BRPI0602372B8 - processo de preparação de compósitos em base de biocerâmicas e polímeros biodegradáveis e produto derivado - Google Patents

processo de preparação de compósitos em base de biocerâmicas e polímeros biodegradáveis e produto derivado

Info

Publication number
BRPI0602372B8
BRPI0602372B8 BRPI0602372A BRPI0602372A BRPI0602372B8 BR PI0602372 B8 BRPI0602372 B8 BR PI0602372B8 BR PI0602372 A BRPI0602372 A BR PI0602372A BR PI0602372 A BRPI0602372 A BR PI0602372A BR PI0602372 B8 BRPI0602372 B8 BR PI0602372B8
Authority
BR
Brazil
Prior art keywords
composites
bioceramics
biodegradable polymers
angiotensin
containing antibiotics
Prior art date
Application number
BRPI0602372A
Other languages
English (en)
Inventor
Luiz Parato André
Esperanza Cortés Segura Maria
Fabiane De Oliveira Michele
Tereza Paz Lopes Miriam
Maria De Marco Turchetti Maia Regina
Augusto Souza Dos Santos Robson
Dario Sinisterra Millán Rubén
Original Assignee
Einco Biomaterial Ltda
Univ Federal De Minas Gerais Ufmg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Einco Biomaterial Ltda, Univ Federal De Minas Gerais Ufmg filed Critical Einco Biomaterial Ltda
Priority to BRPI0602372A priority Critical patent/BRPI0602372B8/pt
Priority to EP07719328A priority patent/EP2035051A1/en
Priority to EP11006266A priority patent/EP2388023A1/en
Priority to PCT/BR2007/000160 priority patent/WO2007134419A1/en
Publication of BRPI0602372A publication Critical patent/BRPI0602372A/pt
Publication of BRPI0602372B1 publication Critical patent/BRPI0602372B1/pt
Publication of BRPI0602372B8 publication Critical patent/BRPI0602372B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/085—Angiotensins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L31/127—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing fillers of phosphorus-containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/622—Microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/624—Nanocapsules

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Composite Materials (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

processo de preparação de compósitos em base de biocerâmicas e polímeros biodegradáveis, contendo antibióticos e angiotensina (1-7), encapsulados ou não, micro ou nanoparticulados, para restituição tecidual e produtos derivados. a presente invenção caracteriza-se pela preparação de compósitos em base de biocerâmicas, contendo sais de cálcio como ca5(po4)3oh, caco3, caso4, caso2, ca3(po4), caosio2(no3)2, ca10(po4)6(oh)2, conforme patente br pi9104220-8, (2000), polímeros biodegradáveis naturais e/ou sintéticos, contendo antibióticos e angiotensina (1-7), encapsulados ou não, micro ou nanoparticulados, na forma de suspensões, cosméticos, implantes e usos dessas composições no processo de restituição tecidual. a presente tecnologia está relacionada a um método para produzir compósitos, contendo antibióticos e angiotensina (1-7), que podem ser usados como implantes em humanos e medicamentos veterinários, com efeito, antibiótico e osteoconductor. uma outra característica da invenção é o uso de tetraciclinas nos compósitos, em concentrações que podem variar de 0.001% até 5%, com efeito, antiinflamatório, mostrando melhor biocompatibilidade, quando comparados com os materiais encontrados no estado da técnica. os compósitos de biocerâmica:polímero aqui reivindicados apresentam propriedades de indução de dentina reparadora, formação de ponte dentinária compacta e uma matriz com geometria favorável para a deposição mineral com características superiores às apresentadas pelos materiais encontrados no estado da técnica. esse material induz uma reparação tecidual mais efetiva e provoca uma resposta histológica compatível com o processo de regeneração tecidual normal.
BRPI0602372A 2006-05-18 2006-05-18 processo de preparação de compósitos em base de biocerâmicas e polímeros biodegradáveis e produto derivado BRPI0602372B8 (pt)

Priority Applications (4)

Application Number Priority Date Filing Date Title
BRPI0602372A BRPI0602372B8 (pt) 2006-05-18 2006-05-18 processo de preparação de compósitos em base de biocerâmicas e polímeros biodegradáveis e produto derivado
EP07719328A EP2035051A1 (en) 2006-05-18 2007-05-18 Composite preparation process on a basis of bioceramics and biodegradable or non biodegradable polymers, cementing and/or carrier substances containing encapsulated or non-encapsulated micro or nanoparticulated antibiotics and angiostensin (1-7) for tissue restitution and products therefrom
EP11006266A EP2388023A1 (en) 2006-05-18 2007-05-18 Composites on a basis of bioceramics and biodegradable or non biodegradable polymers, containing antibiotics for tissue restitution and products therefrom
PCT/BR2007/000160 WO2007134419A1 (en) 2006-05-18 2007-05-18 Composite preparation process on a basis of bioceramics and biodegradable or non biodegradable polymers, cementing and/or carrier substances containing encapsulated or non-encapsulated micro or nanoparticulated antibiotics and angiostensin (1-7) for tissue restitution and products therefrom

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0602372A BRPI0602372B8 (pt) 2006-05-18 2006-05-18 processo de preparação de compósitos em base de biocerâmicas e polímeros biodegradáveis e produto derivado

Publications (3)

Publication Number Publication Date
BRPI0602372A BRPI0602372A (pt) 2008-01-15
BRPI0602372B1 BRPI0602372B1 (pt) 2018-10-30
BRPI0602372B8 true BRPI0602372B8 (pt) 2021-06-22

Family

ID=38722885

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0602372A BRPI0602372B8 (pt) 2006-05-18 2006-05-18 processo de preparação de compósitos em base de biocerâmicas e polímeros biodegradáveis e produto derivado

Country Status (3)

Country Link
EP (2) EP2035051A1 (pt)
BR (1) BRPI0602372B8 (pt)
WO (1) WO2007134419A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0906274A8 (pt) * 2009-12-22 2018-04-03 Einco Biomaterial Ltda Me Processo de produção, compósitos, sistema e dispositivos médico-veterinários bio-ativos, biointegráveis, condutores, indutores teciduais para fixação, reparo, reconstrução, remodelação, plastias intra, supra teciduais e/ou totais, permanentes, biológica e fisiologicamente biocompatíveis
CN113698720A (zh) * 2021-08-09 2021-11-26 华合新材料科技股份有限公司 一种高抗菌、可生物降解的pmma合金材料及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US459135A (en) 1891-09-08 Alonzo french
US466897A (en) 1892-01-12 Finishing of house-interiors
US905516A (en) 1908-01-18 1908-12-01 Cushman & Denison Mfg Company Hand numbering-machine.
US4704383A (en) 1983-12-29 1987-11-03 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
JP3016587B2 (ja) 1989-12-04 2000-03-06 ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク 非ステロイド抗炎症剤及びテトラサイクリンの配合
US5290271A (en) 1990-05-14 1994-03-01 Jernberg Gary R Surgical implant and method for controlled release of chemotherapeutic agents
US6541037B1 (en) 1995-05-19 2003-04-01 Etex Corporation Delivery vehicle
US6472210B1 (en) 1997-11-14 2002-10-29 Bonetec Corporation Polymer scaffold having microporous polymer struts defining interconnected macropores
DE69824445T2 (de) * 1997-12-12 2005-06-30 University Of Southern California, Los Angeles Zusammensetzungen zur wundheilung
US6905516B1 (en) 1999-05-19 2005-06-14 Ecole Polytechnique Federale De Lausanne (Epfl) Calcium phosphate bone substitute
DE10114364A1 (de) 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Verfahren zur Herstellung von antibiotischen Kompositen
BRPI0105509B8 (pt) * 2001-11-05 2021-05-25 Univ Minas Gerais formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga
DE10351150A1 (de) * 2003-11-03 2005-05-25 Blue Membranes Gmbh Verfahren und Vorrichtung zum Auftragen einer definierten Menge eines Beschichtungsmaterials auf die Oberfläche eines zu beschichtenden Körpers
DE602005017807D1 (de) * 2004-10-21 2009-12-31 Medtronic Inc Angiotensin-(1-7) freisetzende polymerbeschichtete medizinische vorrichtung zur reduzierung von restenose und zur verbesserung von endothelzellfunktionen

Also Published As

Publication number Publication date
BRPI0602372B1 (pt) 2018-10-30
WO2007134419A1 (en) 2007-11-29
BRPI0602372A (pt) 2008-01-15
EP2035051A1 (en) 2009-03-18
EP2388023A1 (en) 2011-11-23

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