ZA200606176B - Novel Hydroxy-6-heteroarylphenanthridines and their as PDE4 inhibitors - Google Patents

Novel Hydroxy-6-heteroarylphenanthridines and their as PDE4 inhibitors

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Publication number
ZA200606176B
ZA200606176B ZA200606176A ZA200606176A ZA200606176B ZA 200606176 B ZA200606176 B ZA 200606176B ZA 200606176 A ZA200606176 A ZA 200606176A ZA 200606176 A ZA200606176 A ZA 200606176A ZA 200606176 B ZA200606176 B ZA 200606176B
Authority
ZA
South Africa
Prior art keywords
heteroarylphenanthridines
pde4 inhibitors
novel hydroxy
hydroxy
novel
Prior art date
Application number
ZA200606176A
Other languages
English (en)
Inventor
Beate Schmidt
Dieter Flockerzl
Armin Hatzelmann
Christof
Johannes Barsig
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of ZA200606176B publication Critical patent/ZA200606176B/xx

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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/473Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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ZA200606176A 2004-03-03 2006-07-26 Novel Hydroxy-6-heteroarylphenanthridines and their as PDE4 inhibitors ZA200606176B (en)

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EP04004973 2004-03-03
EP04106359 2004-12-07

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Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004019945A1 (en) 2002-08-29 2004-03-11 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
WO2005077906A1 (en) 2004-02-18 2005-08-25 Altana Pharma Ag Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors
PL2589599T4 (pl) 2004-03-03 2015-06-30 Takeda Gmbh Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4
AU2006210231A1 (en) 2005-02-01 2006-08-10 Nycomed Gmbh Novel 6-pyridylphenanthridines
AU2006219862A1 (en) * 2005-03-02 2006-09-08 Nycomed Gmbh 6-Heteroaryl-1,2,3,4,4a, 10b-hexahydro-phenanthridines as PDE-4 inhibitors for the treatment of inflammatory disorders
US7718668B2 (en) * 2005-03-02 2010-05-18 Nycomed Gmbh Salts of 6-heterocycle substituted hexahydrophenanthridine derivatives
MX2009002282A (es) * 2006-09-07 2009-03-20 Nycomed Gmbh Tratamiento de combinacion para diabetes mellitius.
US8013003B2 (en) 2007-05-17 2011-09-06 Cortex Pharmaceuticals, Inc. Di-substituted amides for enhancing glutamatergic synaptic responses
WO2009025823A1 (en) * 2007-08-21 2009-02-26 Amgen Inc. Phosphodiesterase 10 inhibitors
WO2009109525A1 (en) * 2008-03-03 2009-09-11 Nycomed Gmbh Use of a specific pde4 inhibitor for the treatment and/or prophylaxis of non-alcoholic fatty liver disease
AR074318A1 (es) 2008-11-14 2011-01-05 Nycomed Gmbh Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias.
JP2017503814A (ja) * 2014-01-22 2017-02-02 タケダ ゲー・エム・ベー・ハーTakeda GmbH 部分的コントロール状態の重症喘息またはコントロール不良状態の重症喘息のpde4インヒビターを用いた(およびロイコトリエン調節薬と組み合わせて用いた)治療
CN103936661B (zh) * 2014-04-04 2016-08-24 常州大学 一种6-烷基菲啶衍生物的合成方法
MA42519A (fr) * 2015-07-29 2018-06-06 Takeda Gmbh Inhibiteur de la pde4 pour le traitement de la néphropathie diabétique
WO2018037109A1 (en) 2016-08-26 2018-03-01 Takeda Gmbh Treatment of nonalcoholic fatty liver disease
CN110573148A (zh) * 2017-03-16 2019-12-13 武田有限公司 特发性肺纤维化的治疗
WO2020113094A1 (en) * 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
US11292782B2 (en) 2018-11-30 2022-04-05 Nuvation Bio Inc. Diarylhydantoin compounds and methods of use thereof
TWI785816B (zh) * 2019-08-30 2022-12-01 國立陽明交通大學 11-芳香基噌啉[2,3-f]菲啶鹽化合物及其製造方法
TWI753296B (zh) * 2019-08-30 2022-01-21 國立陽明交通大學 11-芳香基噌啉[2,3-f]菲啶鹽化合物及其製造方法

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9027055D0 (en) * 1990-12-13 1991-02-06 Sandoz Ltd Organic compounds
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
CZ290266B6 (cs) 1993-07-02 2002-06-12 Byk Gulden Lomberg Chemische Fabrik Gmbh Substituované benzamidy, způsob jejich výroby a farmaceutické prostředky s jejich obsahem
US6191138B1 (en) 1996-01-31 2001-02-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines
US6127378A (en) 1996-03-26 2000-10-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines substituted in the 6 position
JP4141501B2 (ja) * 1996-03-26 2008-08-27 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規の6位置換フェナントリジン
JPH1020274A (ja) * 1996-07-05 1998-01-23 Fujitsu Ltd 液晶表示駆動回路及び液晶表示装置
EA001551B1 (ru) 1996-11-11 2001-04-23 Бык Гюльден Ломберг Хемише Фабрик Гмбх Бензонафтиридины в качестве бронхиальных терапевтических средств
AU6825898A (en) 1997-03-07 1998-09-29 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel tetrazoles
ES2193539T3 (es) 1997-06-03 2003-11-01 Altana Pharma Ag Benzonaftiridinas.
ES2189235T3 (es) 1997-07-25 2003-07-01 Altana Pharma Ag 6-fenilfenantridinas sustituidas.
DE69808099T2 (de) 1997-07-25 2003-05-15 Altana Pharma Ag Substituierte 6-alkylphenanthridine
CA2297923A1 (en) 1997-07-25 1999-02-04 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel tetrazole-substituted 6-phenyl-pheanathridines as pde inhibitors
CA2309175A1 (en) * 1997-11-04 1999-05-14 Pfizer Products Inc. Therapeutically active compounds based on indazole bioisostere replacement of catechol in pde4 inhibitors
DE59904535D1 (de) 1998-05-05 2003-04-17 Altana Pharma Ag Neue Benzonaphtyridin-N-oxide
AU5970199A (en) 1998-08-31 2000-03-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity
ATE295352T1 (de) 1999-01-15 2005-05-15 Altana Pharma Ag Phenanthridine-n-oxide mit pde-iv hemmender wirkung
ES2255483T3 (es) 1999-01-15 2006-07-01 Altana Pharma Ag 6-arilfenantridinas con actividad inhibidora de pde-iv.
PT1147103E (pt) 1999-01-15 2005-08-31 Altana Pharma Ag Fenantridina-n-oxidos com actividade inibitoria de pde-iv
US6534518B1 (en) 1999-01-15 2003-03-18 Altana Pharma Ag Polysubstituted 6-phenylphenanthridines with PDE-IV inhibiting activity
DE60024581T2 (de) 1999-01-15 2006-08-10 Altana Pharma Ag 6-phenylphenanthridine mit pde-iv hemmender wirkung
IL148807A0 (en) * 1999-10-25 2002-09-12 Byk Gulden Lomberg Chem Fab Tetrahydrothiopyran derivatives and pharmaceutical compositions containing the same
ATE394378T1 (de) 2000-01-11 2008-05-15 Nycomed Gmbh Phenanthridin -n- oxide
DE60125026T2 (de) 2000-03-23 2007-06-28 Takeda Pharmaceutical Co. Ltd. Fluorisochinolinderivate, verfahren zu ihrer herstellung und ihre anwendung
AU2001283935B2 (en) * 2000-07-14 2006-07-13 Altana Pharma Ag Novel 6-heteroarylphenanthridines
WO2002006238A1 (en) 2000-07-14 2002-01-24 Altana Pharma Ag Cycloalkyl - or cycloalkylmethyl-substituted 6-phenylphenanthridines
WO2002005616A1 (en) 2000-07-14 2002-01-24 Altana Pharma Ag Novel 6-phenylphenanthridines
US6936622B2 (en) 2001-02-21 2005-08-30 Altana Pharma Ag 6-phenylbenzonaphthyridines
CA2495597A1 (en) 2002-08-17 2004-03-04 Altana Pharma Ag Novel phenanthridines
WO2004018465A2 (en) 2002-08-17 2004-03-04 Altana Pharma Ag Benzonaphthyridines with pde 3/4 inhibiting activity
WO2004019945A1 (en) 2002-08-29 2004-03-11 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
WO2004019944A1 (en) 2002-08-29 2004-03-11 Altana Pharma Ag 2-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
RU2247262C2 (ru) 2003-05-19 2005-02-27 Федеральное государственное унитарное предприятие Российский Федеральный Ядерный Центр-Всероссийский Научно-исследовательский институт технической физики им. акад. Е.И. Забабахина (РФЯЦ- ВНИИТФ) Плунжерный насос сверхвысокого давления
WO2005077906A1 (en) 2004-02-18 2005-08-25 Altana Pharma Ag Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors
PL2589599T4 (pl) 2004-03-03 2015-06-30 Takeda Gmbh Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4
AR049419A1 (es) 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
US20070191414A1 (en) 2004-03-09 2007-08-16 Altana Pharma Ag Novel isoamido-substituted hydroxy-6-phenylphenanthridines
CA2558532A1 (en) 2004-03-10 2005-09-15 Altana Pharma Ag Novel difluoroethoxy-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
EP1725533A1 (en) 2004-03-10 2006-11-29 Altana Pharma AG Novel thio containing hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
US20070185149A1 (en) 2004-03-10 2007-08-09 Altana Pharma Ag Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibtors
US7718668B2 (en) 2005-03-02 2010-05-18 Nycomed Gmbh Salts of 6-heterocycle substituted hexahydrophenanthridine derivatives

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