ZA200900204B - Substituted piperidines that increase P53 activity and the uses thereof - Google Patents
Substituted piperidines that increase P53 activity and the uses thereofInfo
- Publication number
- ZA200900204B ZA200900204B ZA200900204A ZA200900204A ZA200900204B ZA 200900204 B ZA200900204 B ZA 200900204B ZA 200900204 A ZA200900204 A ZA 200900204A ZA 200900204 A ZA200900204 A ZA 200900204A ZA 200900204 B ZA200900204 B ZA 200900204B
- Authority
- ZA
- South Africa
- Prior art keywords
- activity
- increase
- substituted piperidines
- piperidines
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81775306P | 2006-06-30 | 2006-06-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200900204B true ZA200900204B (en) | 2010-01-27 |
Family
ID=38656615
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200900204A ZA200900204B (en) | 2006-06-30 | 2009-01-09 | Substituted piperidines that increase P53 activity and the uses thereof |
Country Status (17)
Country | Link |
---|---|
US (1) | US7884107B2 (es) |
EP (1) | EP2035416A1 (es) |
JP (1) | JP2009542666A (es) |
KR (1) | KR20090042779A (es) |
CN (1) | CN101595107A (es) |
AR (1) | AR061726A1 (es) |
AU (1) | AU2007269836A1 (es) |
BR (1) | BRPI0713119A2 (es) |
CA (1) | CA2656398A1 (es) |
CO (1) | CO6150158A2 (es) |
IL (1) | IL196152A0 (es) |
MX (1) | MX2009000285A (es) |
NO (1) | NO20090469L (es) |
PE (1) | PE20081238A1 (es) |
TW (1) | TW200808781A (es) |
WO (1) | WO2008005268A1 (es) |
ZA (1) | ZA200900204B (es) |
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WO2008005266A2 (en) * | 2006-06-30 | 2008-01-10 | Schering Corporation | Method of using substituted piperidines that increase p53 activity |
US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
US20080051375A1 (en) * | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same |
AU2008210434C8 (en) | 2007-01-31 | 2014-03-27 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
BRPI0809366B8 (pt) | 2007-03-28 | 2021-05-25 | Harvard College | polipeptídeo substancialmente alfa-helicoidal, método para fabricação do mesmo, aminoácido e composição farmacêutica |
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AR073578A1 (es) | 2008-09-15 | 2010-11-17 | Priaxon Ag | Pirrolidin-2-onas |
PE20110367A1 (es) | 2008-09-18 | 2011-06-13 | Hoffmann La Roche | DERIVADOS DE 4-CIANO-4-FENIL-PIRROLIDIN-2-CARBOXAMIDAS SUSTITUIDAS COMO INHIBIDORES DE LA INTERACCION p53-MDM2 |
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US7928233B2 (en) | 2009-02-10 | 2011-04-19 | Hoffmann-La Roche Inc. | Spiroindolinone pyridine derivatives |
US8217051B2 (en) | 2009-02-17 | 2012-07-10 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
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WO2011046771A1 (en) * | 2009-10-14 | 2011-04-21 | Schering Corporation | SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF |
US8017607B2 (en) | 2009-10-14 | 2011-09-13 | Hoffmann-La Roche Inc. | N-substituted-pyrrolidines as inhibitors of MDM2-P-53 interactions |
ES2938049T3 (es) | 2009-10-16 | 2023-04-04 | Scripps Research Inst | Inducción de células pluripotentes |
US8088815B2 (en) | 2009-12-02 | 2012-01-03 | Hoffman-La Roche Inc. | Spiroindolinone pyrrolidines |
US8288431B2 (en) | 2010-02-17 | 2012-10-16 | Hoffmann-La Roche Inc. | Substituted spiroindolinones |
CA2800498C (en) | 2010-03-31 | 2021-11-16 | The Scripps Research Institute | Reprogramming cells |
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ES2670842T3 (es) | 2010-06-15 | 2018-06-01 | Cellular Dynamics International, Inc. | Generación de células madre pluripotentes inducidas a partir de pequeños volúmenes de sangre periférica |
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US8859723B2 (en) | 2010-08-13 | 2014-10-14 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
FR2967072B1 (fr) | 2010-11-05 | 2013-03-29 | Univ Dundee | Procede pour ameliorer la production de virus et semences vaccinales influenza |
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CN114164167A (zh) | 2010-12-22 | 2022-03-11 | 菲特治疗公司 | 用于单细胞分选与增强ipsc重新编程的细胞培养平台 |
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EP3013833B1 (en) * | 2013-06-26 | 2019-03-06 | Universidade Do Porto | Tryptophanol-derived oxazoloisoindolinones: small-molecule p53 activators |
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US10576064B2 (en) | 2014-07-03 | 2020-03-03 | Boehringer Ingelheim International Gmbh | Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors |
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WO2016074580A1 (zh) * | 2014-11-14 | 2016-05-19 | 中国科学院上海生命科学研究院 | 一种提高cd4阳性t淋巴细胞存活率和活性的试剂及其应用 |
US11596652B2 (en) | 2015-02-18 | 2023-03-07 | Enlivex Therapeutics R&D Ltd | Early apoptotic cells for use in treating sepsis |
US11304976B2 (en) | 2015-02-18 | 2022-04-19 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
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IL297418B2 (en) | 2015-02-18 | 2023-11-01 | Enlivex Therapeutics Rdo Ltd | Combined immunotherapy and cytokine control therapy for cancer treatment |
US11000548B2 (en) | 2015-02-18 | 2021-05-11 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
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MX2017011834A (es) | 2015-03-20 | 2018-04-11 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos y usos de los mismos. |
WO2016162229A1 (en) | 2015-04-10 | 2016-10-13 | Capsugel Belgium N.V. | Abiraterone acetate lipid formulations |
IL287500B2 (en) | 2015-04-21 | 2023-12-01 | Enlivex Therapeutics Rdo Ltd | Therapeutic preparations from pooled apoptotic blood cells and their use |
EP3347372A4 (en) | 2015-09-10 | 2019-09-04 | Aileron Therapeutics, Inc. | PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF MCL-1 |
LT3359542T (lt) | 2015-10-09 | 2021-05-25 | Boehringer Ingelheim International Gmbh | Spiro[3h-indolo-3,2 -pirolidin]-2(1h)-ono junginiai ir dariniai, kaip mdm2-p53 inhibitoriai |
CN117737124A (zh) | 2015-10-16 | 2024-03-22 | 菲特治疗公司 | 用于诱导和维护基态多能性的平台 |
JP6983771B2 (ja) | 2015-10-30 | 2021-12-17 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California | 幹細胞からt細胞を作製する方法および該t細胞を用いた免疫療法的方法 |
US11730761B2 (en) | 2016-02-18 | 2023-08-22 | Enlivex Therapeutics Rdo Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
TW201825458A (zh) | 2016-09-20 | 2018-07-16 | 英商葛蘭素史克智慧財產(第二)有限公司 | Trpv4拮抗劑 |
JP2019532054A (ja) | 2016-09-20 | 2019-11-07 | グラクソスミスクライン、インテレクチュアル、プロパティー、(ナンバー2)、リミテッドGlaxosmithkline Intellectual Property (No.2) Limited | Trpv4拮抗薬 |
JP7106528B2 (ja) | 2016-09-20 | 2022-07-26 | グラクソスミスクライン、インテレクチュアル、プロパティー、(ナンバー2)、リミテッド | Trpv4拮抗薬 |
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WO2019134070A1 (en) * | 2018-01-02 | 2019-07-11 | Rui Jin Hospital, Shanghai Jiao Tong University School Of Medicine | Panda as novel therapeutic |
CN108864113B (zh) * | 2018-08-03 | 2021-08-13 | 南方科技大学 | 一种mdm2-hdac双靶点抑制剂、药物组合物及其制备和用途 |
CN109293630A (zh) * | 2018-11-15 | 2019-02-01 | 山东大学 | 含取代吡唑类化合物及其制备方法与应用 |
CN110628735B (zh) * | 2019-04-23 | 2022-04-08 | 天津科技大学 | 一种5α-还原酶突变体,基因工程菌及其在高效催化5α-AD生产中的应用 |
CN113633642A (zh) * | 2021-08-26 | 2021-11-12 | 山东第一医科大学附属青岛眼科医院(山东省眼科研究所、青岛眼科医院) | Abt-263在制备抑制角膜移植免疫排斥反应的药物中的应用 |
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CN1182113C (zh) * | 2002-07-19 | 2004-12-29 | 中国科学院上海有机化学研究所 | 2,5-cis-二取代的吡咯烷衍生物、合成方法及其用途 |
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RS51981B (en) | 2005-12-13 | 2012-02-29 | Schering Corporation | POLYCYCLIC INDASOL DERIVATIVES WHICH ARE ERK INHIBITORS |
-
2007
- 2007-06-27 CA CA002656398A patent/CA2656398A1/en not_active Abandoned
- 2007-06-27 KR KR1020097001772A patent/KR20090042779A/ko not_active Application Discontinuation
- 2007-06-27 BR BRPI0713119-4A patent/BRPI0713119A2/pt not_active IP Right Cessation
- 2007-06-27 MX MX2009000285A patent/MX2009000285A/es unknown
- 2007-06-27 JP JP2009518257A patent/JP2009542666A/ja active Pending
- 2007-06-27 AU AU2007269836A patent/AU2007269836A1/en not_active Abandoned
- 2007-06-27 US US11/769,030 patent/US7884107B2/en active Active
- 2007-06-27 EP EP07796521A patent/EP2035416A1/en not_active Withdrawn
- 2007-06-27 CN CNA2007800306960A patent/CN101595107A/zh active Pending
- 2007-06-27 WO PCT/US2007/014958 patent/WO2008005268A1/en active Application Filing
- 2007-06-28 AR ARP070102892A patent/AR061726A1/es not_active Application Discontinuation
- 2007-06-29 TW TW096123818A patent/TW200808781A/zh unknown
- 2007-07-02 PE PE2007000844A patent/PE20081238A1/es not_active Application Discontinuation
-
2008
- 2008-12-23 IL IL196152A patent/IL196152A0/en unknown
-
2009
- 2009-01-09 ZA ZA200900204A patent/ZA200900204B/xx unknown
- 2009-01-29 NO NO20090469A patent/NO20090469L/no not_active Application Discontinuation
- 2009-01-30 CO CO09008866A patent/CO6150158A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
IL196152A0 (en) | 2009-09-22 |
CN101595107A (zh) | 2009-12-02 |
AR061726A1 (es) | 2008-09-17 |
CO6150158A2 (es) | 2010-04-20 |
EP2035416A1 (en) | 2009-03-18 |
TW200808781A (en) | 2008-02-16 |
PE20081238A1 (es) | 2008-09-04 |
CA2656398A1 (en) | 2008-01-10 |
WO2008005268A1 (en) | 2008-01-10 |
KR20090042779A (ko) | 2009-04-30 |
BRPI0713119A2 (pt) | 2012-04-17 |
US20080004287A1 (en) | 2008-01-03 |
US7884107B2 (en) | 2011-02-08 |
AU2007269836A1 (en) | 2008-01-10 |
NO20090469L (no) | 2009-03-27 |
JP2009542666A (ja) | 2009-12-03 |
MX2009000285A (es) | 2009-06-08 |
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