ZA200804489B - 1-orthofluorophenyl substituted 1, 2, 5-thiazolidinedione derivatives as PTP-AS inhibitors - Google Patents

1-orthofluorophenyl substituted 1, 2, 5-thiazolidinedione derivatives as PTP-AS inhibitors

Info

Publication number
ZA200804489B
ZA200804489B ZA200804489A ZA200804489A ZA200804489B ZA 200804489 B ZA200804489 B ZA 200804489B ZA 200804489 A ZA200804489 A ZA 200804489A ZA 200804489 A ZA200804489 A ZA 200804489A ZA 200804489 B ZA200804489 B ZA 200804489B
Authority
ZA
South Africa
Prior art keywords
orthofluorophenyl
ptp
inhibitors
substituted
thiazolidinedione derivatives
Prior art date
Application number
ZA200804489A
Other languages
English (en)
Inventor
Barnes David
Coppola Gary Mark
Stams Travis
Topiol Sidney Wolf
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37903424&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200804489(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ZA200804489B publication Critical patent/ZA200804489B/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A—HUMAN NECESSITIES
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    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/12—Antihypertensives
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles

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  • Cardiology (AREA)
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  • Diabetes (AREA)
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  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
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  • Psychiatry (AREA)
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  • Child & Adolescent Psychology (AREA)
ZA200804489A 2005-12-08 2008-05-27 1-orthofluorophenyl substituted 1, 2, 5-thiazolidinedione derivatives as PTP-AS inhibitors ZA200804489B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74849205P 2005-12-08 2005-12-08

Publications (1)

Publication Number Publication Date
ZA200804489B true ZA200804489B (en) 2009-08-26

Family

ID=37903424

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Application Number Title Priority Date Filing Date
ZA200804489A ZA200804489B (en) 2005-12-08 2008-05-27 1-orthofluorophenyl substituted 1, 2, 5-thiazolidinedione derivatives as PTP-AS inhibitors

Country Status (23)

Country Link
US (1) US8252820B2 (zh)
EP (1) EP1963293A1 (zh)
JP (1) JP2009518419A (zh)
KR (1) KR20080075218A (zh)
CN (1) CN101336235A (zh)
AR (1) AR058285A1 (zh)
AU (1) AU2006321902B2 (zh)
BR (1) BRPI0619567A2 (zh)
CA (1) CA2631007A1 (zh)
CR (1) CR10047A (zh)
EC (1) ECSP088509A (zh)
GT (1) GT200800093A (zh)
IL (1) IL191711A0 (zh)
MA (1) MA30018B1 (zh)
NO (1) NO20083030L (zh)
NZ (1) NZ568663A (zh)
PE (2) PE20100470A1 (zh)
RU (1) RU2008127262A (zh)
TN (1) TNSN08248A1 (zh)
TW (1) TW200800928A (zh)
UA (1) UA94921C2 (zh)
WO (1) WO2007067612A1 (zh)
ZA (1) ZA200804489B (zh)

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WO2021127586A1 (en) * 2019-12-20 2021-06-24 Calico Life Sciences Llc Protein tyrosine phosphatase degraders and methods of use thereof
CN116829555A (zh) * 2020-09-11 2023-09-29 卡里科生命科学有限责任公司 蛋白酪氨酸磷酸酶抑制剂及其使用方法
JP2024505192A (ja) 2021-01-27 2024-02-05 ビーエーエスエフ ソシエタス・ヨーロピア ジアミノトリアジン化合物
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TW202345805A (zh) * 2022-01-31 2023-12-01 美商必治妥美雅史谷比公司 蛋白酪胺酸磷酸酶抑制劑、其組合物及使用方法
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EP1963294B1 (en) 2005-12-08 2012-10-10 Novartis AG 1,2,5-thiazolidine derivatives useful for treating conditions mediated by protein tyrosine phosphatases (ptpase)
BRPI0710182A2 (pt) 2006-03-31 2012-08-07 Novartis Ag compostos orgÂnicos.

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BRPI0619567A2 (pt) 2011-10-04
RU2008127262A (ru) 2010-01-20
EP1963293A1 (en) 2008-09-03
CA2631007A1 (en) 2007-06-14
KR20080075218A (ko) 2008-08-14
MA30018B1 (fr) 2008-12-01
US8252820B2 (en) 2012-08-28
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