotetracyclines and pharmaceutical preparations containing same |
US2895880A (en) * | 1955-05-13 | 1959-07-21 | Smith Kline French Lab | Sustained release pharmaceutical product |
GB925282A (en) * | 1960-05-04 | 1963-05-08 | Lepetit Spa | Fermentation process for the production of demethyltetracycline |
US3304227A (en) * | 1965-07-15 | 1967-02-14 | Loyal E Loveless | Antibiotic-containing animal feed |
US3636202A (en) * | 1968-02-12 | 1972-01-18 | Lewis A Klein | Treatment of rheumatoid arthritis and related diseases |
US4371465A (en) * | 1981-10-07 | 1983-02-01 | American Home Products Corporation | Mammalian collagenase inhibitors |
US4454110A (en) * | 1982-05-24 | 1984-06-12 | Forsyth Dental Infirmary For Children | Self-gelling liquid composition for topical application in the oral cavity |
-
1985
- 1985-02-07 US US06/699,048 patent/US4704383A/en not_active Expired - Lifetime
-
1986
- 1986-01-21 CA CA000500004A patent/CA1297410C/en not_active Expired - Lifetime
- 1986-02-04 GR GR860333A patent/GR860333B/el unknown
- 1986-02-04 AU AU52984/86A patent/AU583884B2/en not_active Expired
- 1986-02-05 ZA ZA86838A patent/ZA86838B/xx unknown
- 1986-02-05 IE IE33386A patent/IE58813B1/en not_active IP Right Cessation
- 1986-02-06 EP EP86101528A patent/EP0195906B1/en not_active Expired - Lifetime
- 1986-02-06 ES ES551701A patent/ES8708182A1/es not_active Expired
- 1986-02-06 DE DE8686101528T patent/DE3686956T2/de not_active Expired - Lifetime
- 1986-02-06 AT AT86101528T patent/ATE81460T1/de not_active IP Right Cessation
- 1986-02-07 DK DK198600622A patent/DK174997B1/da not_active IP Right Cessation
- 1986-02-07 JP JP61026651A patent/JP2676080B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DK62286D0 (da) | 1986-02-07 |
AU583884B2 (en) | 1989-05-11 |
EP0195906B1 (en) | 1992-10-14 |
EP0195906A3 (en) | 1988-10-19 |
DK174997B1 (da) | 2004-04-13 |
ZA86838B (en) | 1986-10-29 |
EP0195906A2 (en) | 1986-10-01 |
CA1297410C (en) | 1992-03-17 |
JPS61243023A (ja) | 1986-10-29 |
DE3686956T2 (de) | 1993-05-06 |
GR860333B (en) | 1986-06-13 |
JP2676080B2 (ja) | 1997-11-12 |
US4704383A (en) | 1987-11-03 |
DE3686956D1 (de) | 1992-11-19 |
ES8708182A1 (es) | 1987-10-01 |
AU5298486A (en) | 1986-08-14 |
IE860333L (en) | 1986-08-07 |
IE58813B1 (en) | 1993-11-17 |
ES551701A0 (es) | 1987-10-01 |
ATE81460T1 (de) | 1992-10-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUP | Patent expired |