PL2736918T3 - Antagoniści progesteronu - Google Patents
Antagoniści progesteronuInfo
- Publication number
- PL2736918T3 PL2736918T3 PL12748307T PL12748307T PL2736918T3 PL 2736918 T3 PL2736918 T3 PL 2736918T3 PL 12748307 T PL12748307 T PL 12748307T PL 12748307 T PL12748307 T PL 12748307T PL 2736918 T3 PL2736918 T3 PL 2736918T3
- Authority
- PL
- Poland
- Prior art keywords
- progesterone antagonists
- progesterone
- antagonists
- Prior art date
Links
- 239000000044 progesterone antagonist Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0092—Alkenyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/193,426 US20130029953A1 (en) | 2011-07-28 | 2011-07-28 | Progesterone antagonists |
| PCT/US2012/048805 WO2013016725A1 (en) | 2011-07-28 | 2012-07-30 | Progesterone antagonists |
| EP12748307.1A EP2736918B1 (en) | 2011-07-28 | 2012-07-30 | Progesterone antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2736918T3 true PL2736918T3 (pl) | 2020-01-31 |
Family
ID=46690705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12748307T PL2736918T3 (pl) | 2011-07-28 | 2012-07-30 | Antagoniści progesteronu |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20130029953A1 (pl) |
| EP (1) | EP2736918B1 (pl) |
| CN (1) | CN103842370A (pl) |
| AU (1) | AU2012286648B2 (pl) |
| BR (1) | BR112014001973A2 (pl) |
| CA (1) | CA2846573A1 (pl) |
| ES (1) | ES2687686T3 (pl) |
| HU (1) | HUE039607T2 (pl) |
| MX (1) | MX360774B (pl) |
| PL (1) | PL2736918T3 (pl) |
| RU (1) | RU2608521C2 (pl) |
| WO (1) | WO2013016725A1 (pl) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9096641B2 (en) * | 2013-06-05 | 2015-08-04 | Evestra, Inc. | Imidazolyl progesterone antagonists |
| RU2667942C2 (ru) * | 2013-07-11 | 2018-09-27 | Эвестра, Инк. | Соединения, образующие пролекарства |
| WO2015089338A2 (en) * | 2013-12-11 | 2015-06-18 | Sloan-Kettering Institute For Cancer Research | Glucocorticoid inhibitors for treatment of prostate cancer |
| DE102014005819B4 (de) * | 2014-04-24 | 2016-08-04 | Carl Freudenberg Kg | Thermisch fixierbares Flächengebilde und Verfahren zu seiner Herstellung |
| CN113559075A (zh) * | 2014-11-17 | 2021-10-29 | 康泰科思特生物制药公司 | 奥那司酮延长释放组合物和方法 |
| CA2998924A1 (en) | 2015-09-25 | 2017-03-30 | Context Biopharma Inc. | Methods of making onapristone intermediates |
| JP2019503353A (ja) | 2015-12-15 | 2019-02-07 | コンテキスト・バイオファーマ・インコーポレイテッド | 非晶質オナプリストン組成物およびそれを作製する方法 |
| US11110103B2 (en) | 2015-12-23 | 2021-09-07 | Oric Pharmaceuticals, Inc. | Inhibitors of glucocorticoid receptor |
| AU2016379417B2 (en) | 2015-12-23 | 2020-09-24 | Oric Pharmaceuticals, Inc. | Inhibitors of glucocorticoid receptor |
| US11124537B2 (en) | 2015-12-23 | 2021-09-21 | Oric Pharmaceuticals, Inc. | Inhibitors of glucocorticoid receptor |
| JP2019513706A (ja) * | 2016-03-21 | 2019-05-30 | コンテキスト・バイオファーマ・インコーポレイテッド | オナプリストン代謝物質組成物及び方法 |
| PT3523315T (pt) | 2016-10-07 | 2021-04-29 | Oric Pharmaceuticals Inc | Inibidor de recetor de glucocorticoide |
| US20180148471A1 (en) | 2016-11-30 | 2018-05-31 | Arno Therapeutics, Inc. | Methods for onapristone synthesis dehydration and deprotection |
| WO2023000135A1 (en) * | 2021-07-19 | 2023-01-26 | Context Biopharma Inc. | Processes of making onapristone and intermediates thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA8231B (en) * | 1981-01-09 | 1982-11-24 | Roussel Uclaf | New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained |
| FR2598421B1 (fr) * | 1986-05-06 | 1988-08-19 | Roussel Uclaf | Nouveaux produits 19-nor ou 19-nor d-homo steroides substitues en position 11b par un radical phenyle portant un radical alkynyle, leur procede de preparation, leur application comme medicaments et les compositions les renfermant |
| FR2651435A1 (fr) * | 1989-09-07 | 1991-03-08 | Roussel Uclaf | Nouvelle utilisation de composes anti-progestomimetiques. |
| DE19706061A1 (de) * | 1997-02-07 | 1998-08-13 | Schering Ag | Antigestagen wirksame Steroide mit fluorierter 17alpha-Alkylkette |
| US6172052B1 (en) * | 1998-12-04 | 2001-01-09 | Research Triangle Institute | 17β-acyl-17α-propynyl-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
| ATE367817T1 (de) * | 2001-01-09 | 2007-08-15 | Bayer Schering Pharma Ag | Verwendung von antigestagene zur verschiebung der endometrialen reifung wahrend infertilitätbehandlung |
| US20020143000A1 (en) * | 2001-01-09 | 2002-10-03 | Christa Hegele-Hartung | Use of antigestagens for inhibiting accelerated endometrial maturation during infertility treatment |
| WO2003093292A1 (de) * | 2002-05-03 | 2003-11-13 | Schering Ag | 17α-FLUORALKYL-11β-BENZALDOXIM-STEROIDE, VERFAHREN ZU DEREN HERSTELLUNG, DIESE STEROIDE ENTHALTENDE PHARMAZEUTISCHE PRÄPARATE SOWIE DEREN VERWENDUNG ZUR HERSTELLUNG VON ARZNEIMITTELN |
| DE102006054535A1 (de) | 2006-11-15 | 2008-05-21 | Bayer Schering Pharma Aktiengesellschaft | Progesteronrezeptorantagonisten |
-
2011
- 2011-07-28 US US13/193,426 patent/US20130029953A1/en not_active Abandoned
-
2012
- 2012-07-30 WO PCT/US2012/048805 patent/WO2013016725A1/en not_active Ceased
- 2012-07-30 CN CN201280042912.4A patent/CN103842370A/zh active Pending
- 2012-07-30 RU RU2014107331A patent/RU2608521C2/ru not_active IP Right Cessation
- 2012-07-30 HU HUE12748307A patent/HUE039607T2/hu unknown
- 2012-07-30 BR BR112014001973A patent/BR112014001973A2/pt not_active Application Discontinuation
- 2012-07-30 MX MX2014001111A patent/MX360774B/es active IP Right Grant
- 2012-07-30 CA CA2846573A patent/CA2846573A1/en not_active Abandoned
- 2012-07-30 PL PL12748307T patent/PL2736918T3/pl unknown
- 2012-07-30 AU AU2012286648A patent/AU2012286648B2/en not_active Ceased
- 2012-07-30 EP EP12748307.1A patent/EP2736918B1/en not_active Not-in-force
- 2012-07-30 ES ES12748307.1T patent/ES2687686T3/es active Active
-
2017
- 2017-12-04 US US15/830,669 patent/US20180155386A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012286648A1 (en) | 2014-03-13 |
| RU2608521C2 (ru) | 2017-01-19 |
| EP2736918B1 (en) | 2018-08-29 |
| RU2014107331A (ru) | 2015-09-10 |
| WO2013016725A1 (en) | 2013-01-31 |
| MX360774B (es) | 2018-11-15 |
| HUE039607T2 (hu) | 2019-01-28 |
| AU2012286648B2 (en) | 2017-06-08 |
| BR112014001973A2 (pt) | 2017-02-21 |
| ES2687686T3 (es) | 2018-10-26 |
| CA2846573A1 (en) | 2013-01-31 |
| US20180155386A1 (en) | 2018-06-07 |
| MX2014001111A (es) | 2014-10-17 |
| CN103842370A (zh) | 2014-06-04 |
| US20130029953A1 (en) | 2013-01-31 |
| EP2736918A1 (en) | 2014-06-04 |
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