NO20070635L - Faste former av magnesiumsalt av S-omeprazol og fremgangsmater for deres fremstilling - Google Patents

Faste former av magnesiumsalt av S-omeprazol og fremgangsmater for deres fremstilling

Info

Publication number
NO20070635L
NO20070635L NO20070635A NO20070635A NO20070635L NO 20070635 L NO20070635 L NO 20070635L NO 20070635 A NO20070635 A NO 20070635A NO 20070635 A NO20070635 A NO 20070635A NO 20070635 L NO20070635 L NO 20070635L
Authority
NO
Norway
Prior art keywords
omeprazole
magnesium salt
solid forms
solvent
processes
Prior art date
Application number
NO20070635A
Other languages
English (en)
Inventor
Ramon Berenguer Maimo
Laura Coppi
Yolanda Gasanz Guillen
Jorge Medrano Ruperez
Original Assignee
Esteve Quimica Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Quimica Sa filed Critical Esteve Quimica Sa
Publication of NO20070635L publication Critical patent/NO20070635L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Det beskrives nye faste former av aktivt magnesiumsalt av S-omeprazol som kan oppnås ved en fremstillingsprosess som omfatter: a) krystallisering av et magnesiumsalt av S-omeprazol fra en oppløsning av et magnesiumsalt av S-omeprzol i et oppløsningsmiddelsystem som omfatter en blanding av metanol/vann med en mengde vann lik større enn 0,01 ml/g av magnesiumsaltet av S-omeprazol utgangsmateriale; b) isolering av magnesiumsaltet av S-omeprazol fra det foregående trinn; c) separering av det frie, organiske oppløsningsmiddel fra magnesiumsaltet av S-omeprazol oppnådd som ovenfor, eller altemativt, å separere fritt oppløsningsmiddel og desolvatiserende oppløsningsmiddel. De nye faste former oppnås ved en reproduserbar og robust prosess med høye utbytter og høy optisk renhet, og er nyttige for fremstilling av farmasøytiske produkter som inneholder nevnte aktive bestanddeler.
NO20070635A 2004-07-02 2007-02-02 Faste former av magnesiumsalt av S-omeprazol og fremgangsmater for deres fremstilling NO20070635L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200401729A ES2246149B1 (es) 2004-07-02 2004-07-02 Formas solidas de la sal magnesica de s-omeprazol y procedimientos para su preparacion.
PCT/EP2005/053062 WO2006003163A1 (en) 2004-07-02 2005-06-29 Solid forms of the magnesium salt of (s)-omeprazole and processes for their preparation

Publications (1)

Publication Number Publication Date
NO20070635L true NO20070635L (no) 2007-03-20

Family

ID=34972307

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20070635A NO20070635L (no) 2004-07-02 2007-02-02 Faste former av magnesiumsalt av S-omeprazol og fremgangsmater for deres fremstilling

Country Status (19)

Country Link
US (1) US7902370B2 (no)
EP (1) EP1765807B1 (no)
JP (2) JP5575366B2 (no)
KR (1) KR101290035B1 (no)
CN (1) CN1976923B (no)
AT (1) ATE425975T1 (no)
AU (1) AU2005259205B2 (no)
CA (1) CA2570559C (no)
CY (1) CY1109048T1 (no)
DE (1) DE602005013382D1 (no)
DK (1) DK1765807T3 (no)
ES (2) ES2246149B1 (no)
HR (1) HRP20090211T1 (no)
MX (1) MXPA06014736A (no)
NO (1) NO20070635L (no)
NZ (1) NZ552458A (no)
PT (1) PT1765807E (no)
WO (1) WO2006003163A1 (no)
ZA (1) ZA200700865B (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2246149B1 (es) * 2004-07-02 2007-06-01 Esteve Quimica, S.A. Formas solidas de la sal magnesica de s-omeprazol y procedimientos para su preparacion.
FR2920428B1 (fr) * 2007-08-29 2012-06-15 Univ Rouen Procede de dedoublement de sels de l'omeprazole
EP2147918A1 (en) * 2008-07-21 2010-01-27 LEK Pharmaceuticals D.D. Process for the preparation of S-omeprazole magnesium in a stable form
CN103044400A (zh) * 2012-12-21 2013-04-17 北京华禧联合科技发展有限公司 埃索美拉唑镁盐及其制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9302396D0 (sv) * 1993-07-09 1993-07-09 Ab Astra A novel compound form
CA2170647C (en) * 1994-07-08 2001-03-13 Pontus John Arvid Bergstrand Multiple unit tableted dosage form i
SE508669C2 (sv) 1996-04-26 1998-10-26 Astra Ab Nytt förfarande
SE510666C2 (sv) * 1996-12-20 1999-06-14 Astra Ab Nya Kristallmodifikationer
SE510650C2 (sv) * 1997-05-30 1999-06-14 Astra Ab Ny förening
US6326384B1 (en) * 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6312712B1 (en) * 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
CN1636564A (zh) * 1999-08-26 2005-07-13 艾伊法马公司 含烷氧基取代苯并咪唑化合物的组合物和药物制剂及其制法
US20030212274A1 (en) * 2000-05-15 2003-11-13 Bakthavathsalan Vijayaraghavan Novel amorphous form of omeprazole salts
CA2386716C (en) * 2002-05-17 2012-07-24 Bernard Charles Sherman Magnesium salt of s-omeprazole
EP1306375B1 (en) * 2000-08-04 2006-10-11 Takeda Pharmaceutical Company Limited Salts of benzimidazole compound and application thereof
SI20875A (sl) * 2001-04-25 2002-10-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristalna oblika omeprazola
WO2003089408A2 (en) 2002-04-22 2003-10-30 Sun Pharmaceutical Industries Limited Optically active substituted pyridinylmethyl-sulphinyl-benzimidazole and salts
US6894066B2 (en) * 2002-05-09 2005-05-17 Bernard Charles Sherman Magnesium salt of S-omeprazole
CA2501424A1 (en) * 2002-08-30 2004-03-11 Dr. Reddy's Laboratories Limited Amorphous hydrates of esomeprazole magnesium and process for the preparation thereof
EP1556043A1 (en) 2002-10-22 2005-07-27 Ranbaxy Laboratories, Ltd. Amorphous form of esomeprazole salts
WO2004046134A2 (en) * 2002-11-18 2004-06-03 Dr. Reddy's Laboratories Limited Crystalline form ii of esomeprazole magnesium trihydrate and process for its preparation
WO2004089935A1 (en) * 2003-04-10 2004-10-21 Hetero Drugs Limitd Novel crystalline forms of s-omeprazole magnesium
ES2246149B1 (es) * 2004-07-02 2007-06-01 Esteve Quimica, S.A. Formas solidas de la sal magnesica de s-omeprazol y procedimientos para su preparacion.

Also Published As

Publication number Publication date
DE602005013382D1 (de) 2009-04-30
CA2570559A1 (en) 2006-01-12
ES2246149B1 (es) 2007-06-01
US20070249684A1 (en) 2007-10-25
HRP20090211T1 (en) 2009-05-31
EP1765807B1 (en) 2009-03-18
AU2005259205B2 (en) 2011-01-27
KR101290035B1 (ko) 2013-07-30
AU2005259205A1 (en) 2006-01-12
KR20070031992A (ko) 2007-03-20
CY1109048T1 (no) 2014-07-02
CA2570559C (en) 2012-08-28
ZA200700865B (en) 2009-09-30
JP2008505160A (ja) 2008-02-21
US7902370B2 (en) 2011-03-08
CN1976923A (zh) 2007-06-06
JP2014169302A (ja) 2014-09-18
MXPA06014736A (es) 2007-06-25
PT1765807E (pt) 2009-04-13
CN1976923B (zh) 2011-08-24
DK1765807T3 (da) 2009-06-08
ES2246149A1 (es) 2006-02-01
NZ552458A (en) 2010-07-30
EP1765807A1 (en) 2007-03-28
JP5575366B2 (ja) 2014-08-20
ES2323319T3 (es) 2009-07-13
ATE425975T1 (de) 2009-04-15
WO2006003163A1 (en) 2006-01-12

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