HUS1900034I1 - 6,7-telítetlen-7-karbamoil-szubsztituált morfinán-származékok - Google Patents

6,7-telítetlen-7-karbamoil-szubsztituált morfinán-származékok

Info

Publication number
HUS1900034I1
HUS1900034I1 HUS1900034C HUS1900034C HUS1900034I1 HU S1900034 I1 HUS1900034 I1 HU S1900034I1 HU S1900034 C HUS1900034 C HU S1900034C HU S1900034 C HUS1900034 C HU S1900034C HU S1900034 I1 HUS1900034 I1 HU S1900034I1
Authority
HU
Hungary
Prior art keywords
unsaturated
carbamoyl substituted
morphinan derivative
substituted morphinan
derivative
Prior art date
Application number
HUS1900034C
Other languages
English (en)
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of HUS1900034I1 publication Critical patent/HUS1900034I1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HUS1900034C 2005-05-25 2019-07-03 6,7-telítetlen-7-karbamoil-szubsztituált morfinán-származékok HUS1900034I1 (hu)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2005151864 2005-05-25
JP2006065762 2006-03-10
PCT/JP2006/310231 WO2006126529A1 (ja) 2005-05-25 2006-05-23 ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
EP06746833.0A EP1889848B8 (en) 2005-05-25 2006-05-25 6,7-unsaturated-7-carbamoyl substituted morphinan derivative

Publications (1)

Publication Number Publication Date
HUS1900034I1 true HUS1900034I1 (hu) 2019-07-29

Family

ID=37451954

Family Applications (1)

Application Number Title Priority Date Filing Date
HUS1900034C HUS1900034I1 (hu) 2005-05-25 2019-07-03 6,7-telítetlen-7-karbamoil-szubsztituált morfinán-származékok

Country Status (19)

Country Link
US (4) US8084460B2 (hu)
EP (1) EP1889848B8 (hu)
JP (1) JP4323547B2 (hu)
KR (1) KR100912782B1 (hu)
CN (1) CN101228172B (hu)
AU (1) AU2006250390B2 (hu)
BR (1) BRPI0610343B8 (hu)
CA (1) CA2609733C (hu)
DK (1) DK1889848T3 (hu)
ES (1) ES2525215T3 (hu)
FR (1) FR19C1042I2 (hu)
HU (1) HUS1900034I1 (hu)
MX (1) MX2007014588A (hu)
NL (1) NL300996I2 (hu)
PL (1) PL1889848T3 (hu)
PT (1) PT1889848E (hu)
RU (1) RU2403255C2 (hu)
TW (1) TWI311056B (hu)
WO (2) WO2006126529A1 (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006126529A1 (ja) 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates
CA2905541C (en) * 2008-01-09 2020-02-11 Charleston Laboratories, Inc. Pharmaceutical compositions comprising an antiemetic and an opioid analgesic
JP5252391B2 (ja) * 2008-02-21 2013-07-31 学校法人北里研究所 オキサビシクロ［２．２．２］オクタンを有するモルヒナン誘導体およびその医薬用途
CA2734333A1 (en) * 2008-09-16 2010-03-25 Nektar Therapeutics Pegylated opioids with low potential for abuse
NZ598783A (en) * 2009-09-18 2013-07-26 Adolor Corp Use of opioid receptor antagonist for gastrointestinal tract disorders
CN102906099A (zh) * 2010-05-13 2013-01-30 株式会社绿十字 作为神经保护剂的基于(+)-3-羟基吗啡喃的多环衍生物
MX338392B (es) * 2010-11-12 2016-04-13 Shionogi & Co Cristal de derivado de 6,7-insaturado-7-carbamoil morfinano y metodo para producir el mismo.
WO2013172297A1 (ja) 2012-05-14 2013-11-21 塩野義製薬株式会社 ６，７－不飽和－７－カルバモイルモルヒナン誘導体含有製剤
JP7076171B2 (ja) 2016-12-26 2022-05-27 塩野義製薬株式会社 含量均一性を改善した製剤の製造方法
CN112312910A (zh) 2018-04-12 2021-02-02 莫菲克医疗股份有限公司 人整合素α4β7拮抗剂
KR102201609B1 (ko) * 2019-04-19 2021-01-12 연성정밀화학(주) 날데메딘의 제조방법
TW202332675A (zh) 2019-10-16 2023-08-16 美商莫菲克醫療股份有限公司 抑制人類整合素α4β7
WO2021100728A1 (ja) 2019-11-20 2021-05-27 塩野義製薬株式会社 ６，７－不飽和－７－カルバモイルモルヒナン誘導体含有固形製剤
CN111905111B (zh) * 2020-09-16 2023-03-31 地奥集团成都药业股份有限公司 一种评价复方谷氨酰胺组方对腹泻型肠易激综合征疗效的方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4272541A (en) 1978-06-02 1981-06-09 Miles Laboratories, Inc. 7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them
US4275205A (en) 1980-05-05 1981-06-23 Miles Laboratories, Inc. 7,7-Ditosyloxymethyl-4,5α-epoxy-morphinan-6-ols
US4347361A (en) 1980-12-10 1982-08-31 Sisa, Incorporated 4,5α-Epoxy-3-hydroxy or methoxy-7-(1-hydroxy-alkyl or 1-oxoalkyl)morphinan-6-one compounds
US4370333A (en) 1981-06-29 1983-01-25 Sisa, Incorporated 17-Cyclopropylmethyl-3-hydroxy-14-methoxy 7α-methyl-morphinan-6-one and therapeutic method of treating pain with it
US4443605A (en) 1982-07-30 1984-04-17 Miles Laboratories, Inc. 7β-Arylalkyl-6α, 7 α-oxymethylene-3-methoxy or 3-hydroxy-4, 5α-epoxy-17 methyl or 17-cycloalkyl-methyl morphinans
US4440932A (en) 1982-09-09 1984-04-03 Miles Laboratories, Inc. 7β-Arylalkyl-7α-methyl-6-oxo or 6α-hydroxy-3-methoxy or 3-hydroxy-4,5α-epoxy-17-methyl or 17-cycloalkyl-methylmorphinans
JP3843456B2 (ja) 1993-07-23 2006-11-08 東レ株式会社 モルヒナン誘導体および医薬用途
US5464841A (en) 1993-11-08 1995-11-07 Univ Minnesota Use of delta opioid receptor antagonists to treat immunoregulatory disorders
PL327943A1 (en) 1996-01-10 1999-01-04 Smithkline Beecham Spa Condensed heterocyclic derivatives of morphonoide (ii)
AU5891600A (en) 1999-07-01 2001-01-22 Chemrx Advanced Technologies, Inc. Process for synthesizing oxadiazoles
IL149600A0 (en) * 1999-11-29 2002-11-10 Adolor Corp Novel methods and compositions involving opioids and antagonists thereof
US20040024004A1 (en) 2001-05-04 2004-02-05 Sherman Barry M. Novel compositions and methods for enhancing potency or reducing adverse side effects of opioid agonists
AU5945801A (en) 2000-05-05 2001-11-20 Pain Therapeutics Inc Opoid antagonist compositions and dosage forms
JP2004501094A (ja) * 2000-05-05 2004-01-15 ペイン・セラピューティクス・インコーポレイテッド オピオイドアゴニストの効力を増強するか、またはオピオイドアゴニストの有害な副作用を減弱するための新規な組成物および方法
AU2002227135B2 (en) * 2000-10-31 2008-01-03 Rensselaer Polytechnic Institute 8- substituted-2, 6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents
KR20030053530A (ko) * 2000-11-22 2003-06-28 도레이 가부시끼가이샤 인돌 유도체 및 그 의약용도
DE10161963A1 (de) 2001-12-17 2003-07-03 Johannes Schuetz 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
DE10229842A1 (de) * 2002-07-03 2004-02-05 Helmut Prof. Dr. Schmidhammer Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung
US20060052409A1 (en) 2002-07-11 2006-03-09 Koji Kawai Therapeutic or preventive agent for nausea/vomiting
JP2006502190A (ja) 2002-09-18 2006-01-19 ザ キュレイターズ オブ ザ ユニバーシティー オブ ミズーリ デルタ−オピオイド受容体に選択的なオピエート類似物
US20040157784A1 (en) 2003-02-10 2004-08-12 Jame Fine Chemicals, Inc. Opiod tannate compositions
WO2005105093A2 (en) 2003-08-26 2005-11-10 Duke University METHOD OF ARRESTING THE SIDE EFFECTS OF µ-OPIOID RECEPTOR AGONISTS DURING THEIR ADMINISTRATION
AU2005249508A1 (en) 2004-05-28 2005-12-15 Human Biomolecular Research Institute Synthesis of metabolically stable analgesics, pain medications and other agents
US20060063792A1 (en) 2004-09-17 2006-03-23 Adolor Corporation Substituted morphinans and methods of their use
US7142420B2 (en) 2004-09-20 2006-11-28 Qualcomm, Incorporated Devices and methods for controlling relative movement between layers of an electronic device
WO2006126529A1 (ja) 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
MX338392B (es) 2010-11-12 2016-04-13 Shionogi & Co Cristal de derivado de 6,7-insaturado-7-carbamoil morfinano y metodo para producir el mismo.

Also Published As

Publication number Publication date
BRPI0610343B8 (pt) 2021-05-25
ES2525215T3 (es) 2014-12-19
EP1889848B8 (en) 2014-12-17
US8536192B2 (en) 2013-09-17
CN101228172A (zh) 2008-07-23
NL300996I2 (nl) 2019-07-30
NL300996I1 (nl) 2019-07-03
WO2006126529A1 (ja) 2006-11-30
US8084460B2 (en) 2011-12-27
JP4323547B2 (ja) 2009-09-02
AU2006250390A1 (en) 2006-11-30
CA2609733A1 (en) 2006-11-30
US20120135978A1 (en) 2012-05-31
USRE46375E1 (en) 2017-04-25
KR100912782B1 (ko) 2009-08-18
USRE46365E1 (en) 2017-04-11
CN101228172B (zh) 2013-04-03
FR19C1042I1 (hu) 2019-08-09
US20090203723A1 (en) 2009-08-13
TW200726470A (en) 2007-07-16
CA2609733C (en) 2011-07-19
WO2006126637A1 (ja) 2006-11-30
MX2007014588A (es) 2008-01-24
EP1889848A4 (en) 2011-08-10
FR19C1042I2 (fr) 2020-06-19
TWI311056B (en) 2009-06-21
BRPI0610343A2 (pt) 2010-06-15
DK1889848T3 (en) 2014-12-01
EP1889848A1 (en) 2008-02-20
RU2007148412A (ru) 2009-06-27
KR20080014791A (ko) 2008-02-14
RU2403255C2 (ru) 2010-11-10
AU2006250390B2 (en) 2010-07-08
PT1889848E (pt) 2014-12-09
PL1889848T3 (pl) 2015-04-30
JPWO2006126637A1 (ja) 2008-12-25
EP1889848B1 (en) 2014-10-15
BRPI0610343B1 (pt) 2020-03-10

Similar Documents

Publication Publication Date Title
HUS1900034I1 (hu) 6,7-telítetlen-7-karbamoil-szubsztituált morfinán-származékok
ZA200606974B (en) Substituted 1,2,3,4-tetrahydrolsoquinoline derivatives
TWI369351B (en) 2,4-diamino-pyrimidines as aurora inhibitors
HK1129305A1 (zh) 取代的 -氨基-吡咯並三嗪衍生物
EP1942105A4 (en) AMINODIHYDROTHIAZINE DERIVATIVE
IL180331A0 (en) 3-carbamoyl - 2 - pyridone derivative
EP1878727A4 (en) 2-AMINOQUINAZOLINE DERIVATIVES
IL201973A0 (en) 3,3-spiroindolinone derivatives
EP1955697A4 (en) 2-AMINOBENZAMIDE DERIVATIVE
PL1954674T3 (pl) Nowe pochodne N-fenetylokarboksyamidu
ZA201001797B (en) 1,1,1-trifluoro-2-hydroxy-3-phenylpropane derivatives
EP1944301A4 (en) NEW BENZOXATHIIN DERIVATIVES
EP1820797A4 (en) SUBSTITUTED PYRIDONE DERIVATIVE
IL183140A0 (en) Substituted benzoquinolizine derivatives
IL184841A0 (en) Substituted aminoalkyl-and amidoalkyl-benzopyran derivatives
EP1830858A4 (en) 3,6-BICYCLOLIDE
EP1971588A4 (en) TIGLIEN-3-one derivatives
HK1115123A1 (en) Pyridylmethylsulfone derivative
TWI315670B (en) Substituted aryl 1,4-pyrazine derivatives
EP2202231A4 (en) 2,3-DIHYDROIMINOISOINDOLE DERIVATIVE
GB0507114D0 (en) No 1 timemachine
IL182538A0 (en) 1,5-diheterocycle-1h-triazole derivative
IL184677A0 (en) Substituted 1,1,1-trifluoro-3-[(benzyl)-
ZA200711025B (en) N-dihydroxyalkyl-substituted 2-oxoimidazole derivative
GB0511410D0 (en) Benzotrizepinone derivatives