ZA201306744B - Antagonists of the interleukin-1 receptor - Google Patents

Antagonists of the interleukin-1 receptor

Info

Publication number
ZA201306744B
ZA201306744B ZA2013/06744A ZA201306744A ZA201306744B ZA 201306744 B ZA201306744 B ZA 201306744B ZA 2013/06744 A ZA2013/06744 A ZA 2013/06744A ZA 201306744 A ZA201306744 A ZA 201306744A ZA 201306744 B ZA201306744 B ZA 201306744B
Authority
ZA
South Africa
Prior art keywords
interleukin
antagonists
receptor
Prior art date
Application number
ZA2013/06744A
Other languages
English (en)
Inventor
Vladimir Berezin
Elisabeth Bock
Original Assignee
Phlogo Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phlogo Aps filed Critical Phlogo Aps
Publication of ZA201306744B publication Critical patent/ZA201306744B/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
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ZA2013/06744A 2011-03-14 2013-09-09 Antagonists of the interleukin-1 receptor ZA201306744B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201170120 2011-03-14
PCT/DK2012/000022 WO2012122985A1 (en) 2011-03-14 2012-03-14 Antagonists of the interleukin- 1 receptor

Publications (1)

Publication Number Publication Date
ZA201306744B true ZA201306744B (en) 2014-11-26

Family

ID=45876525

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2013/06744A ZA201306744B (en) 2011-03-14 2013-09-09 Antagonists of the interleukin-1 receptor

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Country Link
US (1) US9359405B2 (enExample)
EP (1) EP2686431B1 (enExample)
JP (1) JP6120782B2 (enExample)
KR (1) KR20140012127A (enExample)
CN (1) CN103476933B (enExample)
AU (1) AU2012228769B2 (enExample)
BR (1) BR112013023309A2 (enExample)
CA (1) CA2828504A1 (enExample)
ES (1) ES2600616T3 (enExample)
MX (1) MX2013010171A (enExample)
RU (1) RU2013145283A (enExample)
WO (1) WO2012122985A1 (enExample)
ZA (1) ZA201306744B (enExample)

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SG10201707477SA (en) 2013-03-13 2017-10-30 Eleven Biotherapeutics Inc Chimeric cytokine formulations for ocular delivery
AU2014274044B2 (en) * 2013-05-31 2019-06-27 Regeneron Pharmaceuticals, Inc. Methods of using IL-1 antagonists to treat Alzheimer's Disease
CN104711214B (zh) * 2015-04-09 2019-02-12 武汉联程生物科技有限公司 一种大肠杆菌bbm2015001菌株及其用途
WO2017063657A1 (en) 2015-10-14 2017-04-20 Phlogo Aps Il1ra-derived peptide antagonist
SG11201907159SA (en) * 2017-02-16 2019-09-27 Xbiotech Inc Treatment of hidradenitis suppurativa
WO2019200213A1 (en) * 2018-04-12 2019-10-17 Mayo Foundation For Medical Education And Research Methods for guiding therapy decisions in seizure disorders
KR102022118B1 (ko) * 2019-01-07 2019-09-18 주식회사 아스트로젠 중추신경계 질환의 예방 또는 치료용 세린 유도체 화합물
AU2021455992A1 (en) * 2021-07-13 2024-01-18 Serodus Aps Il1ra derived peptides for treatment of diabetic nephropathy
CN114177295B (zh) * 2021-12-16 2023-09-19 上海市第五人民医院 白细胞介素1受体拮抗剂治疗非酒精性脂肪性肝病的应用
CN116144668A (zh) * 2023-02-13 2023-05-23 杭州吉倍思生物制药有限公司 人il-1r1基因、蛋白、同源二聚体蛋白质与用途
JP7786006B1 (ja) * 2023-04-14 2025-12-15 メルク・シャープ・アンド・ドーム・エルエルシー インターロイキン－１ベータを捕捉するための環状ペプチド
WO2025101453A1 (en) * 2023-11-07 2025-05-15 University Of Washington De novo design of potent minibinder antagonists of il-6r, gp130, and il1-r1

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CA2828504A1 (en) 2012-09-20
BR112013023309A2 (pt) 2017-09-19
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ES2600616T3 (es) 2017-02-10
MX2013010171A (es) 2013-11-20
EP2686431B1 (en) 2016-08-03
WO2012122985A1 (en) 2012-09-20
AU2012228769B2 (en) 2016-09-08
AU2012228769A1 (en) 2013-10-10
CN103476933B (zh) 2016-04-13
JP6120782B2 (ja) 2017-04-26
US9359405B2 (en) 2016-06-07
NZ615710A (en) 2015-10-30
CN103476933A (zh) 2013-12-25
KR20140012127A (ko) 2014-01-29
JP2014510082A (ja) 2014-04-24
EP2686431A1 (en) 2014-01-22

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