ZA775910B - Trisubstituted 1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine compounds - Google Patents

Trisubstituted 1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine compounds

Info

Publication number
ZA775910B
ZA775910B ZA00775910A ZA775910A ZA775910B ZA 775910 B ZA775910 B ZA 775910B ZA 00775910 A ZA00775910 A ZA 00775910A ZA 775910 A ZA775910 A ZA 775910A ZA 775910 B ZA775910 B ZA 775910B
Authority
ZA
South Africa
Prior art keywords
trisubstituted
tetrahydro
phenyl
benzazepine compounds
benzazepine
Prior art date
Application number
ZA00775910A
Other languages
English (en)
Inventor
J Weinstock
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Corp filed Critical Smithkline Corp
Priority to US05/885,823 priority Critical patent/US4197297A/en
Priority to US05/892,063 priority patent/US4192872A/en
Priority to US05/893,238 priority patent/US4255422A/en
Publication of ZA775910B publication Critical patent/ZA775910B/xx
Priority to US06/158,833 priority patent/US4352754A/en
Priority to US06/289,949 priority patent/US4359464A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA00775910A 1976-11-17 1977-10-04 Trisubstituted 1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine compounds ZA775910B (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US05/885,823 US4197297A (en) 1976-11-17 1978-03-13 6-Halo-7,8-dihydroxy-1-(hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepines
US05/892,063 US4192872A (en) 1976-11-17 1978-03-31 6-Halo-3-lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
US05/893,238 US4255422A (en) 1976-11-17 1978-04-04 6-Halo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
US06/158,833 US4352754A (en) 1976-11-17 1980-06-12 3-Thienylmethyl-6-halo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
US06/289,949 US4359464A (en) 1976-11-17 1981-08-04 3-Furylmethyl-6-halo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines and antihypertensive use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/742,965 US4160765A (en) 1976-11-17 1976-11-17 Method for 6-bromination of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds

Publications (1)

Publication Number Publication Date
ZA775910B true ZA775910B (en) 1978-05-30

Family

ID=24986959

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00775910A ZA775910B (en) 1976-11-17 1977-10-04 Trisubstituted 1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine compounds

Country Status (37)

Country Link
US (1) US4160765A (sk)
JP (3) JPS5363335A (sk)
AR (1) AR224495A1 (sk)
AT (1) AT362379B (sk)
AU (1) AU509754B2 (sk)
BE (1) BE860774A (sk)
BG (1) BG30019A3 (sk)
CA (1) CA1092107A (sk)
CH (1) CH635079A5 (sk)
CS (1) CS219333B2 (sk)
CY (1) CY1246A (sk)
DD (1) DD133563A5 (sk)
DE (1) DE2751258A1 (sk)
DK (1) DK156057C (sk)
ES (1) ES464044A1 (sk)
FI (1) FI67374C (sk)
FR (1) FR2371430A1 (sk)
GB (1) GB1595502A (sk)
HU (1) HU176709B (sk)
IE (1) IE46087B1 (sk)
IL (1) IL53377A (sk)
IN (1) IN150172B (sk)
IT (1) IT1126216B (sk)
LU (1) LU78513A1 (sk)
MX (1) MX4682E (sk)
MY (1) MY8500382A (sk)
NL (2) NL185563C (sk)
NO (1) NO147029C (sk)
PH (2) PH13611A (sk)
PL (1) PL109672B1 (sk)
PT (1) PT67260B (sk)
RO (1) RO72905A (sk)
SE (1) SE436646B (sk)
SG (1) SG31784G (sk)
SU (1) SU976847A3 (sk)
YU (1) YU40490B (sk)
ZA (1) ZA775910B (sk)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4192872A (en) * 1976-11-17 1980-03-11 Smithkline Corporation 6-Halo-3-lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5481290A (en) * 1977-11-17 1979-06-28 Smithkline Corp Benzazepin compound
US4171359A (en) * 1978-04-12 1979-10-16 Smithkline Corporation Benz-tetrasubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
ZA792043B (en) * 1978-05-08 1980-05-28 Scherico Ltd Esters of substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines,process for the preparation thereof and pharmaceutical compositions containing them
US4251525A (en) * 1979-05-25 1981-02-17 Smithkline Corporation 3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives
ATE5634T1 (de) * 1979-07-10 1984-01-15 Smithkline Beckman Corporation Synergistische blutdrucksenkende zusammensetzungen.
US4285938A (en) * 1979-10-11 1981-08-25 Smithkline Corporation 7,8-Dihydroxy-1-(sulfamylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives
US4284556A (en) * 1980-01-31 1981-08-18 Smithkline Corporation 7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
US4328153A (en) * 1980-07-17 1982-05-04 Smith Kline Corporation Dopaminergic benzazepines
EP0081006B1 (en) * 1981-12-08 1985-09-25 Smithkline Beckman Corporation Pharmaceutical compositions comprising 7,8-dihydroxy-1(hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine derivatives and a beta-adrenergic blocking compound
US4782163A (en) * 1984-10-05 1988-11-01 Smithkline Beckman Corporation 2-(2-halo-3,4-dimethoxybenzyl)-5-(4-methoxyphenyl)-oxazolidines
US4705862A (en) * 1984-10-05 1987-11-10 Smithkline Beckman Corporation Chemical processes for 2-(2-halo-3,4-dimethoxybenzyl)-5-(4-methoxyphenyl)oxazolidines
US5068326A (en) * 1989-04-03 1991-11-26 Kung Hank F Dopamine receptor ligands and imaging agents
KR20010113006A (ko) * 2000-06-15 2001-12-24 주정호 항암제로서 유용한 ｎ-치환된 벤즈아제피닐우레아 유도체및 그의 제조방법
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US7090830B2 (en) 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
ATE510174T1 (de) 2003-05-21 2011-06-15 Alexza Pharmaceuticals Inc Schlag gezündete unabhängige heizeinheit
GB0412314D0 (en) 2004-06-02 2004-07-07 Glaxo Group Ltd Compounds
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
EP2246086A3 (en) 2004-08-12 2012-11-21 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heating unit
US20060194967A1 (en) * 2005-01-24 2006-08-31 Ettore Bigatti Process for the preparation of Fenoldopam Mesylate
ES2594867T3 (es) 2007-03-09 2016-12-23 Alexza Pharmaceuticals, Inc. Unidad de calentamiento para usar en un dispositivo de administración de fármaco
CN104876869B (zh) * 2011-12-22 2017-06-30 四川科伦药物研究院有限公司 一种手性菲诺多泮的拆分方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3393192A (en) * 1965-04-26 1968-07-16 Schering Corp Novel benzazepines
CH555831A (de) * 1967-02-17 1974-11-15 Scherico Ltd Verfahren zur herstellung von neuen benzazepinen.
GB1118688A (en) * 1967-02-17 1968-07-03 Scherico Ltd Novel benzazepines and process for making same
CH498122A (de) * 1968-02-09 1970-10-31 Geigy Ag J R Verfahren zur Herstellung eines neuen Tetrahydroazepinderivates
DE1695844C3 (de) * 1967-02-21 1980-01-17 Scherico Ltd., Luzern (Schweiz) l-Phenyl-23,43-tetrahydro-lH^benzazepin-Derivate und sie enthaltende pharmazeutische Zusammensetzungen
US3609138A (en) * 1967-12-22 1971-09-28 Ciba Geigy Corp 1-aryl-3-benzazepines
US4011319A (en) * 1975-07-02 1977-03-08 Smithkline Corporation Pharmaceutical compositions and methods involving benzazepine derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4192872A (en) * 1976-11-17 1980-03-11 Smithkline Corporation 6-Halo-3-lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines

Also Published As

Publication number Publication date
AU509754B2 (en) 1980-05-22
YU40490B (en) 1986-02-28
NO147029B (no) 1982-10-11
SE7712944L (sv) 1978-05-18
CA1092107A (en) 1980-12-23
BE860774A (fr) 1978-05-16
CY1246A (en) 1984-08-31
JPS5363335A (en) 1978-06-06
JPS6225658B2 (sk) 1987-06-04
SE436646B (sv) 1985-01-14
AR224495A1 (es) 1981-12-15
AT362379B (de) 1981-05-11
MY8500382A (en) 1985-12-31
JPS6366808B2 (sk) 1988-12-22
NO147029C (no) 1983-01-19
FI773448A (fi) 1978-05-18
YU270777A (en) 1983-02-28
RO72905A (ro) 1981-11-04
PL109672B1 (en) 1980-06-30
PT67260B (en) 1979-04-18
LU78513A1 (sk) 1978-03-20
FI67374B (fi) 1984-11-30
PT67260A (en) 1977-12-01
IL53377A (en) 1982-09-30
HU176709B (en) 1981-04-28
DE2751258C2 (sk) 1990-01-04
FI67374C (fi) 1985-03-11
ES464044A1 (es) 1978-08-01
IE46087B1 (en) 1983-02-23
DK156057C (da) 1989-11-13
PH13611A (en) 1980-08-05
AU3062677A (en) 1979-05-24
NL185563C (nl) 1990-05-16
US4160765A (en) 1979-07-10
NL185563B (nl) 1989-12-18
JPS6125697B2 (sk) 1986-06-17
GB1595502A (en) 1981-08-12
IL53377A0 (en) 1978-01-31
CH635079A5 (de) 1983-03-15
ATA816377A (de) 1980-10-15
DK156057B (da) 1989-06-19
PL202177A1 (pl) 1978-09-25
NL930026I2 (nl) 1993-11-01
SG31784G (en) 1985-03-08
NL7712567A (nl) 1978-05-19
MX4682E (es) 1982-07-28
DK500477A (da) 1978-05-18
CS219333B2 (en) 1983-03-25
DE2751258A1 (de) 1978-06-01
IT1126216B (it) 1986-05-14
FR2371430A1 (fr) 1978-06-16
IN150172B (sk) 1982-04-07
IE46087L (en) 1978-05-17
NO773901L (no) 1978-05-19
DD133563A5 (de) 1979-01-10
BG30019A3 (en) 1981-03-16
PH14740A (en) 1981-11-20
SU976847A3 (ru) 1982-11-23
JPS58113153A (ja) 1983-07-05
NL930026I1 (nl) 1993-06-01
JPS62155218A (ja) 1987-07-10
FR2371430B1 (sk) 1980-06-27

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