ZA202304180B - Crystalline forms of a kras g12c inhibitor - Google Patents

Crystalline forms of a kras g12c inhibitor

Info

Publication number
ZA202304180B
ZA202304180B ZA2023/04180A ZA202304180A ZA202304180B ZA 202304180 B ZA202304180 B ZA 202304180B ZA 2023/04180 A ZA2023/04180 A ZA 2023/04180A ZA 202304180 A ZA202304180 A ZA 202304180A ZA 202304180 B ZA202304180 B ZA 202304180B
Authority
ZA
South Africa
Prior art keywords
crystalline forms
kras
inhibitor
relates
present
Prior art date
Application number
ZA2023/04180A
Other languages
English (en)
Inventor
Patricia Andres
Samuel Andrew
Cheng Yi Chen
Susana Del Rio Gancedo
Tawfik Gharbaoui
Jennifer Nelson
Original Assignee
Mirati Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mirati Therapeutics Inc filed Critical Mirati Therapeutics Inc
Publication of ZA202304180B publication Critical patent/ZA202304180B/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA2023/04180A 2020-09-11 2023-04-05 Crystalline forms of a kras g12c inhibitor ZA202304180B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063077553P 2020-09-11 2020-09-11
US202063093673P 2020-10-19 2020-10-19
PCT/US2021/049940 WO2022056307A1 (en) 2020-09-11 2021-09-10 Crystalline forms of a kras g12c inhibitor

Publications (1)

Publication Number Publication Date
ZA202304180B true ZA202304180B (en) 2024-10-30

Family

ID=80629890

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2023/04180A ZA202304180B (en) 2020-09-11 2023-04-05 Crystalline forms of a kras g12c inhibitor

Country Status (13)

Country Link
US (3) US12286431B2 (https=)
EP (1) EP4210833A4 (https=)
JP (1) JP2023540809A (https=)
KR (1) KR20230137286A (https=)
AU (1) AU2021340716A1 (https=)
BR (1) BR112023004569A2 (https=)
CA (1) CA3190944A1 (https=)
CL (1) CL2023000693A1 (https=)
CO (1) CO2023004141A2 (https=)
IL (1) IL301236A (https=)
MX (1) MX2023002942A (https=)
WO (1) WO2022056307A1 (https=)
ZA (1) ZA202304180B (https=)

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