ZA200603177B - Benzazepine derivatives as MAO-B inhibitors - Google Patents
Benzazepine derivatives as MAO-B inhibitors Download PDFInfo
- Publication number
- ZA200603177B ZA200603177B ZA200603177A ZA200603177A ZA200603177B ZA 200603177 B ZA200603177 B ZA 200603177B ZA 200603177 A ZA200603177 A ZA 200603177A ZA 200603177 A ZA200603177 A ZA 200603177A ZA 200603177 B ZA200603177 B ZA 200603177B
- Authority
- ZA
- South Africa
- Prior art keywords
- benzo
- hydrogen
- benzyloxy
- tetrahydro
- compound
- Prior art date
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- 229910017604 nitric acid Inorganic materials 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
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- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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- 238000006798 ring closing metathesis reaction Methods 0.000 description 1
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- MEZLKOACVSPNER-GFCCVEGCSA-N selegiline Chemical group C#CCN(C)[C@H](C)CC1=CC=CC=C1 MEZLKOACVSPNER-GFCCVEGCSA-N 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
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- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
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- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
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- 208000011580 syndromic disease Diseases 0.000 description 1
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- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- TUQOTMZNTHZOKS-UHFFFAOYSA-N tributylphosphine Chemical compound CCCCP(CCCC)CCCC TUQOTMZNTHZOKS-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07D223/16—Benzazepines; Hydrogenated benzazepines
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- C07—ORGANIC CHEMISTRY
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
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- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| EP03024297 | 2003-10-23 |
Publications (1)
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| ZA200603177B true ZA200603177B (en) | 2007-09-26 |
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| ZA200603177A ZA200603177B (en) | 2003-10-23 | 2006-04-20 | Benzazepine derivatives as MAO-B inhibitors |
Country Status (19)
| Country | Link |
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| US (2) | US7173023B2 (zh) |
| EP (1) | EP1680127B1 (zh) |
| JP (1) | JP2007509094A (zh) |
| KR (1) | KR100856141B1 (zh) |
| CN (1) | CN100441188C (zh) |
| AR (1) | AR046133A1 (zh) |
| AT (1) | ATE411027T1 (zh) |
| AU (1) | AU2004283452A1 (zh) |
| BR (1) | BRPI0415842A (zh) |
| CA (1) | CA2543287A1 (zh) |
| CO (1) | CO5680409A2 (zh) |
| DE (1) | DE602004017206D1 (zh) |
| IL (1) | IL174845A0 (zh) |
| MX (1) | MXPA06004307A (zh) |
| NO (1) | NO20061907L (zh) |
| RU (1) | RU2006117366A (zh) |
| TW (1) | TWI254707B (zh) |
| WO (1) | WO2005039591A1 (zh) |
| ZA (1) | ZA200603177B (zh) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2423353C1 (ru) | 2002-12-20 | 2011-07-10 | Глэксо Груп Лимитед | Новые производные бензазепина |
| GB0408083D0 (en) * | 2004-04-08 | 2004-05-12 | Glaxo Group Ltd | Novel compounds |
| US20070293475A1 (en) * | 2006-06-20 | 2007-12-20 | Alcon Manufacturing Ltd. | Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma |
| FR2932800B1 (fr) * | 2008-06-20 | 2015-02-20 | Servier Lab | Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| KR101220182B1 (ko) * | 2009-02-25 | 2013-01-11 | 에스케이바이오팜 주식회사 | 치환된 아졸 유도체 화합물, 이를 포함하는 약제학적 조성물 및 이를 이용한 파킨슨씨 병 치료방법 |
| JP6346658B2 (ja) | 2013-03-14 | 2018-06-20 | ダート・ニューロサイエンス・（ケイマン）・リミテッド | Ｍａｏ阻害剤としての置換ナフチリジン及びキノリン化合物 |
| CN114437068A (zh) * | 2022-02-21 | 2022-05-06 | 深圳市儿童医院 | 一种萘啶衍生物及其作为单胺氧化酶抑制剂的用途 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DE1003753B (de) | 1953-11-07 | 1957-03-07 | Dr Karl Kindler | Verfahren zur Herstellung von N-Dialkylaminoacylaminophenolaethern |
| US3719669A (en) * | 1972-03-27 | 1973-03-06 | Pennwalt Corp | Amino(or amido)-phenyl-alkyl-benzazepine analgesics and narcotic antagonists |
| US4210749A (en) * | 1974-11-12 | 1980-07-01 | Pennwalt Corporation | Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines |
| US4348393A (en) * | 1978-06-09 | 1982-09-07 | Delalande S.A. | N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones |
| FR2500831A1 (fr) | 1981-02-27 | 1982-09-03 | Delalande Sa | Nouvelles n-aryl-oxazolidinones et -pyrrolidinones |
| US4524206A (en) * | 1983-09-12 | 1985-06-18 | Mead Johnson & Company | 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives |
| CA1261335A (en) * | 1984-08-29 | 1989-09-26 | Hoffmann-La Roche Limited/Hoffmann-La Roche Limitee | Ethylenediamine monoamide derivatives |
| HUT43322A (en) * | 1985-09-24 | 1987-10-28 | Schering Ag | Compositions with herbicidal effect comprising imidazolinyl derivatives as active substance and process for preparing the active substances |
| JPS6259973U (zh) | 1985-10-04 | 1987-04-14 | ||
| CA1332151C (en) | 1988-01-28 | 1994-09-27 | Roman Amrein | Use of a benzamide to treat cognitive disorder |
| DE3834861A1 (de) * | 1988-10-13 | 1990-04-19 | Basf Ag | Arylalkoxycumarine, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel |
| JPH02142774A (ja) | 1988-11-25 | 1990-05-31 | Mitsui Toatsu Chem Inc | ２−（４−置換フェニル）イミダゾリノン類、その製造法、およびそれらを有効成分として含有する除草剤 |
| FR2645019A1 (zh) | 1989-03-30 | 1990-10-05 | Fournier Innovation Synergie | |
| IL94466A (en) | 1989-05-25 | 1995-01-24 | Erba Carlo Spa | Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation |
| CA2090857A1 (en) | 1990-09-17 | 1992-03-18 | David A. Clark | 5-trifluoroacylamino-2-aryloxazoles 2-aryl-5-trifluoroacylaminooxazoles |
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-
2004
- 2004-10-14 EP EP04790400A patent/EP1680127B1/en active Active
- 2004-10-14 CA CA002543287A patent/CA2543287A1/en not_active Abandoned
- 2004-10-14 JP JP2006536004A patent/JP2007509094A/ja active Pending
- 2004-10-14 MX MXPA06004307A patent/MXPA06004307A/es not_active Application Discontinuation
- 2004-10-14 DE DE602004017206T patent/DE602004017206D1/de not_active Expired - Fee Related
- 2004-10-14 AT AT04790400T patent/ATE411027T1/de not_active IP Right Cessation
- 2004-10-14 AU AU2004283452A patent/AU2004283452A1/en not_active Abandoned
- 2004-10-14 WO PCT/EP2004/011541 patent/WO2005039591A1/en active Application Filing
- 2004-10-14 RU RU2006117366/04A patent/RU2006117366A/ru not_active Application Discontinuation
- 2004-10-14 KR KR1020067007779A patent/KR100856141B1/ko not_active IP Right Cessation
- 2004-10-14 BR BRPI0415842-3A patent/BRPI0415842A/pt not_active IP Right Cessation
- 2004-10-14 CN CNB2004800309236A patent/CN100441188C/zh not_active Expired - Fee Related
- 2004-10-18 US US10/967,567 patent/US7173023B2/en not_active Expired - Fee Related
- 2004-10-20 TW TW093131855A patent/TWI254707B/zh not_active IP Right Cessation
- 2004-10-21 AR ARP040103808A patent/AR046133A1/es unknown
-
2006
- 2006-04-06 IL IL174845A patent/IL174845A0/en unknown
- 2006-04-18 CO CO06036626A patent/CO5680409A2/es not_active Application Discontinuation
- 2006-04-20 ZA ZA200603177A patent/ZA200603177B/en unknown
- 2006-04-28 NO NO20061907A patent/NO20061907L/no not_active Application Discontinuation
-
2007
- 2007-01-12 US US11/652,970 patent/US20070117791A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL174845A0 (en) | 2006-08-20 |
| EP1680127A1 (en) | 2006-07-19 |
| KR20060061390A (ko) | 2006-06-07 |
| CN100441188C (zh) | 2008-12-10 |
| TWI254707B (en) | 2006-05-11 |
| KR100856141B1 (ko) | 2008-09-03 |
| US20070117791A1 (en) | 2007-05-24 |
| CN1871013A (zh) | 2006-11-29 |
| US7173023B2 (en) | 2007-02-06 |
| MXPA06004307A (es) | 2006-06-05 |
| RU2006117366A (ru) | 2007-12-10 |
| NO20061907L (no) | 2006-07-12 |
| BRPI0415842A (pt) | 2007-01-02 |
| WO2005039591A1 (en) | 2005-05-06 |
| AU2004283452A1 (en) | 2005-05-06 |
| EP1680127B1 (en) | 2008-10-15 |
| JP2007509094A (ja) | 2007-04-12 |
| AR046133A1 (es) | 2005-11-23 |
| CO5680409A2 (es) | 2006-09-29 |
| CA2543287A1 (en) | 2005-05-06 |
| US20050107360A1 (en) | 2005-05-19 |
| TW200524875A (en) | 2005-08-01 |
| ATE411027T1 (de) | 2008-10-15 |
| DE602004017206D1 (de) | 2008-11-27 |
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