ZA839651B - Depolymerized and supersulfated heparin,process for its preparation and pharmaceutical compositions - Google Patents
Depolymerized and supersulfated heparin,process for its preparation and pharmaceutical compositionsInfo
- Publication number
- ZA839651B ZA839651B ZA839651A ZA839651A ZA839651B ZA 839651 B ZA839651 B ZA 839651B ZA 839651 A ZA839651 A ZA 839651A ZA 839651 A ZA839651 A ZA 839651A ZA 839651 B ZA839651 B ZA 839651B
- Authority
- ZA
- South Africa
- Prior art keywords
- preparation
- pharmaceutical compositions
- depolymerized
- heparin
- supersulfated
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Polymers & Plastics (AREA)
- Animal Behavior & Ethology (AREA)
- Materials Engineering (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8221934A FR2538404B1 (pl) | 1982-12-28 | 1982-12-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA839651B true ZA839651B (en) | 1985-02-27 |
Family
ID=9280592
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA839652A ZA839652B (en) | 1982-12-28 | 1983-12-28 | Process for the depolymerisation and sulfation of polysaccharides |
ZA839651A ZA839651B (en) | 1982-12-28 | 1983-12-28 | Depolymerized and supersulfated heparin,process for its preparation and pharmaceutical compositions |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA839652A ZA839652B (en) | 1982-12-28 | 1983-12-28 | Process for the depolymerisation and sulfation of polysaccharides |
Country Status (14)
Country | Link |
---|---|
US (1) | US4727063A (pl) |
EP (1) | EP0116801B1 (pl) |
JP (2) | JPH0629282B2 (pl) |
KR (1) | KR910008329B1 (pl) |
AT (1) | ATE26281T1 (pl) |
AU (1) | AU563289B2 (pl) |
CA (1) | CA1210760A (pl) |
DE (1) | DE3370632D1 (pl) |
DK (1) | DK597983A (pl) |
FR (1) | FR2538404B1 (pl) |
IE (1) | IE56566B1 (pl) |
IL (1) | IL70512A (pl) |
NZ (1) | NZ206697A (pl) |
ZA (2) | ZA839652B (pl) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2555993B1 (fr) * | 1983-12-06 | 1986-11-07 | Anic Spa | Chitosanes 6-sulfates et procede pour leur preparation |
US4948881A (en) * | 1982-12-28 | 1990-08-14 | Sanofi | Process for the depolymerization and sulfation of polysaccharides |
IT1163772B (it) * | 1983-07-13 | 1987-04-08 | Baldacci Lab Spa | Oligosaccaridi eterogenei complessabili ed alfa-idosani ad attivita' terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche |
IT1214609B (it) * | 1985-05-17 | 1990-01-18 | Opocrin Spa | Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono. |
FR2584728B1 (fr) * | 1985-07-12 | 1987-11-20 | Choay Sa | Procede de sulfatation de glycosaminoglycanes et de leurs fragments |
US5262403A (en) * | 1986-03-10 | 1993-11-16 | Board Of Regents, The University Of Texas System | Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness of metastatic profusion-II |
AR243204A1 (es) * | 1986-11-21 | 1993-07-30 | Ajorca Sa | Un metodo para la depolimerizacion quimica de polisacaridos. |
US5668116A (en) * | 1987-03-19 | 1997-09-16 | Anthropharm Pty. Limited | Anti-inflammatory compounds and compositions |
EP0356435B1 (en) * | 1987-03-19 | 1995-10-18 | Arthropharm Pty. Limited | Anti-inflammatory compounds and compositions |
DE3744119A1 (de) * | 1987-12-24 | 1989-07-06 | Basf Ag | Verwendung von polysulfatierten heparinen |
AU3434889A (en) * | 1988-03-15 | 1989-10-05 | Jewish Hospital Of St. Louis, The | Inhibition of intestinal cholesterol and fatty acid absorption |
US4945086A (en) * | 1988-05-03 | 1990-07-31 | The Board Of Trustees Of The Leland Stanford Junior University | Smooth muscle cell growth inhibitor |
MC2098A1 (fr) * | 1988-06-03 | 1991-02-15 | Italfarmaco Spa | Sels de glycosaminoglycanes,procedes pour leur preparation et compositions pharmaceutiques les contenant |
US5484777A (en) * | 1989-04-20 | 1996-01-16 | Lange, Iii; Louis G. | Pancreatic cholesterol esterase inhibitor |
US5017565A (en) * | 1989-04-20 | 1991-05-21 | Lange Iii Louis G | Use of sulfated polysaccharides to inhibit pancreatic cholesterol esterase |
US5063210A (en) * | 1989-04-20 | 1991-11-05 | Lange Iii Louis G | Use of sulfated polysaccharides to decrease cholesterol and fatty acid absorption |
US5340932A (en) * | 1989-08-18 | 1994-08-23 | Ajorca S.A. | Substances with heparin-like structure and their method of production |
EP0421508B1 (en) * | 1989-10-04 | 1993-12-15 | Akzo Nobel N.V. | Sulphated glycosaminoglycuronan with antithrombotic activity |
IT1237518B (it) * | 1989-11-24 | 1993-06-08 | Renato Conti | Eparine supersolfatate |
WO1991015217A1 (en) * | 1990-04-06 | 1991-10-17 | Washington University | Anticoagulant oligosaccharides |
IT1243987B (it) * | 1990-10-29 | 1994-06-28 | Derivati Organici Lab | Procedimento per la preparazione di epossi-eparidi prodotti ottenuti ecomposizioni farmaceutiche che li contengono |
FR2669932B1 (fr) * | 1990-12-03 | 1994-07-01 | Sanofi Sa | Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent. |
IT1244373B (it) * | 1991-01-18 | 1994-07-08 | Sclavo Spa | Composizioni farmaceutiche per uso orale contenenti eparina a basso peso molecolare, loro preparazione ed uso |
SE9101155D0 (sv) * | 1991-04-18 | 1991-04-18 | Kabi Pharmacia Ab | Novel heparin derivatives |
GB9206291D0 (en) * | 1992-03-23 | 1992-05-06 | Cancer Res Campaign Tech | Oligosaccharides having growth factor binding affinity |
US6750207B1 (en) * | 1992-05-01 | 2004-06-15 | Yeda Research And Development Co. Ltd. | Compositions for the regulation of cytokine activity |
US5861382A (en) * | 1992-05-01 | 1999-01-19 | Yeda Research And Development Co. Ltd. | Methods for regulation of active TNF-α |
HUT70945A (en) * | 1992-11-10 | 1995-11-28 | Yeda Res & Dev | Compositions for the regulation of cytokine activity contg. oligosaccharides and process to prepare them |
AU2560995A (en) * | 1994-06-06 | 1996-01-04 | Per Bjorn Ostergaard | A pharmaceutical composition comprising oligosaccharides binding to lipoprotein lipase |
AU682792B2 (en) | 1994-10-13 | 1997-10-16 | Cv Therapeutics, Inc. | Method of manufacturing non-absorbable synthetic sulfated polysaccharides |
US5922690A (en) * | 1996-04-25 | 1999-07-13 | Van Gorp; Cornelius L. | Dermatan disulfate, an inhibitor of thrombin generation and activation |
CA2260183A1 (en) | 1996-07-09 | 1998-01-15 | Keith A. Crutcher | Methods for the treatment of apolipoprotein e related diseases |
IT1290814B1 (it) * | 1997-03-24 | 1998-12-11 | Istituto Scient Di Chimica E B | Glicosaminoglicani aventi elevata attivita' antitrombotica |
US6388060B1 (en) | 1998-11-06 | 2002-05-14 | Vascular Therapeutics Inc. | Process for the sulfation of uronic acid-containing polysaccharides |
DE29900874U1 (de) | 1999-01-20 | 1999-07-22 | Knoll AG, 67061 Ludwigshafen | Organprotektive Lösungen |
US6409987B1 (en) | 1999-04-07 | 2002-06-25 | Intimax Corporation | Targeted agents useful for diagnostic and therapeutic applications |
MXPA02000142A (es) * | 1999-06-30 | 2003-07-21 | Hamilton Civic Hospitals Res | Composiciones de heparina que inhiben los factores de coagulacion asociados con el coagulo. |
US8227449B2 (en) | 2000-03-30 | 2012-07-24 | Glycores 2000 S.R.L. | Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation |
FR2807918B1 (fr) | 2000-04-21 | 2003-07-04 | Equip Tech Ind Alimentaires | Retourneur avec galets mobiles sur surfaces de guidage |
CN1473061A (zh) * | 2000-09-08 | 2004-02-04 | ���ܶ�����ҽԺ�о���չ����˾ | 抗血栓形成的组合物 |
EP1421091A4 (en) * | 2001-08-31 | 2008-02-20 | Ivax Research Inc | PROCESSES FOR SULFATATION OF SACCHARIDES |
US7285536B2 (en) * | 2001-12-05 | 2007-10-23 | Yeda Research And Development Co., Ltd. | Anti-cancer therapeutic compounds |
US8071569B2 (en) * | 2002-09-20 | 2011-12-06 | Mousa Shaker A | Oxidized heparin fractions and their use in inhibiting angiogenesis |
JP4636818B2 (ja) * | 2004-06-07 | 2011-02-23 | マルホ株式会社 | 多硫酸化コンドロイチン硫酸の製造方法 |
AU2005265412B2 (en) * | 2004-07-19 | 2010-09-02 | Onconova Therapeutics, Inc. | Formulations for parenteral administration of (e)-2,6-dialkoxystyryl 4-substituted benzylsulfones |
ES2299795T3 (es) * | 2004-09-13 | 2008-06-01 | Laboratori Derivati Organici S.P.A. | Procedimiento de sulfatacion de la condroitina. |
JP5107246B2 (ja) * | 2005-07-29 | 2012-12-26 | オンコノバ・セラピューティックス・インコーポレーテッド | 放射線防護α,β−不飽和アリールスルホンの製剤 |
EP2769719A1 (en) * | 2006-07-28 | 2014-08-27 | Onconova Therapeutics, Inc. | Formulations of radioprotective alpha, beta unsaturated aryl sulfones |
US8569262B2 (en) | 2007-11-02 | 2013-10-29 | Momenta Pharmaceuticals, Inc. | Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization |
WO2009059284A2 (en) * | 2007-11-02 | 2009-05-07 | Momenta Pharmaceuticals, Inc. | Non-anticoagulant polysaccharide compositions |
US8592393B2 (en) | 2007-11-02 | 2013-11-26 | Momenta Pharmaceuticals, Inc. | Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization |
CN101597343B (zh) * | 2009-05-07 | 2011-06-15 | 张丽萍 | 一种低分子肝素的基团修饰方法 |
EP2558506B1 (en) | 2010-04-16 | 2019-06-26 | Momenta Pharmaceuticals, Inc. | Tissue targeting |
WO2011159770A2 (en) | 2010-06-17 | 2011-12-22 | Momenta Pharmaceuticals, Inc. | Methods and compositions for modulating hair growth |
SI2710043T1 (sl) * | 2011-05-20 | 2016-08-31 | Gnosis S.P.A. | Morskemu psu-podoben hondroitin sulfat in postopek za njegovo pripravo |
JP2016520613A (ja) | 2013-05-28 | 2016-07-14 | モメンタ ファーマシューティカルズ インコーポレイテッド | 薬学的組成物 |
CN103833869B (zh) * | 2014-02-26 | 2016-01-20 | 上海中医药大学 | 一种木香硫酸化多糖及其制备方法和用途 |
JP6741277B2 (ja) * | 2015-12-30 | 2020-08-19 | シェンツェン ヘパリンク ファーマスーティカル グループ カンパニー リミテッドShenzhen Hepalink Pharmaceutical Group Co., Ltd. | 硫酸化ヘパリン由来オリゴ糖及びその調製法と施用 |
SG11202001824RA (en) | 2016-08-31 | 2020-04-29 | Oji Holdings Corp | Production method for acidic xylooligosaccharide, and acidic xylooligosaccharide |
JP6225321B1 (ja) | 2016-08-31 | 2017-11-08 | 王子ホールディングス株式会社 | ポリ硫酸ペントサンの製造方法 |
JP6281659B1 (ja) | 2017-02-28 | 2018-02-21 | 王子ホールディングス株式会社 | ポリ硫酸ペントサン、医薬組成物及び抗凝固剤 |
BR112019025030A2 (pt) | 2017-05-31 | 2020-06-16 | Oji Holdings Corporation | Preparação umidificante tópica. |
BR112020004787A2 (pt) | 2017-09-12 | 2020-09-24 | Oji Holdings Corporation | polissulfato de pentosano, composição farmacêutica, anticoagulante, e, método para produzir polissulfato de pentosano |
CN111511773B (zh) | 2017-12-20 | 2023-01-13 | 王子控股株式会社 | 戊聚糖多硫酸酯以及含有戊聚糖多硫酸酯的药物 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE498062A (pl) * | ||||
US2599172A (en) * | 1948-11-29 | 1952-06-03 | Searle & Co | Sulfuric acid esters of hyaluronic acid and processes for the production thereof |
CH277483A (de) * | 1949-10-20 | 1951-08-31 | Hoffmann La Roche | Verfahren zur Herstellung eines hochaktiven blutgerinnungshemmenden Mittels. |
US2697093A (en) * | 1949-12-16 | 1954-12-14 | Phillips Petroleum Co | Process for production of alkali metal polysaccharide sulfates |
US2755275A (en) * | 1952-08-29 | 1956-07-17 | Abbott Lab | Process for sulfating chitin |
ES343957A1 (es) * | 1967-08-09 | 1968-10-01 | Rocador Sa | Procedimiento de obtencion de polisacaridos sulfatados an- tilipemicos activos por via oral. |
JPS5027884A (pl) * | 1973-07-12 | 1975-03-22 | ||
IT1083903B (it) * | 1977-08-09 | 1985-05-25 | Lobo Srl | Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche |
SE7811306L (sv) * | 1978-11-01 | 1980-05-02 | Rothman Gunnvor | Antikoagulationsmedel samt sett for dess framstellning |
CA1136620A (en) * | 1979-01-08 | 1982-11-30 | Ulf P.F. Lindahl | Heparin fragments having selective anticoagulation activity |
US4281168A (en) * | 1979-04-02 | 1981-07-28 | The Upjohn Company | 11-Deoxy-inter-oxa-19-oxo-PGE1 compounds |
JPS56803A (en) * | 1979-06-18 | 1981-01-07 | Mitsubishi Chem Ind Ltd | Preparation of vegetable polysaccharide sulfate ester |
US4266077A (en) * | 1979-12-26 | 1981-05-05 | American Cyanamid Company | Naphthalenetetrayltetrakis(sulfonylimino)-aryl multicarboxylic acids and salts thereof |
US4281108A (en) * | 1980-01-28 | 1981-07-28 | Hepar Industries, Inc. | Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained |
JPS56120704A (en) * | 1980-01-28 | 1981-09-22 | Hepar Ind Inc | Method of obtaining low molecular weight heparin having heightened pharmacologic property* product manufactured thereby and its use |
IL70511A (en) | 1982-12-28 | 1990-01-18 | Anic Spa | Process for the concurrent depolymerization and sulfation of polysaccharides at hydroxyl groups |
-
1982
- 1982-12-28 FR FR8221934A patent/FR2538404B1/fr not_active Expired
-
1983
- 1983-12-21 IL IL70512A patent/IL70512A/xx not_active IP Right Cessation
- 1983-12-21 CA CA000443860A patent/CA1210760A/en not_active Expired
- 1983-12-22 NZ NZ206697A patent/NZ206697A/en unknown
- 1983-12-23 AU AU22855/83A patent/AU563289B2/en not_active Ceased
- 1983-12-23 IE IE3062/83A patent/IE56566B1/en not_active IP Right Cessation
- 1983-12-23 DK DK597983A patent/DK597983A/da not_active Application Discontinuation
- 1983-12-26 EP EP83402533A patent/EP0116801B1/fr not_active Expired
- 1983-12-26 AT AT83402533T patent/ATE26281T1/de active
- 1983-12-26 DE DE8383402533T patent/DE3370632D1/de not_active Expired
- 1983-12-27 KR KR1019830006212A patent/KR910008329B1/ko not_active IP Right Cessation
- 1983-12-28 ZA ZA839652A patent/ZA839652B/xx unknown
- 1983-12-28 JP JP58252446A patent/JPH0629282B2/ja not_active Expired - Lifetime
- 1983-12-28 JP JP58252447A patent/JPS59133201A/ja active Pending
- 1983-12-28 ZA ZA839651A patent/ZA839651B/xx unknown
-
1985
- 1985-05-24 US US06/737,496 patent/US4727063A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE26281T1 (de) | 1987-04-15 |
DE3370632D1 (en) | 1987-05-07 |
FR2538404B1 (pl) | 1985-08-23 |
IE56566B1 (en) | 1991-09-11 |
KR840006812A (ko) | 1984-12-03 |
IL70512A0 (en) | 1984-03-30 |
EP0116801A1 (fr) | 1984-08-29 |
AU2285583A (en) | 1984-07-05 |
JPS59133202A (ja) | 1984-07-31 |
JPH0629282B2 (ja) | 1994-04-20 |
IE833062L (en) | 1984-06-28 |
DK597983D0 (da) | 1983-12-23 |
EP0116801B1 (fr) | 1987-04-01 |
CA1210760A (en) | 1986-09-02 |
IL70512A (en) | 1989-08-15 |
FR2538404A1 (pl) | 1984-06-29 |
JPS59133201A (ja) | 1984-07-31 |
KR910008329B1 (ko) | 1991-10-12 |
ZA839652B (en) | 1984-08-29 |
DK597983A (da) | 1984-06-29 |
AU563289B2 (en) | 1987-07-02 |
NZ206697A (en) | 1986-10-08 |
US4727063A (en) | 1988-02-23 |
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