ZA200700865B - Solid forms of the magnesium salt of (S)-omeprazole and processes for their preparation - Google Patents
Solid forms of the magnesium salt of (S)-omeprazole and processes for their preparationInfo
- Publication number
- ZA200700865B ZA200700865B ZA200700865A ZA200700865A ZA200700865B ZA 200700865 B ZA200700865 B ZA 200700865B ZA 200700865 A ZA200700865 A ZA 200700865A ZA 200700865 A ZA200700865 A ZA 200700865A ZA 200700865 B ZA200700865 B ZA 200700865B
- Authority
- ZA
- South Africa
- Prior art keywords
- omeprazole
- magnesium salt
- solid forms
- preparation
- solvent
- Prior art date
Links
- 159000000003 magnesium salts Chemical class 0.000 title abstract 7
- 238000002360 preparation method Methods 0.000 title abstract 3
- 239000007787 solid Substances 0.000 title abstract 3
- SUBDBMMJDZJVOS-DEOSSOPVSA-N esomeprazole Chemical compound C([S@](=O)C1=NC2=CC=C(C=C2N1)OC)C1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-DEOSSOPVSA-N 0.000 title 1
- 229960004770 esomeprazole Drugs 0.000 title 1
- 229960000381 omeprazole Drugs 0.000 abstract 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- 239000004480 active ingredient Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 238000012776 robust process Methods 0.000 abstract 1
- 238000007614 solvation Methods 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200401729A ES2246149B1 (es) | 2004-07-02 | 2004-07-02 | Formas solidas de la sal magnesica de s-omeprazol y procedimientos para su preparacion. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200700865B true ZA200700865B (en) | 2009-09-30 |
Family
ID=34972307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200700865A ZA200700865B (en) | 2004-07-02 | 2005-06-29 | Solid forms of the magnesium salt of (S)-omeprazole and processes for their preparation |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7902370B2 (zh) |
| EP (1) | EP1765807B1 (zh) |
| JP (2) | JP5575366B2 (zh) |
| KR (1) | KR101290035B1 (zh) |
| CN (1) | CN1976923B (zh) |
| AT (1) | ATE425975T1 (zh) |
| AU (1) | AU2005259205B2 (zh) |
| CA (1) | CA2570559C (zh) |
| CY (1) | CY1109048T1 (zh) |
| DE (1) | DE602005013382D1 (zh) |
| DK (1) | DK1765807T3 (zh) |
| ES (2) | ES2246149B1 (zh) |
| HR (1) | HRP20090211T1 (zh) |
| MX (1) | MXPA06014736A (zh) |
| NO (1) | NO20070635L (zh) |
| NZ (1) | NZ552458A (zh) |
| PT (1) | PT1765807E (zh) |
| WO (1) | WO2006003163A1 (zh) |
| ZA (1) | ZA200700865B (zh) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2246149B1 (es) * | 2004-07-02 | 2007-06-01 | Esteve Quimica, S.A. | Formas solidas de la sal magnesica de s-omeprazol y procedimientos para su preparacion. |
| FR2920428B1 (fr) * | 2007-08-29 | 2012-06-15 | Univ Rouen | Procede de dedoublement de sels de l'omeprazole |
| EP2147918A1 (en) | 2008-07-21 | 2010-01-27 | LEK Pharmaceuticals D.D. | Process for the preparation of S-omeprazole magnesium in a stable form |
| CN103044400A (zh) * | 2012-12-21 | 2013-04-17 | 北京华禧联合科技发展有限公司 | 埃索美拉唑镁盐及其制备方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9302396D0 (sv) | 1993-07-09 | 1993-07-09 | Ab Astra | A novel compound form |
| MX9600857A (es) * | 1994-07-08 | 1997-06-28 | Astra Ab | Forma de dosificacion i en tabletas, con unidades multiples. |
| SE508669C2 (sv) * | 1996-04-26 | 1998-10-26 | Astra Ab | Nytt förfarande |
| SE510666C2 (sv) * | 1996-12-20 | 1999-06-14 | Astra Ab | Nya Kristallmodifikationer |
| SE510650C2 (sv) * | 1997-05-30 | 1999-06-14 | Astra Ab | Ny förening |
| US6326384B1 (en) * | 1999-08-26 | 2001-12-04 | Robert R. Whittle | Dry blend pharmaceutical unit dosage form |
| US6312712B1 (en) * | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Method of improving bioavailability |
| KR100712039B1 (ko) * | 1999-08-26 | 2007-04-27 | 에이에이아이파머 인코포레이티드 | 알콕시로 치환된 벤즈이미다졸 화합물, 상기 화합물을포함하는 약학적 제제, 및 상기 화합물의 이용방법 |
| CA2409258A1 (en) | 2000-05-15 | 2001-11-22 | Ranbaxy Laboratories Limited | Novel amorphous form of omeprazole salts |
| CA2386716C (en) * | 2002-05-17 | 2012-07-24 | Bernard Charles Sherman | Magnesium salt of s-omeprazole |
| US7271182B2 (en) * | 2000-08-04 | 2007-09-18 | Takeda Pharmaceutical Company Limited | Salts of benzimidazole compound and use thereof |
| SI20875A (sl) * | 2001-04-25 | 2002-10-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Kristalna oblika omeprazola |
| WO2003089408A2 (en) * | 2002-04-22 | 2003-10-30 | Sun Pharmaceutical Industries Limited | Optically active substituted pyridinylmethyl-sulphinyl-benzimidazole and salts |
| US6894066B2 (en) * | 2002-05-09 | 2005-05-17 | Bernard Charles Sherman | Magnesium salt of S-omeprazole |
| US7612098B2 (en) * | 2002-08-30 | 2009-11-03 | Dr. Reddy's Laboratories Limited | Amorphous hydrous esomeprazole magnesium |
| EA200500673A1 (ru) * | 2002-10-22 | 2005-12-29 | Рэнбакси Лабораториз Лимитед | Аморфная форма соли эзомепразола, способ ее получения и фармацевтическая композиция на её основе |
| WO2004046134A2 (en) * | 2002-11-18 | 2004-06-03 | Dr. Reddy's Laboratories Limited | Crystalline form ii of esomeprazole magnesium trihydrate and process for its preparation |
| WO2004089935A1 (en) * | 2003-04-10 | 2004-10-21 | Hetero Drugs Limitd | Novel crystalline forms of s-omeprazole magnesium |
| ES2246149B1 (es) * | 2004-07-02 | 2007-06-01 | Esteve Quimica, S.A. | Formas solidas de la sal magnesica de s-omeprazol y procedimientos para su preparacion. |
-
2004
- 2004-07-02 ES ES200401729A patent/ES2246149B1/es not_active Expired - Fee Related
-
2005
- 2005-06-29 JP JP2007519776A patent/JP5575366B2/ja not_active Expired - Fee Related
- 2005-06-29 NZ NZ552458A patent/NZ552458A/en not_active IP Right Cessation
- 2005-06-29 CN CN2005800215619A patent/CN1976923B/zh not_active Expired - Fee Related
- 2005-06-29 AU AU2005259205A patent/AU2005259205B2/en not_active Ceased
- 2005-06-29 ZA ZA200700865A patent/ZA200700865B/xx unknown
- 2005-06-29 US US11/571,564 patent/US7902370B2/en not_active Expired - Fee Related
- 2005-06-29 ES ES05760736T patent/ES2323319T3/es active Active
- 2005-06-29 AT AT05760736T patent/ATE425975T1/de active
- 2005-06-29 PT PT05760736T patent/PT1765807E/pt unknown
- 2005-06-29 KR KR1020077000063A patent/KR101290035B1/ko not_active IP Right Cessation
- 2005-06-29 CA CA2570559A patent/CA2570559C/en not_active Expired - Fee Related
- 2005-06-29 MX MXPA06014736A patent/MXPA06014736A/es active IP Right Grant
- 2005-06-29 EP EP05760736A patent/EP1765807B1/en active Active
- 2005-06-29 DE DE602005013382T patent/DE602005013382D1/de active Active
- 2005-06-29 WO PCT/EP2005/053062 patent/WO2006003163A1/en active Application Filing
- 2005-06-29 DK DK05760736T patent/DK1765807T3/da active
-
2007
- 2007-02-02 NO NO20070635A patent/NO20070635L/no not_active Application Discontinuation
-
2009
- 2009-04-08 HR HR20090211T patent/HRP20090211T1/xx unknown
- 2009-04-29 CY CY20091100473T patent/CY1109048T1/el unknown
-
2014
- 2014-04-22 JP JP2014088458A patent/JP2014169302A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NZ552458A (en) | 2010-07-30 |
| ES2323319T3 (es) | 2009-07-13 |
| CN1976923A (zh) | 2007-06-06 |
| CN1976923B (zh) | 2011-08-24 |
| DK1765807T3 (da) | 2009-06-08 |
| KR20070031992A (ko) | 2007-03-20 |
| US20070249684A1 (en) | 2007-10-25 |
| AU2005259205A1 (en) | 2006-01-12 |
| ATE425975T1 (de) | 2009-04-15 |
| WO2006003163A1 (en) | 2006-01-12 |
| PT1765807E (pt) | 2009-04-13 |
| JP2014169302A (ja) | 2014-09-18 |
| US7902370B2 (en) | 2011-03-08 |
| ES2246149A1 (es) | 2006-02-01 |
| NO20070635L (no) | 2007-03-20 |
| JP5575366B2 (ja) | 2014-08-20 |
| JP2008505160A (ja) | 2008-02-21 |
| KR101290035B1 (ko) | 2013-07-30 |
| CY1109048T1 (zh) | 2014-07-02 |
| AU2005259205B2 (en) | 2011-01-27 |
| EP1765807A1 (en) | 2007-03-28 |
| CA2570559C (en) | 2012-08-28 |
| EP1765807B1 (en) | 2009-03-18 |
| CA2570559A1 (en) | 2006-01-12 |
| DE602005013382D1 (de) | 2009-04-30 |
| HRP20090211T1 (en) | 2009-05-31 |
| ES2246149B1 (es) | 2007-06-01 |
| MXPA06014736A (es) | 2007-06-25 |
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