ZA745317B - Novel benzylpyrimidines - Google Patents

Novel benzylpyrimidines

Info

Publication number
ZA745317B
ZA745317B ZA00745317A ZA745317A ZA745317B ZA 745317 B ZA745317 B ZA 745317B ZA 00745317 A ZA00745317 A ZA 00745317A ZA 745317 A ZA745317 A ZA 745317A ZA 745317 B ZA745317 B ZA 745317B
Authority
ZA
South Africa
Prior art keywords
benzylpyrimidines
novel
novel benzylpyrimidines
Prior art date
Application number
ZA00745317A
Other languages
English (en)
Inventor
G Rey-Bellet
G Zanetti
I Kompis
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA745317B publication Critical patent/ZA745317B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48Two nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48Two nitrogen atoms
    • C07D239/49Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA00745317A 1973-09-12 1974-08-19 Novel benzylpyrimidines ZA745317B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1305773A CH591456A5 (fi) 1973-09-12 1973-09-12

Publications (1)

Publication Number Publication Date
ZA745317B true ZA745317B (en) 1975-11-26

Family

ID=4388903

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00745317A ZA745317B (en) 1973-09-12 1974-08-19 Novel benzylpyrimidines

Country Status (28)

Country Link
JP (1) JPS6042238B2 (fi)
AR (2) AR207764A1 (fi)
AT (1) AT338797B (fi)
BE (1) BE819773A (fi)
BR (1) BR7407614D0 (fi)
CA (1) CA1037476A (fi)
CH (1) CH591456A5 (fi)
CU (1) CU34115A (fi)
DD (2) DD122785A5 (fi)
DE (1) DE2443682C2 (fi)
DK (1) DK135683B (fi)
ES (7) ES429949A1 (fi)
FI (1) FI58638C (fi)
FR (1) FR2242984B1 (fi)
GB (3) GB1484483A (fi)
HK (1) HK181A (fi)
HU (1) HU170427B (fi)
IE (1) IE40523B1 (fi)
IL (1) IL45510A (fi)
LU (1) LU70878A1 (fi)
NL (1) NL155827B (fi)
NO (1) NO140858C (fi)
PH (1) PH10643A (fi)
PL (2) PL99159B1 (fi)
SE (1) SE419443B (fi)
SU (3) SU577987A3 (fi)
YU (3) YU217874A (fi)
ZA (1) ZA745317B (fi)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515948A (en) * 1973-09-12 1985-05-07 Hoffmann-La Roche Inc. 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines
EP0001633A1 (en) * 1977-10-18 1979-05-02 The Wellcome Foundation Limited Processes for preparing tri-heterocyclic substituted methanes and their conversion into further intermediates useful in the preparation of pharmacologically active compounds
CH639273A5 (de) * 1978-09-12 1983-11-15 Hoffmann La Roche Diuretische mittel.
CH664959A5 (de) * 1981-11-09 1988-04-15 Wellcome Found Verfahren zur herstellung von substituierten 2,4-diamino-5-benzylpyrimidinen.
DE3250132C2 (de) * 1981-11-09 1997-01-16 Mallinckrodt Veterinary Inc Verfahren zur Herstellung von 2,4-Diamino-5-benzyl-pyrimidinen und neue Zwischenprodukte des Verfahrens
GB2180836A (en) * 1985-09-27 1987-04-08 William James Stephen Barker Sunscreen
JPH0431685Y2 (fi) * 1987-06-01 1992-07-30
US4900859A (en) * 1987-12-03 1990-02-13 Hoffman-La Roche Inc. Process for 4-dimethylamino-3,5-dimethoxybenzaldehyde
CA1300166C (en) * 1987-12-03 1992-05-05 Alfredo Guerrato Process for the preparation of a benzoic acid ester

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1103931B (de) * 1957-02-21 1961-04-06 Wellcome Found Verfahren zur Herstellung von 2, 4-Diamino-5-benzylpyrimidinderivaten
US3485840A (en) * 1964-11-12 1969-12-23 Hoffmann La Roche 2,4-diamino - 5 - (2',4',5'-substituted benzyl) pyrimidines,intermediates and processes

Also Published As

Publication number Publication date
IE40523B1 (en) 1979-06-20
YU217874A (en) 1982-06-18
DK468374A (fi) 1975-05-12
FI58638C (fi) 1981-03-10
FI256174A (fi) 1975-03-13
YU37153B (en) 1984-08-31
SU571189A3 (ru) 1977-08-30
NO140858C (no) 1979-11-28
IL45510A0 (en) 1974-11-29
YU301580A (en) 1983-04-27
NO743271L (fi) 1975-04-07
YU37154B (en) 1984-08-31
AR211387Q (es) 1977-12-15
JPS6042238B2 (ja) 1985-09-20
YU301680A (en) 1983-04-27
AR207764A1 (es) 1976-10-29
CA1037476A (en) 1978-08-29
AU7263174A (en) 1976-02-26
CU34115A (es) 1983-10-04
HK181A (en) 1981-01-16
BR7407614D0 (pt) 1975-07-08
SE419443B (sv) 1981-08-03
ATA735174A (de) 1977-01-15
DE2443682A1 (de) 1975-03-20
DD116824A5 (fi) 1975-12-12
CH591456A5 (fi) 1977-09-15
FR2242984A1 (fi) 1975-04-04
NL155827B (nl) 1978-02-15
HU170427B (fi) 1977-06-28
JPS5053385A (fi) 1975-05-12
PL99159B1 (pl) 1978-06-30
DK135683B (da) 1977-06-06
DK135683C (fi) 1977-11-14
ES437009A1 (es) 1977-04-01
ES429949A1 (es) 1976-10-01
SU609465A3 (ru) 1978-05-30
NO140858B (no) 1979-08-20
ES437007A1 (es) 1977-04-01
ES437013A1 (es) 1977-04-01
SE7411382L (fi) 1975-03-13
PH10643A (en) 1977-07-22
BE819773A (fr) 1975-03-11
NL7411685A (nl) 1975-03-14
FI58638B (fi) 1980-11-28
FR2242984B1 (fi) 1977-11-04
CU21022L (en) 1981-09-09
DE2443682C2 (de) 1983-11-10
ES437008A1 (es) 1977-04-01
GB1484481A (en) 1977-09-01
SU577987A3 (ru) 1977-10-25
ES437012A1 (es) 1977-04-01
IE40523L (en) 1975-03-12
GB1484483A (en) 1977-09-01
GB1484482A (en) 1977-09-01
LU70878A1 (fi) 1976-08-19
DD122785A5 (fi) 1976-11-05
IL45510A (en) 1978-08-31
AT338797B (de) 1977-09-12
ES437011A1 (es) 1977-04-01
PL97757B1 (pl) 1978-03-30

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