ZA200900562B - Dimeric IAP Antagonists - Google Patents

Dimeric IAP Antagonists

Info

Publication number
ZA200900562B
ZA200900562B ZA200900562A ZA200900562A ZA200900562B ZA 200900562 B ZA200900562 B ZA 200900562B ZA 200900562 A ZA200900562 A ZA 200900562A ZA 200900562 A ZA200900562 A ZA 200900562A ZA 200900562 B ZA200900562 B ZA 200900562B
Authority
ZA
South Africa
Prior art keywords
iap antagonists
dimeric iap
dimeric
antagonists
iap
Prior art date
Application number
ZA200900562A
Other languages
English (en)
Inventor
Stephen M Condon
Matthew G Laporte
Yijun Deng
Susan R Rippin
Original Assignee
Tetralogic Pharmaceuticals Cor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tetralogic Pharmaceuticals Cor filed Critical Tetralogic Pharmaceuticals Cor
Publication of ZA200900562B publication Critical patent/ZA200900562B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA200900562A 2006-07-24 2009-01-23 Dimeric IAP Antagonists ZA200900562B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82015606P 2006-07-24 2006-07-24

Publications (1)

Publication Number Publication Date
ZA200900562B true ZA200900562B (en) 2010-06-30

Family

ID=38904713

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200900562A ZA200900562B (en) 2006-07-24 2009-01-23 Dimeric IAP Antagonists

Country Status (15)

Country Link
US (2) US7985735B2 (enExample)
EP (2) EP2409984A1 (enExample)
JP (1) JP5228202B2 (enExample)
KR (1) KR20090041391A (enExample)
CN (1) CN101516904A (enExample)
AR (1) AR063943A1 (enExample)
AU (1) AU2007276760B2 (enExample)
BR (1) BRPI0715195A2 (enExample)
CA (1) CA2657706A1 (enExample)
CL (1) CL2007002167A1 (enExample)
IL (1) IL196423A0 (enExample)
MX (1) MX2009000824A (enExample)
NZ (1) NZ574311A (enExample)
WO (1) WO2008014263A2 (enExample)
ZA (1) ZA200900562B (enExample)

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EA012810B1 (ru) 2005-02-25 2009-12-30 Тетралоджик Фармасеутикалс Димерные ингибиторы ингибиторов белков апоптоза (iap)
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ES2525585T3 (es) * 2006-05-05 2014-12-26 The Regents Of The University Of Michigan Intermedios para la preparación de miméticos de SMAC bivalentes
US8202902B2 (en) * 2006-05-05 2012-06-19 The Regents Of The University Of Michigan Bivalent SMAC mimetics and the uses thereof
BRPI0711591A2 (pt) 2006-05-16 2011-11-16 Aegera Therapeutics, Inc. composto de ligação de domìnio bir da iap
US8445473B2 (en) 2008-04-11 2013-05-21 The Regents Of The University Of Michigan Heteroaryl-substituted bicyclic Smac mimetics and the uses thereof
US9266630B2 (en) * 2009-02-25 2016-02-23 Liqui-Box Corporation Process for pouch forming with optimized fill-accuracy and headspace
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US8283372B2 (en) * 2009-07-02 2012-10-09 Tetralogic Pharmaceuticals Corp. 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
NZ602368A (en) 2010-02-12 2014-10-31 Pharmascience Inc Iap bir domain binding compounds
UY33236A (es) * 2010-02-25 2011-09-30 Novartis Ag Inhibidores dimericos de las iap
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UY33794A (es) 2010-12-13 2012-07-31 Novartis Ag Inhibidores diméricos de las iap
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CN105492011A (zh) 2013-04-08 2016-04-13 丹尼斯·M·布朗 不理想给药化学化合物的治疗增效
WO2015109391A1 (en) * 2014-01-24 2015-07-30 Children's Hospital Of Eastern Ontario Research Institute Inc. Smc combination therapy for the treatment of cancer
CN105566447B (zh) * 2016-01-20 2019-09-20 广东工业大学 一种凋亡抑制蛋白的类肽拮抗剂及其合成方法与应用
CN105585583B (zh) * 2016-01-20 2018-04-13 广东工业大学 一种非肽类凋亡抑制蛋白拮抗剂及其合成方法与应用
JP2019514900A (ja) * 2016-04-27 2019-06-06 メッドシャイン ディスカバリー インコーポレイテッド 新規な二価のｉａｐアンタゴニストとしてのベンズイミダゾール結合インドール化合物
CN106188098B (zh) * 2016-07-06 2017-11-03 广东工业大学 一种杂化抗癌药物及其制备方法与应用
CN106265764B (zh) * 2016-08-18 2018-03-16 广州威溶特医药科技有限公司 Iap抑制剂和溶瘤病毒在制备抗肿瘤药物中的应用
CN108440507B (zh) * 2017-02-16 2022-10-18 南京圣和药物研发有限公司 作为细胞凋亡蛋白抑制剂的化合物及其应用
CA3063938A1 (en) * 2017-05-17 2018-11-22 Denali Therapeutics Inc. Compounds, compositions and methods
WO2019080928A1 (zh) * 2017-10-27 2019-05-02 南京明德新药研发股份有限公司 一种iap拮抗剂的晶型及其制备方法
CN111655713B (zh) * 2018-02-09 2023-06-27 广东东阳光药业有限公司 Iap抑制剂及其在药物中的应用
JP2021038192A (ja) * 2019-05-31 2021-03-11 均 石井 Ｄｎａ変性剤を使用する成長促進剤。
CN112521372B (zh) * 2019-09-18 2022-07-08 南京华威医药科技集团有限公司 一种细胞凋亡蛋白抑制剂及其制备方法和用途

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Also Published As

Publication number Publication date
EP2049563B1 (en) 2014-03-12
MX2009000824A (es) 2009-02-04
AR063943A1 (es) 2009-03-04
EP2049563A2 (en) 2009-04-22
WO2008014263A3 (en) 2008-03-13
US20110305777A1 (en) 2011-12-15
BRPI0715195A2 (pt) 2013-06-11
US20080020986A1 (en) 2008-01-24
EP2409984A1 (en) 2012-01-25
CN101516904A (zh) 2009-08-26
AU2007276760B2 (en) 2012-01-19
JP2009544728A (ja) 2009-12-17
NZ574311A (en) 2011-12-22
AU2007276760A1 (en) 2008-01-31
WO2008014263A2 (en) 2008-01-31
CA2657706A1 (en) 2008-01-31
US7985735B2 (en) 2011-07-26
JP5228202B2 (ja) 2013-07-03
IL196423A0 (en) 2011-08-01
CL2007002167A1 (es) 2009-01-23
KR20090041391A (ko) 2009-04-28

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