ZA200609677B - Chiral heptyne derivatives for the preparation of epothilones and processes for their preparation - Google Patents
Chiral heptyne derivatives for the preparation of epothilones and processes for their preparation Download PDFInfo
- Publication number
- ZA200609677B ZA200609677B ZA200609677A ZA200609677A ZA200609677B ZA 200609677 B ZA200609677 B ZA 200609677B ZA 200609677 A ZA200609677 A ZA 200609677A ZA 200609677 A ZA200609677 A ZA 200609677A ZA 200609677 B ZA200609677 B ZA 200609677B
- Authority
- ZA
- South Africa
- Prior art keywords
- compound
- formula
- alkyl
- group
- chem
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 31
- 229930013356 epothilone Natural products 0.000 title claims abstract description 20
- HESCAJZNRMSMJG-KKQRBIROSA-N epothilone A Chemical class C/C([C@@H]1C[C@@H]2O[C@@H]2CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 HESCAJZNRMSMJG-KKQRBIROSA-N 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title description 7
- YVXHZKKCZYLQOP-UHFFFAOYSA-N hept-1-yne Chemical class CCCCCC#C YVXHZKKCZYLQOP-UHFFFAOYSA-N 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 71
- 238000003786 synthesis reaction Methods 0.000 claims abstract description 24
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 20
- 150000003883 epothilone derivatives Chemical class 0.000 claims abstract description 18
- 238000004519 manufacturing process Methods 0.000 claims abstract description 18
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 16
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 9
- 239000001257 hydrogen Substances 0.000 claims description 9
- 150000002431 hydrogen Chemical group 0.000 claims description 8
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 8
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 6
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 239000007800 oxidant agent Substances 0.000 claims description 4
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 4
- 150000002367 halogens Chemical group 0.000 claims description 3
- BTJIUGUIPKRLHP-UHFFFAOYSA-N 4-nitrophenol Chemical compound OC1=CC=C([N+]([O-])=O)C=C1 BTJIUGUIPKRLHP-UHFFFAOYSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 150000008064 anhydrides Chemical class 0.000 claims description 2
- 239000003638 chemical reducing agent Substances 0.000 claims 5
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 239000000543 intermediate Substances 0.000 abstract description 9
- -1 n-octyl Chemical group 0.000 description 15
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 12
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 11
- 238000006243 chemical reaction Methods 0.000 description 9
- 125000006239 protecting group Chemical group 0.000 description 6
- 239000000047 product Substances 0.000 description 5
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 5
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 4
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 4
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 description 4
- MZRVEZGGRBJDDB-UHFFFAOYSA-N n-Butyllithium Substances [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 239000007858 starting material Substances 0.000 description 4
- 238000005160 1H NMR spectroscopy Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 239000012752 auxiliary agent Substances 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 229930012538 Paclitaxel Natural products 0.000 description 2
- 150000001336 alkenes Chemical class 0.000 description 2
- XXROGKLTLUQVRX-UHFFFAOYSA-N allyl alcohol Chemical compound OCC=C XXROGKLTLUQVRX-UHFFFAOYSA-N 0.000 description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
- 244000309464 bull Species 0.000 description 2
- HESCAJZNRMSMJG-HGYUPSKWSA-N epothilone A Natural products O=C1[C@H](C)[C@H](O)[C@H](C)CCC[C@H]2O[C@H]2C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C HESCAJZNRMSMJG-HGYUPSKWSA-N 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 238000005984 hydrogenation reaction Methods 0.000 description 2
- 239000012074 organic phase Substances 0.000 description 2
- 229960001592 paclitaxel Drugs 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- YRIZYWQGELRKNT-UHFFFAOYSA-N 1,3,5-trichloro-1,3,5-triazinane-2,4,6-trione Chemical compound ClN1C(=O)N(Cl)C(=O)N(Cl)C1=O YRIZYWQGELRKNT-UHFFFAOYSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- 125000003229 2-methylhexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000004217 4-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])* 0.000 description 1
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 1
- QXRSDHAAWVKZLJ-OXZHEXMSSA-N Epothilone B Natural products O=C1[C@H](C)[C@H](O)[C@@H](C)CCC[C@@]2(C)O[C@H]2C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C QXRSDHAAWVKZLJ-OXZHEXMSSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241001532577 Sorangium Species 0.000 description 1
- 238000006859 Swern oxidation reaction Methods 0.000 description 1
- 229940123237 Taxane Drugs 0.000 description 1
- 238000007239 Wittig reaction Methods 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 238000005575 aldol reaction Methods 0.000 description 1
- 150000001345 alkine derivatives Chemical class 0.000 description 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 239000000010 aprotic solvent Substances 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 125000001589 carboacyl group Chemical group 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000011210 chromatographic step Methods 0.000 description 1
- 229960002303 citric acid monohydrate Drugs 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229930004069 diterpene Natural products 0.000 description 1
- 125000000567 diterpene group Chemical group 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- QXRSDHAAWVKZLJ-PVYNADRNSA-N epothilone B Chemical compound C/C([C@@H]1C[C@@H]2O[C@]2(C)CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 QXRSDHAAWVKZLJ-PVYNADRNSA-N 0.000 description 1
- 150000002168 ethanoic acid esters Chemical class 0.000 description 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- DLEDOFVPSDKWEF-UHFFFAOYSA-N lithium butane Chemical compound [Li+].CCC[CH2-] DLEDOFVPSDKWEF-UHFFFAOYSA-N 0.000 description 1
- 239000003120 macrolide antibiotic agent Substances 0.000 description 1
- NXPHGHWWQRMDIA-UHFFFAOYSA-M magnesium;carbanide;bromide Chemical compound [CH3-].[Mg+2].[Br-] NXPHGHWWQRMDIA-UHFFFAOYSA-M 0.000 description 1
- CCERQOYLJJULMD-UHFFFAOYSA-M magnesium;carbanide;chloride Chemical compound [CH3-].[Mg+2].[Cl-] CCERQOYLJJULMD-UHFFFAOYSA-M 0.000 description 1
- GDOPTJXRTPNYNR-UHFFFAOYSA-N methyl-cyclopentane Natural products CC1CCCC1 GDOPTJXRTPNYNR-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000003136 n-heptyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 150000003333 secondary alcohols Chemical class 0.000 description 1
- 229950009390 symclosene Drugs 0.000 description 1
- 238000006257 total synthesis reaction Methods 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04090157A EP1589011A1 (en) | 2004-04-22 | 2004-04-22 | Novel chiral heptyne derivates for the preparation of epothilones and processes for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200609677B true ZA200609677B (en) | 2008-01-30 |
Family
ID=34928801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200609677A ZA200609677B (en) | 2004-04-22 | 2006-11-21 | Chiral heptyne derivatives for the preparation of epothilones and processes for their preparation |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7326798B2 (es) |
| EP (2) | EP1589011A1 (es) |
| JP (1) | JP2007533700A (es) |
| CN (1) | CN1942462B (es) |
| AT (1) | ATE374758T1 (es) |
| AU (1) | AU2005235376A1 (es) |
| BR (1) | BRPI0510109A (es) |
| CA (1) | CA2560455A1 (es) |
| DE (1) | DE602005002750T2 (es) |
| DK (1) | DK1758875T3 (es) |
| ES (1) | ES2293574T3 (es) |
| MX (1) | MXPA06012212A (es) |
| PL (1) | PL1758875T3 (es) |
| PT (1) | PT1758875E (es) |
| RU (1) | RU2006140967A (es) |
| SI (1) | SI1758875T1 (es) |
| WO (1) | WO2005101950A1 (es) |
| ZA (1) | ZA200609677B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007114199A1 (ja) | 2006-03-28 | 2007-10-11 | Sumitomo Chemical Company, Limited | 光学活性（ｓ）－７－ヒドロキシ－６－メチルヘプタン－２－オンおよびその前駆体の製造方法 |
| EP2893884A1 (en) | 2014-01-08 | 2015-07-15 | Cook Medical Technologies LLC | ECM strip to plug percutaneous heart valve leaks |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6320045B1 (en) * | 1997-12-04 | 2001-11-20 | Bristol-Myers Squibb Company | Process for the reduction of oxiranyl epothilones to olefinic epothilones |
| GB9810659D0 (en) | 1998-05-18 | 1998-07-15 | Ciba Geigy Ag | Organic compounds |
| EA200100833A1 (ru) * | 1999-02-11 | 2002-02-28 | Шеринг Акциенгезельшафт | Производные эпотилона, способ их получения и их применение в фармацевтике |
| US6593115B2 (en) | 2000-03-24 | 2003-07-15 | Bristol-Myers Squibb Co. | Preparation of epothilone intermediates |
-
2004
- 2004-04-22 EP EP04090157A patent/EP1589011A1/en not_active Withdrawn
-
2005
- 2005-04-21 DE DE602005002750T patent/DE602005002750T2/de active Active
- 2005-04-21 JP JP2007508870A patent/JP2007533700A/ja active Pending
- 2005-04-21 US US11/110,959 patent/US7326798B2/en not_active Expired - Fee Related
- 2005-04-21 WO PCT/EP2005/004492 patent/WO2005101950A1/en active Application Filing
- 2005-04-21 MX MXPA06012212A patent/MXPA06012212A/es not_active Application Discontinuation
- 2005-04-21 PL PL05740374T patent/PL1758875T3/pl unknown
- 2005-04-21 AT AT05740374T patent/ATE374758T1/de not_active IP Right Cessation
- 2005-04-21 EP EP05740374A patent/EP1758875B1/en active Active
- 2005-04-21 PT PT05740374T patent/PT1758875E/pt unknown
- 2005-04-21 DK DK05740374T patent/DK1758875T3/da active
- 2005-04-21 CN CN2005800116115A patent/CN1942462B/zh not_active Expired - Fee Related
- 2005-04-21 ES ES05740374T patent/ES2293574T3/es active Active
- 2005-04-21 CA CA002560455A patent/CA2560455A1/en not_active Abandoned
- 2005-04-21 BR BRPI0510109-3A patent/BRPI0510109A/pt not_active IP Right Cessation
- 2005-04-21 AU AU2005235376A patent/AU2005235376A1/en not_active Abandoned
- 2005-04-21 RU RU2006140967/04A patent/RU2006140967A/ru not_active Application Discontinuation
- 2005-04-21 SI SI200530107T patent/SI1758875T1/sl unknown
-
2006
- 2006-11-21 ZA ZA200609677A patent/ZA200609677B/en unknown
-
2007
- 2007-12-12 US US11/954,348 patent/US20080108838A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1942462A (zh) | 2007-04-04 |
| PL1758875T3 (pl) | 2008-02-29 |
| BRPI0510109A (pt) | 2007-10-30 |
| DE602005002750D1 (de) | 2007-11-15 |
| CA2560455A1 (en) | 2005-11-03 |
| SI1758875T1 (sl) | 2008-02-29 |
| EP1758875B1 (en) | 2007-10-03 |
| US20060100442A1 (en) | 2006-05-11 |
| US7326798B2 (en) | 2008-02-05 |
| US20080108838A1 (en) | 2008-05-08 |
| CN1942462B (zh) | 2011-05-25 |
| JP2007533700A (ja) | 2007-11-22 |
| RU2006140967A (ru) | 2008-05-27 |
| PT1758875E (pt) | 2007-12-14 |
| WO2005101950A1 (en) | 2005-11-03 |
| MXPA06012212A (es) | 2007-04-17 |
| AU2005235376A1 (en) | 2005-11-03 |
| DK1758875T3 (da) | 2008-01-21 |
| EP1758875A1 (en) | 2007-03-07 |
| DE602005002750T2 (de) | 2008-07-17 |
| ES2293574T3 (es) | 2008-03-16 |
| EP1589011A1 (en) | 2005-10-26 |
| ATE374758T1 (de) | 2007-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR20010040760A (ko) | 심바스타틴의 제조 방법 | |
| KR20060130765A (ko) | 스타틴, 특히 로수바스타틴의 제조방법 및 상기 제조에유용한 중간체 화합물 | |
| US6946556B1 (en) | Preparation of opioid analgesics by a one-pot process | |
| ZA200609677B (en) | Chiral heptyne derivatives for the preparation of epothilones and processes for their preparation | |
| CN110937985B (zh) | 一种姜酮酚的合成方法 | |
| KR100980379B1 (ko) | 광학활성을 갖는 5-히드록시-3-옥소헵타노에이트 유도체의제조방법 | |
| Kido et al. | Carbocyclic construction by the [2, 3] sigmatropic rearrangement of cyclic sulfonium ylides. A new entry for the stereoselective synthesis of substituted cyclohexanones | |
| Schneider et al. | General and Asymmetric Synthesis of Protected 1, 3, 5‐Triols with Pendant Functional Groups | |
| US5214197A (en) | 2,4-dihydroxyadipic acid derivative | |
| US8067583B2 (en) | Method for synthesizing furanosteroids | |
| Martín et al. | High‐Yielding Enantioselective Synthesis of the Macrolactam Aglycon of Sch 38516 from Two Units of (2R)‐2‐Ethyl‐4‐penten‐1‐ol | |
| US7745649B2 (en) | Processes for preparing tetrahydropyran-4-one and pyran-4-one | |
| KR20070027536A (ko) | 에포틸론의 제조를 위한 키랄 헵틴 유도체 및 그의 제조방법 | |
| JPH04234379A (ja) | ５−置換δ−ラクトンの立体選択的製法およびその使用 | |
| JP3565587B2 (ja) | １５−ヒドロキシミルベマイシン誘導体の新規合成法 | |
| US8754243B2 (en) | Process for the preparation of 1, 2, 4-trioxolane antimalarials | |
| JP2788333B2 (ja) | シクロペンタノール類の製造法 | |
| CN114524753A (zh) | 一种多取代异羟肟酸衍生物的合成方法 | |
| CN110015996A (zh) | 一种合成2′-螺环基取代三元碳环核苷的方法 | |
| JPH0948773A (ja) | プロスタグランジンの中間体及びその製造方法 | |
| JPH0687781A (ja) | アセタール類の製造方法 | |
| EP1174409A1 (en) | Novel bicycloheptene derivatives and process for the preparation thereof | |
| JPH04270259A (ja) | ビシクロ［８．３．０］トリデカ−９，１３−ジエン−２，７−ジイン誘導体 | |
| JPH062709B2 (ja) | イソカルバサイクリン中間体の製法 | |
| JPH04283530A (ja) | ４−置換−２−メチル−１，２−ブタンジオール誘導体の製造方法 |