ZA200603414B - Spirocyclic heterocyclic derivatives and methods of their use - Google Patents
Spirocyclic heterocyclic derivatives and methods of their use Download PDFInfo
- Publication number
- ZA200603414B ZA200603414B ZA200603414A ZA200603414A ZA200603414B ZA 200603414 B ZA200603414 B ZA 200603414B ZA 200603414 A ZA200603414 A ZA 200603414A ZA 200603414 A ZA200603414 A ZA 200603414A ZA 200603414 B ZA200603414 B ZA 200603414B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- aryl
- independently
- taken together
- membered
- Prior art date
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- 238000000034 method Methods 0.000 title description 42
- 125000000217 alkyl group Chemical group 0.000 claims description 381
- 150000001875 compounds Chemical class 0.000 claims description 257
- 125000003118 aryl group Chemical group 0.000 claims description 242
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 139
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 135
- -1 Cisalkoxy Chemical group 0.000 claims description 126
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 111
- 125000004429 atom Chemical group 0.000 claims description 108
- 125000004432 carbon atom Chemical group C* 0.000 claims description 101
- 150000003839 salts Chemical class 0.000 claims description 92
- 125000003342 alkenyl group Chemical group 0.000 claims description 81
- 125000000304 alkynyl group Chemical group 0.000 claims description 78
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 76
- 125000001072 heteroaryl group Chemical group 0.000 claims description 76
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- 125000001153 fluoro group Chemical group F* 0.000 claims description 58
- 125000003545 alkoxy group Chemical group 0.000 claims description 56
- 229910052736 halogen Inorganic materials 0.000 claims description 54
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 47
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 12
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| WO2004035541A1 (en) | 2002-10-15 | 2004-04-29 | Janssen Pharmaceutica, N.V. | Benzyl substituted (piperidin-4-yl) aminobenzamido derivatives as delta-opiod receptor modulators |
| SE0203302D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203301D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| US7314880B2 (en) | 2003-01-02 | 2008-01-01 | Mount Cook Biosciences, Inc. | Cardioprotective delta opioid receptor agonists and methods of using same |
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| SE0300105D0 (sv) | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof |
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| US7576207B2 (en) * | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
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2004
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- 2004-10-01 JP JP2006534173A patent/JP4976134B2/ja not_active Expired - Fee Related
- 2004-10-01 KR KR1020067008451A patent/KR101255074B1/ko not_active Expired - Fee Related
- 2004-10-01 AU AU2004278414A patent/AU2004278414B2/en not_active Ceased
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- 2004-10-01 CN CN2009101634060A patent/CN101921279A/zh active Pending
- 2004-10-01 CN CNB2004800356909A patent/CN100549004C/zh not_active Expired - Fee Related
- 2004-10-01 CA CA002541014A patent/CA2541014A1/en not_active Abandoned
- 2004-10-01 BR BRPI0415165-8A patent/BRPI0415165A/pt not_active IP Right Cessation
- 2004-10-01 WO PCT/US2004/032479 patent/WO2005033073A2/en not_active Ceased
- 2004-10-01 EP EP04817130A patent/EP1675847B1/en not_active Expired - Lifetime
- 2004-10-01 US US10/957,554 patent/US7338962B2/en not_active Expired - Fee Related
- 2004-10-01 KR KR1020127001970A patent/KR20140015122A/ko not_active Abandoned
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- 2006-03-30 IL IL174702A patent/IL174702A/en not_active IP Right Cessation
- 2006-04-21 CO CO06037980A patent/CO5690640A2/es not_active Application Discontinuation
- 2006-04-28 ZA ZA200603414A patent/ZA200603414B/en unknown
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2007
- 2007-12-20 US US11/960,845 patent/US7638527B2/en not_active Expired - Fee Related
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- 2010-02-19 NZ NZ583451A patent/NZ583451A/en not_active IP Right Cessation
- 2010-03-05 US US12/718,439 patent/US8071611B2/en not_active Expired - Fee Related
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- 2011-10-17 US US13/274,616 patent/US20120165356A1/en not_active Abandoned
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